Celebrity Inventors
Glam girl Heddy Lamar may have used her good looks to good effect on the silver screen, but she put her smarts to better use as an inventor. During World War II, she co-patented a frequency-switching system for torpedo guidance that was considered years ahead of its time.
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| Number | Title | Issue Date |
| 8030300 | Ligands for nicotinic acetylcholine receptors, and methods of making and using them One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the invention for modulation of a mammalian nicotinic acetylcholine rec... | 10/04/2011 |
| 8003618 | Focal calcium channel modulation Disclosed is an invention for focally modulating the activity of a calcium channel in a mammal. In one aspect, the invention features a method that includes contacting a pre-determined tissue or organ region with a nucleic acid sequence encoding a GEM protein or a v... | 08/23/2011 |
| 7985736 | High throughput screen utilizing newly discovered intramolecular neuronal calcium channel interactions to discover new analgesics The present invention relates to compositions to treat CaV2 disorders. The invention also relates to methods treating CaV2 disorders. The invention further relates to kits for treating CaV2 disorders in a subject. The invention furth... | 07/26/2011 |
| 7901881 | Diagnostic tool for diagnosing benign versus malignant thyroid lesions The present invention relates to the use of genes differentially expressed in benign thyroid lesions and malignant thyroid lesions for the diagnosis and staging of thyroid cancer. ... | 03/08/2011 |
| 7901357 | Robotic 5-dimensional ultrasound A robotic 5D ultrasound system and method, for use in a computer integrated surgical system, wherein 3D ultrasonic image data is integrated over time with strain (i.e., elasticity) image data. By integrating the ultrasound image data and the strain image data, the p... | 03/08/2011 |
| 7867492 | Compounds for hedgehog pathway blockade in proliferative disorders, including hematopoietic malignancies Elevated Hedgehog (Hh) pathway activity, including ligand stimulated Hh pathway activity, was detected in hematopoietic malignancy cells, and determined to be associated with growth and proliferation of the malignancy cells. Accordingly, methods are provided for tre... | 01/11/2011 |
| 7833732 | Acute renal injury We disclose a new and useful biomarker for acute kidney injury (i.e., AKI), renal ischemia reperfusion injury (i.e., IRI), ischemic acute kidney injury, and/or ischemic acute tubular necrosis (i.e., ATN). The biomarker is GRO-alpha (i.e., CXCL1, chemokine C-X-C liga... | 11/16/2010 |
| 7776565 | Engineering intracellular sialylation pathways Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable ... | 08/17/2010 |
| 7759121 | Methods for generating hypermutable yeast Yeast cells are mutagenized to obtain desirable mutants. Mutagenesis is mediated by a defective mismatch repair system which can be enhanced using conventional exogenously applied mutagens. Yeast cells with the defective mismatch repair system are hypermutable, but ... | 07/20/2010 |
| 7745165 | Phosphatase associated with metastasis Among the genes identified, in a comparison of the global gene expression profile of metastatic colorectal cancer to that of primary cancers, benign colorectal tumors, and normal colorectal epithelium, the PRL-3 protein tyrosine phosphatase gene was of particular in... | 06/29/2010 |
| 7723505 | EAAT2 promoter and uses thereof The present invention provides nucleic acid molecules comprising the EAAT2 promoter, as well as screening assays useful for identifying compounds which modulate the activity of the EAAT2 promoter, and methods of treating neurological disorders comprising administrat... | 05/25/2010 |
| 7646299 | Anti-tampering security material Security material such as cloth, either normal strength or armored, or fragile webbing into which electronic micro-devices are woven to detect and react to tampering of the monitored article at the scene or via a network. Also disclosed are the use of fuses connecte... | 01/12/2010 |
| 7601533 | Reverse two-hybrid systems Disclosed are methods for identifying molecular interactions (e.g., protein/protein, protein/DNA, protein/RNA, or RNA/RNA interactions). All of the methods within the invention employ counterselection and at least two hybrid molecules. Molecules which interact recon... | 10/13/2009 |
| 7574497 | System and method for an open autonomy kernel (oak) The Open Autonomy Kernel (OAK) addresses critical infrastructure requirements for next generation autonomous and semi-autonomous systems (24), including performance tracking, anomaly detection, diagnosis, fault recovery, and plant “safing”. OAK combines t... | 08/11/2009 |
| 7510842 | Biomarker for ovarian and endometrial cancer: hepcidin The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status as well as endometrical cancer status in a patient. In particular, it has been found that hepcidin is a biomarker for both ovarian ... | 03/31/2009 |
| 7504493 | Characterization of the yeast transcriptome Yeast genes which are differentially expressed during the cell cycle are described. They can be used to study, affect, and monitor the cell cycle of a eukaryotic cell. They can be used to obtain human homologs involved in cell cycle regulation. They can be used to i... | 03/17/2009 |
| 7326778 | Mutator gene and hereditary non-polyposis colorectal cancer The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the seque... | 02/05/2008 |
| 7297837 | Method for generating hypermutable organisms Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more... | 11/20/2007 |
| 7294476 | Isoform specific inhibition for treatment of pain and reduction of anesthetic threshold Several lines of evidence have shown a role for the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway in the development of spinal hyperalgesia. However, the roles of effectors for cGMP are not fully understood in the processing of pain in th... | 11/13/2007 |
| 7282915 | Multi-turn element RF coil array for multiple channel MRI An RF coil assembly for use in a multiple receive-channel MRI system is provided. The RF coil assembly is configured as a multi-turn-element RF coil assembly to operate as a surface-coil array in cooperation with the MRI system which is configured to operate in a mu... | 10/16/2007 |
| 7247116 | Planetary motor A motor suitable for use in a medical imaging environment has (a) a cylindrical outer gear having a bore with a centerline and an internal surface with circumferentially distributed and radially directed teeth, (b) a means for mounting this outer gear such that it i... | 07/24/2007 |
| 7132275 | Multifunctional magnetic nanowires The invention provides multisegmented, multifunctional magnetic nanowires for the probing and manipulation of molecules at the cellular and subcellular level. The different segments of the nanowire may have differing properties, including a variety of magnetic, non-... | 11/07/2006 |
| 7088104 | MRI tunable antenna and system A strip array antenna including a number of conductors (14) that are connected to ground or virtual ground though at least one reactive component (150). The apparent electrical length of conductors (140) is tuned so that it equals an integer mul... | 08/08/2006 |
| 7033768 | Reverse two-hybrid systems Disclosed are methods for identifying molecular interactions (e.g., protein/protein, protein/DNA, protein/RNA, or RNA/RNA interactions). All of the methods within the invention employ counterselection and at least two hybrid molecules. Molecules which interact recon... | 04/25/2006 |
| 7021173 | Remote center of motion robotic system and method A remote center of motion robotic system including a base unit and a plurality of linking units. The base unit is rotatable about a first axis. The plurality of linking units are coupled with one another. At least two of the linking units are kept parallel to each a... | 04/04/2006 |
| 7019875 | Method and apparatus for single-photon source and quantum memory An optical switch and optical storage loop are used as the basis of a single-photon source and a quantum memory for photonic qubits. To operate as a single-photon source, the techniques include a source of a pair of photons, such as a parametric down-conversion crys... | 03/28/2006 |
| 7003155 | System and method for creating unclassified line drawings from classified NTM images A system and method of automatically creating a NIMA certified line drawing from a National Imagery Transmission Format (NITF) image file. A grayscale (electro-optical) image and its associated metadata from a NITF file is input into the computer based system. Pre-s... | 02/21/2006 |
| 6934630 | GPS receiver tracking system A receiving station tracking system for receiving GPS data and tracking a mobile vehicle. The receiving station tracking system includes at least one processing stage receiving and processing at least a portion of the GPS data, and a control module receiving and fil... | 08/23/2005 |
| 6841263 | Method of adhering a solid polymer to a substrate and resulting article An improved method for adhering a solid polymer component to a substrate is provided. An intermediate polymer adhesion promoting coating of metal oxide is applied to the substrate which enhances the adhesion of the subsequently applied solid polymer component to the... | 01/11/2005 |
| 6675166 | Integrated multidimensional database A method of distributing research data from a common database to a user of the common database is provided. Data concerning research results and data upon which the research results are based are stored in a local database and are linked to each other. Da... | 01/06/2004 |
| 6589190 | Quantification of muscle tone A method and device for the quantification of muscle tone, particularly the wrist, wherein non-sinusoidal and non ramp trajectories are used to drive the wrist. Equation 1 is utilized determine the stiffness, viscosity and inertial parameters. ͌s | 07/08/2003 |
| 6504014 | Tissue specific prodrug The invention provides novel peptide prodrugs which contain cleavage sites specifically cleaved by prostate specific antigen (PSA). These prodrugs are useful for substantially inhibiting the non-specific toxicity of a variety of therapeutic drugs. PSA is ... | 01/07/2003 |
| 6492143 | Olfactory receptor expression libraries and methods of making and using them This invention provides novel libraries of olfactory receptor odorant/ligand-binding domains and methods of making and using them. The invention also provides libraries of vectors and cells comprising these nucleic acid constructs. The compositions and me... | 12/10/2002 |
| 6369383 | Flexboard reflector A novel technique utilizing the precision of printed circuit board design and the physical versatility of thin, flexible substrates is disclosed to produce a new type of ion reflector. A precisely defined series of thin conductive strips (traces) are etch... | 04/09/2002 |
| 6309969 | Copper metallization structure and method of construction The invention is directed to the use of copper as via and interconnect structures for an integrated circuit. The process in accordance with a preferred embodiment produces an interconnect layer of continuous copper with superior adhesion while requiring o... | 10/30/2001 |
| 6183126 | Method for nondestructive/noncontact microwave detection of electrical and magnetic property discontinuities in materials Nondestructive/noncontact evaluation of a material for electrical and magnetic property discontinuities, e.g., a dielectric loss or the presence of a conducting contaminant, is accomplished by using microwaves to heat microwave-absorbing regions of the ma... | 02/06/2001 |
| 6171467 | Electrochemical-control of abrasive polishing and machining rates An apparatus and method is disclosed; both of which use electrochemistry to selectively grow and remove hard oxide coatings on metals, and capacitive double layers on non-metals and semiconductors in order to predict and control the rate of surface abrasi... | 01/09/2001 |
| 6150160 | Compositions and methods of use of mammalian retrotransposons The invention relates to an isolated DNAc molecule comprising a promoter P and an L1 cassette sequence comprising a core L1 retrotransposon element and methods of use thereof.... | 11/21/2000 |
| 6117641 | Assays and reagents for identifying anti-fungal agents and uses related thereto The present invention relates to rapid, reliable and effective assays for screening and identifying pharmaceutically effective compounds that specifically inhibit the biological activity of fungal GTPase proteins, particularly GTPases involved in cell wal... | 09/12/2000 |
| 6022544 | Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry The invention features a method for reducing an undesired antibody response in a mammal by administering to the mammal a non-immunogenic construct which is free of high molecular weight immunostimulatory molecules. The construct which contains at least tw... | 02/08/2000 |
