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| Number | Title | Issue Date |
| 8367644 | Methods and compounds useful to induce apoptosis in cancer cells The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative. ... | 02/05/2013 |
| 8273705 | Conversion of apoptotic proteins Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing ap... | 09/25/2012 |
| 8188051 | Metadherin polypeptides, encoding nucleic acids and methods of use Metadherin, a protein that controls metastasis, and variants of metadherin are described. DNA sequences encoding the same and methods of production are described. Therapies involving the application of metadherin, binding agents that bind to metadherin, such as anti... | 05/29/2012 |
| 8105798 | Cytoplasmic activity of retinoid X receptor and its regulation by ligands and dimerization This invention relates to methods for identifying agents useful for treatment of diseases and pathological conditions affected by Retinoid X Receptor apoptosis. The invention also relates to methods for treating diseases and pathological conditions affected by RXR a... | 01/31/2012 |
| 8039255 | Compositions and methods for inhibiting cell migration The finding that Dickkopf1 (Dkk1) is a dual function protein demonstrates a mechanism for the coordination of cell migration and antagonism of Wnt/β-catenin signaling during developmental and pathological processes. The profile of Dkk proteins expressed by human br... | 10/18/2011 |
| 8037094 | Annotation and publication framework A hybrid annotation and publication system can access content in a scalable manner from databases, allowing for its editing and publication via wiki-style programs, while at the same time allowing for peer-review of such content via peer-review programs. This system... | 10/11/2011 |
| 7833980 | Compositions and methods for inhibiting cell migration The finding that Dickkopf1 (Dkk1) is a dual function protein demonstrates a mechanism for the coordination of cell migration and antagonism of Wnt/β-catenin signaling during developmental and pathological processes. The profile of Dkk proteins expressed by human br... | 11/16/2010 |
| 7812058 | Methods and compounds useful to induce apoptosis in cancer cells The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative. ... | 10/12/2010 |
| 7745574 | Compounds that regulate apoptosis Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for ... | 06/29/2010 |
| 7741521 | Inhibition of bid-induced cell-death using small organic molecules Various phenylamine derivatives are described as well as the use of compounds to inhibit BID protein for controlling apoptotic cascade. ... | 06/22/2010 |
| 7723076 | Use of selective labeling to detect and characterize molecular interactions by nuclear magnetic resonance spectroscopy Methods of detecting interactions of a putative ligand with a selectively labeled target molecule, methods of screening for compounds which bind to a selectively labeled target molecule, methods for calculating the dissociation constant of a ligand that binds to a s... | 05/25/2010 |
| 7674577 | Diagnosis of human glycosylation disorders This invention provides methods and kits for use in diagnosing genetically transmitted diseases that are associated with deficiencies in glycosylation of glycoconjugates such as glycoproteins, glycolipids, and proteoglycans. The methods and kits are also useful for ... | 03/09/2010 |
| 7655634 | Use of hepatitis B X-interacting protein (HBXIP) in modulation of apoptosis Novel methods of regulating cellular apoptosis by affecting the interaction of hepatitis B X-interacting protein (HBXIP) with Survivin are described. More specifically, these novel methods of enhancing apoptosis of neoplastic cells comprises inhibiting interaction o... | 02/02/2010 |
| 7560242 | Metadherin polypeptides, encoding nucleic acids and methods of use Metadherin, a protein that controls metastasis, and variants of metadherin are described. DNA sequences encoding the same and methods of production are described. Therapies involving the application of metadherin, binding agents that bind to metadherin, such as anti... | 07/14/2009 |
| 7544478 | Method for screening for compounds that modulate P16 mediated regulation of NMDA receptors Discovered is a novel protein and variants thereof whose activity at the NMDA receptor causes an increased efflux of calcium ions through the channel of said receptor. This activity is downregulated by the NR3A subunit of NMDA. Also discovered are the nucleic acid s... | 06/09/2009 |
| 7491700 | Conversion of apoptotic proteins Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing ap... | 02/17/2009 |
| 7465585 | Compositions and methods for inhibiting cell migration The finding that Dickkopf1 (Dkk1) is a dual function protein demonstrates a mechanism for the coordination of cell migration and antagonism of Wnt/β-catenin signaling during developmental and pathological processes. The profile of Dkk proteins expressed by human br... | 12/16/2008 |
| 7422862 | Methods for identifying modulators of apoptosis The invention provides a method of identifying an effective compound that modulates the binding of Humanin to Bax or Bid. The invention also provides a method of identifying an effective compound that modulates an activity of Bax or Bid. In addition, the invention p... | 09/09/2008 |
| 7393653 | Methods of modulating cell death based on the Bit1/AES regulatory pathway The present invention provides a method of identifying an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. The method is practiced by contacting a Bit1 polypeptide, or active fragment thereof, and an AES polypeptide, or acti... | 07/01/2008 |
| 7390656 | Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or S... | 06/24/2008 |
| 7365158 | PR-domain containing nucleic acids, polypeptides, antibodies and methods The invention provides an isolated PR Family Member (PFM) nucleic acid molecule that contains a PFM PR domain nucleotide sequence, a PFM ZF domain nucleotide sequence, or a modification thereof. The invention also provides an isolated PFM nucleic acid molecule that ... | 04/29/2008 |
| 7341710 | Method of identifying molecules that home to a selected organ in vivo The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ. ... | 03/11/2008 |
| 7335475 | PR/SET-domain containing nucleic acids, polypeptides, antibodies and methods of use The present invention provides an isolated nucleic acid molecule encoding a PFM/SET polypeptide. Also provided is an isolated nucleic acid molecule encoding a functional fragment of a PFM/SET polypeptide that contains a PR, SET, PRAZ or PKZL domain of a PFM/SET poly... | 02/26/2008 |
| 7273711 | Diagnosis of human glycosylation disorders This invention provides methods and kits for use in diagnosing genetically transmitted diseases that are associated with deficiencies in glycosylation of glycoconjugates such as glycoproteins, glycolipids, and proteoglycans. The methods and kits are also useful for ... | 09/25/2007 |
| 7217688 | Methods and compositions for derepression of IAP-inhibited caspase The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay ... | 05/15/2007 |
| 7217551 | ATM releated kinase ATX, nucleic acids encoding same and methods of use The invention provides an isolated nucleic acid molecule having substantially the same nucleotide sequence as SEQ ID NO:1. Also provided is an isolated oligonucleotide having at least 15 contiguous nucleotides of a nucleotide sequence referenced as SEQ ID NO:11. An ... | 05/15/2007 |
| 7208581 | TRAF family proteins In accordance with the present invention, there are provided novel TRAF-Protein-Binding-Domain polypeptides (TPBDs). The invention also provides nucleic acid molecules encoding TPBDs, vectors containing these nucleic acid molecules and host cells containing the vect... | 04/24/2007 |
| 7196182 | Card domain containing polypeptides, encoding nucleic acids, and methods of use The invention provides caspase recruitment domain (CARD)-containing polypeptides, CARD, NB-ARC, ANGIO-R, LRR and SAM domains therefrom, as well as encoding nucleic acid molecules and specific antibodies. The invention also provides related screening, diagnostic and ... | 03/27/2007 |
| 7192921 | Peptides that home to tumor lymphatic vasculature and methods of using same The present invention provides a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature. The invention also provides a method of directing a moiety to tumor lymphatic vasculature in a subject by administering ... | 03/20/2007 |
| 7192728 | Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the... | 03/20/2007 |
| 7176277 | Conversion of apoptotic proteins Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing ap... | 02/13/2007 |
| 7166716 | ATM related kinase ATX, nucleic acids encoding same and methods of use The invention provides an isolated nucleic acid molecule having substantially the same nucleotide sequence as SEQ ID NO:1. Also provided is an isolated oligonucleotide having at least 15 contiguous nucleotides of a nucleotide sequence referenced as SEQ ID NO:11. An ... | 01/23/2007 |
| 7163801 | Methods for determining the prognosis for cancer patients using tucan The invention provides methods for determining a prognosis for survival for a cancer patient. One method involves (a) measuring a level of a TUCAN in a neoplastic cell-containing sample from the cancer patient, and (b) comparing the level of TUCAN in the sample to a... | 01/16/2007 |
| 7144860 | Heart homing conjugates The present invention provides a heart homing peptide that contains the amino acid sequence GGGVFWQ (SEQ ID NO: 2); HGRVRPH (SEQ ID NO: 3); VVLVTSS (SEQ ID NO: 4); CLHRGNSC (SEQ ID NO: 9); or CRSWNKADNRSC (SEQ ID NO: 10) and further provides conjugates in which a he... | 12/05/2006 |
| 7087386 | Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or S... | 08/08/2006 |
| 7053071 | Induction of apoptosis in cancer cells The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of... | 05/30/2006 |
| 7041783 | Survivin-binding proteins, encoding nucleic acids, and methods of use In accordance with the present invention, there are provided novel Survivin-binding-proteins (SBPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SBPs can be employed in a variety of ways, for example, for... | 05/09/2006 |
| 7018615 | Method of identifying molecules that home to a selected organ in vivo The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ. ... | 03/28/2006 |
| 6994979 | Conversion of apoptotic proteins Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing ap... | 02/07/2006 |
| 6989245 | Screening, diagnostic and therapeutic methods relating to RIZ The invention provides a method of screening for a compound that modulates RIZ histone methyltransferase (HMT) activity, by contacting a RIZ or RIZ fragment having HMT activity with one or more candidate compounds, and determining histone methyltransferase activity ... | 01/24/2006 |
