Assignee: The Johns Hopkins University School of Medicine

Location: Baltimore, MD
No. of patents: 191

Number	Title	Issue Date
8133986	Methylated CpG island amplification (MCA) The present invention provides a method for identifying a methylated CpG containing nucleic acid by contacting a nucleic acid with a methylation sensitive restriction endonuclease that cleaves unmethylated PcG sites and contacting the sample with an isoschizomer of ...	03/13/2012
8124830	Transgenic non-human animals expressing a truncated activin type II receptor The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF recept...	02/28/2012
8076073	Cholesterol and hedgehog signaling The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the i...	12/13/2011
8071733	Antibodies that specifically bind hedgehog-derived polypeptides The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic do...	12/06/2011
7981603	Methods for identifying cancer risk The present invention provides methods and kits for identifying an increased risk of developing cancer in a subject. The methods include analyzing a first biological sample, such as a blood sample, from the subject for loss of imprinting of the IGF2 gene. According ...	07/19/2011
7964342	Methods for analyzing methylated CpG islands and GC rich regions The present invention provides CpG islands and GC rich regions and methods for identifying methylation states for these CpG islands and GC rich regions. The present invention also provides methods for identifying genes regulated by these CpG islands and GC rich regi...	06/21/2011
7829333	Modulation of hedgehog-mediated signaling pathway The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provi...	11/09/2010
7795026	Methods for obtaining human embryoid body-derived cells The invention is directed to novel cells that are derived from human embryoid bodies. Such embryoid body-derived (EBD) cells are relatively uncommitted or progenitor (e.g., pluripotent) cells. EBD cells, while not immortal, display long-term proliferation in culture...	09/14/2010
7794929	Genomic screen for epigenetically silenced genes associated with cancer A method of identifying epigenetically silenced genes, e.g., methylation silenced genes, in cancer cells is provided. In addition, methods of identifying a cancer by detecting epigenetic silencing of gene expression are provided, as are methods of treating a subject...	09/14/2010
7781161	Genomic screen for epigenetically silenced tumor suppressor genes Methods of genomic screening to identify epigenetically silenced genes, including epigenetically silenced tumor suppressor genes are provided. Also provided are methods of detecting a cancer, for example, an esophageal squamous cell carcinoma or a head and neck squa...	08/24/2010
7749709	SOCS-1 gene methylation in cancer Methods are provided for identifying a cell exhibiting unregulated growth associated with methylation-silenced transcription of a suppressor of cytokine signaling (SOCS)/cytokine-inducible SH2 protein (CIS) family member (SOCS/CIS) gene such as the SOCS-1 gene. In a...	07/06/2010
7741451	Antibodies that specifically bind hedgehog-derived polypeptides The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic do...	06/22/2010
7732571	Chicken growth differentiation factor-8 Chicken growth differentiation factor-8 (GDF-8) is disclosed along with fragments and pharmaceutical compositions thereof. ...	06/08/2010
7700324	Methylated CpG island amplification (MCA) The present invention provides a method for identifying a methylated CpG containing nucleic acid by contacting a nucleic acid with a methylation sensitive restriction endonuclease that cleaves unmethylated CpG sites and contacting the sample with an isoschizomer of ...	04/20/2010
7655444	Method of predicting the clinical response to chemotherapeutic treatment with alkylating agents The present invention provides methods relating to chemotherapeutic treatment of a cell proliferative disorder. In particular, a method is provided for predicting the clinical response to certain types of chemotherapeutic agents. Alkylating agents, used for the trea...	02/02/2010
7611870	Methods for identifying cancer risk The present invention provides methods and kits for identifying an increased risk of developing cancer in a subject. The methods include analyzing a first biological sample, such as a blood sample, from the subject for loss of imprinting of the IGF2 gene. According ...	11/03/2009
7601521	Detection of nucleic acid mutation associated with cancer by analysis of saliva Methods for detection of a cell proliferative disorder, such as cancer, are provided utilizing analysis of target mutant nucleic acids in saliva specimens. The presence of the target mutant nucleic acids is indicative of a neoplastic disorder of the lung or the head...	10/13/2009
7589080	β-cyclodextrin compositions, and use to prevent transmission of sexually transmitted diseases Methods of reducing the risk of transmission of a sexually transmitted pathogen by contacting the pathogen or cells susceptible to infection by the pathogen with a β-cyclodextrin are provided. Methods for reducing the risk of transmission of a sexually transmitted ...	09/15/2009
7572906	Viral vectors and host cells and methods of making and using them The present invention provides a conditionally replicating viral vector, methods of making, modifying, propagating and selectively packaging, and using such a vector, isolated molecules of specified nucleotide and amino acid sequences relevant to such vectors, a pha...	08/11/2009
7572599	Metalloprotease activation of myostatin, and methods of modulating myostatin activity It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are prov...	08/11/2009
7566768	Promyostatin peptides and methods of using same The present invention provides substantially purified peptide portions of a promyostatin polypeptide. For example, the invention provides proteolytic fragments of a promyostatin polypeptide such as a myostatin prodomain or a mature myostatin peptide, as well as func...	07/28/2009
7553644	Detection and treatment of polycystic kidney disease Compositions useful for examining the PKD1 gene are provided. In addition, methods for detecting mutations of the PKD1 gene, which can be associated with autosomal dominant polycystic kidney disease in humans, are provided. Methods for diagnosing a mutant PKD1 gene ...	06/30/2009
7534432	Methods of treating musculodegenerative disease with an antibody that binds growth differentiation factor-8 Growth differentiation factor-8 (GDF-8) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-8 polypeptide and polynucleotide sequences. ...	05/19/2009
7524633	Method of detection of prostate cancer The present invention provides methods and kits useful for detecting neplasia by measuring the methylation level of biomarkers, especially the promoter region of GSTP1 for the detection of prostate adenocarcinoma. ...	04/28/2009
7521536	Glutamate transporter associated protein Glutamate Transporter Associated Proteins and nucleotide encoding Glutamate Transporter Associated Proteins are provided. Also provided is a method for identifying a compound that modulates a cellular response mediated by a Glutamate Transporter Associated Protein. ...	04/21/2009
7495075	Growth differentiation factor-16 Growth differentiation factor-16 (GDF-16) is disclosed along with its polynucleotide sequence and amino acid sequence Also disclosed are diagnostic and therapeutic methods of using the GDF-16 polypeptide and polynucleotide sequences. ...	02/24/2009
7427476	PITX2 polynucleotide, polypeptide and methods of use therefor A novel T-type calcium channel (CACNA1G) is provided, as are polynucleotides encoding the same. CACNA1G has been implicated in cellular proliferative disorders. More specifically, it has been observed that the methylation state of specific regions within CpG islands...	09/23/2008
7399848	Polynucleotides encoding growth differentiation factor-8 Disclosed are polynucleotides encoding growth differentiation factor-8 (GDF-8) useful for increasing the muscle mass in chickens. ...	07/15/2008
7393682	Polynucleotides encoding promyostatin polypeptides The present invention provides isolated polynucleotides encoding promyostatin polypeptides or a peptide portion thereof, polynucleotides complementary thereto, and oligonucleotides that can specifically hybridize to such polynucleotides. The present invention also p...	07/01/2008
7385086	Antimicrobial compounds This invention provides compounds and methods for treating, with said compound, a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R—SOn-Z-CO—Y, where R is an alkyl groups havi...	06/10/2008
7384753	Growth differentiation factor-11 Growth differentiation factor-11 (GDF-11) is disclosed along with its polynucleotide sequence and amino acid sequence. The invention provides a method for identifying a compound that affects GDF-11 activity or gene expression. ...	06/10/2008
7381528	Methods for detection of mutations in myostatin variants Methods for detecting allelic variants of the myostatin (growth and differentiation factor-8) gene are provided. Specifically provided are methods of identifying subjects having or having a predisposition for increased muscle mass as compared to subjects having wild...	06/03/2008
7378498	Protein encoded by a nucleic acid A method is provided for identifying a compound that modulates a cellualr response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mo...	05/27/2008
7371067	Simulation method for designing customized medical devices The invention provides a system for virtually designing a medical device conformed for use with a specific patient. Using the system, a three-dimensional geometric model of a patient-specific body cavity or lumen is reconstructed from scanned volume images such as o...	05/13/2008
7368109	Monoclonal antibodies against leukocyte adhesion receptor β-chain, methods of producing these antibodies and use therefore Monoclonal antibodies and method for ameliorating an immune response disorder. The monoclonal antibodies are specific for an epitope present on the leukocyte adhesion receptor β-chain. ...	05/06/2008
7348139	SOCS-1 gene methylation in cancer Methods are provided for identifying a cell exhibiting unregulated growth associated with methylation-silenced transcription of a suppressor of cytokine signaling (SOCS)/cytokine-inducible SH2 protein (CIS) family member (SOCS/CIS) gene such as the SOCS-1 gene. In a...	03/25/2008
7332575	Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species Purified GDF-8 polypeptides of aquatic organisms. ...	02/19/2008
7319036	Method for generating hypermutable organisms Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more...	01/15/2008
7279312	Nucleic acid mutation detection by analysis of saliva Methods for detection of a cell proliferative disorder, such as cancer, are provided utilizing analysis of target mutant nucleic acids in saliva specimens. The presence of the target mutant nucleic acids is indicative of a neoplastic disorder of the lung or the head...	10/09/2007
7270963	Growth differentiation factor, lefty-2 Growth differentiation factor, Lefty-2, is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the Lefty-2 polypeptide and polynucleotide sequences. ...	09/18/2007

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Assignee: The Johns Hopkins University School of Medicine