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| Number | Title | Issue Date |
| 8168771 | Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants The invention provides consensus sequences for hepatitis C virus 1a and 1b. Also provided are non-synonymous changes for each residue of the consensus sequences. These sequences are useful as compositions or vaccines for prophylactic use or treating HCV-infected ind... | 05/01/2012 |
| 8160338 | X-ray CT apparatus and myocardial perfusion image generating system An apparatus includes a transformation table acquiring unit, a blood-flow information acquisition unit and a blood-flow image generating unit. The transformation table acquiring unit obtains a transformation table for transforming unspecified information representin... | 04/17/2012 |
| 8153595 | B7-DC variants immunogenic compositions and methods of use thereof Compositions and methods for costimulating T cells (i.e., increasing antigen-specific proliferation of T cells, enhancing cytokine production by T cells, stimulating differentiation ad effector functions of T cells and/or promoting T cell survival) are provided. Sui... | 04/10/2012 |
| 8152756 | Active cannula for bio-sensing and surgical intervention Disclosed is a surgical needle, or active cannula, that is capable of following a complex path through cavities and tissue within a patient's anatomy. The needle has a plurality of overlapping flexible tubes, each of which has a pre-formed curvature and a pre-determ... | 04/10/2012 |
| 8148577 | Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors Polyamine, polyamine/guanidino, and polyamine/biguanide compounds are disclosed. The compounds are useful as anti-cancer and anti-parasitic treatments. The compounds are also useful as inhibitors of the enzyme lysine-specific demethylase-1. ... | 04/03/2012 |
| 8148347 | Inhibition of interaction of PSD93 and PSDS95 with nNOS and NMDA receptors PSD-95/SAP90 antisense-treated animals not only experience a significant decrease in MAC for isoflurane, but also experience an attenuation in the NMDA-induced increase in isoflurane MAC. PSD-95/SAP90 appears to mediate the role of the NMDA receptor in determining t... | 04/03/2012 |
| 8148095 | Methods for predicting psychotropic drugs which elicit weight gain The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We found that orexigenic AAPDs potently and selectively activate hypothalamic AMP kinase ... | 04/03/2012 |
| 8137962 | Compositions for treating cystic fibrosis The invention relates to compositions and methods of treating cystic fibrosis. More specifically, this invention relates to the use the AAV vectors and constructs to provide gene therapy to cystic fibrosis patients. ... | 03/20/2012 |
| 8137908 | Mesothelin vaccines and model systems Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either polynucleotide- or polypeptide-based. Carriers for raising a cytolytic T cell res... | 03/20/2012 |
| 8123742 | Catheter and method for ablation of atrial tissue Featured is a catheter device for ablating tissue that includes an elongated body member having a distal portion and a deflection mechanism operably coupled to the distal portion so as to cause the distal portion to deflect with respect to a longitudinal axis of the... | 02/28/2012 |
| 8114619 | Methods for diagnosis and optimizing treatment of multiple sclerosis Biological markers for multiple sclerosis, and their use in the diagnosis and prognosis of the disease, are described. Also described are methods for treating multiple sclerosis by administering an inhibitor of cathepsin B activity or a neuroprotective composition c... | 02/14/2012 |
| 8110356 | Method for generating hypermutable plants Blockade of mismatch repair in a plant can lead to hypermutation and a new genotype and/or phenotype. One approach used to generate hypermutable plants is through the expression of dominant negative alleles of mismatch repair genes in transgenic plants or derived ce... | 02/07/2012 |
| RE43152 | Method and apparatus for segmenting small structures in images A method for segmenting a small feature in a multidimensional digital array of intensity values in a data processor computes an edge metric along each ray of a plurality of multidimensional rays originating at a local intensity extreme (local maximum or minimum). A ... | 01/31/2012 |
| 8094810 | Unidirectional proxy re-encryption A method for performing unidirectional proxy re-encryption includes generating a first key pair comprising a public key (pk) and a secret key (sk) and generating a re-encryption key that changes encryptions under a first public key pka into encryptions un... | 01/10/2012 |
| 8094081 | Dual band radio frequency (RF) and optical communications antenna and terminal design methodology and implementation A dual-band antenna is provided that combines two normally disparate communications modes into a single compact aperture minimizing overall mass and volume, while maintaining high performance efficiency and reciprocity of each individual mode. The antenna is compati... | 01/10/2012 |
| 8093261 | Rapid release mini-tablets provide analgesia in laboratory animals Pellets containing an analgesic uniformly dispersed in a lipid carrier such as cholesterol mixed with fatty acid esters, can be used to provide long term pain relief. 5 mg cholesterol-tryglyceride-buprenorphine pellets released the majority of drug in 24-48 hours af... | 01/10/2012 |
| 8093013 | Claudins as markers for early detection, diagnosis, prognosis and as targets of therapy for breast and metastatic brain or bone cancer Methods of diagnosis, prognosis, and treatment of breast cancer, and of metastatic brain cancer, are provided The diagnostic and prognostic methods involve the immunohistochemical detection of the level of expression of the proteins claudin 1, 3, 4, and 7 in tissue ... | 01/10/2012 |
| 8091429 | Apparatus and method for high frequency low pressure arc flash sensor A pressure sensor for detecting an electric arc in an electrical switchboard, the sensor being in an enclosed case containing a conical opening, the case being placed in the switchboard. A pressure switch in the sensor is attached to the interior of the case and is ... | 01/10/2012 |
| 8088621 | Adenoviral fiber exchange shuttle system The instant invention provides methods and compositions for generating recombinant adenoviral vectors. The invention also provides kits comprising for the generation of recombinant adenoviral vectors. ... | 01/03/2012 |
| 8088074 | Cerebral vascular reactivity monitoring A monitoring device may include logic to receive arterial blood pressure data associated with a patient and receive tissue hemoglobin data associated with the patient. The logic may also calculate a linear correlation between the arterial blood pressure data and the... | 01/03/2012 |
| 8081991 | Wireless based positioning method and apparatus A system and method is described herein to determine the physical location of a user within an edifice. At least three wireless access points, for example, 802.11 nodes, receives and transmits information to a handheld device in order to determine the location infor... | 12/20/2011 |
| 8080533 | Hypoxia induced mitogenic factor We found that FIZZ1/RELMα is inducible by hypoxia in lung. The hypoxia-upregulated expression of FIZZ1/RELMα was located in the pulmonary vasculature, bronchial epithelial cells, and type II pneumocytes. Recombinant FIZZ1/RELMα protein stimulates rat pulmonary mi... | 12/20/2011 |
| 8080367 | Regulation of cell survival by HSP90 and IP6K2 Anti-cancer drugs are identified by screening for agents and compounds which inhibit the binding of HSP90 and IP6K2. In vitro and in vivo assays can be used. Any phenomenon associated with the binding or inhibition can be monitored, including cell death, subcellular... | 12/20/2011 |
| 8080235 | Protein kinase A reporters useful in high throughput assays Protein kinase A reporters useful for obtaining measurements of protein kinase A activity with high spatial and temporal resolution can be used in high throughput assays to identify potentially therapeutic compounds. ... | 12/20/2011 |
| 8078262 | Method for imaging and spectroscopy of tumors and determination of the efficacy of anti-tumor drug therapies The present invention relates to methods of passive infrared imaging and dynamic infrared imaging of a tumor or lesion (“DIR”) where multiple images are taken before, during and after heating or cooling the tumor or lesion. Patterns of intensity of infrared emis... | 12/13/2011 |
| 8071304 | Methods for detecting a polymorphism in the NFKB1 gene promoter The present invention discloses a functional relationship between a recognized disease condition and a polymorphism in the nucleotide factor kappa B promoter (NFKB1). This relationship provides a platform for methods of altering promoter activity and for determining... | 12/06/2011 |
| 8067608 | Hedgehog pathway antagonists Aromatic compounds for treating various diseases and pathologies are disclosed. The methods use of such compounds are also provided. Accordingly, the present invention makes available methods and compositions for inhibiting aberrant growth states resulting from hedg... | 11/29/2011 |
| 8063818 | Cross-PRN phase correction for GPS processing Methods and systems are provided for accessing GPS signals in faded environments. Means are provided for predicting the nonlinear phase induced by the receiver's own clock, when there is at least one GPS satellite link strong enough to calculate a phase profile. In ... | 11/22/2011 |
| 8062849 | Quantitative multiplex methylation-specific PCR Methods are provided for diagnosing in a subject a condition, such as a carcinoma, sarcoma or leukemia, associated with hypermethylation of genes by isolating the genes from tissue containing as few as 50 to 1000 tumor cells. Using quantitative multiplex methylation... | 11/22/2011 |
| 8061262 | Pneumatic stepper motor A stepper motor suitable for use in a medical imaging environment has (a) a cylindrical central gear having an external surface with circumferentially distributed and radially directed teeth, (b) a shaft for mounting the central gear such that it is constrained to m... | 11/22/2011 |
| 8060195 | Devices, systems and methods for bioimpedance measurement of cervical tissue and methods for diagnosis and treatment of human cervix Featured are apparatuses for measuring bioimpendence of tissues of the cervix, more specifically the mammalian cervix. Also featured are methods for examining the tissues of the cervix for clinical or diagnostic purposes such as during routine gynecological examinat... | 11/15/2011 |
| 8058208 | Process for preparing molecularly imprinted polymer ion exchange resins A molecularly imprinted polymer ion exchange resin for selectively removing one or more inorganic ions in a liquid medium is disclosed and described. The exchange resin can include a bead having a porous structure and comprising a cross-linked molecularly imprinted ... | 11/15/2011 |
| 8054182 | Remotely directed vehicle inspection method and apparatus A method of inspecting a vehicle, comprising providing at an inspection site a hand-held inspection wand that transceives audio-visual information with a command/remote site a safe distance from the inspection site and that is staffed by law enforcement personnel, s... | 11/08/2011 |
| 8054075 | Method for magnetic resonance imaging using inversion recovery with on-resonant water suppression including MRI systems and software embodying same Featured are methods for magnetic resonance imaging of a volume, such a volume having susceptibility-generating objects or interfaces having susceptibility mismatches therein. Such a method includes selectively visualizing one of susceptibility-generating objects or... | 11/08/2011 |
| 8053558 | Dendritic cell co-stimulatory molecules A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transfo... | 11/08/2011 |
| 8053414 | Methods of using B7-DC molecules to induce or enhance an immune response A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transfo... | 11/08/2011 |
| 8048627 | Method and compositions for detection and enumeration of genetic variations Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. Each DNA molecule in a collection of such mole... | 11/01/2011 |
| 8039210 | Protein tyrosine phosphatase mutations in cancers Tyrosine phosphorylation, regulated by protein tyrosine phosphatases (PTPs) and kinases (PTKs), is important in signaling pathways underlying tumorigenesis. A mutational analysis of the tyrosine phosphatase gene superfamily in human cancers identified 83 somatic mut... | 10/18/2011 |
| 8034609 | Ablation based laser machining of biomolecule patterns on substrates A method for patterning a one or more biomolecules on a substrate that includes coating the substrate with a coating of the one or more biomolecules, applying a laser to the coating, and ablating a portion of the one or more biomolecules with the laser in a predeter... | 10/11/2011 |
| 8030356 | N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including... | 10/04/2011 |
