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| Number | Title | Issue Date |
| 8183285 | Therapeutic agent for irritable bowel syndrome and methods thereof The present invention provides a therapeutic agent and methods thereof for the treatment for irritable bowel syndrome. The agent comprises a compound represented by formula (I): wherein, R1 represents an optional... | 05/22/2012 |
| 8178555 | Apoptosis signal-regulating kinase 1 inhibitors The present invention relates to apoptosis signal-regulating kinase 1 (“ASK1”) inhibiting compounds of the formula wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, ... | 05/15/2012 |
| 8178543 | Bi- and tricyclic fused pyrimidines as tyrosine kinase inhibitors The present invention relates to a compound represented by the formula: wherein W is C(R1) or N, each A is an optionally substituted aryl group or a heteroaryl group, X1 is —NR3—Y1 | 05/15/2012 |
| 8178534 | cMET inhibitors Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; meth... | 05/15/2012 |
| 8173663 | Dipeptidyl peptidase inhibitors Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independen... | 05/08/2012 |
| 8173360 | Cell death inhibitor The cell death inhibitor comprising a substance capable of binding to macrophage migration inhibitory factor is useful as a preventive/therapeutic agent for, e.g., heart diseases, neurodegenerative diseases, cerebrovascular diseases, central nervous infections, trau... | 05/08/2012 |
| 8163935 | Fused heterocyclic compounds There is provided a CRF receptor antagonist comprising a compound of the formula (I): wherein R1 is an optionally substituted hydrocarbyl, an optionally substituted C-linked heterocyclic group, an optionally subs... | 04/24/2012 |
| 8163755 | Hexahydrooxazinopterine compounds The present invention provides mTOR inhibitors of the formula wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods o... | 04/24/2012 |
| 8158617 | Fused heterocyclic compound and use thereof The present invention relates to a serotonin 5-HT2C receptor activator containing a compound represented by the formula wherein ring A is a 5- or 6-membered aromatic heterocycle optionally having substituent(s), ... | 04/17/2012 |
| 8153694 | Cyclopropanecarboxylic acid compound A compound of the formula (I): wherein each symbol is as defined in the description, a salt thereof, and a prodrug thereof of the present invention unexpectedly have a superior GPR40 receptor agonist activity and superior p... | 04/10/2012 |
| 8148383 | Fused ring compound and use thereof Provided is a novel compound represented by the following formula Wherein each symbol is as defined in the specification, or a salt thereof, which has an angiotensin II receptor antagonistic activity and a peroxisome prolif... | 04/03/2012 |
| 8148367 | Renin inhibitors Disclosed are compounds, pharmaceutical compositions, kits, articles of manufacture, methods of using, and methods of preparing compounds having the formula: wherein the variables are as defined herein. The disclosed compou... | 04/03/2012 |
| 8143258 | Benzothiazole compounds useful for Raf inhibition Provided is a fused heterocycle derivative showing a strong Raf inhibitory activity. A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof. ... | 03/27/2012 |
| 8138168 | Renin inhibitors The invention relates to compounds having the formulae: wherein the variables are as defined herein. The invention further relates to methods of making and using these compounds, and pharmaceutical compositions, kits and ar... | 03/20/2012 |
| 8138123 | Gene expressing analysis tool The present invention provides a tool for analysis of expression of Macaca fascicularis gene expression analysis tool containing a set of nucleic acids containing base sequences the same or substantially the same as two or more base sequences selected from th... | 03/20/2012 |
| 8133898 | Renin inhibitors The invention provides compounds, pharmaceutical compositions, kits, method of preparing, and method of using the compounds which exhibit renin and other S9 proteases activities and consist of the formula:—wherein the variables are as defined herein. | 03/13/2012 |
| 8129538 | Renin inhibitors The invention relates to compounds having the formula: wherein the variables are as defined herein. The invention further relates to methods of making and using these compounds, and pharmaceutical compositions, kits and art... | 03/06/2012 |
| 8124617 | Imidazopyridine compounds Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein. ... | 02/28/2012 |
| 8124606 | Substituted 7,8,9,10-tetrahydro-5H-dipyrido[1,2-a:3′,2′-e]pyrazin-6(6aH)-ones Disclosed are compounds of the following formula: in which R1, R2, R5, R6, R7, R11, X, and m are defined in the specification. Also disclosed are pharmaceuti... | 02/28/2012 |
| 8119655 | Kinase inhibitors Compounds, pharmaceutical compositions, kits and methods are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. ... | 02/21/2012 |
| 8114620 | Diagnostic and therapeutic target PRKX proteins for neurodegenerative diseases The present invention discloses a dysregulation of a PRKX gene and the protein products thereof in Alzheimer's disease patients and individuals being at risk of developing Alzheimer's disease. Based on this finding, the invention provides methods for diagnosing and ... | 02/14/2012 |
| 8110585 | Bicyclic compound and pharmaceutical use thereof The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substit... | 02/07/2012 |
| 8105626 | Granules containing acid-unstable chemical in large amount It is intended to provide preparations such as capsules containing an acid-unstable medicament (in particular, a benzimidazole compound having an antiulcer effect, etc.) at a high concentration which are prepared by using about 12% by weight or more (based on the to... | 01/31/2012 |
| 8093403 | Process for producing fused imidazole compound, reformatsky reagent in stable form, and process for producing the same The present invention provides an industrially advantageous process for producing a steroid C17,20 lyase inhibitor represented by the general formula (I); and a Reformatsky reagent in a stable form suitable for t... | 01/10/2012 |
| 8093382 | Dipeptidyl peptidase inhibitors Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of: wherein E is CH or N, Q is selected from the group consistin... | 01/10/2012 |
| 8092830 | Lactic acid polymer and process for producing the same A process for producing a lactic acid polymer of 15,000 to 50,000 in weight-average molecular weight, the content of polymeric materials having not more than about 5,000 in weight-average molecular weight therein being not more than about 5% by weight, characterized... | 01/10/2012 |
| 8088821 | Fused cyclic compounds The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof. The compound or a salt thereof or a prodrug thereof has a GPR40 receptor fun... | 01/03/2012 |
| 8088726 | Process for producing sustained-release composition A process for producing a sustained-release composition which comprises mixing an aqueous solution containing a physiologically active substance and an acid or base in a molar amount of 1.5 or more times that of the physiologically active substance with a solution o... | 01/03/2012 |
| 8071766 | HSP90 inhibitors The invention relates to HSP90 inhibiting compounds consisting of the formula: wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture compris... | 12/06/2011 |
| 8071130 | Solid preparation The present invention intends to provide a solid preparation which contains an insulin sensitizer and an active ingredient other than an insulin sensitizer, and exhibits dissolution behavior of an insulin sensitizer similar to that of an insulin sensitizer from “a... | 12/06/2011 |
| 8067453 | Neurotrophin production/secretion promoting agent A neurotrophin production/secretion promoting agent which comprises an azole derivative of the formula: wherein R1 represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy gr... | 11/29/2011 |
| 8067030 | Controlled release composition and method of producing the same A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided. A controlled release composition comprising (1... | 11/29/2011 |
| 8063066 | MAPK/ERK kinase inhibitors Compounds are provided for use with MEK that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and inte... | 11/22/2011 |
| 8057990 | Screening method The present invention provides a medicament for preventing/treating cancer, comprising a tacrine compound, or a compound promoting the binding between the tacrine compound and a protein comprising the same or substantially the same amino acid sequence as the amino a... | 11/15/2011 |
| 8053604 | Process for preparation of diphosphine compounds and intermediates for the process A production method of a compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c, R2d | 11/08/2011 |
| 8048909 | Proton pump inhibitors A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R1 is an option... | 11/01/2011 |
| 8044049 | Fused heterocyclic derivative and use thereof The present invention provides a fused heterocyclic derivative having a potent kinase inhibitory activity and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the specifica... | 10/25/2011 |
| 8039500 | Fused heterocyclic compounds There is provided a compound of the formula: wherein R1 is an optionally substituted hydrocarbyl, a substituted amino, etc.; R2 is an aromatic group substituted with one or two substituents at the posi... | 10/18/2011 |
| 8034812 | Imidazopyridazine derivative having kinase inhibitory activity and pharmaceutical agent thereof The present invention provides an imidazopyridazine derivative compound having a potent kinase inhibitory activity and a pharmaceutical agent thereof useful for treatment or prevention of cancer and the like. One such compound is represented by the formula: | 10/11/2011 |
| 8030337 | Tricyclic compound and pharmaceutical use thereof The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof and the like. ... | 10/04/2011 |
