Assignee: The NutraSweet Company

Location: Chicago, IL
No. of patents: 32

Number	Title	Issue Date
8034969	Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using 3,3-dimethylbutyraldehyde precursors N—[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of L-α-aspartyl-L-phenylalanine 1-methyl ester and 3,3-dimethylbutyraldehyde produced in situ by the hydrolysis or cleavage of a 3,3-dimethylbutyraldehyde precurso...	10/11/2011
7351867	Catalyst system for aerobic oxidation of primary and secondary alcohols The present invention relates to a process of oxidation of alcohols selectively to aldehydes or ketones with molecular oxygen using a TEMPO based catalyst, Fe-bipyridyl or Fe-phenantroline co-catalyst and N-bromosuccinimide promoter in acetic acid solvent. The oxida...	04/01/2008
7326430	Method of preparing liquid compositions for delivery of N-[N- (3,3-dimethylbutyl-L-α-aspartyl]-L-phenylalanine 1-methyl ester in food and beverage systems This invention provides a method for preparing a liquid composition of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester comprising the steps of (a) providing a liquid carrier; and (b) mixing N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalani...	02/05/2008
7288670	Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using 3,3-dimethylbutyraldehyde precursors N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of L-α-aspartyl-L-phenylalanine 1-methyl ester and 3,3-dimethylbutyraldehyde produced in situ by the hydrolysis or cleavage of a 3,3-dimethylbutyraldehyde precursor....	10/30/2007
7193103	Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester by treating N-(3,3-dimethylbutyl)-L-aspartic acid with ketones to give oxazolidinone derivatives, which are condensed with L-phenylalanine methyl ester. ...	03/20/2007
7030281	Synthesis of 3,3,-dimethylbutyraldehyde by the reduction of 3,3,-dimethylbutyric acid A process for the production of 3,3-dimethylbutyraldehyde is disclosed. The 3,3-dimethylbutyraldehyde is obtained by the reduction of 3,3-dimethylbutyric acid using trimethylacetic anhydride and a phosphine. The 3,3-dimethylbutyric acid is preferably obtained by a p...	04/18/2006
6852875	Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester by treating N-(3,3-dimethylbutyl)-L-aspartic acid with ketones to give oxazolidinone derivatives, which are condensed with L-phenylalanine methyl ester. ...	02/08/2005
6825384	Bromine free TEMPO based catalyst system for oxidation of primary and secondary alcohols using NaOCl as an oxidant The present invention relates to a process of oxidation of alcohols selectively to aldehydes or ketones with NaOCl using a TEMPO—borate catalyst system. It is shown that the oxidation can be efficiently carried out without KBr additives under solvent free conditio...	11/30/2004
6784309	Method for the purification of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester This invention relates to the purification of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester by slurrying a mixture containing N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester with organic or aqueous organic solvents.	08/31/2004
6720446	Catalyst modification to enhance neotame production Processes for using modified catalysts with improved functionality in the production of neotame are disclosed. The modified catalysts surprisingly have been found to improve the selectivity over conventional catalysts and to reduce the level of certain impurities in...	04/13/2004
6642406	Synthesis of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester using L-଱-aspartyl-L-phenylalanine 1-methyl ester precursors N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of a mixture of 3,3-dimethylbutyraldehyde and a precursor of L-଱-aspartyl-L-phenylalanine 1-methyl ester. In particular, N-[N-(3,3-dimethylbutyl...	11/04/2003
6627431	Chemoenzymatic synthesis of neotame A chemoenzymatic method is disclosed for preparing N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester via the enzymatic regioselective hydrolysis of neotame esters using lipases or esterases....	09/30/2003
6506434	Process for coating N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester onto a carrier The present invention relates to a process for coating N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester onto a carrier. The invention also relates to N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl est...	01/14/2003
6465677	Method for the preparation of N-neohexyl-଱-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates The synthesis of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester via conversion under reducing conditions of novel imidazolidinone(s) is disclosed....	10/15/2002
6423864	Purification of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester via crystallization N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester is crystallized in order to give highly pure product in high yield. In a preferred embodiment of the present invention, N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanin...	07/23/2002
6368651	Use of additives to modify the taste characteristics of N-neohexyl-଱-aspartyl-L-phenylalanine methyl ester This invention relates to the use of at least one taste modifying ingredient to modify at least one taste characteristic imparted by N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester, or neotame, compositions containing the same,...	04/09/2002
6365217	N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester agglomerate This invention provides a process for preparing an agglomerate of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester and a carrier including the steps of: (a) providing a premix solution containing N-[N-(3,3-dimethylbutyl)-L-...	04/02/2002
6365216	Particles of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester is converted from a light powder to relatively dustless, free-flowing particles with and without the use of binders using extrusion and spheronization processes. These particles a...	04/02/2002
6291004	Basic salts of n-[n-(3,3-dimethylbutyl)-l-଱-aspartyl]-l-phenylalanine 1-methyl ester Dipeptide sweeteners are disclosed that are basic salts of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester represented by the formula ##STR1## wherein Xm+ is selected from the group consisting of Na+, ...	09/18/2001
6281380	Synthesis of N-(N-(3,3-dimethylbutyl)-L-଱-aspartyl)L-phenylalanine1-methyl ester by reductive alkylation and crystallization/ isolation in aqueous methanol N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester is produced by reductive alkylation and crystallization/isolation in methanol and water. The production method is efficient and low cost, as compared with conventional N-[N-(...	08/28/2001
6225493	Metal ion assisted N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester isomer resolution This invention relates to the purification of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester by resolving a mixture of the alpha- and beta-isomers of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl e...	05/01/2001
6214402	Co-crystallization of sugar and n-[n-(3,3-dimethylbutyl)-l 댚spartyl]-l-phenylalanine 1-methyl ester This disclosure relates to the co-crystallization of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester with sugar in various ratios. The sugar co-crystallized sweetener is very soluble in water and has no dusting problems....	04/10/2001
6180157	Process for preparing an N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester agglomerate A process for preparing an agglomerate of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester and a carrier including the steps of: (a) providing a premix solution comprising N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phen...	01/30/2001
6180156	Acid salts of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester Dipeptide sweeteners are disclosed that are salts of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester represented by the formula ##STR1## wherein X- is selected from the group consisting of Cl-, HSO	01/30/2001
6146680	Metal complexes of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester Dipeptide sweeteners are disclosed that are metal complexes of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester represented by the formula ##STR1## wherein Xp+ is selected from the group consisting of Al3+	11/14/2000
6129942	Sweetener salts of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester Dipeptide sweeteners are disclosed that are sweetener salts of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester represented by the formula ##STR1## wherein Xm- is a conjugate base derived by deprotonation of an ...	10/10/2000
6077962	N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the process of preparing the same, and the process for preparing N-(N-(3,3-dimethylbutyl) -଱ L-aspartyl)-L- phenylalanine 1-methyl ester therefrom This invention relates to the chemical synthesis of N-[N-(3,3-dimethylbutyl)-L-଱-aspartyl]-L-phenylalanine 1-methyl ester using peptide coupling methods. The coupling reaction is conducted by condensation of an activated derivative of novel N-neohex...	06/20/2000
5994593	Synthesis and purification of 3,3-dimethylbutyraldehyde via hydrolysis of 1,1-dichloro-3,3-dimethylbutane or 1-bromo-1-chloro-3,3-dimethylbutane 3,3-Dimethylbutyraldehyde is synthesized via hydrolysis of 1,1-dichloro-3,3-dimethylbutane or 1-bromo-1-chloro-3,3-dimethylbutane in the presence of water and a base and is purified via an aldehyde/bisulfite adduct....	11/30/1999
5977415	Preparation of 3, 3-dimethylbutyraldehyde from a tert-butyl cation precursor, vinyl chloride and an acidic catalyst This invention provides a method for preparing 3,3-dimethylbutyraldehyde from a tert-butyl cation precursor and vinyl chloride. The tert-butyl cation precursor is contacted with vinyl chloride in the presence of an inorganic acid, and the product is allow...	11/02/1999
5973209	Method for preparing 3, 3-dimethybutyraldehyde A method is disclosed for preparing 3,3-dimethylbutyraldehyde by using silica gel to isomerize 3,3-dimethyl-1,2-epoxybutane, which in turn may be prepared by oxidation of dimethylbutene. Also disclosed is a method for oxidizing dimethylbutene with dimethy...	10/26/1999
5905175	Synthesis and purification of 3,3-dimethylbutyraldehyde via oxidation of 1-chloro-3,3-dimethylbutane with dimethyl sulfoxide 1-chloro-3,3-dimethylbutane is oxidized by dimethyl sulfoxide, in the presence of an effective amount of inorganic bromide or iodide, and in the present of an effective amount of base, to produce 3,3-dimethylbutyraldehyde....	05/18/1999
5856584	Preparation of 3,3-dimethylbutyraldehyde by oxidation of 3, 3-dimethylbutanol This invention provides a method for preparing 3,3-dimethylbutyraldehyde from 3,3-dimethylbutanol using an oxidizing component. In one embodiment, 3,3-dimethylbutanol is oxidized to 3,3-dimethylbutyraldehyde in the vapor phase by contacting it with an oxi...	01/05/1999

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Assignee: The NutraSweet Company