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| Number | Title | Issue Date |
| 4069105 | Lidocaine antigens and antibodies Derivatives of anesthetics involving anilides, lidocaine being illustrative, are provided, having an annular amino group. A difunctional linking group is provided, which provides a link to the annular amino group and an antigen, with the resulting conjuga... | 01/17/1978 |
| 4067774 | Compounds for enzyme amplification assay Novel biological assay method for determining the presence of a specific organic material by employing a modified enzyme for amplification. By employing receptors specific for one or a group of materials (hereinafter referred to as "ligands") and binding ... | 01/10/1978 |
| 4065354 | Lysozyme conjugates for enzyme immunoassays Novel conjugated enzyme compositions are provided for use in homogeneous immunoassays. A wide variety of haptenic compounds, such as drugs of abuse, therapeutic drugs, naturally occurring hormones, and the like, are conjugated to the enzyme lysozyme for u... | 12/27/1977 |
| 4058511 | Tegretol antigens and antibodies Derivatives of dibenz[b,f]azepine drugs are provided for preparation of antigens and antibodies, the antibodies finding use in immunoassays for the dibenz[b,f]azepine drugs. Specifically, N-oxoaliphatic substituted carbamoyl dibenz[b,f]azepine compounds a... | 11/15/1977 |
| 4056608 | Cardiac glycoside or aglycone assays Immunoassays for digoxin and its congeners are provided by pre-treating the serum sample with dilute aqueous alkaline solutions under mild conditions and for short periods of time, preferably in combination with a chelating agent, prior to carrying out th... | 11/01/1977 |
| 4046636 | Diazepam enzyme conjugates Novel compositions are provided for the determination of one or a group of organic materials (hereinafter referred to as "ligands"), where the compositions have a ligand or ligand counterfeit bonded to an enzyme, the conjugate referred to as "enzyme-bound... | 09/06/1977 |
| 4045420 | Non-oxo-carbonyl containing benzoyl ecgonine and cocaine compounds polypeptide and derivatives thereof Non-oxo-carbonyl substituted derivatives of cocaine are provided for conjugation with other compounds to provide reagents for use in a diversity of immunoassay techniques. Specifically, carboxy or imidoyl derivatives are provided which may be conjugated w... | 08/30/1977 |
| 4043989 | Oxazepam derivatives for immunoassay reagents Compounds are provided for use in the preparation of reagents which can be used in immunoassays for benzdiazepines, particularly as their urinary metabolites. The compounds are non-oxo-carbonyl derivatives conjugated to the 3-position of the benzdiazepine... | 08/23/1977 |
| 4043872 | Polyiodothyronine immunoassay Method and enzyme conjugates are provided for determining physiological amounts of polyiodothyronine in physiological fluid, particularly serum. A homogeneous enzyme immunoassay is provided employing an enzyme-bound-polyiodothyronine having less than about 50 ... | 08/23/1977 |
| 4040907 | Iodothyronine enzyme conjugates Polyiodothyronine conjugates to enzymes are provided which find use in the determination of polyiodothyronine compounds, particularly thyroxine, normally in physiological fluids, such as serum. The enzymes can provide substantial variation in activity whe... | 08/09/1977 |
| 4039385 | Cardiac glycoside enzyme conjugates Enzyme conjugates are prepared of cardiac glycosides and aglycones for use in homogeneous enzyme immunoassays. The conjugates retain a substantial degree of the original activity of the enzyme and upon binding of receptor to the steroid moiety, a substant... | 08/02/1977 |
| 4032519 | Diazacyclobutanes Novel four-membered ring heterocycles are provided having two nitrogen atoms in the ring bonded to each other and being bonded to exocyclic oxygen atoms. Both reduced and oxidized forms of the diazacyclobutane are provided. Depending on the particular com... | 06/28/1977 |
| 4025501 | Polypeptide propoxyphene derivatives for immunoassay reagents Novel compounds are provided which are derivatives of 1,2-diphenyl-3-methyl-4-dimethylamino-2-butanol. The indicated alcohol is employed to prepare the monoester of a dibasic acid which is conjugated with an antigen for the production of antibodies which ... | 05/24/1977 |
| 3998943 | Double receptor fluorescent immunoassay A sensitive method for determining qualitatively and quantitatively the presence of a wide variety of physiologically active organic compounds (ligand) is provided. The method employs a reagent which involves bonding a compound having structural similarit... | 12/21/1976 |
| 3996345 | Fluorescence quenching with immunological pairs in immunoassays Immunoassays employing antibodies and a fluorescer-quencher (F-Q) chromophoric pair, wherein one or both of the chromophoric pair are bonded to antibodies. Depending on the particular ligand of interest, various reagent combinations can be employed, where... | 12/07/1976 |
| 3975237 | Compounds for enzyme amplification assay - - ecgonine analogs Novel biological assay method for determining the presence enzyme a specific organic material by employing a modified enayme for amplification. By employing receptors specific for one or a group of materials (hereinafter referred to as "ligands") and bind... | 08/17/1976 |
| 3966744 | Spin labeled compounds Compounds are provided for use in assays of organic compounds, where organic compounds of biological interest are determined at extremely low concentrations by combining in a medium, the composition to be determined, hereinafter referred to as ligand, a h... | 06/29/1976 |
| 3966764 | Ligand determination of spin labeled compounds by receptor displacement-amphetamine analogs Compounds are provided for use in assays of organic compounds, where organic compounds of biological interest are determined at extremely low concentrations by combining in a medium, the composition to be determined, hereinafter referred to as ligand, a h... | 06/29/1976 |
| 3966556 | Compounds for enzyme amplification assay methadone analogs Novel biological assay method for determining the presence of a specific organic material by employing a modified enzyme for amplification. By employing receptors specific for one or a group of material (hereinafter referred to as "ligands") and binding a... | 06/29/1976 |
| 3965144 | Carbanilate compound for erythemal protection Compounds are provided for reducing erythemal response which are photoreactive precursors to para-aminobenzoic acid or its physiologically acceptable esters. Upon exposure to ultraviolet radiation of greater than about 280nm, the compounds of this inventi... | 06/22/1976 |
| 3959287 | Ligand determination of spin labeled compounds by receptor displacement Compounds are provided for use in assays of organic compounds, where organic compounds of biological interest are determined at extremely low concentrations by combining in a medium, the composition to be determined, hereinafter referred to as ligand, a h... | 05/25/1976 |
| 3953444 | Cyclic and polycyclic diazadioxides as quenchers and radical inhibitors Heterocyclic diazadioxides, having the two nitrogen atoms as annular atoms, are employed as quenchers for molecules in the excited state. The compounds can be used in combination with polymers and pigments for protection against light and oxidative attack... | 04/27/1976 |
| 3935074 | Antibody steric hindrance immunoassay with two antibodies A novel immunoassay is provided, as well as particular reagents, for determining the presence of a ligand. A Reagent is employed having at least two epitopes, one of the epitopes being common with the ligand, and the other epitopes being foreign to the li... | 01/27/1976 |
