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| Number | Title | Issue Date |
| 8093387 | Process of making crystalline type II aripiprazole Crystalline aripiprazole Type II can be formed without solid state heat treatment. Instead a liquid is used such as in crystallizing from a solvent, especially 2-propanol, dimethyl sulfoxide, or a combination thereof with ethyl acetate, or in a solvent mediated soli... | 01/10/2012 |
| 8030355 | Tablet composition with a prolonged release of tamsulosin A tamsulosin controlled release tablet is formed using a water-swellable matrix-forming composition as a release controlling mechanism. The matrix forming composition comprises (i) a pH-sensitive swellable hydrophilic polymer, which is a cross-linked polyacrylic aci... | 10/04/2011 |
| 8026388 | Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids Synthesis of biphosphonate compounds can be advantageously carried out in a solvent/diluent comprising a compound of formula (3) wherein R is hydrogen or a C1-C6 alkyl group; each of R1 is a C1-C6 alkyl group or both R1 gro... | 09/27/2011 |
| 7989623 | Process for making n-(diphenylmethyl)piperazines The compound of formula (8), in racemic or single enantiomeric form, is useful in making N-(diphenylmethyl)-piperazines such as cetirizine and levocetrizine. wherein Z is preferably phenyl. ... | 08/02/2011 |
| 7977480 | Synthesis of paliperidone A 9-hydroxy or 9-acyloxy group can be added to a pyridopyrimidinone ring structure by a process comprising acylating a compound of formula (5) under Vilsmeier-Haack or Friedel-Crafts conditions to form a compound (6); and transforming with a peroxo-compound to obtai... | 07/12/2011 |
| 7959948 | Pharmaceutical composition of quetiapine fumarate A pharmaceutical composition comprising (i) quetiapine or a pharmaceutically acceptable salt thereof, especially quetiapine fumarate; (ii) a mixed excipient comprising an intimate admixture of polyvinylacetate and polyvinylpyrrolidone in a weight ratio from 5:2 to 1... | 06/14/2011 |
| 7932385 | Paliperidone ketone A compound of formula (7.2) or an acid addition salt thereof. The compound can be used as a reference standard for monitoring the presence thereof in a paliperidone sample, including monitoring the completion of a paliperid... | 04/26/2011 |
| 7928250 | Process for making duloxetine and related compounds A compound of formula 10 is useful in making duloxetine. ... | 04/19/2011 |
| 7928114 | Crystalline erlotinib Crystalline Forms of erlotinib are made. The crystalline materials are useful as pharmaceutical active agents in treating various cancers as well as in forming erlotinib salts. ... | 04/19/2011 |
| 7902198 | Crystalline aripiprazole solvates Alcoholates of aripiprazole are useful as pharmaceuticals and/or as intermediates in making aripiprazole Form A or Form B. ... | 03/08/2011 |
| 7875729 | Process for making asenapine Asenapine and related trans-isomer bicyclic compounds can be obtained by reducing a compound of formula (C) to preferentially form a trans-isomer compound of formula (D), followed by subsequent ring closure to form a compound of formula (B) such as asenapine. | 01/25/2011 |
| 7786138 | Process for making montelukast and intermediates therefor A compound of the following formula wherein R′ is a straight or branched C1-C4 alkyl group is useful in processes associated with the synthesis of montelukast and its salts. ... | 08/31/2010 |
| 7655806 | Process for purification of anastrozole Anastrozole can be purified by crystallization from an aqueous-based solvent system. The aqueous-based solvent system can contain dilute acid, or an alcohol or both. ... | 02/02/2010 |
| 7655798 | Process of making crystalline Type II aripiprazole Crystalline aripiprazole Type II can be formed without solid state heat treatment. Instead a liquid is used such as in crystallizing from a solvent, especially 2-propanol, dimethyl sulfoxide, or a combination thereof with ethyl acetate, or in a solvent mediated soli... | 02/02/2010 |
| 7642353 | Process of making crystalline aripiprazole Crystalline aripiprazole Form B can be formed by crystallizing from a solvent selected from 1-propanol, 2-propanol, 1-butanol, ethyl acetate, acetonitrile or a combination thereof. ... | 01/05/2010 |
| 7601741 | Process for making montelukast and intermediates therefor The reaction of methylmagnesium halide is improved by the presence of a cerium (III) salt such as cerium trichloride. The reactions are typically associated with the production of montelukast, a pharmaceutically useful compound of the following formula | 10/13/2009 |
| 7566793 | Process for resolving citalopram The (S)-citalopram content of a mixture of (R)- and (S)-citalopram can be enriched by using L-tartaric acid as the resolving agent in the presence of formaldehyde. ... | 07/28/2009 |
| 7553853 | Solid-state montelukast A solid form of a compound of formula 1: is provided. The compound of formula 1 can be obtained in solid state by precipitation from a solution containing the same. The compound is useful as leukotriene antagonist and can b... | 06/30/2009 |
| 7531684 | Process for making aminoalkylphenyl carbamates and intermediates therefor A process for making aminoalkylphenyl carbamates, especially rivastigmine, can use less severe conditions using bis(p-nitrophenyl)carbonate (IX) as a phenol activator compound. ... | 05/12/2009 |
| 7476748 | Process for making montelukast and intermediates therefor A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (11) is provided. ... | 01/13/2009 |
| 7446116 | Montelukast amantadine salt An amantadine salt of montelukast is useful in purification of montelukast or its salts and as a pharmaceutical active ingredient. ... | 11/04/2008 |
| 7018658 | Pharmaceutical pellets comprising tamsulosin Tamsulosin pellets having an advantageous release profile are formed. The pellets have an enteric coating and release less than 10% of the tamsulosin in two hours in SGF. ... | 03/28/2006 |
| 6919087 | Pharmaceutical compositions comprising amlodipine maleate An amlodipine maleate pharmaceutical composition is provided with good stability when formulated with a pH within the range of 5.5 to 7, when measured as a 20 wt % aqueous slurry. The stability can also be aided by making the pharmaceutical composition from amlodipi... | 07/19/2005 |
| 6858738 | Process for making amlodipine, derivatives thereof, and precursors therefor Amlodipine and related analogues thereof are prepared by the following general reaction scheme: R1 and R2 each independently represent a C1-C4 alkyl group. The process provid... | 02/22/2005 |
| 6835853 | Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith Optically impure tamsulosin including racemic tamsulosin can be resolved into optically pure (R)- or (S)-tamsulosin by the use of diastereomeric sulfonate salts of tamsulosin in a fractional crystallization technique. Racemic tamsulosin free base is a useful startin... | 12/28/2004 |
| 6830933 | Reference standards for determining the purity or stability of amlodipine maleate and processes therefor Amlodipine aspartate and amlodipine maleamide are used as reference standards or markers in determining the purity of amlodipine maleate substances and products. ... | 12/14/2004 |
| 6828339 | Amlodipine salt forms and processes for preparing them Amlodipine besylate forms are described, including amlodipine besylate hydrates and novel amlodipine besylate anhydrates. A method of making various amlodipine besylate forms from an aqueous medium as well as the use of the same as a calcium channel blocker are desc... | 12/07/2004 |
| 6818766 | Process for making bicalutamide and intermediates thereof Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent. ... | 11/16/2004 |
| 6770761 | Process for preparation of 2-amino-6 (alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles A new process to obtain pramipexole and related products is described. The process involves the reaction of new compounds of formula (6), wherein R is hydrogen or acyl group, R3 and R4 are either the same and each of them represents an alkoxy g... | 08/03/2004 |
| 6727367 | Process for resolution of 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole and compounds therefor A process for resolving or enriching (R,S) 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole (pramipexole) into optical isomers uses a monovalent salt thereof, e.g. pramipexole monohydrochloride, as a substrate. The monovalent salt is treated with an optically a... | 04/27/2004 |
| 6717015 | Venlafaxine besylate Venlafaxine besylate compounds provide certain advantages over venlafaxine hydrochloride and are useful in forming pharmaceutical compositions and n treating venlafaxine-treatable diseases and conditions. Venlafaxine besylate can be easily formulated into an extende... | 04/06/2004 |
| 6696496 | Low water-soluble venlafaxine salts Low water soluble salts of venlafaxine, especially venlafaxine maleate, are provided. Such salts can provide a variety of dosage forms including hydrogel-based extended release dosage forms.... | 02/24/2004 |
| 6653481 | Process for making amlodipine Amlodipine and related analogues thereof are prepared by the following general reaction scheme: ##STR1## R1 and R2 each independently represent a C1 -C4 alkyl group. The process provides for the formation of com... | 11/25/2003 |
| 6638535 | Modified release formulations containing a hypnotic agent Hypnotic pharmaceutical compositions are made from pellets and exhibit a modified release. Zolpidem or a pharmaceutically acceptable salt thereof is a typical hypnotic. The pellets are preferably spherical and exhibit a dissolution profile that includes 6... | 10/28/2003 |
| 6602893 | Amide derivative of amlodipine A derivative of amlodipine having the following formula is useful as a pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension. ##STR1##... | 08/05/2003 |
| 6600047 | Process for making amlodipine maleate A process for making amlodipine maleate comprises reacting amlodipine or an acid addition salt thereof with maleic acid under an acidic environment to form an amlodipine maleate product. The process allows for the formation of amlodipine maleate substanti... | 07/29/2003 |
| 6562984 | Lactonization process Lactonization of statins can be achieved using a lactonization agent that forms a hydrated complex with the produced water that is insoluble in the reaction solvent. By binding the produced water in an insoluble complex, the reaction is pulled to the lact... | 05/13/2003 |
| 6538012 | Amlodipine hemimaleate Amlodipine hemimaleate is useful as a calcium channel blocker and can be used to treat or prevent angina or hypertension.... | 03/25/2003 |
| 6518288 | Amlodipine fumarate Amlodipine fumarate salt compounds are useful as calcium channel blockers and in treating or preventing angina or hypertension. The fumarate salts avoid the formation of certain potential impurities that have been found to be associated with amlodipine ma... | 02/11/2003 |
| 6479525 | Aspartate derivative of amlodipine An amlodipine derivative having the following formula is useful, either alone or in combination with amlodipine, as a pharmaceutical in treating angina and hypertension. ##STR1##... | 11/12/2002 |
