Assignee: The Administrators of the Tulane Educational Fund

Location: New Orleans, LA
No. of patents: 34

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Number	Title	Issue Date
8153360	Flavivirus fusion inhibitors The present invention provides an isolated peptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1 to SEQ ID NO:36, as well as derivatives thereof comprising various N-terminal and C-terminal chemical moieties, substituted analogs the...	04/10/2012
8044292	Homogeneous thermoelectric nanocomposite using core-shell nanoparticles A thermoelectric material comprises core-shell particles having a core formed from a core material and a shell formed from a shell material. In representative examples, the shell material is a material showing an appreciable thermoelectric effect in bulk. The core m...	10/25/2011
8003567	Nanocomposite support materials The present teachings are directed toward hexagonally patterned porous titania synthesized from a titanium isopropoxide precursor using a viscous template of surface-active agents separating nanoscopic bicontinuous channels of water and isooctane. Subsequent catalys...	08/23/2011
7888039	Assay for transmissible spongiform encephalopathies Provided is a novel method for detecting Transmissible Spongiform encephalopathies (TSE). The method comprises: selecting a body fluid sample from a subject to determine whether the subject has transmissible spongiform encephalopathy; and detecting antibodies that i...	02/15/2011
7883995	Method of forming stable functionalized nanoparticles A novel top-down procedure for synthesis of stable passivated nanoparticles uses a one-step mechanochemical process to form and passivate the nanoparticles. High-energy ball milling (HEBM) can advantageously be used to mechanically reduce the size of material to nan...	02/08/2011
7854937	Flavivirus fusion inhibitors The present invention relates to peptides and methods of inhibiting fusion between the virion envelope of Flaviviruses and membranes of the target cell, the process that delivers the viral genome into the cell cytoplasm. The invention provides for methods which empl...	12/21/2010
7790137	Metal telluride nanocrystals and synthesis thereof A process for synthesizing a metal telluride is provided that includes the dissolution of a metal precursor in a solvent containing a ligand to form a metal-ligand complex soluble in the solvent. The metal-ligand complex is then reacted with a telluride-containing r...	09/07/2010
7771727	Conjugates of therapeutic or cytotoxic agents and biologically active peptides The invention features conjugates of therapeutic or cytotoxic agents and biologically active peptides and methods of use thereof. ...	08/10/2010
7759329	Method of treating human preeclampsia employing resibufagenin A method of treating preeclampsia including administering a therapeutically effective dose of resibufagenin to a patient having preeclampsia. Effecting the determination of the presence of preeclampsia may be by determining whether there has been a substantial eleva...	07/20/2010
7716969	Methods and devices for simultaneously monitoring colloid particles and soluble components during reactions A method and apparatus for continuously extracting liquid in at least two separate streams from a vessel, continuously diluting and/or conditioning a first stream in one or more stages, producing, as a result of the extraction, dilution and/or conditioning, the firs...	05/18/2010
7695719	Conjugates of therapeutic or cytotoxic agents and biologically active peptides The invention features conjugates of therapeutic or cytotoxic agents and biologically active peptides and methods of use thereof. ...	04/13/2010
7550423	Somatostatin antagonists The invention features somatostatin antagonists having a D-amino acid at the second residue. ...	06/23/2009
7491793	Influenza virus inhibiting peptides The present invention relates to a method of preventing or inhibiting viral infection of a cell and/or fusion between the envelope of a virus and the membranes of a cell targeted by the virus (thereby preventing delivery of the viral genome into the cell cytoplasm, ...	02/17/2009
7439071	Method of employing elevation of marinobufagenin in determining the presence of preeclampsia and related apparatus A method of determining the presence of preeclampsia is provided wherein a determination is made as to whether there has been a substantial elevation in marinobufagenin which may be a blood-derived or urine-derived and if such elevation does exist concluding that pr...	10/21/2008
7416733	Flavivirus fusion inhibitors The present invention relates to peptides and methods of inhibiting fusion between the virion envelope of Flaviviruses and membranes of the target cell, the process that delivers the viral genome into the cell cytoplasm. The invention provides for methods which empl...	08/26/2008
7408024	Somatostatin antagonists The present invention is directed to a somatostatin antagonist according to formula (I): A1-cyclo {D-Cys-A2-D-Trp-A3-A4-Cys}-A5Y1, wherein A1 is an optionally substituted aromatic a-amino a...	08/05/2008
7381705	Inhibitors of hepatitis C virus The present invention relates to methods that employ peptides or peptide derivatives to inhibit hepatitis C virus infection. The present invention is based in part on the discovery that E2 envelope glycoprotein of hepatitis C virus has previously undescribed domains...	06/03/2008
7378488	Somatostatin antagonists The present invention is directed to a somatostatin antagonist according to formula (I), wherein A1 is an optionally substituted aromatic ∝-amino acid; A2 is an optionally substituted aromatic ∝-amino acid; A3 is Dab, Dap, Lys or...	05/27/2008
7368427	GLP-1 analogues The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues. ...	05/06/2008
7326685	Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof Disclosed are peptide agents and uses thereof that are analogs of biologically active peptides such as somatostatin and bombesin. The compounds of the invention have the general formula X-Y-Z-Q, where X is a cytotoxic agent, therapeutic agent, detectable label or ch...	02/05/2008
7312304	Somatostatin agonists Claimed are a series of somatostatin agonists and uses thereof, according to formula (I), A1-cyclo[Cys-A2-D-Trp-A3-A4-Cys]-A5-Y1, (I) wherein A1, A2, A	12/25/2007
7309830	Nanostructured bulk thermoelectric material A thermoelectric material comprises two or more components, at least one of which is a thermoelectric material. The first component is nanostructured, for example as an electrically conducting nanostructured network, and can include nanowires, nanoparticles, or othe...	12/18/2007
7250399	Compounds having growth hormone releasing activity Compounds that promote growth hormone releasing activity are disclosed. These compounds have the formula: A1-A2-X; A1′-X′; or A1′-Y These compounds can be present in a pharmaceutical composition. Th...	07/31/2007
7241737	Urotensin-II agonists and antagonists The present invention is directed to a novel class of cyclic polypeptides of the formula: (R1)a-AA1-cyclo[AA2-AA3-AA4-AA5-AA6-Cys]-AA7-R2, pharmaceutically ...	07/10/2007
7189691	Methods and compositions for treating leukemia A compound of the formula R1-Leu-A2-Val-A4-Ile-A6-Leu-A8-A9-A10-R2 SEQ ID NO: 1 or a pharmaceutically acceptable salt thereof, which disrupts the binding between the AF4 and AF9 proteins in mammalian cells in vitro and in vivo is useful in the treatment, prophylaxsi...	03/13/2007
7063852	Hybrid LT-A/CT-B holotoxin for use as an adjuvant The present invention provides a novel composition which is a hybrid heat labile enterotoxin comprising the A-subunit of the heat labile toxin of Escherichia coli (LT-A) and the B-subunit of the cholera enterotoxin of Vibrio cholerae (CT-B). The hybrid...	06/20/2006
7026281	Antagonistic analogs of GH-RH inhibiting IGF-I and -II There is provided a novel series of synthetic analogs of hGH-RH(1–29)NH2. These analogs inhibit the activity of endogenous hGH-RH, and therefore prevent the release of growth hormone. The stronger inhibitory potencies of the new analogs, as compared to ...	04/11/2006
6395964	Oral immunization with transgenic plants The oral antigens and adjuvants of the present invention are produced in transgenic plants and then administered through the consumption of the transgenic plant. DNA sequences both natural and synthetic encoding for the expression of immunogenic agents wh...	05/28/2002
6204049	Fungal compositions for bioremediation Compositions and methods for bioremediation of sites contaminated with chemical pollutants, wherein survival and colonization of a polluted medium by a fungal microorganism having the capacity to degrade a chemical pollutant is enhanced; and microorganism...	03/20/2001
6033673	Double mutant enterotoxin for use as an adjuvant The present invention is directed towards a novel composition which is a genetically distinct mutant of E. coli heat-labile enterotoxin (LT). Specifically, the mutant LT designated LT(R192G/L211A) is modified by two amino acid substitutions, i.e., the arg...	03/07/2000
5723578	Peptide analogs of bombesin Linear peptide analogs of bombesin with modified amino acid residues at various positions. A peptide of a group of bombesin analogs according to this invention contains either a --CH2 NH2 -- pseudopeptide bond, a (3S,4S)-4-amino-3-hy...	03/03/1998
5580772	Association between a novel human intracisternal A-type retroviral particle-type II (HIAP-II) and idiopathic CD4+ T-lymphocytopenia (ICL) The present invention relates to the discovery of a novel retroviral particle associated with idiopathic CD4+ T-lymphocytopenia (ICL). New methods of diagnosis and treatment of ICL, novel cell lines comprising the new retrovirus, assay systems that may be...	12/03/1996
5416073	Growth hormone-releasing peptides and method of treating animals, therewith The present invention relates to novel growth hormone-releasing peptides and method for increasing the release of growth hormone levels in mammals, as well as method for increasing milk production in dairy cows and increasing growth rates of animals, such...	05/16/1995
4914189	Synthetic GHRH analogs Human pancreatic GRF (hpGRF), rat hypothalamic GRF (rGRF) and porcine hypothalamic GRF (pGRF) have been earlier characterized and synthesized. The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH ...	04/03/1990

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Assignee: The Administrators of the Tulane Educational Fund