Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 8183373 | Solid state forms of sitagliptin salts Crystalline forms of Sitagliptin salts, processes for preparing crystalline forms of Sitagliptin salts, and pharmaceutical compositions of Sitagliptin salts are provided. ... | 05/22/2012 |
| 8178537 | Solid state forms of varenicline salts and processes for preparation thereof Salts and crystalline forms of several salts of Varenicline, i.e., Varenicline sulfate: are provided, along with methods of preparing the solid states and processes for preparing Varenicline base from those Varenicline salt... | 05/15/2012 |
| D659550 | Package for medicines | 05/15/2012 |
| 8158146 | Stable combinations of amlodipine besylate and benazepril hydrochloride The present invention provides a pharmaceutical composition comprising benazepril and amlodipine wherein the benazepril and the amlodipine are in physical contact with one another, and methods for making the same. ... | 04/17/2012 |
| 8148576 | Solid state forms of aliskiren compounds The invention relates to solid states of pharmaceutically acceptable compounds of aliskiren, and processes for preparation thereof. The invention further provides pharmaceutical formulations comprising the amorphous or crystalline forms of pharmaceutically acceptabl... | 04/03/2012 |
| 8129173 | Selective enzymatic esterification and solvolysis of epimeric vitamin D analog and separation of the epimers Provided is a method of selectively enzymatically esterifying or selectively enzymatically solvolyzing epimers of analogs of vitamin D having a stereogenic center at C-24 that has a free or esterified OH group. The metod can be used, for example, for separating mixe... | 03/06/2012 |
| 8124644 | Carvedilol phosphate The invention encompasses novel amorphous and crystalline forms of carvedilol phosphate, carvedilol hydrogen phosphate, and carvedilol dihydrogen phosphate as well as methods of making the novel amorphous and crystalline forms. Also disclosed are pharmaceutical comp... | 02/28/2012 |
| 8114900 | Amorphous carvedilol dihydrogen phosphate The invention encompasses novel amorphous and crystalline forms of carvedilol phosphate, carvedilol hydrogen phosphate, and carvedilol dihydrogen phosphate as well as methods of making the novel amorphous and crystalline forms. Also disclosed are pharmaceutical comp... | 02/14/2012 |
| 8097754 | Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid Provided are syntheses of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin via a chiral intermediate of the following formula 4 wherein Ar is a C6-10 aromatic group, R is a straight or branched C | 01/17/2012 |
| 8084630 | Process for the synthesis of ramelteon and its intermediates The present invention provides processes and intermediates for the synthesis of ramelteon. ... | 12/27/2011 |
| 8071638 | Solid states of atorvastatin potassium Atorvastatin potassium crystalline Forms A, B, E, F, and G are provided. Also provided are methods of preparing atorvastatin potassium crystalline Forms A, B, E, F, and G. Atorvastatin potassium crystalline Forms A, B, E, F, and G may be used to prepare pharmaceutic... | 12/06/2011 |
| 8067423 | Polymorphs of dasatinib isopropyl alcohol and process for preparation thereof The invention provides crystalline forms of isopropyl alcohol solvate of dasatinib, methods for their preparation, and pharmaceutical compositions thereof. ... | 11/29/2011 |
| 8039620 | Varenicline tosylate, an intermediate in the preparation process of varenicline L-tartrate Crystalline forms of Varenicline Tosylate: are provided, along with processes for preparing those crystalline forms of Varenicline Tosylate, and processes for obtaining high purity Varenicline base using Varenicline Tosylat... | 10/18/2011 |
| 8022094 | Carvedilol phosphate The invention encompasses novel amorphous and crystalline forms of carvedilol phosphate, carvedilol hydrogen phosphate, and carvedilol dihydrogen phosphate as well as methods of making the novel amorphous and crystalline forms. Also disclosed are pharmaceutical comp... | 09/20/2011 |
| 7973196 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid The invention encompasses processes for the synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, and intermediates of (S)-Pregabalin. ... | 07/05/2011 |
| 7973045 | Anhydrous form of dasatinib and process for preparation thereof The invention provides anhydrous forms of dasatinib, methods for their preparation, and pharmaceutical compositions thereof. ... | 07/05/2011 |
| 7960586 | Purification of armodafinil The invention encompasses processes for obtaining pure armodafinil substantially free of disulfide impurities that is suitable for use on an industrial scale. In particular, a processes for purifying armodafinil from bis(diphenylmethyl)disulfide comprising: dissolvi... | 06/14/2011 |
| 7960583 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid The invention encompasses processes for the synthesis of (S)-(+)-3-(aminomethyl) -5-methylhexanoic acid, (S)-Pregabalin, and intermediates of (S)-Pregabalin. ... | 06/14/2011 |
| 7871993 | Tigecycline crystalline forms and processes for preparation thereof The present invention relates to solid crystalline Tigecycline, and crystalline forms thereof. ... | 01/18/2011 |
| 7851651 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (S)-Pregabalin, which has the chemical name (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, is useful in anticonvulsant therapy, primarily due a mechanism that serves to promote the production of gamma-amino butyric acid, an inhibitory neurotransmitter. The invention... | 12/14/2010 |
| 7842717 | DNT-maleate and methods of preparation thereof (S)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine maleate (DNT-maleate) and polymorphs of DNT-maleate, compositions of DNT-maleate and its polymorphs, processes for the preparation of DNT-maleate and its polymorphs, and processes for the preparation of... | 11/30/2010 |
| 7838683 | Synthesis of irbesartan Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4′-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected ... | 11/23/2010 |
| 7820816 | Process for the synthesis of CMHTP and intermediates thereof The present invention provides 3-benzyloxy-2-aminopyridine (BOPA), 3-(2-Hydroxyethyl)-2-methyl-9-hydoxy-4H-pyrido[1,2-a]pyrimidine-4-one (HMBP), 3-(2-Chloroethyl)-2-methyl-9-hydoxy-4H-pyrido[1,2-a]pyrimidine-4-one (CMHP) and 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hy... | 10/26/2010 |
| 7812168 | Purification of montelukast The present invention provides methods of purifying montelukast, a new isolated impurity of montelukast, method for its isolation, and method of using montelukast impurity as a reference marker and a reference standard. ... | 10/12/2010 |
| 7777034 | Crystalline ammonium salts of rosuvastatin Provided are alkyl ammonium crystalline salts of rosuvastatin that provide for purification of rosuvastatin and its pharmaceutically acceptable salts. ... | 08/17/2010 |
| 7763749 | Method for the preparation of Pregabalin and salts thereof Processes for preparing and purifying Pregabalin and salts thereof are provided. ... | 07/27/2010 |
| 7759500 | 2-(N-methyl-propanamine)-3-(2-naphthol)thiophene, an impurity of duloxetine hydrochloride The invention encompasses 2-(N-methyl-propanamine)-3-(2-naphthol)thiophene, a duloxetine hydrochloride impurity, as well as its use as a reference marker and reference standard. ... | 07/20/2010 |
| 7749536 | Pharmaceutical formulations of aliphatic amine polymers and methods for their manufacture The present invention provides pharmaceutical compositions comprising aliphatic amine polymers such as for example Sevelamer HCl as the active pharmaceutical ingredient, wherein the aliphatica amine polymers are spray granulated. The present invention further provid... | 07/06/2010 |
| 7741482 | Reference standard for characterization of rosuvastatin Provided are rosuvastatin degradation products and their use as a reference standard (including reference marker) for analysis of rosuvastatin. ... | 06/22/2010 |
| 7732623 | Polymorphic form of atorvastatin calcium The present invention relates to atorvastatin calcium, a useful agent for lowering serum cholesterol levels. New atorvastatin calcium Form V, processes for preparing the new form, and pharmaceutical compositions and dosage forms containing the new form are disclosed... | 06/08/2010 |
| 7714129 | Methods of preparing anhydrous aripiprazole form II Provided is a method of preparing aripiprazole anhydrous Form II from aripiprazole. ... | 05/11/2010 |
| 7692034 | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc a... | 04/06/2010 |
| 7692023 | Candesartan cilexetil polymorphs Provided are candesartan cilexetil forms and methods of their preparation. Also provided are pharmaceutical compositions prepared by combining at least one pharmaceutically-acceptable execipient with at least one candesartan cilexetil form of the invention. ... | 04/06/2010 |
| 7692010 | Reference standard for characterization of rosuvastatin Provided are rosuvastatin degradation products and their use as a reference standard (including reference marker) for analysis of rosuvastatin. ... | 04/06/2010 |
| 7692009 | Reference standard for characterization of rosuvastatin Provided are rosuvastatin degradation products and their use as a reference standard (including reference marker) for analysis of rosuvastatin. ... | 04/06/2010 |
| 7692008 | Reference standard for characterization of rosuvastatin Provided are rosuvastatin degradation products and their use as a reference standard (including reference marker) for analysis of rosuvastatin. ... | 04/06/2010 |
| 7687660 | Process for preparing intermediates of HMG-CoA reductase inhibitors The present invention relates to intermediates of rosuvastatin and processes for the production thereof. ... | 03/30/2010 |
| 7687656 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid The invention encompasses processes for the synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, and intermediates of (S)-Pregabalin. ... | 03/30/2010 |
| 7687642 | Fluvastatin sodium crystal forms, processes for preparing them, compositions containing them and methods of using them Provided are crystalline forms of fluvastatin sodium and processes for their preparation. ... | 03/30/2010 |
| 7683080 | Stable iansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol The present invention provides a stable 2-(2-pyridylmethyl) sulfinyl-1H-benzimidazole (lansoprazole) comprising either greater than 500 ppm and not more than about 3,000 ppm water or greater than 200 ppm and not more than about 5,000 ppm alcohol, or both. The presen... | 03/23/2010 |
