Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Location: Boston, MA
No. of patents: 76

Number	Title	Issue Date
8175355	Factor analysis in medical imaging A method for estimating kinetic parameters from image data includes using a processor to execute instructions for providing a model of kinetic contributions from first and second physiological regions; grouping voxels of the image data into first and second groups; ...	05/08/2012
8173616	RNA-induced translational silencing and cellular apoptosis The invention is directed to RNA molecules that can be used to inhibit protein synthesis and to induce cells to undergo apoptosis. It also includes pharmaceutical compositions containing the RNAs that can be used in treating or preventing tumors; abnormal dermatolog...	05/08/2012
8168393	Compositions and methods for diagnosing tumors using LEDGF/p75 The invention provides methods for diagnosing tumors in mammals using a reagent that bind to LEDGF/p75 or to a nucleic acid encoding LEDGF/p75. For example, the tumor may be located in the CNS, the prostate, the skin, the bone marrow, or the gut of the mammal. Also ...	05/01/2012
8147817	IL-33 in the treatment and diagnosis of diseases and disorders This invention relates to methods and compositions for the treatment and diagnosis of cardiac diseases and disorders, such as cardiac hypertrophy, myocardial infarction, stroke, arteriosclerosis and heart failure. The invention also relates to methods and compositio...	04/03/2012
8143300	Inhibitors of cellular necrosis The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly u...	03/27/2012
8129344	Method of reducing cell death by administering a Sfrp polypeptide A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic condtions. ...	03/06/2012
8119684	Thiophene derivatives for up-regulating HLA-DM activity Compounds of formula (I), compositions, methods and kits are provided. The compounds and compositions may be particularly useful for modulating immunological responses. Formula (I) wherein, R1 is alkyl, aryl, or heterocyclyl; R2 is H, alkyl, ar...	02/21/2012
8110189	T cell inhibitory receptor compositions and uses thereof The invention relates to compositions which bind T cell inhibitory receptor molecules and modulate T cell activity, and methods of using such compositions. Such compositions include biliary glycoprotein binding agents. Methods for modulating killer T cell activities...	02/07/2012
8106037	Identification and treatment of estrogen responsive prostate tumors The present invention is directed to specific chromosomal rearrangements that are associated with prostate tumors that respond to compounds acting at estrogen receptors. Patients having the TMPRSS2-ERG fusion, may be treated with agonists of the estrogen beta recept...	01/31/2012
8101363	Inflammatory markers as tools in the detection and prevention of diabetes mellitus and as tools to aid in the selection of agents to be used for the prevention and treatment of diabetes The invention involves methods for characterizing an individual's risk profile of developing future diabetes or complications of diabetes by obtaining a level of an inflammatory marker in the individual. Preferred inflammatory markers according to the present invent...	01/24/2012
8101176	Compositions and methods related to TIM-3, a TH1-specific cell surface molecule The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is r...	01/24/2012
8084595	Poly-N-acetyl glucosamine (PNAG/dPNAG)-binding peptides and methods of use thereof The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention fur...	12/27/2011
8076283	Methods for treating congestive heart failure The invention features methods of treating or preventing congestive heart failure by administering a polypeptide containing an epidermal growth factor-like domain encoded by a neuregulin gene. ...	12/13/2011
8076091	Gene encoding a multidrug-resistance human P-glycoprotein homologue on chromosome 7P15-21 and uses thereof The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed ag...	12/13/2011
8057446	Wound healing device Methods and devices transmit micromechanical forces locally on the millimeter to micron scale for promoting wound healing. Micromechanical forces can selectively be applied directly to tissue, in some embodiments, by using microchambers fluidically connected to micr...	11/15/2011
8022105	Prevention of neutrophil recruitment Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II. ...	09/20/2011
8008276	Use of zwitterionic polysaccharides for the specific modulation of immune processes The invention relates to three-dimensional molecular structure determination of polymers, three-dimensional computer molecular modeling, rational drug design, and immunomodulatory polymers. In particular the invention is directed to immunomodulatory polymers, as wel...	08/30/2011
7999067	Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-1...	08/16/2011
7994219	Approach to anti-microbial host defense with molecular shields with lipoxin compounds Methods to cause tissue, such as mucosal cells, to express increased amounts of bactericidal permeability increasing protein (BPI) are described. The BPI inducing agents include, for example, lipoxin compounds. ...	08/09/2011
7989210	IL1RL-1 as a cardiovascular disease marker and therapeutic target Methods for evaluating the likelihood that a subject will benefit from treatment with an agent for reducing the risk of a cardiovascular condition, by evaluating levels of Interleukin 1 Receptor-Like 1 (IL1RL-1) polypeptides in a sample comprising serum from the sub...	08/02/2011
7985558	Methods for diagnosis of cardiovascular disease This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to diagnose and/or treat cardiovascular conditions including cardiac hyp...	07/26/2011
7981609	Methods for identifying and using SNP panels Described are methods for identifying single nucleotide polymorphism (SNPs) that are useful for analyzing genetic samples, and for using said SNPs to determine genetic identity of samples. ...	07/19/2011
7964614	Systemic inflammatory markers as diagnostic tools in the prevention of atherosclerotic diseases and as tools to aid in the selection of agents to be used for the prevention and treatment of atherosclerotic disease The invention involves methods for characterizing an individual's risk profile of developing a future cardiovascular disorder by obtaining a level of the marker of systemic inflammation in the individual. The invention also involves methods for evaluating the likeli...	06/21/2011
7943317	Polymorphism in the Apo(a) gene predict responsiveness to acetylsalicylic acid treatment This invention relates to nucleotide polymorphisms in the human Apo(a) gene and to the use of Apo(a) nucleotide polymorphisms in identifying whether a human subject will respond or not to treatment with acetylsalicylic acid. ...	05/17/2011
7939056	Interleukin-10 compositions for the treatment of adenocarcinomas The present invention is directed to methods for the treatment of adenocarcinomas that are characterized by the overexpression of a particular oncogene, Pim-1. The procedure involves administering a therapeutically effective amount of interleukin-10 that has been co...	05/10/2011
7931901	T-cell membrane protein (TIRC7), peptides and antibodies derived therefrom and uses thereof Described are generally a T cell immune response cDNA 7 (TIRC7) encoding a novel T-cell transmembrane protein as well as peptides und polypeptides derived therefrom and antibodies recognizing said (poly)peptides. More particularly, peptide and polypeptide as well as...	04/26/2011
7928202	Targeting ABCB5 for cancer therapy The invention relates to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof. ...	04/19/2011
7915311	Approach to anti-microbial host defense with molecular shields with lipoxin compounds Methods to cause tissue, such as mucosal cells, to express increased amounts of bactericidal permeability increasing protein (BPI) are described. The BPI inducing agents include, for example, lipoxin compounds. ...	03/29/2011
7883703	Methods of modulating immunity The invention provides novel methods of administering anti-CD3 antibodies, e.g., via oral or mucosal delivery. The invention also provides methods of treating, preventing, or delaying the onset of autoimmune disorders by oral or mucosal administration of anti-CD3 an...	02/08/2011
7872152	Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma The present invention is generally drawn to novel isolated therapeutic agents, termed resolving, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygen...	01/18/2011
7869639	Magnetic resonance imaging by subspace projection Reconstructing an image from MRI data provided by an MRI machine includes: selecting a system transformation based on the MRI machine; selecting a subspace based on the system transformation; and obtaining a solution vector that solves a minimization problem. The mi...	01/11/2011
7858332	Chemoprevention of endometrial cancer The present invention is directed to intrauterine devices that release progestins or an inflammatory cytokine after placement. These devices can be used to reduce the risk of a woman developing endometrial cancer. The invention is also directed to therapeutic method...	12/28/2010
7858101	Modified streptococcal polysaccharides and uses thereof Modified streptococcal polysaccharides and methods of using the modified polysaccharides are provided herein. ...	12/28/2010
7825271	Lipoxin compounds and their use in treating cell proliferative disorders Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed. ...	11/02/2010
7803557	Methods for identification of eicosapentaenoic acid analogs using anti-inflammatory receptors The present invention is directed to methods for the identification and uses of a receptors that interact with anti-inflammatory compounds derived from eicosapentaenoic acid (EPA). The receptors are of the G-protein coupled receptor (GPCR) family, and are useful to ...	09/28/2010
7795242	Methods and compositions for immunomodulation Novel antigens are provided herein. The antigens are associated with recognition of CD1 molecules by T cells. These antigens can be used as antigens, adjuvants or as immunomodulatory agents in a variety of therapeutic and prophylactic applications. ...	09/14/2010
7790404	Excitatory glycine receptors and methods The invention provides isolated N-methyl-D-aspartate type 3B (NR3B) polypeptides, functional fragments and peptides, encoding nucleic acid molecules and polynucleotides, and specific antibodies. Also provided are excitatory glycine receptors, containing either NR3B ...	09/07/2010
7759395	Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygen...	07/20/2010
7741369	Lipoxin compounds and their use in treating cell proliferative disorders Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed. ...	06/22/2010
7741368	Approach to antimicrobial host defense with molecular shields with EPA and DHA analogs Methods to cause tissue, such as mucosal cells, to express increased amounts of bactericidal permeability increasing protein (BPI) are described. Various BPI inducing agents include icosapentanoic acid (EPA) analogs and docosahexaenoic acid (DHA) analogs. ...	06/22/2010

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Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.