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| Number | Title | Issue Date |
| 8183384 | Triazole compounds that modulate HSP90 activity The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treati... | 05/22/2012 |
| 8163777 | Benzimidazolyl-pyridine compounds for inflammation and immune-related uses The invention relates to compounds of formula (XVI): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein Y2, Z, L1, R9, R10 | 04/24/2012 |
| 8148426 | Bis(thio-hydrazide amides) for increasing Hsp70 expression A method of treating a Hsp70-responsive disorder in a subject includes administering to the subject an effective amount of a compound represented by Structural Formula I, or a pharmaceutically acceptable salt or solvate thereof. ... | 04/03/2012 |
| 8119643 | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses Biologically active chemical compounds, namely benzoimidazolyl-pyrazine derivatives and structurally related compounds, are disclosed herein. Such compounds include those represented by structural formula (II): and as descr... | 02/21/2012 |
| 8106083 | Triazole compounds that modulate HSP90 activity The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperprolif... | 01/31/2012 |
| 8093425 | Compounds for treating proliferative disorders Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharma... | 01/10/2012 |
| 8063083 | Method for treating non-Hodgkin's lymphoma The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating non-Hodgkin's lymphoma, in a subject in need thereof. ... | 11/22/2011 |
| 8058297 | Compounds for the treatment of proliferative disorders The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 ... | 11/15/2011 |
| 8053456 | Triazole compounds that modulate Hsp90 activity The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treati... | 11/08/2011 |
| 8048925 | Bis(thio-hydrazide amide) salts for treatment of cancers Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1-R4 are inde... | 11/01/2011 |
| 8034834 | Method for treating proliferative disorders with HSP90 inhibitors The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating Bcr-Abl, FLT-3, EGFR, c-Kit, B-raf, and NPM-ALK associated cancers, in a subject in need thereof. ... | 10/11/2011 |
| 8017654 | Combination cancer therapy with bis(thiohydrazide) amide compounds A method of treating a subject with cancer includes the step of co-administering to the subject over three to five weeks, a taxane in an amount of between about 243 μmol/m2 to 315 μmol/m2 (e.g., equivalent to paclitaxel in about 210-270 mg/m2); and a bis(thiohydra... | 09/13/2011 |
| 7939564 | Combination with bis(thiohydrazide amides) for treating cancer Disclosed herein are methods of treating a proliferative disease, such as cancer, with bis(thio-hydrazide amides) or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, in combination with hyperthermia treatment. Also disclosed are ... | 05/10/2011 |
| 7884094 | Compounds for the treatment of proliferative disorders The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 ... | 02/08/2011 |
| 7863270 | IL-12 modulatory compounds The invention relates to cyclic hydrazone compounds and compositions including the cyclic hydrazone compounds according to formula (I): The compounds (and compositions) are useful, inter alia, in modulating IL-12 production... | 01/04/2011 |
| 7851466 | Pyrimidine compounds and uses thereof This invention features pyrimidine compounds of formula (I): aryl, or heteroaryl; each of R2 and R4, independently, is Rc, halogen, nitro, cyano, isothionit... | 12/14/2010 |
| 7825148 | Triazole compounds that modulate Hsp90 activity The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treati... | 11/02/2010 |
| 7816535 | Vinyl-phenyl derivatives for inflammation and immune-related uses The invention relates to compounds of structural formula (Ia): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein X1, X2, X3, X4, X6... | 10/19/2010 |
| 7795313 | Bis(thio-hydrazide amide) salts for treatment of cancers Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1 | 09/14/2010 |
| 7781462 | Compounds for the treatment of proliferative disorders The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 ... | 08/24/2010 |
| 7763658 | Treatment for cancers One embodiment of the present invention is a method of treating a subject with a multi-drug resistant cancer. The method comprises administering to the subject an effective amount of a compound represented by Structural Formula (I): ... | 07/27/2010 |
| 7750042 | Paclitaxel enhancer compound One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In additio... | 07/06/2010 |
| 7709683 | Synthesis of bis(thio-hydrazide amide) salts A method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide), an organic solvent and a base to form a bis(thio-hydrazide amide) solution; and combining the solution and methyl tert-butyl ether, thereby ... | 05/04/2010 |
| 7709518 | Compounds for inflammation and immune-related uses The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are u... | 05/04/2010 |
| 7705029 | Acrylonitrile derivatives for inflammation and immune-related uses What is claimed is a compound represented by the following structural formula: or a pharmaceutically acceptable salt, solvate or clathrate thereof. The variables for Structural Formula (I) are as described herein. ... | 04/27/2010 |
| 7696202 | IL-12 modulatory compounds The invention relates to heterocyclic compounds, compositions including the compounds and methods of using and methods of making thereof. The compounds (and compositions) are useful, inter alia, in modulating IL-12 production and processes mediated by IL-12. ... | 04/13/2010 |
| 7678832 | Bis(thio-hydrazide amide) formulation Disclosed herein are compositions comprising a compound represented by structural formula (I): 2 g of which is reconstitutable in 10 mL of a water in less than 10 minutes, and methods for preparing these compositions. ... | 03/16/2010 |
| 7671092 | Paclitaxel enhancer compounds Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken... | 03/02/2010 |
| 7662813 | Triazole compounds that modulate HSP90 activity The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treati... | 02/16/2010 |
| 7652168 | Synthesis of taxol enhancers Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound is represe... | 01/26/2010 |
| 7645904 | Purification of bis(thiohydrazide amides) Disclosed herein are methods of purifying a bis(thio-hydrazide amides) compounds of the following structural formula: wherein R1, R2, R3, R4, R7, R8, Z, and ... | 01/12/2010 |
| 7615552 | Fused heterocyclic compounds This invention provides fused heterocyclic compounds, pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12 related disease and disorders. ... | 11/10/2009 |
| 7608635 | Pyrazole compounds that modulate HSP90 activity Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of fo... | 10/27/2009 |
| 7579503 | BIS (thio-hydrazide amide) salts for treatment of cancers Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R1-R4 are inde... | 08/25/2009 |
| 7572821 | Compounds for the treatment of proliferative disorders The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 ... | 08/11/2009 |
| 7470685 | Pyrimidine compounds This invention features pyrimidine compounds of formula (I): R1 is in which one of Ra and Rb is H or alkyl, and the other is aryl or heteroaryl op... | 12/30/2008 |
| 7470681 | Pyrimidine compounds This invention features pyrimidine compounds of formula (I): R1 is each of R2 and R4 is H;... | 12/30/2008 |
| 7465725 | Pyrimidine compounds This invention features pyrimidine compounds of formula (I): R1 is aryl, or heteroaryl; each of R2 and R4, independently, is Rc, halogen, ... | 12/16/2008 |
| 7435843 | Synthesis of taxol enhancers Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound is represe... | 10/14/2008 |
| 7410990 | Heterocyclic compounds This invention features a compound of formula (I): R1 is aryl or heteroaryl; each of R2 and R4, independently, is H, halogen, CN, alkyl, ORa, or NRaRb; R | 08/12/2008 |
