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| Number | Title | Issue Date |
| 6756229 | Human cell line showing stable expression of cytochromes P450 This invention relates to cell lines that are obtained using cultured cell lines derived from human liver as a host and that stably express a number of human cytochromes P450. The human liver-derived cultured cell lines of the present invention are useful in, for ex... | 06/29/2004 |
| 7462757 | Animal with gene hypoexpression The present invention relates to non-human animal embryonic stem cells in which a lecithin:cholesterol acyltransferase-like lysophospholipase endogenous gene is inactivated; non-human animals deficient in expression of LLPL gene; methods of screening for prophylacti... | 12/09/2008 |
| 7375074 | Body weight gain inhibitor The present invention intends to provide a body weight gain inhibitor and the like. The ligand of the present invention is useful as a superior body weight gain inhibitor and the like, or for a screening of the superior body weight gain inhibitor and the like. ... | 05/20/2008 |
| 7342105 | Antibody and use thereof The antibody of the present invention, which specifically reacts with the N-terminal or C-terminal partial peptide of TGR23-2 ligand, is useful in detecting and quantifying the TGR23-2 ligand. Moreover, it is useful as a preventing/treating agent and a diagnostic ag... | 03/11/2008 |
| 7309693 | Preventives and remedies for pulmonary hypertension The present invention provides a prophylactic and/or therapeutic agent for pulmonary hypertension, comprising an antagonistic mutein of MCP-1 or a salt thereof, a DNA molecule comprising a nucleotide sequence encoding the antagonistic mutein of MCP-1, or a neutraliz... | 12/18/2007 |
| 7294475 | Gene and use thereof A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention... | 11/13/2007 |
| 7262185 | Benzazepine derivative, process for producing the same, and use The present invention provides a novel benzazepine derivative represented by formula: wherein, R1 is a 5- or 6-membered aromatic ring, R2 is lower alkyl group, etc., Y is an optionally subst... | 08/28/2007 |
| 7144720 | Protein and DNA thereof The present invention relates to a novel protein belonging to an ADAM family, a partial peptide thereof or a salt thereof, a DNA encoding the protein, a recombinant vector comprising the DNA, a transformant, a method for producing the protein, a medicine comprising ... | 12/05/2006 |
| 7067268 | Antibodies and utilization thereof The anti-19P2 ligand monoclonal antibodies of the invention (in particular P2L-1Ca) have very high binding ability and can neutralize the arachidonic acid metabolite releasing activity of the 19P2 ligand. Therefore, they can be used, among others, as diagnostic, pro... | 06/27/2006 |
| 7064106 | Gene and use thereof A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention... | 06/20/2006 |
| 7053053 | Humanin-like peptide and use thereof A novel polypeptide having a cell death inhibitory activity and use thereof is provided. The polypeptide and the polynucleotide encoding it can be used as a diagnostic, therapeutic or prophylactic agent for various diseases and disorders. Certain suitable diseases a... | 05/30/2006 |
| 7045497 | Use of peptide The present invention relates to use of peptide to which G-protein coupled receptor protein recognizes as a ligand. Since the ligand polypeptide of the present invention has a stimulating action on oxytocin secretion, it is useful as a drug for ameliorating, preserv... | 05/16/2006 |
| 7008950 | Benzofurans as suppressors of neurodegeneration A compound of the formula: wherein R1 and R2 each is H or a hydrocarbon group which may be substituted, or R1 and R2 form a 3- to 8-membered carbo or heterocyclic ring which ... | 03/07/2006 |
| 7001997 | Proteins, their production and use This invention relates to a novel metalloprotease having a proteolytic activity, its partial peptide or a salt either of them, a DNA coding for the protein, a recombinant vector comprising the DNA, a transformant carrying the recombinant vector, a process for produc... | 02/21/2006 |
| 6991908 | Antiobestic agents methods for screening antiobestic agents and kits comprising same The present invention provides a method for screening a compound or its salt that alters the binding property between MCH or its salt and SLC-1 or its salt, characterized by using MCH or its derivative or a salt thereof and SLC-1 or its salt is useful for screening ... | 01/31/2006 |
| 6953789 | Thiol compounds, their production and use The present invention provides a compound represented by Formula: wherein ring A and ring B may be same or different and each is an optionally substituted homocyclic or heterocyclic ring and the like, each R1 | 10/11/2005 |
| 6936602 | Benzazepine derivatives, process for the preparation of the same and uses thereof Compounds of the general formula (I): or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R1 is a 5- to 6-membered aromatic ring which... | 08/30/2005 |
| 6930104 | Heterocyclic derivatives The object of the present invention is to provide soluble β-amyloid precursor protein secretory stimulators, which are effective in treating neurodegenerative diseases as well as cerebrovascular disorder-induced neuronopathy. More specifically, the present inventio... | 08/16/2005 |
| 6930185 | Melanin-concentrating hormone antagonist A melanin-concentrating hormone antagonist comprising a compound of the formula (I): wherein Ar1 is a cyclic group which may be substituted; X and Y are the same or different and are a spacer having a main c... | 08/16/2005 |
| 6924300 | Oxyiminoalkanoic acid derivatives To provide a novel oxyiminoalkanoic acid derivative which has excellent hypoglycemic and hypolipidemic actions and which is used for the prevention or treatment of diabetes mellitus, hyperlipemia, insulin insensitivity, insulin resistance and impaired glucose tolera... | 08/02/2005 |
| 6924292 | Furoisoquinoline derivatives, process for producing the same and use thereof A compound having a partial structure represented by Formula: or a salt thereof has an excellent phosphodiesterase (PDE) IV-inhibiting effect, and is useful as a prophylactic or therapeutic agent against inflammatory d... | 08/02/2005 |
| 6911459 | Pharmaceutical composition Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis ... | 06/28/2005 |
| 6911468 | Tyrosine phosphatase inhibitors A compound of the formula (I): wherein X1 and X2 are the same or different and each is a bond or a spacer having 1 to 20 atom(s) in the main chain; one of... | 06/28/2005 |
| 6906177 | GABA transporter protein and DNA thereof The present invention provides a novel protein and its use. The protein or its salt, the partial protein, its amide or ester, or salts, and DNA encoding the same can be employed for obtaining antibodies and antisera, constructing the expression system of the protein... | 06/14/2005 |
| 6906055 | Phosphonocephem compound A cephem compound (particularly its crystal) represented by the formula [I], wherein X is CH3COOH, CH3CH2COOH or CH3CN, and n is 0 to 5, is useful as an antibacterial agent (particularly anti-MRSA agent) and shows superior... | 06/14/2005 |
| 6881842 | Process for producing tricyclic fused heterocyclic derivative A process for easily and industrially advantageously producing both a tricyclic fused heterocyclic derivative having acetylcholinesterase inhibitory activity and an intermediate for the derivative. The process for producing the target compounds comprises the followi... | 04/19/2005 |
| 6881545 | Polypeptides, their production and use The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medici... | 04/19/2005 |
| 6878831 | Process for preparing optically active 2,3-dihydrobenzofuran compounds A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: ... | 04/12/2005 |
| 6872718 | Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents A compound represented by the formula: wherein Ring A is a non-aromatic 5- to 7-membered nitrogen-containing heterocyclic ring which may be further substituted, Ring B is benzene ring which is further substituted, Ring... | 03/29/2005 |
| 6864367 | Process for producing cyclic compound A process suitable for safely mass-producing, through a short step, cyclic compounds useful in medicines, agricultural chemicals, foods, cosmetics, and chemical products or as intermediates therefor. The process, which is for producing a compound represented by the ... | 03/08/2005 |
| 6849738 | Processes for the production of thienopyrimidine derivatives The present invention provides a process for producing an intermediate for thienopyrimidine derivatives having the GnRH antagonistic activity at an industrial large scale. The process for production of the present invention relates to a process for producing ... | 02/01/2005 |
| 6844179 | Protein and DNA thereof The protein of the present invention and a DNA encoding the same can be used as therapeutic/prophylactic agents for diseases such as infectious diseases. The protein of the present invention is also useful as a reagent for screening a compound or its salt capable of... | 01/18/2005 |
| 6838259 | Process for producing kiss-1 peptide A KiSS-1 peptide or a salt thereof can be produced in a large scale by subjecting a fusion protein or peptide in which a KiSS-1 peptide is ligated to the N-terminal of a protein or peptide having cysteine at the N-terminal, to the reaction of cleaving the peptide bo... | 01/04/2005 |
| 6833457 | Process for preparation of benzylpiperidine compounds According to the process as shown in the following scheme having a step for reacting Compound (I) with Compound (II) to produce Compound (III), benzylpiperidine compounds useful as synthesis starting materials of pharmaceutical agents, agricultural chemicals and the... | 12/21/2004 |
| 6833381 | TNF-α inhibitors TNF-α inhibitors containing a heterocyclic compound having angiotensin II antagonistic activity which are useful as preventives/remedies for inflammatory diseases, etc. ... | 12/21/2004 |
| 6827949 | Wood preservative A wood preservative that comprises as an active ingredient a Piper methysticum, plant or a processed product thereof or a compound represented by Formula (I): wherein R1, R2, R3, R... | 12/07/2004 |
| 6825165 | Betacellulin modification The betacellulin mutein or its salt of the present invention is useful for better therapeutic drug for diabetes. Since they have intact BTC activity and reduced EGF activity, and no antigenicity-related problems. ... | 11/30/2004 |
| 6815194 | Cytidine deaminase Genes encoding novel proteins named AID (Activation-Induced cytidine Deaminase), that are structurally related to APOBEC-1, an RNA editing enzyme, and have a cytidine deaminase activity similar to APOBEC-1, have been found by preparing cDNA libraries from mouse B ce... | 11/09/2004 |
| 6800778 | Process for producing optically active naphthalene derivative and optical resolver therefor The present invention provides a method of producing an optically active form of a compound represented by the formula (I) having a steroid C17,20-lyase inhibitory activity and is useful as an agent for the prophylaxis or treatment of prostatism, tumor su... | 10/05/2004 |
| 6800611 | Metastin derivatives and their use The invention relates to metastin derivatives represented by the formula: X-AA1-AA2-AA3-AA4-Z (I), or a salt thereof, or a pro-drug thereof, which have cancer metastatis suppressing activity and cancer proliferation suppre... | 10/05/2004 |