Assignee: The California Institute of Technology

Location: Pasadena, CA
No. of patents: 26

Number	Title	Issue Date
7955561	Colloidal particles used in sensing array Chemical sensors for detecting analytes in fluids comprising a plurality of alternating nonconductive regions (comprising a nonconductive material) and conductive regions (comprising a conductive material). In preferred embodiments, the conducting region comprises a...	06/07/2011
7951349	Method and system for storing and generating hydrogen A method and system for storing and generating hydrogen. The method comprises generating hydrogen and heat from the reaction of a metal or metal compound with water. The heat generated from this reaction may then be converted to other forms of energy such as by pass...	05/31/2011
7863030	Regio- and enantioselective alkane hydroxylation with modified cytochrome P450 Cytochrome P450 BM-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively using atmospheric dioxygen as an oxidant. Mutant 9-10A-A328V hydro...	01/04/2011
7842793	Methods of making nucleic acid nanostructures The disclosure relates to methods and composition for generating nanoscale devices, systems, and enzyme factories based upon a nucleic acid nanostructure the can be designed to have a predetermined structure. ...	11/30/2010
7670429	High throughput screening of crystallization of materials High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated...	03/02/2010
7595023	Spatiotemporal and geometric optimization of sensor arrays for detecting analytes in fluids Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array....	09/29/2009
7491642	Electrical passivation of silicon-containing surfaces using organic layers Electrical structures and devices may be formed and include an organic passivating layer that is chemically bonded to a silicon-containing semiconductor material to improve the electrical properties of electrical devices. In different embodiments, the organic passiv...	02/17/2009
7359802	Methods for remote characterization of an odor Provided are compositions and systems useful in remote monitoring of chemical hazards, air quality, and medical conditions, for example, robotic systems to search for and detect explosives, mines, and hazardous chemicals. In addition, the methods, systems and compos...	04/15/2008
7226768	Cytochrome P450 oxygenases Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P45...	06/05/2007
7189353	Use of spatiotemporal response behavior in sensor arrays to detect analytes in fluids Methods, systems and sensor arrays are provided implementing techniques for detecting an analyte in a fluid. The techniques include providing a sensor array including at least a first sensor and a second sensor in an arrangement having a defined fluid flow path, exp...	03/13/2007
7144553	Use of an array of polymeric sensors of varying thickness for detecting analytes in fluids Chemical sensors for detecting the activity of a molecule or analyte of interest is provided. The chemical sensors comprise and array or plurality of sensors that are capable of interacting with a molecule of interest, wherein the interaction provides a response fin...	12/05/2006
7122152	Spatiotemporal and geometric optimization of sensor arrays for detecting analytes fluids Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array....	10/17/2006
7115403	Directed evolution of galactose oxidase enzymes This invention relates to the expression of improved polynucleotide and polypeptide sequences encoding for eukaryotic enzymes, particularly oxidase enzymes. The enzymes are advantageously produced in conventional or facile expression systems. Various methods for dir...	10/03/2006
6950754	Apparatus and method for automated protein design The present invention relates to apparatus and methods for quantitative protein design and optimization. ...	09/27/2005
6890715	Sensors of conducting and insulating composites The present invention provides a class of sensors prepared from at least a first material having a positive temperature coefficient of resistance and a second non-conductive or insulating material compositionally different than the first material that show an increa...	05/10/2005
6306601	Detection and treatment of duplex polynucleotide damage Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or dam...	10/23/2001
5562891	Method for the production of carbon dioxide hydrates A method is provided for producing CO2 hydrates. In the subject method, CO2 is first dissolved in water to produce a CO2 hydrate precursor. The CO2 hydrate precursor is then mixed with CO2 gas, result...	10/08/1996
5512197	Near azeotropic mixture substitute for dichlorodifluoromethane The present invention comprises a refrigerant mixture having two halocarbon components. The first component is present in a mole fraction of about 0.7 to less than 1.0 while the second component is present in a mole fraction of more than 0.0 to about 0.3....	04/30/1996
5059814	Winner-take-all circuits for neural computing systems A CMOS analog integrated circuit comprising a plurality of nodes for simultaneously computing the largest of the signals at inputs of the nodes. There is a common line supplying current and producing a maximum voltage potential and a plurality of nodes co...	10/22/1991
5047917	Apparatus for intrasystem communications within a binary n-cube including buffer lock bit An improved communication system for the prevention of lockup in a computer system of the binary n-cube type. Input circuitry at each of the nodes is connected for receiving messages and includes an input buffer for initially receiving the messages. Outpu...	09/10/1991
5030528	Mixed solvent electrolytes for ambient temperature secondary lithium cells The present invention comprises an improved electrolyte for secondary lithium-based cells as well as batteries fabricated using this electrolyte. The electrolyte is a lithium containing salt dissolved in a non-aqueous solvent, which is made from a mixture...	07/09/1991
5019898	Real-time pseudocolor density encoding of an image A method and apparatus are disclosed for real-time optical broadband pseudocolor encoding of an image. A light polarization spatial modulator is utilized to density encode an incident beam of plane-polarized light; the beam is dispersed into its primary c...	05/28/1991
4964881	Calcium impregnation of coal enriched in CO₂ using high-pressure techniques Methods are described for impregnating coal with calcium carbonate by utilizing an aqueous phase ionic reaction between calcium acetate, calcium hydroxide, and water with CO2 contained within the coal. The coal is enriched in CO2 by ...	10/23/1990
4937791	High performance dynamic ram interface A method and associated apparatus for accessing a plurality of DRAMs in the static column mode by a high performance instruction processor to provide minimum wait state accessing thereby. The method comprises the steps of, having the instruction processor...	06/26/1990
4933933	Torus routing chip A deadlock-free routing system for a plurality of computers ("nodes") is disclosed wherein each physical communication channel in a unidirectional multi-cycle network is split into a group of virtual channels, each channel of which has its own queue, one ...	06/12/1990
4839859	High density associative memory A multi-layered, thin-film, digital memory having associative recall. There is a first memory matrix and a second memory matrix. Each memory matrix comprises, a first layer comprising a plurality of electrically separated row conductors; a second layer co...	06/13/1989

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Assignee: The California Institute of Technology