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| Number | Title | Issue Date |
| 8138141 | HMG1 antibody for treating inflammatory conditions There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method f... | 03/20/2012 |
| 8129130 | High affinity antibodies against HMGB1 and methods of use thereof Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifical... | 03/06/2012 |
| 8119340 | Methods and compositions for diagnosis and treatment of B cell chronic lymphocytic leukemia Provided are isolated and purified preparations of a combination of a light chain antibody gene and a heavy chain antibody gene, where the light chain and heavy chain antibody genes are the same among more than one patient with B cell chronic lymphocytic leukemia (B... | 02/21/2012 |
| 8080632 | Peptide mimics of melanocyte stimulating hormone Provided are peptides having melanocyte stimulating hormone activity. Also provided are vectors encoding these peptides and transgenic cells comprising the above vectors. Additionally, methods of reducing or preventing release of an inflammatory cytokine from mammal... | 12/20/2011 |
| 8053206 | Antagonists of HMG1 for treating inflammatory conditions There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method f... | 11/08/2011 |
| 8003632 | Cholinesterase inhibitors for treating inflammation A method of treating a subject with a cytokine-mediated inflammatory disorder comprising administering to the subject an effective amount of a pharmaceutically acceptable cholinesterase inhibitor, provided that the inhibitor is not galantamine. ... | 08/23/2011 |
| 7910299 | Methods for diagnosing systemic lupus erythematosus The invention relates to methods and materials involved in diagnosing SLE. More particularly, the invention relates to methods and materials involved in diagnosing SLE, diagnosing severe SLE, and assessing a mammal's susceptibility to develop severe SLE. For example... | 03/22/2011 |
| 7897569 | Use of HMGB fragments as anti-inflammatory agents Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMGB A box, and an antibody preparation t... | 03/01/2011 |
| 7842461 | CD38 as a prognostic indicator in B cell chronic lymphocytic leukemia The subject invention discloses a method for determining the prognosis and probable clinical course of a subject diagnosed with B-CLL. Specifically, the invention involves comparing CD38 expression in a biological sample from the subject containing B-CLL cells to a ... | 11/30/2010 |
| 7829097 | Use of HMGB1 for protection against ischemia reperfusion injury Methods and compositions are disclosed for protecting an organ or tissue from inflammation and organ injury following ischemia, reperfusion, and trauma through the administration of an HMGB1 protein within a time period sufficient to protect the organ or tiss... | 11/09/2010 |
| 7807696 | Isoxazole and isothiazole compounds useful in the treatment of inflammation Compounds of Formula (I), pharmaceutical compositions comprising compounds of Formulae (I a) or (VII) and a method of treating a subject with an inflammatory cytokine-mediated disorder comprising administering to the subject a compound of Formulae (I a) or (VII a). ... | 10/05/2010 |
| 7785808 | Treatment of inflammation using α7 receptor-binding cholinergic agonists A method of treating a patient suffering from pancreatitis comprising treating said patient with a therapeutically effective amount of a cholinergic agonist selective for an α7 nicotinic receptor in an amount sufficient to decrease the amount of the proinflammatory... | 08/31/2010 |
| 7749959 | Use of HMGB fragments as anti-inflammatory agents Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMGB A box, and an antibody preparation t... | 07/06/2010 |
| 7696169 | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents The invention features a method of treating an inflammatory condition in an individual, comprising administering an agent inhibits the interaction between a Toll-like receptor 2 (TLR2) and a high mobility group B (HMGB) polypeptide to the individual. The invention a... | 04/13/2010 |
| 7572446 | Antagonists of HMG1 for treating inflammatory conditions There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method f... | 08/11/2009 |
| 7571055 | Systemic lupus erythematosus This document relates to methods and materials involved in diagnosing SLE. For example, this document relates to methods and materials involved in diagnosing SLE, diagnosing severe SLE, and assessing a mammal's susceptibility to develop severe SLE. For example, this... | 08/04/2009 |
| 7537908 | Methods of diagnosing sepsis by measuring HMG1 There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method f... | 05/26/2009 |
| 7413861 | Methods for predicting increase sperm ejaculate in a varicocele associated fertility patient The present invention provides a method for predicting whether a patient having varicocele-associated infertility will have an increase in sperm in the ejaculate after varicocele repair surgery. In the method of the present invention, the present or absence of undel... | 08/19/2008 |
| 7329643 | Inhibition of HMGB1 release by fetuin Methods of inhibiting HMGB1 release by a mammalian cell are provided. The methods comprise treating the cell with sufficient fetuin to inhibit HMGB1 release. Methods of inhibiting an inflammatory cytokine cascade in a mammal are also provided. These methods comprise... | 02/12/2008 |
| 7316906 | CD38 as a prognostic indicator in B cell chronic lymphocytic leukemia The subject invention discloses a method for determining the prognosis and probable clinical course of a subject diagnosed with B-CLL. Specifically, the invention involves comparing CD38 expression in a biological sample from the subject containing B-CLL cells to a ... | 01/08/2008 |
| 7304034 | Use of HMGB fragments as anti-inflammatory agents Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMGB A box, and an antibody preparation t... | 12/04/2007 |
| 7273872 | Inhibition of inflammation using α 7 receptor-binding cholinergic agonists Methods for inhibiting an inflammatory cytokine cascade in a patient are provided. The methods are directed to treating the patient with a cholinergic agonist in an amount sufficient to inhibit the inflammatory cytokine cascade, wherein the cholinergic agonist is se... | 09/25/2007 |
| 7238715 | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists A method of treating a patient suffering from pancreatitis comprising treating said patient with a therapeutically effective amount of a cholinergic agonist selective for an α7 nicotinic receptor in an amount sufficient to decrease the amount of the proinflammatory... | 07/03/2007 |
| 7220723 | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents The invention features a method of treating an inflammatory condition in an individual, comprising administering an agent that inhibits the interaction between a Toll-like receptor 2 (TLR2) and a high mobility group B (HMGB) polypeptide to the individual. The invent... | 05/22/2007 |
| 7192917 | Antagonists of HMG1 for treating inflammatory conditions There is disclosed a pharmaceutical composition and method for treating sepsis, including, septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method ... | 03/20/2007 |
| 7186555 | Prevention of brain damage in stroke The present invention provides methods and pharmaceutical compositions of the human glycoprotein fetuin, or α2-HS glycoprotein, or fragments thereof to mitigate tissue damage associated with ischemia, particularly in stroke or in myocardial infarction. ... | 03/06/2007 |
| 7179447 | Type I interferon-producing cells and uses thereof The present invention provides compositions for the treatment, inhibition or prevention of diseases or disorders, including cancer, immune diseases or disorders, and infectious diseases, comprising interferon-producing cells (IPCs) and methods of administering the I... | 02/20/2007 |
| 7151082 | Antagonists of HMG1 for treating inflammatory conditions There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method f... | 12/19/2006 |
| 7118865 | Methods for diagnosing severe systemic lupus erythematosus The invention relates to methods and materials involved in diagnosing SLE. More particularly, the invention relates to methods and materials involved in diagnosing SLE, diagnosing severe SLE, and assessing a mammal's susceptibility to develop severe SLE. For example... | 10/10/2006 |
| 7097838 | Antagonists of HMG1 for treating inflammatory conditions There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method f... | 08/29/2006 |
