Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 8012731 | Phosphodiesterase and gene thereof The present invention is to provide a novel phosphodiesterase and a gene thereof, specifically, Type 11 phosphodiesterase (PDE11) and a gene thereof, more specifically, a phosphodiesterase selected from (A) a protein having an amino acid sequenced shown by SEQ.ID.NO... | 09/06/2011 |
| 7799929 | Biotin intermediate and process for preparing the same The present invention is to provide a process for preparing a synthetic intermediate of biotin which is industrially advantageous, and discloses a process for preparing a compound represented by the formula (I): 1 wherein R1 and R2 may be the s... | 09/21/2010 |
| 7385083 | Potassium channel opener A potassium channel opener comprising a compound (e.g., pimaric acid) represented by the formula [I]: wherein R1, R2, R3, R4, R5, R6 | 06/10/2008 |
| 7332487 | Nitrogen-containing 5-membered ring compound The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein symbols in the formula have the following meanings; ... | 02/19/2008 |
| 7332317 | Phosphodiesterase and genes thereof The present invention is to provide a novel phosphodiesterase and a gene thereof, specifically, Type 11 phosphodiesterase (PDE11) and a gene thereof, more specifically, a phosphodiesterase selected from (A) a protein having an amino acid sequenced shown by SEQ.ID.NO... | 02/19/2008 |
| 7323337 | Gene transfer into primate embryonic stem cells using VSV-G pseudotyped simian immunodeficiency virus vectors Highly efficient gene transfer into primate-derived embryonic stem (ES) cells has successfully been achieved by using a simian immunodeficiency virus vector (SIV) pseudotyped with VSV-G protein, which is a surface glycoprotein of vesicular stomatitis virus (VSV) The... | 01/29/2008 |
| 7273868 | Pyrazine derivatives 1. A cyclic compound of the formula (I) or a pharmacologically acceptable salt thereof, wherein X is ═CH— or ═N—, Y is —NH—, —NR4—, —S—, ... | 09/25/2007 |
| 7220736 | Pyrimidine compounds A cyclic compound of the formula (I) or a pharmacologically acceptable salt thereof, wherein X is ═CH— or ═N—, Y is —NH—, —NR4—, —S—, —O—, —CH═N—,... | 05/22/2007 |
| 7220430 | Sustained-release preparation and process for producing the same The present invention is to provide a sustained release preparation comprising a drug-containing core substance and a multilayered coating layer covering the core substance, wherein all adjacent layers in the multilayered coating layer contain mutually different hyd... | 05/22/2007 |
| 7160877 | Aliphatic nitrogen-containing 5-membered ring compound The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein A represents —CH2— or —S—, ... | 01/09/2007 |
| 7153886 | Method for treatment of peripheral inflammation of a loop ileal artificial anus The present invention provides a novel agent for prophylaxis or treatment of inflammatory bowel diseases for oral administration or intra-intestinal infusion, which comprises as an active ingredient a compound of the formula (I): | 12/26/2006 |
| 7153859 | Condensed polycyclic compounds The present invention provides a novel a condensed polycyclic compound useful as a phosphodiesterase 4 inhibitor, which is shown by the formula [I]: or a pharmaceutically acceptable salt thereof and a pharmaceuti... | 12/26/2006 |
| 7138397 | Nitrogenous 5-membered ring compounds The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein symbols in the formula have the following meanings; | 11/21/2006 |
| 7083977 | Monkey-origin embryonic stem cells A method for producing a monkey-derived embryonic stem cell comprising the steps of carrying out fertilization by insemination by in vitro fertilization or intracytoplasmic sperm injection using a monkey ovum and monkey sperms, thereby giving a fertilized ovum, allo... | 08/01/2006 |
| 7078522 | Pyridopyrimidine or naphthyridine derivative A pyridopyrimidine or a naphthyridine derivative of the formula (I): wherein R1 is an optionally substituted nitrogen-containing heterocyclic group, etc.; R2 is H or a lower alkyl group; R | 07/18/2006 |
| 7070946 | Bone metabolism related protein and gene thereof The present invention is directed to a novel method of detecting a function or activity of a polypeptide which is related to bone metabolism, in particular, differentiation (maturation) of osteoblast or morphological change (retraction), specifically relating to a p... | 07/04/2006 |
| 7067535 | 5-Phenylbenzylamine compounds, process for their production and intermediates for their synthesis The present invention relates to a 5-phenylbenzylamine compound represented by the formula [1]: wherein Ring A represents a phenyl group having a substituent(s), Ra | 06/27/2006 |
| 7060832 | Nitrogen-containing fused heterocyclic carboxylic acids having an absolute configuration of “R” Nitrogen-containing fused heterocyclic carboxylic acid having an absolute configuration of “R” of the formula [XIX]: wherein Y is substituted or unsubstituted arylsulfonyl group or an alkylsulfonyl group, and... | 06/13/2006 |
| 7045298 | Method for identifying or screening agonist and antagonist to PPAR A method for identifying or screening an agonist for or antagonist to a peroxisome proliferator activated receptor (PPAR) which comprises allowing a test cell and a substance to be tested to coexist, and detecting a change in a ligand-dependent interaction between t... | 05/16/2006 |
| 7026501 | Inhibitors of α4 mediated cell adhesion The present invention relates to a phenylalanine derivative of Formula (I) wherein X1 is a halogen atom, X2 is a halogen atom, Q is a CH2R— is a carboxyl group which may be esterified; or a pharmaceutically acceptable salt thereof.... | 04/11/2006 |
| 7011776 | Method and apparatus for preparing microspheres An improved method for the preparation of a microsphere from an emulsion wherein an organic phase containing an organic solvent having a boiling point lower than that of water and a hardly-water-soluble polymer is emulsified in an aqueous phase by an in-water drying... | 03/14/2006 |
| 6897225 | Inhibitors of αLβ2 mediated cell adhesion The present invention relates to a compound of the following formula: or a pharmaceutically acceptable salt thereof. Also disclosed are compositions containing the compound and methods of preparing and using the compou... | 05/24/2005 |
| 6855843 | Inhibitors of α4 mediated cell adhesion The present invention relates to a pharmaceutical composition comprising as an active ingredient a compound of formula (I), wherein Ring A is an aromatic or a heterocyclic ring; Q is a bond, carbonyl, lower alkylene, lower alkenylene, —O— -(lower alkylene)-, etc... | 02/15/2005 |
| 6849622 | Aliphatic nitrogenous five-membered ring compounds The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein A represents —CH2— or —S—, | 02/01/2005 |
| 6797709 | Aromatic nitrogen-containing 6-membered cyclic compounds An aromatic nitrogen-containing 6-membered cyclic compound of the formula (I): wherein Ring A is a substituted or unsubstituted nitrogen-containing heterocyclic group; R1 is a substituted or unsubstituted lowe... | 09/28/2004 |
| 6794154 | Remedies for kidney diseases and method for screening the same The present invention provides a method for screening or identifying therapeutic or prophylactic agents for renal diseases, which comprises assaying a test substance for the activity of up-regulating the expression of fatty acid-binding protein (FABP), and novel mou... | 09/21/2004 |
| 6780877 | Acid addition salt of optically active piperidine compound and process for preparing the same The present invention is to provide a benzenesulfonic acid salt and a benzoic acid salt of (S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino]butanoic acid represented by the formula (I): wherein * represents an asy... | 08/24/2004 |
| 6730702 | Therapeutic agents for inflammatory diseases of intestine The present invention provides a novel agent for prophylaxis or treatment of inflammatory bowel diseases for oral administration or intra-intestinal infusion, which comprises as an active ingredient a compound of the formula (I): | 05/04/2004 |
| 6716983 | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof A process for preparing S type 2-substituted hydroxy-2-indolidinylbutyric ester compound [II]: wherein Ro is residue of nitrogen-containing fused heterocyclic carboxylic acid having absolute configuration of ... | 04/06/2004 |
| 6699888 | Inhibitors of L댢 mediated cell adhesion The present invention relates to small molecules according to formula (I) that are potent inhibitors of Lଲ.sub.2 mediated cell adhesion and which could be useful for the treatment of inflammatory diseases: ##STR1##... | 03/02/2004 |
| 6692769 | Sustained-release particles The present invention discloses sustained release particles having a mean particle size of 300 μm, or less, comprising a drug-containing core substance coated with a mixed coating of a hydrophobic organic compound-water-insoluble polymer, which prevents ... | 02/17/2004 |
| 6692768 | Preparation method of drug-containing spherical fine particles The present invention discloses an efficient preparation method of spherical fine particles containing a drug for an easily-swallowed, controlled-release preparation comprising the production of drug-containing spherical fine particles (mean particle size... | 02/17/2004 |
| 6685617 | Inhibitors of 댔댡 mediated cell adhesion The present invention relates to compound of formula (I), that are potent inhibitors of 댔ଲ.sub.1 mediated adhesion to either VCAM or CS-1 and which could be useful for the treatment of inflammatory diseases. Specifically, the molec... | 02/03/2004 |
| 6656935 | Aromatic nitrogen-containing 6-membered cyclic compounds An aromatic nitrogen-containing 6-membered cyclic compound of the formula (I): ##STR1## wherein Ring A is a substituted or unsubstituted nitrogen-containing heterocyclic group; R1 is a substituted or unsubstituted lower alkyl group, --NH--... | 12/02/2003 |
| 6638534 | Preparation capable of releasing drug at target site in intestine A preparation capable of releasing a medicinal substance at a targeted site in the intestine, wherein the preparation dose not releases medicinal substance in endogastri at all, but can quickly release a medicinal substance when it reaches the desired sit... | 10/28/2003 |
| 6617456 | Camptothecin derivatives A camptothecin derivative comprising a compound of the formula [I]: ##STR1## wherein R1, R2, R3, R4 and R5 are (A) adjacent two groups combine to form alkylene, or both are H, and one of the remaining ... | 09/09/2003 |
| 6596752 | Inhibitors of 댔댡 mediated cell adhesion The present invention relates to small molecules according to the formula [I]: ##STR1## which are potent inhibitors of 댔ଲ.sub.1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing | 07/22/2003 |
| 6579679 | Method for examining central nervous system diseases and method for screening remedies The present invention relates to a method for screening and identifying therapeutic agents or preventive agents for central nervous system diseases which comprises assaying a suppressing effect of a test substance on an expression of a splicing variant tr... | 06/17/2003 |
| 6521666 | Inhibitors of 댔 mediated cell adhesion ##STR1## The present invention relates to a pharmaceutical composition comprising as an active ingredient a compound of formula (I), wherein Ring A is an aromatic or a heterocyclic ring; Q is a bond, carbonyl, lower alkylene, lower alkenylene, --O-(lower ... | 02/18/2003 |
| 6512118 | Camptothecin derivatives A camptothecin derivative comprising a compound of the formula [I] is disclosed: ##STR1## wherein R1, R2, R3, R4 and R5 are (A) adjacent two groups combine to form alkylene, or both are H, and one of ... | 01/28/2003 |
