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| Number | Title | Issue Date |
| 8166909 | Apparatus and methods for applying coatings The invention relates to systems and methods for forming coatings that can elute active agents and coating produced by the same. In an embodiment, the invention includes an apparatus for applying a coating to a medical device including a first spray nozzle, a first ... | 05/01/2012 |
| 8163327 | Hydrophilic polymeric coatings for medical articles The invention provides a durable, lubricious coating for a medical article that can be prepared from a first polymer that is synthetic, soluble in a polar liquid, and having first reactive groups, and a second polymer that is synthetic, hydrophilic, and that include... | 04/24/2012 |
| 8158106 | Particle immobilized coatings and uses thereof Surface coatings including microparticles immobilized in a matrix of polymeric material on a substrate are described. The microparticles can also include an agent which can be useful for various applications, such as medical applications. This invention relat... | 04/17/2012 |
| 8143043 | Encapsulated cells using positively-charged initiator polymer Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation of a polymeric matrix on a surface. The initiator polymers are parti... | 03/27/2012 |
| 8142836 | Multi-layered coatings and methods for controlling elution of active agents Embodiments of the invention include multi-layered coatings for controlling the elution rates of active agents and methods. In an embodiment, the invention includes a method of applying an elution control coating to a substrate. The method can include depositing a c... | 03/27/2012 |
| 8129159 | Attachment of molecules to surfaces The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the pr... | 03/06/2012 |
| 8039524 | Reagent and method for providing coatings on surfaces A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and met... | 10/18/2011 |
| 8034369 | Controlled release bioactive agent delivery device The invention provides a controlled release bioactive agent delivery device for treatment of an eye that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at lea... | 10/11/2011 |
| 8021680 | Controlled release bioactive agent delivery device The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body... | 09/20/2011 |
| 8003124 | Sustained release implants and methods for subretinal delivery of bioactive agents to treat or prevent retinal disease The invention relates to sustained release implants and to methods for treating eyes, particularly the eyes of mammals having eye disorders or diseases. By using the implants and methods described herein, the delivery of the one or more bioactive agents can be local... | 08/23/2011 |
| 7976862 | Controlled release bioactive agent delivery device The invention provides implantable sustained release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of... | 07/12/2011 |
| 7968614 | Macromer composition including light activated initiator The invention provides compositions that include macromers and visible light-activated polymerization initiators, and methods for forming a matrix using these compositions in conjunction with a light source that emits light primarily in the visible light spectrum. | 06/28/2011 |
| 7958840 | Method and apparatus for coating of substrates The invention relates to methods and apparatuses that reduce problems encountered during coating of a device, such as a medical device having a cylindrical shape. In an embodiment, the invention includes an apparatus including a bi-directional rotation member. In an... | 06/14/2011 |
| 7919111 | Biodegradable hydrophobic polysaccharide-based drug delivery implants Medical implants formed of hydrophobic derivatives of natural biodegradable polysaccharides and that include bioactive agent are described. The implants demonstrate desirable bioactive agent release profiles and can be prepared to have high drug loading. The implant... | 04/05/2011 |
| 7883749 | Method for coating an object with a graft polymer layer A method for coating a device, such as an industrially or medically applicable device, with a polymer layer is provided. The method includes contacting the device with a grafting initiator comprising at least one photoinitiator group, exposing the device to radiatio... | 02/08/2011 |
| 7833548 | Bioactive agent release coating and controlled humidity method A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous syst... | 11/16/2010 |
| 7829317 | Attachment of molecules to surfaces The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the pr... | 11/09/2010 |
| 7824704 | Controlled release bioactive agent delivery device The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a dista... | 11/02/2010 |
| 7820158 | Ligand-coupled initiator polymers and methods of use Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on... | 10/26/2010 |
| 7807750 | Thermally-reactive polymers A thermally-reactive polymer that forms a polymer-coupled reactive species upon heating is described and useful for forming coated surfaces. The polymer-coated surface has improved lubricity and passivity. A thermally-reactive quaternary amine-containing polymer was... | 10/05/2010 |
| 7794751 | Medicament incorporation matrix A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating composition provides a gel matrix adapted to contain the medicament in a... | 09/14/2010 |
| 7736689 | Reagent and method for providing coatings on surfaces A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and met... | 06/15/2010 |
| 7709049 | Methods, devices, and coatings for controlled active agent release The present invention relates to methods, devices, and coatings, wherein active agent release is determined by deposition rate of a coating or material. In an embodiment, the invention includes a method for coating a medical device, including identifying active agen... | 05/04/2010 |
| 7691787 | Target molecule attachment to surfaces Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain ... | 04/06/2010 |
| 7691476 | Hydrophilic polymeric coatings for medical articles The invention provides a durable, lubricious coating for a medical article that can be prepared from a first polymer that is synthetic, soluble in a polar liquid, and having first reactive groups, and a second polymer that is synthetic, hydrophilic, and that include... | 04/06/2010 |
| 7669548 | Method and apparatus for coating of substrates The invention relates to methods and apparatuses that reduce problems encountered during coating of a device, such as a medical device having a cylindrical shape. In an embodiment, the invention includes an apparatus including a bi-directional rotation member. In an... | 03/02/2010 |
| 7638344 | Active agent eluting matrices with particulates The present invention is directed to polymeric matrices for the controlled release of a hydrophilic bioactive agent. Generally, the elution control matrix includes a polymeric matrix having a first polymer and a plurality of microparticles that include the hydrophil... | 12/29/2009 |
| 7585499 | Method for encapsulation of cellular material using a charged initiator polymer Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation of a polymeric matrix on a surface. The initiator polymers are parti... | 09/08/2009 |
| 7563566 | Stabilization of HOunder alkaline conditions for use in luminescence, fluorescence and colorimetric assays for enhanced detection of peroxidase type assays The invention relates to stannous halide stabilized and/or enhanced alkaline solutions to be used in combination with calorimetric, luminescent and fluorescent assays. The buffered solutions stabilize hydrogen peroxide at a pH greater than 7.0 and preferably greater... | 07/21/2009 |
| 7550444 | Composition and method for preparing biocompatible surfaces The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to rele... | 06/23/2009 |
| 7550443 | Process and systems for biocompatible surfaces The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity that are able to release a bioactive agent, wherein the coatings are formed us... | 06/23/2009 |
| 7547445 | Crosslinkable macromers A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer s... | 06/16/2009 |
| 7544673 | Coating compositions for bioactive agents A coating composition and related method for use in applying a bioactive agent to a surface in a manner that will permit the bioactive agent to be released from the coating in vivo. The composition is particularly well suited for coating the surface of implantable m... | 06/09/2009 |
| RE40722 | Method and apparatus for coating of substrates The invention relates to methods and apparatuses that reduce problems encountered during coating of a device, such as a medical device having a cylindrical shape. In an embodiment, the invention includes an apparatus including a bi-directional rotation member. In an... | 06/09/2009 |
| 7541048 | Coating compositions for bioactive agents A coating composition and related method for use in applying a bioactive agent to a surface in a manner that will permit the bioactive agent to be released from the coating in vivo. The composition is particularly well suited for coating the surface of implantable m... | 06/02/2009 |
| 7442402 | Bioactive agent release coating A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of... | 10/28/2008 |
| RE40359 | Polymer blends as biodegradable matrices for preparing biocomposites The present invention provides bioerodable constructs for controlled release of bioactive materials. In a preferred mode, the constructs may be utilized adjacent to a biological surface. The constructs are based on a blend of two or more poly(ester-amide) polymers (... | 06/03/2008 |
| 7381797 | Stabilization of HOunder alkaline conditions for use in luminescence, fluorescence and colorimetric assays for enhanced detection of peroxidase type assays The invention relates to stannous halide stabilized and/or enhanced alkaline solutions to be used in combination with colorimetric, luminescent and fluorescent assays. The buffered solutions stabilize hydrogen peroxide at a pH greater than 7.0 and preferably greater... | 06/03/2008 |
| 7361724 | Self assembling monolayer compositions A surface coating composition for providing a self-assembling monolayer, in stable form, on a material surface or at a suitable interface, as well as a method of preparing such a composition and a method of using such a composition to coat a surface, such as the sur... | 04/22/2008 |
| 7348055 | Reagent and method for providing coatings on surfaces A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and met... | 03/25/2008 |
