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| Number | Title | Issue Date |
| 8173645 | Glucokinase activators Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compoun... | 05/08/2012 |
| 8163779 | Glucokinase activators Compounds of the following formula are provided for use with glucokinase: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compound... | 04/24/2012 |
| 8124617 | Imidazopyridine compounds Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein. ... | 02/28/2012 |
| 8034822 | Glucokinase activators Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compoun... | 10/11/2011 |
| 8008332 | Substituted indazoles as glucokinase activators Compounds are provided for use with hexokinases that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods ... | 08/30/2011 |
| 7759339 | Hydroxysteroid dehydrogenase inhibitors Compounds, pharmaceutical compositions, kits and methods are provided for use with hydroxysteroid dehydrogenases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. | 07/20/2010 |
| 7741494 | Histone deacetylase inhibitors Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of: wherein the substituents are as defined herein. ... | 06/22/2010 |
| 7732475 | Histone deacetylase inhibitors Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of: wherein the substituents are as defined herein. ... | 06/08/2010 |
| 7723344 | Dipeptidyl peptidase inhibitors Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein. ... | 05/25/2010 |
| 7696218 | Substituted 1,3-dialkyl-2,4-dioxo-6-(arylamino)-1,2,3,4-tetrahydropyrimidine-5-hydroxamic acid inhibitors of MAPK/ERK kinase Compounds of the substituted 1,3-dialkyl-2,4-dioxo-6-(arylamino)-1,2,3,4-tetrahydropyrimidine-5-hydroxamic acids, show below: wherein the variables are as defined herein, and pharmaceutical compositions thereof, are provide... | 04/13/2010 |
| 7687638 | Dipeptidyl peptidase inhibitors Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined herein. ... | 03/30/2010 |
| 7642275 | Histone deacetylase inhibitors Compounds, pharmaceutical compositions, kits and methods are provided for use with histone deacetylases (HDACs) that comprise a compound of the formulae: wherein the variables are as defined herein. ... | 01/05/2010 |
| 7642253 | Histone deacetylase inhibitors Compounds, pharmaceutical compositions, kits and methods useful for inhibiting HDAC, thereby treating a disease state for which HDAC possess activity that contributes to the pathology and/or symptomology of the disease state. The compound is selected from the group ... | 01/05/2010 |
| 7638638 | Dipeptidyl peptidase inhibitors Pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound with the formula: where the labeled substituents are as described herein. ... | 12/29/2009 |
| 7563610 | Crystalline composition of farsenyl pyrophosphate synthase (IspA) Provided are crystals relating to Farsenyl Pvrophosphate Synthase (IspA) from E. coli and its various uses. ... | 07/21/2009 |
| 7556950 | Crystallization of the catalytic domain of human phosphodiesterase 4-D3 (PDE4-D3) Provided are crystals relating to human phosphodiesterase 4-D3 (PDE4-D3), methods for forming crystals comprising PDE4-D3 and crystals comprising PDE4-D3 co-crystallized with a ligand molecule, and methods of using crystals comprising PDE4-D3. ... | 07/07/2009 |
| 7534592 | Crystallization of carboxyltransferase domain of Acetyl-CoEnzyme A Carboxylase 2 with a ligand Provided are crystals relating to the carboxyltransferase domain of human Acetyl-Coenzyme A Carboxylase 2 and its various uses. ... | 05/19/2009 |
| 7510690 | System for performing crystallization trials A crystallization system is provided comprising a trial generation station configured to generate crystallization trials in trial zones of a crystallization plate; an imaging station configured to take images of crystallization trials in the crystallization plate; a... | 03/31/2009 |
| 7507552 | Crystallization of histone deacetylase 2 Provided are crystals relating to histone deacetylase 2 (HDAC-2) and its various uses. ... | 03/24/2009 |
| 7452419 | Method for performing crystallization trials A method is provided for operating a crystallization system comprising identifying a screen storage plate from among the plurality of screen storage plates stored in a screen storage station, each screen storage plate having a plurality of wells that contain a scree... | 11/18/2008 |
| 7444273 | Crystallization of aurora/LPL1P-related kinase Provided are crystals relating to Aurora/LPL1P-related kinase and its various uses. ... | 10/28/2008 |
| 7435397 | System for performing crystallization trials A crystallization system is provided comprising a screen generation station; a screen storage station; including a housing configured to store a plurality of screen storage plates and mechanics for retrieving a selected screen storage plate from among the plurality ... | 10/14/2008 |
| 7435379 | System for performing crystallization trials A trial generation station is provided comprising: a deck configured to receive a crystallization plate from a transport mechanism, the crystallization plate including a plurality of trial zones where crystallization trials are generated; and a head configured to be... | 10/14/2008 |
| 7431769 | Method for performing crystallization trials A method is provided that comprises generating a screen storage plate that contains screen solutions at a screen generation station; employing a transport mechanism to transport the screen storage plate from the screen generation station to a screen storage station;... | 10/07/2008 |
| 7431768 | System for performing crystallization trials A crystallization system is provided comprising: a screen replicator configured to transfer screen solutions from wells of a screen storage plate into well regions of multiple crystallization plates; a trial generation station configured to generate crystallization ... | 10/07/2008 |
| 7416710 | Method and system for performing crystallization trials A crystallization system is provided that comprises a screen replicator having a transfer mechanism configured to transfer portions of different screen solutions contained in a screen storage plate to well regions of a crystallization plate; a screen storage station... | 08/26/2008 |
| 7416709 | Method for performing crystallization trials A method is provided that comprises having a trial generation station generate crystallization trials in a crystallization plate transporting the crystallization plate to an imaging station; and having the imaging station take images of the crystallization trials wi... | 08/26/2008 |
| 7399884 | Histone deacetylase inhibitors Histone deacetylase inhibitors and uses thereof are provided that have the general formula wherein R1, R2, R3 and R4 are each independently selected from the group consist... | 07/15/2008 |
| 7381825 | Histone deacetylase inhibitors Compounds that may be used to inhibit histone deacetylase having the formula Z-Q-L-M or Z-L-M wherein M is a substituent capable of complexing with a deacetylase catalytic site and/or a metal ion; L is a substituent providing between 0-10 atoms s... | 06/03/2008 |
| 7375228 | Histone deacetylase inhibitors Compounds that may be used to inhibit histone deacetylase having the formula Z-Q-L-M or Z-L-M wherein M is a substituent capable of complexing with a deacetylase catalytic site and/or a metal ion; L is a substituent providing between 0-10 atoms s... | 05/20/2008 |
| 7368269 | Crystallization of MAPK/ERK Kinase 2 Provided are crystals relating to human mitogen-activated protein kinase kinase2 (MAPKK2), also known as MAPK/ERK Kinase2 (MEK2) and its various uses. ... | 05/06/2008 |
| 7344852 | Crystallization of dipeptidyl peptidase IV (DPPIV) Provided are crystals relating to DPPIV and its various uses. ... | 03/18/2008 |
| 7326552 | Wild-type kinase domain of human Ephrin receptor A2 (EPHA2) and crystallization thereof Provided are crystals relating to human Ephrin Receptor A2 and its various uses. ... | 02/05/2008 |
| 7319016 | Crystallization of cathepsin S Provided are crystals relating to Cathepsin S and its various uses. ... | 01/15/2008 |
| 7309594 | Crystallization of protein kinase Bα/AKT1 Provided are crystals relating to Protein kinase Bα/AKT1 and its various uses. ... | 12/18/2007 |
| 7303892 | Crystallization of AKT3 Provided are crystals relating to AKT3 and its various uses. ... | 12/04/2007 |
| 7303893 | Crystallization of c-KIT tyrosine kinase leading to autoinhibited crystal structure Provided are crystals relating to the autoinhibited structure of c-KIT tyrosine kinase (c-KIT) and its various uses. ... | 12/04/2007 |
| 7297508 | Crystallization of fibroblast activation protein alpha (FAPα) Provided are crystals relating to FAPα and its various uses. ... | 11/20/2007 |
| 7294309 | Small volume liquid handling apparatus and method A fluid dispensing system comprising: a fluid container; a dispensing head in fluid communication with the fluid container; a displacement mechanism which delivers fluid from the fluid container to the dispensing head such that an aliquot of liquid is delivered to a... | 11/13/2007 |
| 7270987 | Crystallization of FMS-like tyrosine kinase 3 Provided are crystals and structure coordinates relating to FMS-like tyrosine kinase 3 and its various uses. ... | 09/18/2007 |
