Assignee: Synaptic Pharmaceutical Corporation

Location: Paramus, NJ
No. of patents: 126

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Number	Title	Issue Date
7105544	Substituted alkyl amido piperidines This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pha...	09/12/2006
6818445	Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) This invention provides isolated nucleic acid molecules encoding a neuropeptide Y (NPY) Y5 receptor which hybridizes under high stringency conditions to a nucleic acid molecule of SEQ ID NO:3, vectors comprising such isolated nucleic acid molecules, and cells compri...	11/16/2004
6790656	DNA encoding galanin GALR2 receptors This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian...	09/14/2004
6777426	Imidazole and imidazoline derivatives and uses thereof This invention is directed to novel imidazole and imidazoline derivatives which are selective agonists for cloned human α2 adrenergic receptors. This invention is also related to the use of these compounds for the treatment of any disease where modulatio...	08/17/2004
6770444	Methods of identifying or screening for agents that binds the Ob-Re This invention provides an isolated nucleic acid encoding a polypeptide, a purified polypeptide, vectors comprising isolated nucleic acid encoding a polypeptide, cells comprising such vectors, antibodies directed to a polypeptide, nucleic acid probes useful for dete...	08/03/2004
6734182	Aryl sulfonamides and sulfamide derivatives and uses thereof This invention is directed to novel aryl sulfonamide and sulfamide compounds which bind selectively to and inhibit the activity of the human Y5 receptor. This invention is also related to uses of these compounds for the treatment of feeding disorders such as obesity...	05/11/2004
6727257	5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines This invention is directed to dihydropyrimidine compounds of the following formula: wherein A is which are selective antagonists for human α1C receptors. This inv...	04/27/2004
6727264	Substituted anilinic piperidines as MCH selective antagonists This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pha...	04/27/2004
6723741	Benzimidazoles and benzothiazoles and uses thereof This invention is directed to novel indole and benzothiazole compounds which are selective for cloned human alpha 2 receptors. This invention is also related to uses of these compounds for any indication where use of an alpha 2 agonist may be appropriate. Specifical...	04/20/2004
6723552	DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nuc...	04/20/2004
6720324	Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pha...	04/13/2004
6713265	Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) The invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds that are selective agonists or antago...	03/30/2004
6709831	DNA encoding mammalian neuropeptide FF (NPFF) receptors and uses thereof This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nu...	03/23/2004
6706716	Compounds specific for the human α1d adrenergic receptor and uses thereof This invention is directed towards a method of inhibiting activation of a human α1d adrenergic receptor which comprises contacting the receptor with a compound so as to inhibit activation of the receptor, wherein the compound binds selectively to a human...	03/16/2004
6680323	Dihydropyrimidines and uses thereof This invention is directed to dihydropyrimidines which are selective antagonists for human 򳄚 receptors. This invention is also related to uses of these compounds for relaxing lower urinary tract tissue, treating benign prostatic hyperpl...	01/20/2004
6645774	Methods of modifying feeding behavior using compounds with afinity for the human hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) This invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds that are selective agonis...	11/11/2003
6620815	Oxazolidinones and uses thereof This invention is directed to oxazolidinone compounds which are selective antagonists for human 򳄚 receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, ...	09/16/2003
6608086	Dihydropyridines and new uses thereof This invention provides dihydropyridines useful for treatment of prostatic hyperplasia, inhibition of cholesterol synthesis, and/or reduction of intraocular pressure....	08/19/2003
6602888	Use of 򳄜 specific compounds to treat benign prostatic hyperplasia A method of treating benign prostatic hyperplasia in a subject which comprises administering to the subject a therapeutically effective amount of a compound which binds to a human 򳄜 adrenergic receptor with a binding affinity greater th...	08/05/2003
6586191	Method of identifying compounds that bind galanin receptor (GALR2) This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to ...	07/01/2003
6569856	Selective NPY (Y5) antagonists (triazines) This invention is directed to triazine derivatives which are selective antagonists for a NPY (Y5) receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceut...	05/27/2003
6531471	Morpholinone and morpholine derivatives and uses thereof This invention is directed to morpholinone and morpholine derivatives which are selective antagonists for human 򳄚 receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholest...	03/11/2003
6498177	Indole and benzothiazole derivatives This invention is directed to novel indole and benzothiazole compounds which are selective for cloned human alpha 2 receptors. This invention is also related to uses of these compounds for any indication where use of an alpha 2 agonist may be appropriate....	12/24/2002
6495583	Benzimidazole derivatives This invention provides compounds having the structure: ##STR1## wherein each of R1, R2, R3 and R9 is independently H; straight chain or branched, substituted or unsubstituted C1 -C7 alkyl,...	12/17/2002
6475746	Method of obtaining a composition comprising a 5-HT1D selective compound This invention provides isolated nucleic acid molecules encoding human 5-HT1D receptors, isolated proteins which are human 5-HT1D receptors, vectors comprising isolated nucleic acid molecules encoding human 5-HT1D receptor...	11/05/2002
6468767	DNA encoding a human dopamine D1 receptor and uses thereof This invention provides isolated nucleic acid molecules encoding a human dopamine D1 receptor, isolated proteins which are human dopamine D1 receptor, vectors comprising isolated nucleic acid molecules encoding a human dopamine D	10/22/2002
6468756	Methods of identifying compounds that bind to SNORF25 receptors This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalia...	10/22/2002
6448011	DNA encoding human alpha 1 adrenergic receptors and uses thereof This invention provides an isolated nucleic acid, vectors, transformed mammalian cells and non-human transgenic animals that encode and express normal or mutant alpha 1a, alpha 1b and alpha 1c adrenergic receptor genes. This invention also provides a prot...	09/10/2002
6440988	Use of agonists or antagonists of the 5-HT7 receptor to treat disorders of the bladder The present invention provides a method of treating urinary incontinence in a subject which comprises administering to the subject a therapeutically effective amount of a 5-HT7 receptor antagonist or an antagonist that binds to both 5-HT7	08/27/2002
6436982	Benzimidazole derivatives This invention provides compounds having the structure: ##STR1## wherein each of R1, R2, R3 and R9 is independently H; straight chain or branched, substituted or unsubstituted C1 -C7 alkyl,...	08/20/2002
6432655	Method of obtaining compositions This invention provides an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor and an isolated nucleic acid molecule encoding a human 5-HT4B receptor, an isolated protein which is a mammalian 5-HT4B recepto...	08/13/2002
6420532	Method of obtaining compositions comprising Y2 specific compounds This invention provides isolated nucleic acid molecules encoding Y2 receptors, an isolated, purified Y2 receptor protein, vectors comprising isolated nucleic acid molecules encoding Y2 receptors, mammalian, insect, bacterial and yeast cells comprising suc...	07/16/2002
6413731	Methods of screening for compounds which bind to a human SNORF36A receptor This invention provides isolated nucleic acids encoding mammalian SNORF36 receptors, purified mammalian SNORF36 receptors, vectors comprising nucleic acid encoding mammalian SNORF36 receptors, cells comprising such vectors, antibodies directed to mammalia...	07/02/2002
6406859	DNA encoding a 5-HT 1F receptor and uses thereof This invention provides an isolated nucleic acid molecule encoding a human 5-HT1F receptor, an isolated protein which is a human 5-HT1F receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT1F...	06/18/2002
6403626	Benzimidazole derivatives This invention provides compounds having the structure: ##STR1## wherein each of R1, R2, R3 and R9 is independently H; straight chain or branched, substituted or unsubstituted C1 -C7 alkyl,...	06/11/2002
6391877	Aryl sulfonamides and sulfamide derivatives and uses thereof This invention is directed to novel aryl sulfonamide and sulfamide compounds which bind selectively to and inhibit the activity of the human Y5 receptor. This invention is also related to uses of these compounds for the treatment of feeding disorders such...	05/21/2002
6383762	Methods of obtaining compounds that interact with a human serotonin (5-HT2) receptor The present invention provides a method of obtaining a composition which comprises determining whether a chemical compound binds to a human 5-HT2 receptor expressed on the surface of a mammalian cell transfected with a vector adapted for expres...	05/07/2002
6376503	Alpha 1a adrenergic receptor antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds ...	04/23/2002
6376243	DNA encoding a human serotonin receptor (5-HT4B) and uses thereof This invention provides an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor and an isolated nucleic acid molecule encoding a human 5-HT4B receptor, an isolated protein which is a mammalian 5-HT4B recepto...	04/23/2002
6368812	Process for determining the agonist or antagonist of galanin receptor (GALR3) This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directe...	04/09/2002

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Assignee: Synaptic Pharmaceutical Corporation