Bizarre Patents
User-operated amusement apparatus for kicking the user's buttocks
An apparatus including a user-operated and controlled apparatus for self-infliction of repetitive blows to the user's buttocks by a plurality of elongated arms bearing flexible extensions that rotate under the user's control.
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| Number | Title | Issue Date |
| 8124744 | Macrolide derivatives Compounds represented by formula (I) and the formula (IV) have an inhibitory activity of MMP-9 production, therefore, are useful as a medicine agent with fewer side effects than conventional MMP enzyme activity inhibitors, as a prophylactic and therapeutic drug for ... | 02/28/2012 |
| 8106194 | Pyrrolopyrimidine and pyrrolotriazine derivatives An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disea... | 01/31/2012 |
| 8106024 | Method of treating cancer with an RPN2 gene expression inhibitor The present invention uses an RPN2 gene expression inhibitor as a cancer cell growth inhibitor, which further includes a drug showing an anti-cancer action if desired, and is administered in combination with atelocollagen if desired. In addition, the present inventi... | 01/31/2012 |
| 8097708 | 10a-Azalide compound [Object]: To provide a compound having a novel structure effective against Hemophilus influenzae and erythromycin resistant bacteria (for example, resistant pneumococci and streptococci) as well as against conventional erythromycin sensitive bacteria. ... | 01/17/2012 |
| 8039647 | 2-amino-bicyclo (3.1.0) hexane-2,6-dicarboxylic ester derivative A drug effective for the treatment and prevention of psychiatric disorders such as schizophrenia, anxiety and related ailments thereof, depression, bipolar disorder and epilepsy. The drug antagonizes the action of group II metabotropic glutamate receptors and shows ... | 10/18/2011 |
| 8030499 | 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alz... | 10/04/2011 |
| 8022091 | Triazole derivative An object of the present invention is to provide a compound having an action of inhibiting binding between S1P and its receptor, Edg-1 (S1P1), and is useful as a pharmaceutical compound. A compound or a pharmaceutically acceptable salt thereof, which comp... | 09/20/2011 |
| 8017792 | 1-thio-D-glucitol derivatives The present invention provides a 1-thio-D-glucitol compound of the following formula, which shows the action of inhibiting the activity of SGLT2, a pharmaceutically acceptable salt of the compound, or a hydrate of the compound or the salt; and a pharmaceutical compr... | 09/13/2011 |
| 7960579 | 2-amino-bicyclo [3.1.0] hexane-2,6-dicarboxylic ester derivative A drug effective for the treatment and prevention of psychiatric disorders such as schizophrenia, anxiety and related ailments thereof, depression, bipolar disorder and epilepsy. The drug antagonizes the action of group II metabotropic glutamate receptors and shows ... | 06/14/2011 |
| 7951811 | Pyrrolo[2,3-D]pyrimidine derivatives substituted with a cyclic amino group [PROBLEM TO BE SOLVED] An object of the present invention is to provide an antagonist against CRF receptors and/or an agonist for δ receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, su... | 05/31/2011 |
| 7932259 | Pyrrolo[2,3-d]pyrimidine derivatives substituted with a cyclic amino group An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disea... | 04/26/2011 |
| 7910619 | 1-thio-D-glucitol derivatives The present invention provides a 1-thio-D-glucitol compound of the following formula, which shows the action of inhibiting the activity of SGLT2, a pharmaceutically acceptable salt of the compound, or a hydrate of the compound or the salt; and a pharmaceutical compr... | 03/22/2011 |
| 7888392 | Ointment An ointment containing a compound represented by formula (I): [wherein R1 represents any group of a group represented by the formula: —(CH2)4â€... | 02/15/2011 |
| 7737182 | Pharmaceuticals for xerosis A method for or treating xerosis by applying a prostaglandin D receptor selective agonist to a mammal. ... | 06/15/2010 |
| 7718701 | Antipruritic agent A method of treating atopy-evoked pruritic symptoms by administering a prostaglandin derivative. ... | 05/18/2010 |
| 7658338 | Small fixed quantity dispenser for aerosol container A subdivided fixed amount distributing apparatus for aerosol containers is provided in which aerosol contents exceeding a specified amount is prevented from being used in one cycle by keeping constant in total number of injection times at all times. A structure is s... | 02/09/2010 |
| 7601734 | Cyclic amine compound An object of the present invention is to provide a cyclic amine compound which has a potent inhibitory effect on the binding of α2C-adrenoceptor and is useful in preventing and treating disorders attributable to α2C-adrenoceptor. The above-described object ... | 10/13/2009 |
| 7557111 | Substituted thieno[3,2-d]pyrimidines as CRF receptor antagonists An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disea... | 07/07/2009 |
| 7550649 | Transgenic non-human mammal An object of the present invention is to provide a model animal of Parkinson's disease comprising an α-synuclein gene introduced therein. The present invention provides a transgenic non-human mammal or a portion thereof, wherein an α-synuclein gene is introduced a... | 06/23/2009 |
| 7544690 | MCH receptor antagonists The present invention relates to novel compounds of the formula (I) which act as MCH receptor antagonists. These compositions are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of obesity, obesity related disorders, anxiety, or dep... | 06/09/2009 |
| 7528124 | 1,3-dihydro-2H-indol-2-one derivative A 1,3-dihydro-2H-indol-2-one derivative expressed by Formula 1 (wherein R1 is a halogen atom, a C1 to C4 alkyl group, etc., and R2 is a hydrogen atom, a halogen atom, etc., or R2 is in the 6-position of the indo... | 05/05/2009 |
| 7439232 | Heteroaryl 5-thio-β-D-glucopyranoside derivatives and therapeutic agents for diabetes containing the same There is provided a heteroaryl 5-thio-β-D-glucopyranoside compound of the following formula, which has an inhibitory effect on SGLT2 activity, or a pharmaceutically acceptable salt thereof or a hydrate thereof. There is also provided a pharmaceutical preparation, p... | 10/21/2008 |
| 7435590 | Monoclonal antibody and hybridoma producing the same The present invention establishes a simple and a highly sensitive detection method for hEPR and provides a novel detection method for human tumors which express hEPR. In particular, the present invention provides a monoclonal antibody which specifically recognizes h... | 10/14/2008 |
| 7422906 | Apoptosis-inducing gene and utilization of the same The object of the present invention is to provide a protein useful for searching an apoptosis-inhibiting substance or an apoptosis-promoting substance, a gene encoding the above protein, a vector comprising the above gene, and a transformant comprising the above vec... | 09/09/2008 |
| 7414072 | Aryl 5-thio-β-d-glucopyranoside derivatives and therapeutic agents for diabetes containing the same There is provided a 5-thio-β-D-glucopyranoside compound of the following formula, which has an inhibitory effect on SGLT2 activity, or a pharmaceutically acceptable salt thereof or a hydrate thereof. There is also provided a pharmaceutical preparation, particularly... | 08/19/2008 |
| 7393519 | Base for oral composition and the oral composition A non-aqueous toothpaste comprises ascorbic acid or a salt thereof, mixed in a base which is a combination of hydroxypropyl cellulose and 1,3-butylene glycol which is thereby essentially water-free thereby stabilizing the ascorbic acid or a salt thereof. ... | 07/01/2008 |
| 7381746 | 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative One object of the present invention is to provide a drug that is effective in treatments for and prevention of psychiatric disorders and in treatments for and prevention of neurological diseases, inhibiting a Group II metabotropic glutamate receptor. The obje... | 06/03/2008 |
| 7370328 | Method for assigning job in parallel processing method and parallel processing method When parallel processing is executed by parallel computers composed of a host computer and a plurality of processors connected to the host computer through a common bus, there is provided a method of assigning jobs to respective processors with high efficiency. A jo... | 05/06/2008 |
| 7365078 | Triaza-cyclopenta[cd]indene derivatives An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disea... | 04/29/2008 |
| 7307101 | Use of 20-HETE synthesizing enzyme inhibitors as therapy for cerebral vascular disease A method for treating cerebral vascular diseases in a human or non-human animal is disclosed. The method involves inhibiting 20-HETE synthesizing enzyme activity sufficiently to increase or prevent a decrease in cerebral blood flow in the human or non-human animal. | 12/11/2007 |
| 7304166 | Benzenesulfonate salt of 4-fluoro-2-cyanopyrrolidine derivatives A benzenesulfonate salt of (2S,4S)-2-cyano-4-fluoro-1-[(2-hydroxy-1,1-dimethyl)ethylamino]acetylpyrrolidine that has an excellent DPPIV inhibition activity as well as physical properties (e.g., stability) required for pharmaceutical preparations. The present inventi... | 12/04/2007 |
| 7288566 | N-hydroxyformamidine derivatives An N-hydroxyformamidine compound of the following formula or a pharmaceutically acceptable salt thereof: wherein R1, A and R are as defined herein. The compounds inhibit 20-HETE-producing enzymes, 20-H... | 10/30/2007 |
| 7279584 | Method for production of cis-4-fluoro-L-proline derivatives The present invention provides a safer method for production of a cis-4-fluoro-L-proline derivative under milder conditions and in good yield to give a product of high purity on an industrial scale at low cost. Namely, the present invention provides a method for pro... | 10/09/2007 |
| 7250522 | Method for selective preparation of aryl 5-thio-β-D-aldohexopyranosides The present invention provides a method for preparing an aryl 5-thio-β-D-aldohexopyranoside derivative of Formula (III), which comprises reacting a 5-thio-D-aldohexopyranose derivative of Formula (I) with Ar-OH of Formula (II) in the presence of a phosphine represe... | 07/31/2007 |
| 7214714 | 20-hydroxyeicosatetraenoic acid production inhibitors A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof [wherein R1 represents a substituted morpholino group, a substituted piperidino group, a... | 05/08/2007 |
| 7183322 | Remedy for hypertension A therapeutic agent for hypertension, which comprises as an active ingredient a compound capable of inhibiting Na+/Ca2+ exchanger 1. ... | 02/27/2007 |
| 7160900 | Tetrahydropyridino or piperidino heterocyclic derivatives A tetrahydropyridino or piperidino heterocyclic derivative represented by the formula [I]: A-Het [I] has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved. ... | 01/09/2007 |
| 7157594 | 6-Fluorobicyclo[3.1.0]hexane derivatives An antidepressant comprising, as an active ingredient, a compound having an antagonistic effect on group II metabotropic glutamate receptors, as well as a 2-amino-3-alkoxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative of Formula [I]: | 01/02/2007 |
| 7078400 | 20-HETE synthase inhibitor The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or pharmaceutically-acceptable salts thereof. The inhibitors according to the present inv... | 07/18/2006 |
| 7022335 | Suppository of retaining in lower region of rectum A suppository of retaining in a lower region of rectum, which contains a suppository base containing: (A) a fatty acid triglyceride, (B) one or more C14-18 fatty acid glycerides, and (C) a base ingredient for retaini... | 04/04/2006 |
