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| Number | Title | Issue Date |
| 8148128 | Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity This invention provides novel chemically modified mutant serine hydrolases that catalyze a transamidation and/or a transpeptidation and/or a transesterification reaction. The modified serine hydrolases have one or more amino acid residues in a subsite replaced with ... | 04/03/2012 |
| 8143375 | Aziridine aldehydes, aziridine-conjugated amino derivatives, aziridine-conjugated biomolecules and processes for their preparation The present invention relates to unprotected amino aldehydes and applications for same. More particularly, the present invention relates to novel aziridine aldehydes and processes for preparing these novel compounds. The invention also relates to aziridine-conjugate... | 03/27/2012 |
| 8067224 | Presenilin associated membrane protein (PAMP) and uses thereof Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided. PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and treating or preventing neurodegenerative diseases. In a specific embodiment,... | 11/29/2011 |
| 8053239 | Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures A method for extracting proteins from heterogeneous fluids by precipitation using microfluidics. The method uses an automated protocol for precipitation of proteins onto surfaces, rinsing the precipitates to remove impurities, and resolubilization in buffer for furt... | 11/08/2011 |
| 7846679 | Methods for detecting the presence of mutant mammalian presenilin protein The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcri... | 12/07/2010 |
| 7838247 | Antibody specific for mutant presenilin 2 and method of use thereof The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcri... | 11/23/2010 |
| 7767879 | Transgenic animal model of neurodegenerative disorders The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology of the disease as well as for provide a system for the development and... | 08/03/2010 |
| 7758919 | Method of self-assembly and optical applications of crystalline colloidal patterns on substrates This invention describes methods of synthesis and applications of a composite material of a colloidal crystal and a substrate. The method includes steps of (a) providing a substrate having a surface with a surface relief pattern; and (b) applying a liquid dispersion... | 07/20/2010 |
| 7507798 | Antibody specific for mutant presenilin 1 The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcri... | 03/24/2009 |
| 7439326 | Presenilin associated membrane protein (PAMP)and uses thereof Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided. PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and treating or preventing neurodegenerative diseases. In a specific embodiment,... | 10/21/2008 |
| 7371920 | Transgenic mouse model of neurodegenerative disorders The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology of the disease as well as for provide a system for the development and... | 05/13/2008 |
| 7364673 | Widely wavelength tuneable polychrome colloidal photonic crystal device The present invention discloses a widely wavelength tunable polychrome colloidal photonic crystal device whose optical Bragg diffraction stop bands and higher energy bands wavelength, width and intensity can be tuned in a continuous and fine, rapid and reversible, r... | 04/29/2008 |
| 7307905 | Low leakage asymmetric SRAM cell devices Asymmetric SRAM cell designs exploiting data storage patterns found in ordinary software programs wherein most of the bits stored are zeroes for data and instruction streams. The asymmetric SRAM cell designs offer lower leakage power with little impact on latency. I... | 12/11/2007 |
| 7247349 | Method of self-assembly and optical applications of crystalline colloidal patterns on substrates This invention describes methods of synthesis and applications of planarized photonic crystals. Provided are simple, quick, reproducible and inexpensive methods that combine self-assembly and lithography to achieve the first examples of vectorial control of thicknes... | 07/24/2007 |
| 7235383 | Alzheimer's related proteins and methods of use Disclosed is a method for identifying substances that alter the interaction of a presenilin protein with a presenilin-binding protein, including contacting at least the interacting domain of a presenilin protein to a presenilin-binding protein in the presence of a t... | 06/26/2007 |
