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| Number | Title | Issue Date |
| 8084435 | Biodegradable linkers for molecular therapies A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently boun... | 12/27/2011 |
| 8071293 | PRRG4-associated compositions and methods of use thereof in methods of tumor diagnosis Compositions and methods for detecting PRRG4- and PRRG2 associated molecules are provided as are methods of use thereof for the detection and treatment of cancer. ... | 12/06/2011 |
| 8063022 | Methods for preventing formation of inhibitory antibodies in the setting of gene therapy The invention provides a method of preventing the formation of inhibitory antibodies in a mammal undergoing gene therapy. The method comprises administering to the mammal an immunosuppressive agent in conjunction with the gene therapy. ... | 11/22/2011 |
| D646339 | Doll | 10/04/2011 |
| 7998734 | Methods and compositions for use in gene therapy for treatment of hemophilia The invention includes a composition comprising a recombinant adeno-associated viral vector comprising at least two adeno-associated virus inverted terminal repeats, a promoter/regulatory sequence, isolated DNA encoding Factor IX and accompanying 5′ and 3′ untra... | 08/16/2011 |
| 7994147 | Cellular genes regulated by HIV-1 infection and methods of use thereof This invention provides cellular gene products which have anti-apoptotic activity in HIV-1 infected cells and provides agents for the inhibition of the cellular gene products. ... | 08/09/2011 |
| 7939063 | Delivery vehicle for recombinant proteins Recombinant nucleic acid molecules are constructed with a first sequence encoding a transgene under the control of regulatory sequences that direct expression of the transgene product in a hematopoietic stem cell, or a progenitor cell therefrom or cell differentiate... | 05/10/2011 |
| 7846201 | Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex A particle including a matrix-forming agent and a polyelectrolyte-amphiphilic agent adduct wherein the polyelectrolyte-amphiphilic agent adduct is in physical communication with the matrix-forming agent. The particle further includes a coated magnetic field-responsi... | 12/07/2010 |
| 7642233 | Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein The present disclosure relates to the use of AHSP to stabilize the α subunit of rHb. AHSP may be co-expressed with the hemoglobin genes. AHSP stabilization may be used to increase the production of intact rHb in various systems, such as E. coli, other microo... | 01/05/2010 |
| 7635734 | Photochemical activation of surfaces for attaching biomaterial A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group ... | 12/22/2009 |
| 7629122 | Methods and compositions for the diagnosis of Cornelia de Lange Syndrome Compositions and methods for the diagnosis of Cornelia de Lange Syndrome are disclosed. ... | 12/08/2009 |
| 7617000 | Methods for programming a neural prosthesis Methods and apparatuses for programming a neural prosthesis (e.g., a hearing prosthesis), and for fitting a speech processor and implantable cochlear stimulator by programming the speech processor are disclosed. A preferred method and apparatus for fitting a neural ... | 11/10/2009 |
| 7589174 | GRP94-based compositions and methods of use thereof Mini chaperones and methods of use thereof for the treatment of cancer and other disorders are provided. Also provided are tools to facilitate screening therapeutic agents which have selective binding affinity for GRP94. ... | 09/15/2009 |
| 7589070 | Surface modification for improving biocompatibility A therapeutic delivery system efficiently introduces biologically active molecules to mammalian cells without the use of synthetic polymers or biopolymer coatings. Surface modification of a metal support, such as a medical device, results in a single molecular layer... | 09/15/2009 |
| 7553659 | CHD5 encoding nucleic acids, polypeptides, antibodies and methods of use thereof Nucleic acid sequences encoding chromodomain helicase DNA-binding (CHD) proteins, CHD proteins, and antibodies thereto and methods of use thereof are disclosed. ... | 06/30/2009 |
| 7468513 | Fast dynamic imaging protocol using a multi-head single photon emission computed tomography system An imaging system for acquiring multi-dimensional tomographic image data of an object, the imaging system having (1) a plurality of detectors to acquire image data, the detectors coupled to a supporting structure, wherein at least one of the detectors is adapted to ... | 12/23/2008 |
| 7435548 | Methods for producing ex vivo models for inflammatory disease and uses thereof The invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with one or more cytokines, e.g., IL-β, TNFα or both. Methods are also disclosed for identifying genes that regulate re... | 10/14/2008 |
| 7408014 | Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof A modified polyurethane including a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, methods of preparing modified polyurethanes and the use thereof as an implantable biomaterial. ... | 08/05/2008 |
| 7405292 | Cellular genes regulated by HIV-1 infection and methods of use thereof This invention provides cellular gene products which have anti-apoptotic activity in HIV-1 infected cells and provides agents for the inhibition of the cellular gene products. ... | 07/29/2008 |
| 7402405 | Methods and kits for diagnosing a pancreatic-based fat malabsorption disorder The present invention relates to methods and kits useful in the diagnosis of a pancreatic-based fat malabsorption disorder in a mammal. ... | 07/22/2008 |
| 7402404 | Assay method for measurement of net cholesterol flux The present invention relates to an assay for determining net cholesterol flux from lipid loaded cells in the presence of an acceptor (e.g., serum). The present invention also relates to a method for evaluating efficacy of a therapeutic agent for stimulating or inhi... | 07/22/2008 |
| 7288644 | Cellular genes regulated by HIV-1 infection and methods of use thereof This invention provides cellular gene products which have anti-apoptotic activity in HIV-1 infected cells. Other pro-apoptotic genes and methods of use thereof are also disclosed. The compositions of the invention may be used to advantage to develop novel therapeuti... | 10/30/2007 |
| 7282489 | Compositions and methods for performing reverse gene therapy The invention relates to compositions and methods for reverse gene therapy, wherein a gene therapy vector encoding a gene product (e.g. a protein) which is usually only expressed in cells of an abnormal tissue is delivered to a cell of an animal afflicted with a dis... | 10/16/2007 |
| 7244571 | Methods for producing Ex vivo models for inflammatory disease and uses thereof The invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with one or more cytokines, e.g., IL-1β, TNFα or both. Methods are also disclosed for identifying genes that regulate r... | 07/17/2007 |
| 7220849 | Enhanced gamma-carboxylation of recombinant vitamin K-dependent clotting factor The invention relates to methods of optimizing gamma carboxylation of a vitamin K-dependent protein, methods of generating fully gamma carboxylated vitamin K-dependent protein, and compositions comprising chimeric nucleic acids and proteins for use in treatment of v... | 05/22/2007 |
| 7211558 | Compositions and methods for the treatment of hemophilia A Improved materials and methods for the treatment of Hemophilia A are provided. ... | 05/01/2007 |
| 7156881 | Counteracting bioprosthetic calcification Adapting crosslinking with triglycidyl amine (TGA) to incorporate the use of a particular type of anti-calcification agent provides a broad-reaching solution to the problem in vivo bioprosthesis calcification. The anti-calcification agent in question includes a poly... | 01/02/2007 |
| 7078180 | Methods and compositions useful for diagnosis, staging, and treatment of cancers and tumors Methods, compositions and kits which employ one or more ZEB specific detection reagents for detection and localization of ZEB associated molecules in tumor cells are disclosed. Also provided are methods for determining stage and progression of cancer in a mammal bas... | 07/18/2006 |
| 7060452 | Assay method for measurement of net cholesterol flux The present invention relates to an assay for determining net cholesterol flux from lipid loaded cells in the presence of an acceptor (e.g., serum). The present invention also relates to a method for evaluating efficacy of a therapeutic agent for stimulating or inhi... | 06/13/2006 |
| 7029863 | Cell culture system for determining the cholesterol efflux potential for serum The present invention relates to a cell culture system to provide a tool for assessing the potential of a patient's serum for preventing the accumulation of cholesterol in arteries (i.e. serum efflux potential) that leads to atherosclerosis and to screen new drug co... | 04/18/2006 |
| 7026330 | Methods for treatment of acute lymphocytic leukemia Methods for treating patients having an early B cell derived acute lymphoblastic leukemia with rapamycin or a derivative thereof are provided. Also provided are methods for treating patients having an early B cell derived acute lymphoblastic leukemia with rapamycin ... | 04/11/2006 |
| 6997909 | Low profile combination device for gastrostomy or jejunostomy applications having anti-granuloma formation characteristics A combination device for gastrostomy or jejunostomy usage having a retaining member, an elongated member having a gastrostomy lumen and a jejustomy lumen, and an inflatable balloon mounted on the elongated member. The retaining member is of a low profile and is arra... | 02/14/2006 |
| 6979542 | Methods for identifying heterozygous carriers of autosomal recessive diseases Novel methods are provided for identifying heterozygous carriers of autosomal recessive disorders such as Ataxia telangiectasia. ... | 12/27/2005 |
| 6925332 | Methods for programming a neural prosthesis This invention relates to methods for programming a neural prosthesis, more particularly to methods for programming a hearing prosthesis, and most particularly to methods for fitting a speech processor and implantable cochlear stimulator by programming the speech pr... | 08/02/2005 |
| 6919208 | Methods and compositions for enhancing the delivery of a nucleic acid to a cell The present invention relates to methods and compositions useful for enhancing the efficiency of delivery of a nucleic acid to a cell. Preferably the cell is a mammalian cell. The method comprises providing to a cell an agent capable of enhancing the cytoskeletal pe... | 07/19/2005 |
| 6900282 | Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same A process for preparing the polyurethane derivative, the process including: providing a polyurethane having a urethane amino moiety, providing a multifunctional linker reagent of a formula: LG-RL-(FG)n, wherein n is an integer from 1 to 3, FG i... | 05/31/2005 |
| 6893828 | Methods for producing ex vivo models for inflammatory disease and uses thereof The present invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with IL-1β, TNFα or both. Methods are also disclosed for identifying genes that regulate responses to anti-infl... | 05/17/2005 |
| 6890998 | Thiol activation of polyurethanes and methods of making the same A polyurethane having a thiol substituent pendant from at least one nitrogen and/or at least one carbon atom of the polyurethane. A polyurethane having a thiol substituent pendant from at least one nitrogen and/or at least one carbon atom of the polyurethane,... | 05/10/2005 |
| 6861211 | Stabilization of implantable bioprosthetic devices The invention relates to methods of stabilizing glycosaminoglycans in a biological tissue (e.g. a bioprosthetic implant) in conjunction with cross-linking of protein in the tissue. The methods of the invention improve the mechanical integrity of the device and impro... | 03/01/2005 |
| 6852704 | Reverse gene therapy The invention relates to compositions and methods for reverse gene therapy, wherein a gene therapy vector encoding a gene product (e.g. a protein) which is usually only expressed in cells of an abnormal tissue is delivered to a cell of an animal afflicted with a dis... | 02/08/2005 |
