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| Number | Title | Issue Date |
| 6326205 | Methods for use of Mpl ligands with primitive human stem cells Myeloproliferative leukemia receptor (mpl) ligands, such as thrombopoietin, act on a primitive subpopulation of human stem cells having the characteristics of self-renewal and ability to give rise to all hematopoietic cell lineages. Thrombopoietin support... | 12/04/2001 |
| 6060052 | Methods for use of Mpl ligands with primitive human hematopoietic stem cells Myeloproliferative leukemia receptor (mpl) ligands, such as thrombopoietin, act on a primitive subpopulation of human stem cells having the characteristics of self-renewal and ability to give rise to all hematopoietic cell lineages. Thrombopoietin support... | 05/09/2000 |
| 6017761 | Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant This invention provides a method for obtaining a recombinant retroviral packaging cell capable of producing retroviral vectors as well as the recombinant packaging cell obtained by the method. Also provided is a method of producing recombinant retroviral ... | 01/25/2000 |
| 6015554 | Method of reconstituting human lymphoid and dendritic cells The invention relates to methods of enriching for hematopoietic cell populations enriched in myeloid and/or lymphoid progenitor cells based on cell specific markers. The methods also provide an enriched population of prethymic lymphoid-committed progenito... | 01/18/2000 |
| 5985660 | Method of identifying biological response modifiers involved in dendritic and/or lymphoid progenitor cell proliferation and/or differentiation The invention relates to methods of enriching for hematopoietic cell populations enriched in myeloid and/or lymphoid progenitor cells based on cell specific markers. The methods also provide an enriched population of prethymic lymphoid-committed progenito... | 11/16/1999 |
| 5972627 | Method of purifying a population of cells enriched for dendritic and/or lymphoid progenitors and populations of cells obtained thereby The invention relates to methods of enriching for hematopoietic cell populations enriched in myeloid and/or lymphoid progenitor cells based on cell specific markers. The methods also provide an enriched population of prethymic lymphoid-committed progenito... | 10/26/1999 |
| 5928638 | Methods for gene transfer The present invention provides a method for optimizing gene transfer into hematopoietic stem cells (HSCs) by contacting the cells with hydroxyurea prior to gene transfer to induce HSCs in G0 into active cell cycle. This method is useful for treating patie... | 07/27/1999 |
| 5914108 | Human hematopoietic stem cell Human hematopoietic stem cells are provided by separation of the stem cells from dedicated cells. The stem cells may than be maintained by regeneration in an appropriate growth medium. Means are provided for assaying for the stem cells as to their capabil... | 06/22/1999 |
| 5910434 | Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant This invention provides a method for obtaining a recombinant retroviral packaging cell capable of producing retroviral vectors and the recombinant packaging cell obtained by the method. Also provided is a method of producing recombinant retroviral particl... | 06/08/1999 |
| 5824789 | Human growth factors, nucleotide sequence encoding growth factors, and method of use thereof This invention provides novel human growth factor polypeptides, nucleotides encoding the growth factor polypeptides, and uses for the growth factor polypeptides and polynucleotides.... | 10/20/1998 |
| 5814440 | Methods of obtaining compositions enriched for hematopoietic stem cells, antibodies for use therein, compositions derived therefrom and methods of use thereof This invention provides a novel antibody, designated 댞M10, and a hybridoma cell line that produces the 댞M10 antibody. Also provided are methods to obtain compositions enriched for hematopoietic stem cells. The methods employ a separation tec... | 09/29/1998 |
| 5763197 | Human hematopoietic stem cell Human hematopoietic stem cells are provided by separation of the stem cells from dedicated cells. The stem cells may than be maintained by regeneration in an appropriate growth medium. Means are provided for assaying for the stem cells as to their capabil... | 06/09/1998 |
| 5759793 | Method for mammalian cell separation from a mixture of cell populations The invention provides a method for both the positive and negative selection of at least one mammalian cell population from a mixture of cell populations utilizing a magnetically stabilized fluidized bed. One desirable application of this method is the se... | 06/02/1998 |
| 5750397 | Human hematopoietic stem cell Human hematopoietic stem cells are provided by separation of the stem cells from dedicated cells. The stem cells may than be maintained by regeneration in an appropriate growth medium. Means are provided for assaying for the stem cells as to their capabil... | 05/12/1998 |
| 5728581 | Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein The present invention provides methods and bioreactors for expanding stem cells in a population of cells substantially enriched in hematopoietic stem cells and substantially free of stromal cells. The method comprising the steps of inoculating the populat... | 03/17/1998 |
| 5716827 | Human hematopoietic stem cell Human hematopoietic stem cells are provided by separation of the stem cells from dedicated cells. The stem cells may than be maintained by regeneration in an appropriate growth medium. Means are provided for assaying for the stem cells as to their capabil... | 02/10/1998 |
| 5681559 | Method for producing a highly enriched population of hematopoietic stem cells The present invention provides a simple and reliable means for isolating populations of hematopoietic cells enriched for stem cell activity on the basis of possession of high CD34 cell surface antigen density ("CD34hi"). CD34hi cell preparation... | 10/28/1997 |
| 5677136 | Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof A method for obtaining human hematopoietic stem cells is provided by enrichment for stem cells using a novel stem cell marker. Compositions enriched for stem cells are obtained using novel antibody HCC-1 which is specific for a CD59 epitope highly accessi... | 10/14/1997 |
| 5665557 | Method of purifying a population of cells enriched for hematopoietic stem cells populations of cells obtained thereby and methods of use thereof The invention relates to methods of obtaining compositions enriched in hematopoietic stem cells by separating out an enriched fraction of cells expressing the marker CDw109. Methods of obtaining compositions enriched in hematopoietic megakaryocyte progeni... | 09/09/1997 |
| 5665590 | Method for isolating and directly cloning genes which encode cell-surface and secreted proteins Methods and DNA cloning vectors are provided for obtaining genes encoding secreted proteins and cell surface proteins.... | 09/09/1997 |
| 5645982 | Method for screening potential therapeutically effective antiviral agents The invention provides methods for screening agents for potential anti-viral effects by assessing the ability of the agents to suppress viral replication and/or pathology in thymic cells grown in thymic organ culture in vitro. Also provided are methods to... | 07/08/1997 |
| 5643741 | Identification and isolation of human hematopoietic stem cells Human hematopoietic stem cells are identified according to expression of specific cell surface markers. Substantially homogenous stem cell compositions are obtained by selective isolation of cells free of markers associated with differentiated cells, whil... | 07/01/1997 |
| 5643551 | Small animal metastasis model A method for initiating metastasis of human tumor cells under experimental conditions is provided. Immunocompromised non-human mammals having a viable, xenogeneic organ or tissue are used as a host for human tumor cells. The cells are introduced into the ... | 07/01/1997 |
| 5633426 | In vivo use of human bone marrow for investigation and production Chimeric immunocompromised hosts are provided, comprising human bone marrow of at least 4 weeks from the time of implantation. The bone marrow is found to assume the normal population of bone marrow except for erythrocytes. The bone marrow may be used to ... | 05/27/1997 |
| 5625127 | Extended human hematopoiesis in a heterologous host A human hematopoietic system is provided in an immunocompromised mammalian host, where the hematopoietic system is functional for extended periods of time. Particularly, human fetal liver tissue and human fetal thymus is introduced into an appropriate sit... | 04/29/1997 |
| 5612018 | Drug screening and treatment for HIV thymocyte depletion A method is provided for screening compounds for the ability to supress thymocyte depletion in thymuses of HIV-infected individuals, particularly enhancing the CD4+ -expressing population as compared to an untreated individual. Particularly, dr... | 03/18/1997 |
| 5601975 | Method for screening potential therapeutically effective antiviral agents The invention provides methods for screening agents for potential anti-viral effects by assessing the ability of the agents to suppress viral replication and/or pathology in thymic cells grown in thymic organ culture in vitro. Also provided are methods to... | 02/11/1997 |
| 5516977 | Xenogeneic tissue implant in ear pinna Immunocompromised hosts comprising xenogeneic fetal lymph node tissue implanted in the ear pinna are provided. The chimeric hosts are prepared by inserting the xenogeneic lymph node tissue into the ear pinna and closing the incision. The tissue is found t... | 05/14/1996 |
| 5476997 | Extended human hematopoiesis in a heterologous host A human hematopoietic system is provided in an immunocompromised mammalian host, where the hematopoietic system is functional for extended periods of time. Particularly, human fetal liver tissue and human fetal thymus is introduced into an appropriate sit... | 12/19/1995 |
| 5466572 | High speed flow cytometric separation of viable cells Hematopoietic cell populations are separated to provide cell sets and subsets as viable cells with high purity and high yields, based on the number of original cells present in the mixture. High-speed flow cytometry is employed using light characteristics... | 11/14/1995 |
| 5434341 | Xenogeneic lymph node in mammary fat pad Methods and chimeric immunocompromised hosts comprising functional xenogeneic organs are provided, particularly hematopoietic organs, where the xenogeneic organ is engrafted into a mammary fat pad. Exemplary is the engrafting of lymph node with mesenteric... | 07/18/1995 |
| 5411749 | Human lymphoid tissue in an immunocompromised host Human lymphoid tissue is introduced into an immunocompromised host to provide opportunities to investigate the effect of stimuli on the human immune system and obtain information and products from the stimulus. Particularly, methodology is provided for th... | 05/02/1995 |
| 5409813 | Method for mammalian cell separation from a mixture of cell populations The invention provides a method for both the positive and negative selection of at least one mammalian cell population from a mixture of cell populations utilizing a magnetically stabilized fluidized bed. One desirable application of this method is the se... | 04/25/1995 |
| 5147784 | T-lymphocyte progenitor cell assay Methodology is provided for identifying the presence of human T-lymphocyte progenitor cells. Human thymus tissue is depleted of endogenous lymphold cells, repopulated with a human cellular composition which is HLA mismatched with the thymus tissue and imp... | 09/15/1992 |
| 5061620 | Human hematopoietic stem cell Human hematopoietic stem cells are provided by separation of the stem cells from dedicated cells. The stem cells may than be maintained by regeneration in an appropriate growth medium. Means are provided for assaying for the stem cells as to their capabil... | 10/29/1991 |
