Bizarre Patents
Combination Beverage Container and Spittoon
A combination beverage container and spittoon includes a bottom portion including outer wall and a first inner wall defining a spittoon space.
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| Number | Title | Issue Date |
| 7704712 | DNA polymerase fusions and uses thereof The present invention discloses methods of using DNA polymerase fusions at high pH in PCR, DNA sequencing and mutagenesis protocols. ... | 04/27/2010 |
| 7659100 | DNA polymerase fusions and uses thereof The present invention discloses methods of using DNA polymerase fusions at high pH in PCR, DNA sequencing and mutagenesis protocols. ... | 02/09/2010 |
| 7625725 | Polymerase enhancing factor (PEF) extracts, PEF protein complexes, isolated PEF proteins, and methods for purifying and identifying them The invention provides novel extracts, proteins, and complexes that improve the polymerization activity of nucleic acid polymerases. Included within the aspects of the invention are methods for identifying compositions with a polymerase enhancing activity, methods f... | 12/01/2009 |
| 7608841 | System and method for a fluorescence excitation and detection having distinct optical paths A system and method for fluorescence excitation and detection having distinct optical paths is disclosed. A system for detecting fluorescence comprises a light source that emits an excitation light into an illumination tube; a plurality of collection optics located ... | 10/27/2009 |
| 7517688 | Method for ligating nucleic acids and molecular cloning The invention provides cells and methods of circularizing linear DNA molecules. The cell is an isolated Escherichia coli cell which transiently expresses the Cre recombinase protein from an integrated Cre recombinase gene, and which is at least transiently re... | 04/14/2009 |
| 7504218 | Key probe compositions and methods for polynucleotide detection The invention relates to compositions and methods for detection of nucleic acid sequences. The invention further relates to kit format of said compositions for detection of nucleic acid sequences. Oligonucleotide probes of the invention comprise a target binding seq... | 03/17/2009 |
| 7468251 | Compositions for detection of A target nucleic acid sequence The invention relates to compositions for generating a signal indicative of the presence of a target nucleic acid in a sample, where the compositions include an RNA polymerase, a FEN nuclease, and a probe. ... | 12/23/2008 |
| 7459302 | Side-wall heater for thermocycler device The invention relates to an apparatus and methods for preventing condensation on the interior surfaces of sample tubes which are being exposed to temperature cycles, such as during a PCR amplification reaction. In particular, the invention relates to apparatus compr... | 12/02/2008 |
| 7442766 | Pfu replication accessory factors and methods of use This invention provides isolated polynucleotides that encode replication accessory factors. The invention also provides novel DNA replication accessory factors, which have been isolated and purified from the hyperthermophilic archaea Pyrococcus furiosus. The ... | 10/28/2008 |
| 7381532 | Compositions and methods for the detection of a nucleic acid using a cleavage reaction The invention relates to a method of generating a signal indicative of the presence of a target nucleic acid sequence in a sample, where the method includes forming a cleavage structure by incubating a sample containing a target nucleic acid sequence with a nucleic ... | 06/03/2008 |
| 7361469 | Dual labeled fluorescent probes The present invention relates to probes useful for the detection and measurement of target nucleic acids, as well as compositions and kits containing such probes. The probes of the present invention include an interactive pair of labels, as well as a hairpin sequenc... | 04/22/2008 |
| 7361467 | Methods for detection of a target nucleic acid by capture The invention relates to a method of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by incubating a sample comprising a target nucleic acid with a probe having a secondary s... | 04/22/2008 |
| 7363168 | Adaptive baseline algorithm for quantitative PCR The invention relates to baseline subtraction algorithms developed to reduce tube-to-tube and cycle-to-cycle variabilities during real time PCR amplification. Particularly, the invention relates to algorithms for determining the threshold cycle for the first reliabl... | 04/22/2008 |
| 7312052 | Polymerase compositions and uses thereof The subject invention provides novel compositions containing a mixture of (a) an enzyme that possesses substantial 3′–5′ exonuclease activity (b) a DNA polymerase with less 3′–5′ exonuclease activity than the enzyme with substantial 3′–5′ exonuclea... | 12/25/2007 |
| 7309573 | Methods for detection of a nucleic acid by sequential amplification The invention relates to methods and compositions for detecting a target nucleic acid. The methods include subjecting a target, template, cleavage agent, polymerase and first, second and third oligonucleotide to reaction conditions that permit: (1) formation of a du... | 12/18/2007 |
| 7297519 | Polymerase compositions and uses thereof The invention provides compositions containing a mixture of (a) an enzyme that possesses substantial 3′-5′ exonuclease activity (b) a DNA polymerase with less 3′-5′ exonuclease activity than the enzyme with substantial 3′-5′ exonuclease activity. Prefera... | 11/20/2007 |
| 7276597 | Compositions and kits for detection of a nucleic acid by sequential amplification The invention relates to nucleic acid compositions for use in sequential amplification detection assays which permit the detection of a nucleic acid target in a sample. ... | 10/02/2007 |
| 7238478 | Compositions and methods for protein isolation The invention provides for polynucleotides and vectors comprising at least two tag sequences. The invention also provides for polynucleotides and vectors comprising a streptavidin binding peptide sequence and a calmodulin binding peptide sequence. The invention also... | 07/03/2007 |
| 7235362 | Compositions and methods for protein isolation The invention provides for polynucleotides and vectors comprising at least two tag sequences. In particular, preferred vectors are viral vectors. The invention also provides for polynucleotides and vectors comprising a streptavidin binding peptide sequence and a cal... | 06/26/2007 |
| 7189508 | Methods for detection of a target nucleic acid by capture using multi-subunit probes The invention relates to generating a signal indicative of a target nucleic acid sequence, comprising forming a complex by incubating a sample comprising a target nucleic acid sequence with a probe comprising a first and second subunit, and a binding moiety, and dis... | 03/13/2007 |
| 7183052 | Methods for detection of a target nucleic acid using multi-subunit probes The invention relates to a method of generating a signal indicative of the presence of a target nucleic acid sequence in a sample, comprising forming a complex by incubating a sample comprising a target nucleic acid sequence with a probe comprising a first and secon... | 02/27/2007 |
| 7176004 | Circular site-directed mutagenesis The invention provides improved methods of introducing site-directed mutations into circular DNA molecules of interest by means of mutagenic primer pairs. The mutagenic primer pairs are also selected so as to be either completely complementary or partially complemen... | 02/13/2007 |
| 7148339 | Temperature sensitive mutant of bacteriophage T4 endonuclease VII The subject invention provides for a method of selectively cloning homoduplex nucleic acid molecules, in particular, by using a strain of host cells that contains a conditionally expressed and/or conditionally active mismatch-recognizing enzyme, e.g., a temperature ... | 12/12/2006 |
| 7132265 | Circular site-directed mutagenesis The invention provides improved methods of introducing site-directed mutations into circular DNA molecules of interest by means of mutagenic primer pairs. The mutagenic primer pairs are also selected so as to be either completely complementary or partially complemen... | 11/07/2006 |
| 7118860 | Methods for detection of a target nucleic acid by capture The invention relates to a method of generating a signal indicative of the presence of a target nucleic acid in a sample, as well as a method of detecting or measuring a target nucleic acid in a sample. The invention comprises forming a cleavage structure by incubat... | 10/10/2006 |
| 7109178 | Method for ligating nucleic acids and molecular cloning The invention provides methods of covalently joining nucleic acid molecules and methods of molecular cloning. The methods provide either sequential or simultaneous ligation of flanking or vector nucleic acid molecules to nucleic acid insert molecules by topoisomeras... | 09/19/2006 |
| 7090978 | Identification of neoplasms by detection of genetic insertions and deletions The detection of insertions and/or deletions in reiterated nucleotide sequences in tissues provides an identification of neoplastic changes that are associated with malignancy. The mutations are preferably detected by PCR based amplification of target sequences usin... | 08/15/2006 |
| 7083931 | GFP mutants with increased fluorescent intensity and spectral shift The present invention provides a polynucleotides encoding mutants of green fluorescent protein from Renilla reniformis, including humanized sequences which permit enhanced expression of the encoded polypeptides in mammalian cells. ... | 08/01/2006 |
| 7078220 | Highly transformable bacterial cells and methods for producing the same The invention provided herein includes novel gram negative bacteria cells containing the Hte mutation. Other aspects of the invention include methods for rendering gram negative bacterial cells bearing the Hte region, such as E. coli cells competent for DNA t... | 07/18/2006 |
| 7045328 | Purified thermostable DNA polymerase I Purified thermostable Pyrococcus furiosus DNA polymerase that migrates on a non-denaturing polyacrylamide gel faster than phosphorylase B and Taq polymerase and more slowly than bovine serum albumin and has an estimated molecular weight of 90,000–93,000 dal... | 05/16/2006 |
| 7005617 | Apparatus and method for thermally cycling samples of biological material with substantial temperature uniformity An apparatus for thermally cycling samples of a biological material including a thermal block assembly including a plurality of sample holders for receiving samples of biological material; a heat sink thermally coupled to the thermal block assembly, the heat sink tr... | 02/28/2006 |
| 6977164 | Compositions and kits for Herpes Simplex Virus type 1 and 2 nucleic acid detection The invention relates to polynucleotides for HSV detection and the use of these polypeptides in kits and methods for HSV detection. ... | 12/20/2005 |
| 6962821 | Thermal cycler including a temperature gradient block A method in which a temperature gradient is generated across a “gradient” block, and an apparatus comprising a block across which a temperature gradient can be generated. By setting up such a gradient, multiple reaction mixtures held in wells on the gradient blo... | 11/08/2005 |
| 6958390 | Compositions and kits for herpes simplex virus type 1 and 2 nucleic acid detection The invention relates to polynucleotides for HSV detection and the use of these polypeptides in kits and methods for HSV detection. ... | 10/25/2005 |
| 6946273 | Compositions and methods utilizing DNA polymerases The invention features a novel isolated Family B DNA polymerase, a Thermococcus polymerase JDF-3, and mutant recombinant forms thereof. Mutant polymerases of the invention are deficient in 3′ to 5′ exonuclease activity and/or exhibit reduced discriminatio... | 09/20/2005 |
| 6936428 | Dimeric flourescent polypeptides The invention relates to proteins or polypeptides that comprise intramolecular dimers of fluorescent protein monomers. More specifically, the invention relates to recombinant polypeptides comprising a monomer of a fluorescent polypeptide, a linker peptide, and a sec... | 08/30/2005 |
| 6893819 | Methods for detection of a nucleic acid by sequential amplification The invention relates to a method of detecting a target nucleic acid by linear amplification. The invention also relates to a method of detecting a target nucleic acid by amplification. The method of the invention includes the steps of forming at least a first cleav... | 05/17/2005 |
| 6878905 | Apparatus and method for flexible heating cover assembly for thermal cycling of samples of biological material A flexible heating cover assembly for an apparatus for heating samples of biological material with substantial temperature uniformity includes a housing having a plurality of engageable enclosure components; a resistive heater having a plurality of heater element ar... | 04/12/2005 |
| 6869797 | Method for more efficient electroporation This invention provides improved electroporation methods for transferring nucleic acids of interest into host cells, wherein the host cells are (1) suspended in a substantially non-ionic solution comprising at least one sugar or sugar derivative, (2) mixed with the ... | 03/22/2005 |
| 6858393 | Chain terminators for DNA synthesis The invention relates to acyclic chain terminator nucleotide analogs. More particularly, the invention relates to phosphonomethoxyethyl nucleotide analogs and detectably labeled versions thereof, especially fluorescently labeled versions thereof. The invention furth... | 02/22/2005 |
