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| Number | Title | Issue Date |
| 6113900 | Use of IL-2 receptor-targeted therapeutics to inhibit allograft rejection and treat autoimmune disorders Methods of inhibiting allograft rejection and of inhibiting B lymphocyte-mediated autoimmune diseases are provided. The methods involve the use of agents specific for the IL-2 receptor, such as monoclonal antibodies or IL-2, optionally linked to a cytotox... | 09/05/2000 |
| 5916559 | Use of interleukin-2 (IL-2) receptor-specific agents to treat allograft rejection A method of lysing unwanted, non-malignant cells in a mammal, the cells having on their surfaces a receptor for a growth factor, and the method including administering to the mammal a cell-lysing amount of a substance characterized in that it has specific... | 06/29/1999 |
| 5686408 | Method for modifying, diagnosing, and screening for IGF-I sensitive cell barrier properties A method of chronic modification of cell barrier properties by exposing a cell to a modification-effective amount of IGF-I for at least about 7 days wherein the modification effective amount is between about 50 μg/kg and less than about 500 μg/kg is dis... | 11/11/1997 |
| 5674494 | Treating non-malignant disease states with IL-2 receptor-specific substances Methods of treating a non-malignant, disease state-producing immune response in a mammal are provided. The methods involve administering to the mammal an IL-2 receptor-specific substance during a proliferative burst of IL-2 receptor-bearing lymphocytes as... | 10/07/1997 |
| 5651769 | Method for retrieving pancreatic juice utilizing and endoscopically wire-guided catheter A method for accurately and quickly positioning a double lumen gastroduodenal tube into predetermined locations utilizing an endoscopically placed guide wire to retrieve duodenal fluid uncontaminated by gastric fluid, with little or no discomfort to the p... | 07/29/1997 |
| 5637567 | Method for modifying, diagnosing, and screening for IGF-I sensitive cell barrier properties A method of chronic modification of cell barrier properties by exposing a cell to a modification-effective amount of IGF-I for at least about 7 days wherein the modification effective amount is between about 50 μg/kg and less than about 500 μg/kg is dis... | 06/10/1997 |
| 5607675 | Treatment of autoimmune diseases with IL-2 receptor-specific cytotoxin A method of treating a mammal suffering from an autoimmune disease state is provided. The method comprises administering to the mammal a cytotoxin-conjugated IL-2 receptor-specific substance during a proliferative burst of IL-2 receptor-bearing lymphocyte... | 03/04/1997 |
| 5587162 | Treatment of allograft rejection with IL-2 receptor-specific cytotoxins Methods of inhibiting the rejection and prolonging the survival of an allograft in a mammal are provided. The methods involve administering to the mammal a cytotoxin-conjugated IL-2 receptor-specific substance during a proliferative burst of IL-2 receptor... | 12/24/1996 |
| 5395390 | Metal wire stent A stent comprising a wire skeletal frame, the frame being adapted to assume a first condition in which the frame is relatively rigid and substantially tubular in configuration and a second condition in which the frame is flexible, of reduced stress, and c... | 03/07/1995 |
| 5366440 | Methods for treating disease states using oxidized lipoproteins in conjunction with chemotherapeutic effector agents The present invention relates to treating disease states in a living patient using oxidized lipoproteins, preferably low density peroxidized lipoproteins. Methods and apparatus are provided for preparing the oxidized lipoproteins. It has been discovered t... | 11/22/1994 |
| 5336489 | Treatment of allograft rejection with IL-2 receptor-specific cytotoxins A method of lysing unwanted, non-malignant cells in a mammal, the cells having on their surfaces a receptor for a growth factor, and the method including administering to the mammal a cell-lysing amount of a substance characterized in that it has specific... | 08/09/1994 |
| 5268363 | Method of treatment to inhibit the undesirable activation of the complement cascade with factor J, an inhibitor of complement C1 A purified protein, factor J, which has inhibitory properties which prevent the formation or the dissociation of Cl complex and a method of purification for said protein. The method including the following sequential chromatography steps: anion exchange Q... | 12/07/1993 |
| 5264549 | Characterization and method of isolation of factor J, an inhibitor of complement C1 A purified protein, factor J, which has inhibitory properties which prevent the formation or the dissociation of Cl complex and a method of purification for said protein. The method including the following sequential chromatography steps: anion exchange, ... | 11/23/1993 |
| 5261405 | Apparatus and method for detecting cancer using nuclear magnetic resonance A technique and an apparatus are disclosed for the detection of cancer using nuclear magnetic resonance (NMR). Specifically, NMR parameters for protons of lipid methyl and/or methylene groups are determined and compared against a corresponding value for h... | 11/16/1993 |
| 5224953 | Method for treatment of obstructive portions of urinary passageways A method for the treatment of an obstructive portion of a urinary passageway of a mammal, comprising the steps of providing a stent thermally self-movable between a first condition in which the stent is rigid and generally tubular, and a second condition ... | 07/06/1993 |
| 5223425 | DNA encoding human adipsin with complement D activity The invention provides a recombinant purified human protein in substantial quantities which has both adipsin and complement D activity. The invention also provides materials and methods to produce the protein. In addition, antibodies immunoreactive with t... | 06/29/1993 |
| 5217716 | Method for treating viral infections using oxidized lipoproteins This invention provides methods and an apparatus for peroxidizing lipoproteins and introducing them into a person infected with a virus such as HIV to help that person fight the disease. Peroxidized low density lipoproteins are shown to preferentially kil... | 06/08/1993 |
| 5213101 | Process for the detection of cancer using nuclear magnetic resonance A technique is disclosed for the detection of cancer using nuclear magnetic resonance (NMR). Specifically, NMR parameters for protons of lipid methyl and/or methylene groups are determined and compared against a corresponding value for healthy patients. I... | 05/25/1993 |
| 5207715 | Method of detecting cancer by measuring lipid-peroxidation using NMR A technique and an apparatus are disclosed for the detection of cancer using nuclear magnetic resonance (NMR). Specifically, NMR parameters for protons of lipid methyl and/or methylene groups are determined and compared against a corresponding value for h... | 05/04/1993 |
| 5192264 | Methods and apparatus for treating disease states using oxidized lipoproteins The present invention relates to treating disease states in a living patient using oxidized lipoproteins, preferably low density peroxidized lipoproteins. Methods and apparatus are provided for preparing the oxidized lipoproteins. It has been discovered t... | 03/09/1993 |
| 5152980 | Induction of tolerance to a foreign antigen IL-2 receptor-binding substances A method of inducing tolerance to a foreign antigen in a mammal, by administering an IL-2-receptor-positive-cell-destroying amount of a substance capable of destroying IL-2-receptor-positive cells which are newly activated in response to the antigen, to a... | 10/06/1992 |
| 5085861 | Bioerodable implant composition comprising crosslinked biodegradable polyesters An improved bone cement is comprised of a particulate biocompatible calcium phosphate ceramic and particulate resorbable calcium salt dispersed in a cross-linked biodegradable polyester matrix. The polymer/salt-particle composite exhibits good biomechanic... | 02/04/1992 |
| 5002558 | Adjustable urethral catheter and method for treating obstructive prostatism A urethral catheter having an adjustable dilating balloon length for dilating a prostatic urethra and a method for using same. The device includes a catheter to which a Foley balloon is affixed at the distal end, and to which a dilating balloon is annular... | 03/26/1991 |
| 4994237 | Microwave preservation of bioprostheses A method to preserve and sterilize biological tissues by exposing the tissue to microwave irradiation, thereby limiting tissue exposure to standard organic preservatives and retaining tissue pliability and other qualities that characterize natural, unpres... | 02/19/1991 |
| 4966596 | Laser atherectomy catheter Method to remove an eccentric vascular obstruction by excision with laser energy, preferably excimer laser energy, delivered through a mobile fiber optic shelf, and collecting the excised section within a housing. Apparatus to perform a surgically smooth excis... | 10/30/1990 |
| 4955904 | Masked intraocular lens and method for treating a patient with cataracts A masked intraocular lens for implantation into a human eye is presented. The mask, which blocks only part of the lens body, together with the pupil of the eye, defines a small aperture in the eye when the pupil is constricted, thereby increasing the dept... | 09/11/1990 |
| 4918021 | Process for the detection of cancer A technique and an apparatus are disclosed for the detection of cancer using nuclear magnetic resonance (NMR). Specifically, NMR parameters for protons of lipid methyl and/or methylene groups are determined and compared against a corresponding value for h... | 04/17/1990 |
| 4912050 | Process for the screening of cancer using nuclear magnetic resonance A technique is disclosed for the detection of cancer using nuclear magnetic resonance (NMR). Specifically, NMR parameters for protons of lipid methyl and/or methylene groups are determined and compared against a corresponding value for healthy patients. I... | 03/27/1990 |
| 4909258 | Internal mammary artery (IMA) catheter Apparatus for performing subselective arteriography or angioplasty on an internal mammary artery or graft which avoids dissection or stenosis of the internal mammary artery or graft. A catheter having a balloon and a proximal port delivers an angiographic... | 03/20/1990 |
| 4885000 | Isolation, sterilization and maximum observation tent An isolation, sterilization and maximum observation (ISMO) tent for the isolation of a corpse during a medical procedure and to contain matter spilling from the corpse. The ISMO tent includes a frame and a form fitted translucent sheet supported by the fr... | 12/05/1989 |
| 4843112 | Bioerodable implant composition An improved bone cement is comprised of a particulate biocompatible calcium phosphate ceramic and particulate resorbable calcium salt dispersed in a cross-linked biodegradable polyester matrix. The polymer/salt-particle composite exhibits good biomechanic... | 06/27/1989 |
| 4836207 | Method and apparatus to monitor cholesterol levels with photon correlation spectroscopy A method to determine the cholesterol level in a patient in a non-invasive manner by delivering a beam of light to a patient's eye. The intensity of light scattered from the aqueous of the eye and the mobility of the protein scatterers in the eye are meas... | 06/06/1989 |
| 4799479 | Method and apparatus for angioplasty The region surrounding the balloon utilized in percutaneous transluminal coronary angioplasty is heated by means within the balloon or within the skin of the balloon upon inflation of the balloon such that disrupted tissues of the plaque in the arterial w... | 01/24/1989 |
| 4773899 | Method of treatment of artherosclerosis and balloon catheter the same A method for the treatment of atherosclerosis in a mammal by destruction of atheromatous plaque is disclosed. The disclosed method includes injecting a hematoporphyrin into the mammal for selective uptake into the atheromatous plaque, and delivering light... | 09/27/1988 |
| 4735201 | Optical fiber with detachable metallic tip for intravascular laser coagulation of arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas A device is described which includes an optical fiber or fiber bundle for transmission of laser energy with a proximal end for connection to a laser source and a distal end to which a heat generating tip or cap is securely, but detachably, affixed with a ... | 04/05/1988 |
| 4725538 | Method of assaying the presence of cancer cells Method to detect and/or determine the presence of cancer cells in mammals, including humans, and to monitor the progress of treatment for cancer. A human protein marker, the assay-marker, has been ascertained of the molecular weight 70,000-74,000, which i... | 02/16/1988 |
| 4722896 | Method for affinity purification of hybridoma antibodies An efficient process design for purifying large quantities of specific antibodies by affinity chromatography is disclosed. By utilizing the process strategy described, large scale production of highly purified hybridoma antibodies and other proteins becom... | 02/02/1988 |
| 4717385 | Surgical tube anchoring device and method for using same A tube anchoring device for anchoring gastrostomy and similar surgical tubing, for use in conjunction with a flanged pectin and polymethylcellulose wafer where, in one embodiment, the tube anchoring device comprises a tube, for receiving the surgical tubi... | 01/05/1988 |
| 4660560 | Method for treating obstructive prostatism The present invention is a method for treating obstructive prostatism in which a urethral catheter having a remotely fixed annular balloon is inserted into the urethra and urged therethrough until it is adjacent to the prostate gland. The annular balloon ... | 04/28/1987 |
| 4648351 | Animal cage insert and convertible animal cage A convertible animal cage particularly suited for use in laboratories utilizing more than one kind of small rodent to minimize storage area and cage inventories. In one embodiment, a standard hanging cage with a relatively large grid bottom and front is c... | 03/10/1987 |
