Assignee: The Ohio State University Research Foundation

Location: Columbus, OH
No. of patents: 236

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Number	Title	Issue Date
8172969	Apparatus and method for ultrasonic processing of laminates A method for ultrasonic debulking a composite laminate includes the steps of defining a path across the laminate, the path having a starting location and an ending location and applying a force to and transmitting ultrasonic vibration into the laminate along the pat...	05/08/2012
8163263	Catalyst for the growth of carbon single-walled nanotubes Methods and processes for synthesizing single-wall carbon nanotubes are provided. A carbon precursor gas is contacted with metal catalysts deposited on a support material. The metal catalysts are preferably nanoparticles having diameters less than about 3 nm. The re...	04/24/2012
8153680	Alkyl indole-3-carbinol-derived antitumor agents Compounds and methods for treating cancer or inducing apoptosis in proliferating cells. The compounds are shown in formula I: wherein X is selected from hydroxyl, thiol, and amino; Y is selected from carboxyl and sulfonyl; ...	04/10/2012
8133828	Lanthanum oxide-doped glass-ceramics Glass-ceramic compositions exhibiting high reliability and tensile strength are described. The compositions can include crystal phases including roedderite and/or potassium fluorrichterite. The glass-ceramic compositions are bioactive, and can be used as components ...	03/13/2012
8114675	Room temperature CO sensor and method of making same Described are CO sensors, methods for making the CO sensors, and methods for using the CO sensors. An exemplary CO sensor includes a ruthenium oxide present in a form having one or more surfaces, a pair of conductive electrodes operatively connected to a surface of ...	02/14/2012
8110562	Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof This invention provides nuclear hormone receptor binding compounds, compositions comprising the same and methods of uses thereof in treating a variety of diseases or conditions in a subject, including, inter-alia, prostate cancer and/or diseases or disorders of bone...	02/07/2012
8084199	Method of diagnosing poor survival prognosis colon cancer using microRNA-21 The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. The invention also provides methods of identifying inhibitors of tumorigenesis. ...	12/27/2011
8080574	PDK-1/Akt signaling inhibitors Use of a new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I for inducing apoptosis in unwanted rapidly proliferating cells, for treating, inhibiting, or delaying the onset of cancer, and for preventing restenosis in a subject that has u...	12/20/2011
8080253	Chimeric VEGF peptides Compositions for and methods of treating patients with malignancies associated with overexpression of VEGF, particularly ovarian cancer are provided herein. The compositions include but are not limited to certain VEGF epitopes, multivalent peptides comprising the ep...	12/20/2011
8071292	Leukemia diagnostic methods The present invention provides methods and compositions for the diagnosis, prognosis and treatment of chronic lymphocytic leukemia (CLL). The invention also provides methods of identifying anti-CLL agents. ...	12/06/2011
8067368	Vascular endothelial growth factors and methods of their use Vascular endothelial growth factor alternative splice variants and methods of their use are provided. ...	11/29/2011
8066973	Nanoparticulate probe for in vivo monitoring of tissue oxygenation A new class of micro- and nano- particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. A...	11/29/2011
8053186	Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins. ...	11/08/2011
8039502	Anti-infective agents against intracellular pathogens A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I: wherein X wherein X is —CF3, Ar is selected from and R is selected from	10/18/2011
8038907	Aligned nanostructured polymers Novel, simple methods are presented directed to the synthesis of aligned nanofibers of polyaniline and substituted derivatives on a substrate. The production of these fibers is achieved via various methods by controlling the concentration of aniline monomer or subst...	10/18/2011
8034560	MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML) The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML). The invention also provides methods of identifying anti-AML agents. ...	10/11/2011
8022257	Methods for producing polyols using crude glycerin Methods for producing a polyols and polyurethanes are described. The polyols described herein can be produced directly from crude glycerin or through liquefaction of lignocellulosic biomass using a solvent comprising crude glycerin. The polyols produced in accordanc...	09/20/2011
8009115	Reconfigurable antenna using addressable conductive particles An antenna made up of small addressable conductive segments, or pixel elements, located in a dielectric space positioned over a two-dimensional pixel element actuator is presented. The small pixel elements can be actuated in less than a millisecond by the actuator t...	08/30/2011
7985584	MicroRNA fingerprints during human megakaryocytopoiesis The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of cancer and myeloproliferative disorders. The invention also provides methods of identifying anti-cancer agents. ...	07/26/2011
7973062	Androgen receptor-ablative agents Compounds of the thiazolidinedione family are provided and shown to be effective androgen receptor ablative agents that can be used in methods of treating or preventing cancer or precancer, including prostate cancer. Also provided are methods of treating or preventi...	07/05/2011
7960548	Keratinocyte growth factor receptor—tyrosine specific inhibitors for the prevention of cancer metastatis Compounds and methods for treating, inhibiting, or delaying the onset of cancer in a subject by administering a therapeutically effective amount of a keratinocyte growth factor receptor tyrosine kinase (KGFR TK) inhibitor to the subject in need of such treatment. Al...	06/14/2011
7954357	Driver plate for electromagnetic forming of sheet metal A multi-layer driver plate is disclosed for use in electromagnetic sheet metal forming operations. In one embodiment, the driver plate comprises a first layer characterized by low electrical resistivity and thickness for inducement and application of a suitable elec...	06/07/2011
7947251	Catalyst for hydrogen production from water gas shift reaction Fe—Al—Cu catalysts have numerous industrial applications, for example, as catalysts in a water gas shift reactor. A method of producing a Fe—Al—Cu catalyst comprises the steps of providing an organic iron precursor, dissolving the organic iron precursor in a...	05/24/2011
7943568	Antitumor agents Compounds and methods useful for the treatment of cancer in subjects in need of such treatment. The compounds are metabolites of the compound FK228 which have been identified as possessing HDAC inhibitory activity and anticancer properties. Further provided are comp...	05/17/2011
7943318	Microrna-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer. The invention also provide methods of identifying anti-lung cancer agents. ...	05/17/2011
7928145	Zn-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors Zn2+-chelating motif-tethered fatty acids as histone deacetylase (HDAC) inhibitors. Compounds performed well in in vitro and in vivo tests. ...	04/19/2011
7915043	CD34(+) cells and their methods of use The present invention provides isolated cells that are selectively enriched for hematopoietic progenitor cells that are precursors for natural killer (NK) cells. These cells are both CD34 and CD45RA positive and express C-integrin β7, and are referred to...	03/29/2011
7902569	Si/SiGe interband tunneling diodes with tensile strain Some disclosed interband tunneling diodes comprise a plurality of substantially coherently strained layers including layers selected from a group consisting of silicon, germanium, and alloys of silicon and germanium, wherein at least one of said substantially cohere...	03/08/2011
7888491	Outer membrane protein of and Diagnostic tools for for serodiagnosing ehrlichiosis in mammals, particularly in members of the Canidae family and in humans are provided. The diagnostic tools are a group of outer membrane proteins of E. chaffeensis and variants thereof, referred to hereinaf...	02/15/2011
7838519	Maytansinoid analogs as antitumor agents Ansamycin analogs, including maytansinoid analogs, and their use in treating cell proliferative diseases and conditions, and in particular, for use as antitumor agents. ...	11/23/2010
7829557	2-heterosubstituted 3-aryl-4H-1-benzopyran-4-ones as novel therapeutics in breast cancer The present invention provides 2-heterosubstituted 3-aryl-4H-benzopyran-4-one compounds for the treatment of cancers, namely breast cancer. This invention further provides a method of synthesis of 2-(alkylthio)isoflavones that can be carried out at ambient condition...	11/09/2010
7811796	Immobilization of enzyme on a fibrous matrix A multilayer enzyme immobilization process is provided comprising adsorbing a polyethyleneimine (PEI) solution in a fibrous matrix, and adding an enzyme to the fibrous matrix, which comprises a plurality of fibrils. The process further comprises forming at least two...	10/12/2010
7811590	outer membrane protein and use thereof in vaccination This invention relates to recombinant bacterial outer membrane proteins comprising one or more LB1(f) peptides from surface-exposed loop 3 of MOMP P5 of non-typeable H. influenzae. Polynucleotides encoding these recombinant proteins are also covered. The inve...	10/12/2010
7807810	Nucleic acids encoding the major outer membrane protein of the causative agent of human granulocytic ehrlichiosis and peptides encoded thereby The present invention relates to diagnostic tools for serodiagnosing HGE. The diagnostic tools are structurally related proteins, the “Group 44 proteins”, and to antibodies to such proteins. the Group 44 proteins comprise a single central hypervariable region of...	10/05/2010
7807705	Potent indole-3-carbinol-derived antitumor agents Compounds and methods for treating cancer and inducing apoptosis in unwanted rapidly proliferating cells. The compounds are shown in formula I: wherein X is hydroxyl or amino; Y is carboxyl or sulfonyl; R1, R	10/05/2010
7799197	Nanopump devices and methods A nanopump for pumping small volumes of electrolyte solution under the control of a voltage source is described. The device includes a chamber and a nanopore membrane which partitions the chamber into upstream and downstream regions. When a voltage potential is appl...	09/21/2010
7741520	Sulfonanilide analogs as selective aromatase modulators (SAMs) Compounds and methods suppressing aromatase activity expression in cancer cells. Provided are compounds are those of formula I: wherein R1 may be alkyl, cycloalkyl, haloalkyl, aryl, substituted aryl, haloaryl, al...	06/22/2010
7737433	Electronic junction devices featuring redox electrodes The electronic properties of molecular junctions of the general type carbon/molecule/TiO2/Au as examples of “molecular heterojunctions” consisting of a molecular monolayer and a semiconducting oxide. Junctions containing fluorene bonded to pyrolyzed p...	06/15/2010
7737123	Multidrug resistant anticancer anthracyclines Daunorubicin (“DNR”) compounds synthesized with uncommon sugars exhibit enhanced effectiveness in treating various drug-resistant cancers. ...	06/15/2010
7719265	Methods for determining particle size of metal nanocatalyst for growing carbon nanotubes Methods and processes for determining the particle size distribution of metal catalysts are provides. Superconducting Quantum Interference Device (SQUID) magnetometer is used to evaluate the magnetic catalyst particle sizes dispersed in the support material. Depende...	05/18/2010

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Assignee: The Ohio State University Research Foundation