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| Number | Title | Issue Date |
| 7462484 | Amorphous cell delivery vehicle treated with physical/physicochemical stimuli Provided are compositions and methods for in vitro generation and in vivo use of tissue for the repair of defective tissue, especially cartilage. Chondrocytes or other cells are cultured in vitro in a biodegradable amorphous carrier within the confines of a space bo... | 12/09/2008 |
| 7456220 | Immunodulatory compositions and methods of use thereof The invention relates to immunomodulatory compositions and related methods. The immunomodulatory compositions of a formula disclosed herein are useful for the prevention of sepsis and the treatment and prevention of diseases associated with inflammation and/or NOS. | 11/25/2008 |
| 7442783 | Natural IgM antibodies and inhibitors thereof The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders. ... | 10/28/2008 |
| 7432060 | Methods for diagnosis of cardiovascular disease This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to diagnose and/or treat cardiovascular conditions including cardiac hyp... | 10/07/2008 |
| 7429567 | Sustained delivery of PDGF using self-assembling peptide nanofibers The present invention is directed to a therapeutic composition in which human PDGF is bound directly to peptides that self assemble into a biologically compatible gel. When implanted in a patient's body, the composition provides for the slow, sustained release of PD... | 09/30/2008 |
| 7426289 | Overlay of tinted images for visualizing change in serial radiologic images A method for combining serial radiological images includes the projection of each of the images onto a line in a color space, the evaluation of a vector sum of the resulting projections; and the generation of a composite image from the vector sum. ... | 09/16/2008 |
| 7402432 | Process for producing T lymphocytes The present invention is directed to an in vitro method for producing T lymphocytes. The method involves culturing bone marrow cells on a matrix seeded with keratinocytes and fibroblasts. ... | 07/22/2008 |
| 7399831 | Targeted delivery of biological factors using self-assembling peptide nanofibers The present invention is directed to methodology that allows a variety of compounds to be attached to self-assembling peptides using biotin/streptavidin linkages. The peptides can be used to form a biologically compatible membrane that promotes the growth and differ... | 07/15/2008 |
| 7386349 | Rapid analgesia for skin puncture The present invention is directed to a device for providing transcutaneous electrical stimulation (TENS) to the finger of a patient at the same time that the finger is being punctured for the purpose of obtaining a blood sample. The device should reduce the pain ass... | 06/10/2008 |
| 7345076 | Inhibitors of cellular necrosis The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly u... | 03/18/2008 |
| 7341840 | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs The present invention is directed to methods for the identification and uses of receptors that interact with anti-inflammatory compounds derived from eicosapentaenoic acid (EPA). The receptors are of the G-protein coupled receptor (GPCR) family, and are useful to sc... | 03/11/2008 |
| 7297326 | Ocular diagnosis of Alzheimer's disease The invention features a method of diagnosing or providing a prognosis regarding the state of Alzheimer's Disease in a mammal by contacting an ocular tissue with a detectably-labeled compound, which binds to an amyloid protein. An increase in binding of the compound... | 11/20/2007 |
| 7288569 | Lipoxin compounds and their use in treating cell proliferative disorders Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed. ... | 10/30/2007 |
| 7288383 | Eosinophil-derived neurotoxin as a marker for ovarian cancer The present invention is directed to methods of identifying women at increased risk of having ovarian cancer. Identification is based upon the extent to which biological samples derived from the women exhibit elevated levels of eosinophil-derived neurotoxin (EDN). | 10/30/2007 |
| 7279508 | Nanocomposite surgical materials and method of producing them Nanocomposite surgical materials, such as cements, having very fine heterogenous structure are formed by incorporating into a polymeric matrix a well dispersed solid filler having an average mass diameter ranging from about 750 nanometers to about 1 nanometer. The a... | 10/09/2007 |
| 7271313 | Presenilin-deficient mouse model of age-dependent neurodegeneration and cognitive loss The present invention is directed to recombinantly engineered mice that are deficient in the expression of both presenilin-1 and presenilin-2. The mice exhibit characteristics of age-dependent cognitive impairments and neurodegeneration similar to those seen in Alzh... | 09/18/2007 |
| 7252828 | Polysaccharide vaccine for infections The invention relates to compositions of the capsular polysaccharide/adhesin (PS/A) of staphylococci. The PS/A may be isolated or synthesized and includes various modifications to the structure of native PS/A based on the chemical characterization of PS/A. Th... | 08/07/2007 |
| 7253159 | Methods and compositions for immunomodulation using CD1 antigens The invention relates to novel CD1a-presented antigens. These antigens can be used as antigens, adjuvants or as immunomodulatory agents in a variety of diagnostic, therapeutic and prophylactic applications. ... | 08/07/2007 |
| 7241282 | Compositions and methods for prolonging survival of platelets The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical compo... | 07/10/2007 |
| 7235045 | Fluorescence imaging endoscope An endoscope having an optical guide that is optically coupled to a first broadband light source and a second laser light source that emits light at a wavelength in a range of 350 nm to 420 nm. The endoscope has an image sensor at a distal end and collects a reflect... | 06/26/2007 |
| 7229614 | Interferon gamma in the detection and treatment of angiomyolipomas The present invention is directed to methods of treating or preventing angiomyolipomas by administering interferon gamma. It also encompasses methods for assessing the risk of a patient developing angiomyolipomas based upon interferon gamma expression. ... | 06/12/2007 |
| 7227031 | Prevention of neutrophil recruitment Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II. ... | 06/05/2007 |
| 7214501 | Methods of detecting cancer based on osteopontin The present invention is directed to diagnostic methods based upon the expression of the protein prostasin. In particular, it is concerned with assays performed on women to determine their risk of ovarian cancer. ... | 05/08/2007 |
| 7201163 | Method for altering the body temperature of a patient using a nebulized mist Methods for changing the body temperature of a patient by having them breathe a mist created by nebulizer. The temperature of the mist is adjusted using a heat exchanger. The methods may be used to either cool or warm patients for a variety of clinical reasons. In a... | 04/10/2007 |
| 7189518 | Soluble CD40L(CD154) as a prognostic marker of atherosclerotic diseases This invention involves the new use of a diagnostic test to determine the risk of atherosclerotic diseases such as myocardial infarction and stroke, particularly among individuals with no signs or symptoms of current disease and among nonsmokers. Further, this inven... | 03/13/2007 |
| 7183257 | Use of RPL41 to treat infections and inhibit cancer The present invention relates to peptides of RPL41 and their use in the treatment of cancer and microbial infections. It is contemplated that modified forms of RPL41, including substitutional variants and mimetics, will be used. Mono- and combination therapies with ... | 02/27/2007 |
| 7067129 | Receptor specific transepithelial transport in therapeutics The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to metho... | 06/27/2006 |
| 6975901 | Anesthetic-state determing A system for determining anesthetic state of a subject includes a brain monitor configured to measure at least one parameter of brain activity of the subject and to provide at least one brain monitor output signal indicative of the measured at least one parameter, a... | 12/13/2005 |
| 6720354 | Prevention of neutrophil recruitment Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II. ... | 04/13/2004 |
| 6653493 | Lipoxin compounds and their use in treating cell proliferative disorders Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed.... | 11/25/2003 |
| 6635776 | Lipoxin compounds and their use in treating cell proliferative disorders Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed.... | 10/21/2003 |
| 6627658 | Lipoxin analogs as novel inhibitors of angiogenesis The present invention is directed to methods for the prevention or inhibition of angiogenesis. The method is accomplished by the administration of an effective amount of 15-epi-16-(para-fluoro)-phenoxy-lipoxin A4, LXA4, 15-epi-L... | 09/30/2003 |
| 6620919 | Lipoxin compounds and their use in treating cell proliferative disorders Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed.... | 09/16/2003 |
| 6545057 | Tricyclic antidepressants and their analogues as long-acting local anesthetics and analgesics Methods and compositions of tricyclic antidepressants for inducing local long-lasting anesthesia and analgesia are provided. The methods and compositions are useful for alleviating acute and chronic pain, particularly useful for treating a localized pain.... | 04/08/2003 |
| 6458839 | Modulation of inflammation related to columnar epithelia This invention provides pharmaceutical compositions containing lipoxin compounds and therapeutic uses for the compounds in treating or preventing a disease or condition associated with columnar epithelial inflammation. The invention also discloses methods... | 10/01/2002 |
| 6426074 | Group B Streptococcus vaccine The invention concerns a vaccine capable of protecting a recipient from infection caused group B Streptococcus. The vaccine comprises polysaccharide-protein moieties or protein moieties without a polysaccharide. The vaccine can contain, inter alia, (a) a ... | 07/30/2002 |
| 6410335 | Circulating insulin-like growth factor-I and prostate cancer risk Methods of predicting a propensity to developing prostate cancer are presented. The consists of measuring the IGF status of individual. Individuals with high IGF status, as compared with normal reference range values, are at increased risk for developing ... | 06/25/2002 |
| 6303156 | Noninvasive method for increasing or decreasing the body temperature of a patient The present invention is directed to a method for changing the body temperature of a patient by having them hyperventilate a gas mixture containing sulfur hexafluoride and oxygen. The method may be applied to cool patients in any clinical situation where ... | 10/16/2001 |
| 6294384 | Compositions and methods based upon an isoform of p53 The present invention is directed to an isoform of the p53 tumor suppressor and to polynucleotides that encode this isoform. The isoform may be used as a marker to indicate that cardiac cells have experienced hypoxia, as would occur during a myocardial in... | 09/25/2001 |
| 6147109 | Upregulation of Type III endothelial cell Nitric Oxide Synthase by HMG-CoA reductase inhibitors A new use for HMG-CoA reductase inhibitors is provided. In the instant invention, HMG-CoA reductase inhibitors are found to upregulate endothelial cell Nitric Oxide Synthase activity through a mechanism other than preventing the formation of oxidative-LDL... | 11/14/2000 |
