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...When G.G. Hubbard learned of his future son-in-law's invention, he called it "only a toy." His daughter was engaged to a young man named Alexander Graham Bell.
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| Number | Title | Issue Date |
| 8173115 | Particle compositions with a pre-selected cell internalization mode A method of formulating a particle composition having a pre-selected cell internalization mode involves selecting a target cell having surface receptors and obtaining particles that have i) surface moieties, that have an affinity for or are capable of binding to the... | 05/08/2012 |
| 8167593 | System and method for pump with deformable bearing surface Systems and methods for pumping fluid comprising a pumping chamber, a pump inlet, a pump outlet, a valving mechanism, and a drive piston or pumping chamber wall including a deformable surface configured to provide elastohydrodynamic lubrication during operation.... | 05/01/2012 |
| 8165533 | Apparatus and method for beamforming based on generalized eigen-analysis in multiple input multiple output wireless communication system An apparatus and method for beamforming in a Multiple Input Multiple Output (MIMO) wireless communication system are provided. A Base Station (BS) includes a calculator for generating relational expressions between beamforming vectors of Mobile Stations (MSs) using ... | 04/24/2012 |
| 8163881 | Immunoglobulin molecules with improved characteristics The present invention provides for IgG1 molecules with improved characteristics. In particular, substitution mutations are provided that, in combination, facilitate improved placental transfer, improved serum half-life and improved FcRn binding. Substitution mutatio... | 04/24/2012 |
| 8158364 | Methods and compositions involving nucleotide repeat disorders The present invention concerns the methods and compositions involving nucleic acids with long repeat sequences. In some embodiments of the invention, there are methods for generating such a nucleic acid, and in other methods, there are methods for using such a nucle... | 04/17/2012 |
| 8143892 | System and methods for active suppression of superior tagging in flow-sensitive alternating inversion recovery Apparatuses, systems, and methods for suppression of venous artifacts from superior tagging in flow-sensitive alternating inversion recovery. The systems may include an image capture device and a controller. The controller may be configured to cause the image captur... | 03/27/2012 |
| 8142501 | Artificial ligaments and tendons comprising multifilaments and nanofibers and methods for making Prosthetic ligaments and tendons comprising ligament- or tendon-mimicking nanofibers and methods of making such nanofibers and prosthetic ligaments and tendons. ... | 03/27/2012 |
| 8128592 | Methods and systems for performing submucosal medical procedures Instruments, systems and methods are provided for performing submucosal medical procedures in a desired area of the digestive tract using endoscopy. Instruments include a safe access needle injection instrument, a submucosal tunneling instrument, a submucosal dissec... | 03/06/2012 |
| 8127119 | Control-flow prediction using multiple independent predictors The present disclosure generally describes computing systems with a multi-core processor comprising one or more branch predictor arrangements. The branch predictor are configured to predict a single and complete flow of program instructions associated therewith and ... | 02/28/2012 |
| 8124653 | Methods and compositions for the treatment of attention deficit hyperactivity disorder and hyperphenylalanemia Disclosed is a composition that includes a tetrahydrobiopterin in a controlled-release pharmaceutical preparation. Also disclosed is a method of treating a patient with phenylketonuria that includes administering, to the patient, a composition that contains tetrahyd... | 02/28/2012 |
| 8119656 | Inhibitors of the influenza virus non-structural 1 protein The present invention generally relates to compounds to treat viral infections and methods of their use. In particular, compounds of the present invention inhibit the activity of NS1 protein, thereby mitigating viral infection and, in particular, influenza virus inf... | 02/21/2012 |
| 8107714 | Methods for detecting and tagging scene changes Methods for determining a difference between a reference scene and a test scene are provided. An automated process calculates a power of the reference scene and a power of the test scene. The difference between the power of the reference scene and the test scene det... | 01/31/2012 |
| 8099565 | Methods and devices for determining quality of services of storage systems Methods and systems for allowing access to computer storage systems. Multiple requests from multiple applications can be received and processed efficiently to allow traffic from multiple customers to access the storage system concurrently. ... | 01/17/2012 |
| 8084248 | Reverse genetic system for rift valley fever virus and uses thereof The present invention describes a reverse genetic system for Phlebovirus such as Rift Valley fever virus. This system comprised of RNA expression plasmids and protein expression plasmids. Additionally, the present invention also discloses the modification of ... | 12/27/2011 |
| 8076470 | VMP-like sequences of pathogenic species and strains The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequence... | 12/13/2011 |
| 8076099 | Biomarkers of infection The instant invention concerns Francisella bacteria mediated degradation of alkaline phosphatase (AP). Detection of AP degradation may be used to determine the presence of Francisella bacteria in a sample. Furthermore, methods for identifying and treat... | 12/13/2011 |
| 8071652 | Method of treating irritable bowel syndrome A treatment to differentially regulate the expression of genes related to irritable bowel syndrome is provided. ... | 12/06/2011 |
| 8070856 | Polyamine/alkali salt blends for carbon dioxide removal from gas streams Novel solvents and methods of use for the removal of CO2 from flue gas, natural gas, hydrogen gas, synthesis gas, and other process and waste gas streams are provided. The solvent contains an alkali salt such as potassium carbonate and a polyamine such as... | 12/06/2011 |
| 8067390 | Therapeutic targeting of interleukins using siRNA in neutral liposomes The present invention relates to the fields of molecular biology and drug delivery. In certain embodiments, the present invention provides compositions that include an siRNA targeted to an interleukin and a neutral lipid, and methods of treating a human subject with... | 11/29/2011 |
| 8066689 | Methods and systems for submucosal implantation of a device for diagnosis and treatment with a therapeutic agent Instruments, systems, implants, and methods are provided for performing submucosal medical procedures in a desired area of the digestive tract using endoscopy. Instruments include a safe access needle injection instrument, a submucosal tunneling instrument, a submuc... | 11/29/2011 |
| 8062654 | Drug releasing biodegradable fiber for delivery of therapeutics The present invention relates to fiber compositions comprising gels or hydrogels. The invention further relates to the composition of a gel or hydrogel loaded biodegradable fiber and methods of fabricating such fibers. The present invention further provides tissue e... | 11/22/2011 |
| 8062389 | Low vapor pressure fuels for use in catalytic burners Low vapor pressure compound-based fuels are provided. These fuels are useful in catalytic burner systems that can be used to disperse fragrances, insecticides, insect repellants (e.g., citronella), aromatherapy compounds, medicinal compounds, deodorizing compounds, ... | 11/22/2011 |
| 8044033 | Fluorocytidine derivatives and COX-2 inhibitors for the treatment of cancer The present invention provides, in certain embodiments, methods for the treatment of colorectal cancer comprising administering a COX-2 inhibitor and fluorocytidine derivative to a human patient. In certain embodiments, a radiation therapy is also administered to th... | 10/25/2011 |
| 8039008 | Identification of residues critical for the function of the vibrio cholerae virulence regulator ToxT by scanning alanine mutagenesis Disclosed are Vibrio cholerae comprising a mutated transcriptional regulatory protein (ToxT) amino acid sequence, wherein the mutation results in a reduction in the expression of cholera toxin by the Vibrio cholerae. Also disclosed are Vibrio choler... | 10/18/2011 |
| 8031925 | Method and computer-program product for detecting and quantifying protein spots The present inventions is directed to a method and computer program product for detecting and quantifying protein spots, including: generating an average gel image by taking a pixel-by-pixel average of the intensities of a plurality of aligned gel images; detecting ... | 10/04/2011 |
| 8030447 | Substrate peptide sequences for plague plasminogen activator and uses thereof The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for... | 10/04/2011 |
| 8013114 | Fusion proteins based upon somatostatin receptors The present invention is directed to fusion proteins that can be used to assay gene transfer and expression both in vitro and in vivo. The fusion proteins contain a reporter protein, e.g. a somatostatin receptor, fused to a second protein, which may be a protein fus... | 09/06/2011 |
| 8007994 | Compositions and methods of modulating cholesterol metabolism The present invention relates to compositions and methods for reducing cholesterolemia and its effects. More specifically, the invention is directed, in one embodiment, to methods for screening for compounds that affect cholesterol levels generally, and in particula... | 08/30/2011 |
| 7981935 | Stem cell differentiating agents and uses therefor The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and ... | 07/19/2011 |
| 7967750 | Lie detection via electrogastrography The present invention provides a device and methods of lie detection utilizing electrogastrography to monitor changes in the gastric electric rhythm of a subject. Also provided are methods of discriminating between the stress of deception induced in a subject during... | 06/28/2011 |
| 7965861 | Methods and systems for digital image security Methods and systems for securing digital imagery are provided. In one respect, embedding, compression, encryption, data hiding, and other imaging processing techniques and systems may be provided for digital image security. In one non-limiting example, a method for ... | 06/21/2011 |
| 7961922 | Systems and methods for processing medical image data to facilitate comparisons among groups of subjects Systems and methods for processing medical image data with increased sensitivity to facilitate comparisons among groups of subjects are disclosed herein. In one embodiment, a method comprises receiving a first three-dimensional image comprising a plurality of voxels... | 06/14/2011 |
| 7960133 | Methods of diagnosing leiomyoma by measuring catechol-O-methyltransferase The present invention relates to an association between specific polymorphisms of the COMT polypeptide and the development, or risk of developing, preterm labor and uterine diseases and conditions. Disclosed are therapeutic, preventative and diagnostic methods and c... | 06/14/2011 |
| 7959847 | Methods for multi-material stereolithography Methods and systems of stereolithography for building cost-efficient and time-saving multi-material, multi-functional and multi-colored prototypes, models and devices configured for intermediate washing and curing/drying is disclosed including: laser(s), liquid and/... | 06/14/2011 |
| 7959163 | Suspension-related systems and methods In some embodiments, the present systems include, consist of, or consist essentially of a roadarm having a first end, a second end, and an opening near the first end; where the second end is configured for attachment to a passive spring (e.g., an air spring, a coil ... | 06/14/2011 |
| 7954379 | Methods for determining displacement or strain of a target body The invention is directed toward a new method for estimating and imaging the spatial and temporal mechanical behavior of materials in responses to a mechanical stimulus. This method is designed to work in inherently noisy applications, such as the imaging of the tim... | 06/07/2011 |
| 7929130 | Illumination sources and customizable spectral profiles Methods for generating a customized spectral profile, which can be used to generate a corresponding filter, lamp or other type of illuminant. A trial spectrum can be generated. A reference spectrum can be determined or otherwise obtained. A SOURCE spectrum can be de... | 04/19/2011 |
| 7923014 | Expression and purification of HIP/PAP and uses therefor The present invention relates to methods of compositions comprising RegIII and HIP/PAP proteins, including the use of such proteins as diagnostic and therapeutic targets. ... | 04/12/2011 |
| 7923010 | Methods and materials for treating autoimmune diseases and conditions Disclosed are methods for treating an autoimmune disease or condition in a subject. The methods include administering to the subject a compound which inhibits the subject's classical complement pathway. Also disclosed are methods for suppressing hyperacute graft rej... | 04/12/2011 |
| 7919579 | Imaging and therapeutic targeting of prostate and bladder tissues The present invention provides methods for imaging and the treatment of cancer. In certain embodiments, a polyarginine (e.g., R11) may be used to selectively image prostate or bladder cells (e.g., a metastatic prostate cancer). In other embodiments, a DOC-2/DAB2 pep... | 04/05/2011 |
