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| Number | Title | Issue Date |
| 6017522 | Segmented chelating polymers as imaging and therapeutic agents A composition suitable for use in diagnostic imaging or as a cell killing agent comprising a chelating residue linked via an amide linkage to a poly(alkylene oxide) moiety, said compisition having a molecular weight of at least 4,500; ##STR1## w... | 01/25/2000 |
| 5932188 | Therapeutic and diagnostic imaging compositions and methods This invention provides therapeutic and diagnostic imaging compositions and methods featuring a polymer comprising units containing a poly(alkylene oxide) moiety linked to the residue of a chelating agent, said polymer having a cytotoxic agent associated ... | 08/03/1999 |
| 5853713 | Biologically compatible linear block copolymers of polyalkylene oxide and peptide units A linear block copolymer comprising units of an alkylene oxide, linked to units of peptide via a linking group comprising a --CH.sub.2 CHOHCH.sub.2 N(R)-- moiety, is useful as an imaging agent, drug, prodrug or as a delivery system for imaging agents, dru... | 12/29/1998 |
| 5756688 | MR imaging compositions and methods This invention provides compositions useful in MR imaging comprising a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, the polymer having a paramagetic metal ion associated therewith.... | 05/26/1998 |
| 5744119 | Preparation of a radioconjugate formulation The present invention is directed to a method of labeling a protein conjugate with a radionuclide to form a radioconjugate comprising reacting: (a) the radionuclide; and (b) the protein conjugate in an acetate buffer for a time period and under conditions... | 04/28/1998 |
| 5730968 | Segmented chelating polymers as imaging and therapeutic agents A composition suitable for use in diagnostic imaging or as a cell killing agent comprising a chelating residue linked via an amide linkage to a poly(alkylene oxide) moiety, said composition having a molecular weight of at least 4,500; ##STR1## w... | 03/24/1998 |
| 5714585 | Antibodies that are immunoreactive with interleukin-7 Antibodies that are immunoreactive with interleukin-7 (IL-7) proteins are provided. The anti-IL-7 antibodies may be polyclonal or monoclonal. Certain embodiments are directed to antibodies that are immunoreactive with human IL-7.... | 02/03/1998 |
| 5705149 | Use of interleukin-7 to stimulate proliferation of hematopoietic cell precursors Mammalian Interleukin-7 proteins (IL-7s), DNAs and expression vectors encoding mammalian IL-7s, and processes for producing mammalian IL-7s as products of cell culture, including recombinant systems, are disclosed.... | 01/06/1998 |
| 5681557 | Use of interleukin-7 to induce monocytes/macrophages cytotoxic activity There is disclosed a method of treating microbial infections in microbially infected mammals and a method of augmenting antitumor immunotoxicity in a mammal comprising administering a therapeutically effective amount of IL-7 in a pharmaceutically acceptab... | 10/28/1997 |
| 5624922 | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents Aryl-fused- and hetaryl-fused-2,4-diazepines of formula XXXVI, benzodiazocines of formula XXX, benzodiazepines of formula II ##STR1## δ-aminoamides of formula III and aryldimethanamines of formula XXXVII ##STR2## wherein A is an aryl or he... | 04/29/1997 |
| 5622967 | Quinolone carboxamide Calpain inhibitors A compound of the formula ##STR1## wherein: Z is aryl, substituted aryl, phenyl-lower-alkyl, hetero-aryl, substituted heteroaryl, heterocycloalkyl, heterocyclocalkyl-lower-alkyl, hetero-aryl-lower-alkyl wherein one or more hydrogens of aryl and ... | 04/22/1997 |
| 5620677 | Compositions of iodophenoxy alkanes and iodophenyl ethers for visualization of the gastrointestinal tract Disclosed are contrast agents of the formula ##STR1## contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein Z=H, halo, C1 -C20 alkyl, cycloalkyl, lower alkoxy, cyano... | 04/15/1997 |
| 5618528 | Biologically compatible linear block copolymers of polyalkylene oxide and peptide units A linear block copolymer comprising units of an alkylene oxide, linked to units of peptide via a linking group comprising a --CH2 CHOHCH2 N(R)-- moiety, is useful as an imaging agent, drug, prodrug or as a delivery system for imaging... | 04/08/1997 |
| 5614530 | Substituted N-arylmethyl and heterocyclmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines and compositions and methods of use thereof Substituted N-arylmethyl and heterocyclylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) revers... | 03/25/1997 |
| 5607660 | Compositions of iodophenoxy alkanes and iodophenyl ethers in combination with cellulose derivatives for visualization of the gastrointestinal tract Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an iodophenoxy alkane, iodophenyl alkenylalkyl ether or an iodophenyl alkynylalkyl ether x-ray producing agent in combination with a cell... | 03/04/1997 |
| 5607933 | 3-arylcarbonyl-1(C-attached-N-heteryl)-1H-indoles 2--R2 --R4 -substituted-3--R3 --CO--1--[(C-attached-N-heteryl)-(Alk)n ]--1H-indoles useful as analgesic, anti-rheumatic, anti-inflammatory or anti-glaucoma agents.... | 03/04/1997 |
| 5604224 | Substituted heterocyclylisoquinolinium salts and compositions and methods of use thereof Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.... | 02/18/1997 |
| 5597841 | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof 4-R4 -R5 -2-Saccharinylmethyl aryl carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R4 -R5 -2-halomethylsaccharin with an arylcarboxylic acid in the presence of an aci... | 01/28/1997 |
| 5596012 | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof Novel 2-substituted saccharins which inhibit the enzymatic activity of proteolytic enzymes, are useful in the treatment of degenerative diseases and have the formula ##STR1## wherein: L is --O--, --S--, --SO--or --SO2 --; m and n are each ... | 01/21/1997 |
| 5585486 | Peptidic ketones as interleukin-1ଲ-converting enzyme inhibitors Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R1 is (CR5 R6)n, (CR5 R6)n,-aryl, (CR5 R6) | 12/17/1996 |
| 5583206 | Chelating polymers In accordance with this invention, there is provided a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, and a method for the preparation thereof. The polymer is particularly useful in therapeuti... | 12/10/1996 |
| 5578601 | Nonpeptide bradykinin antagonists Disclosed are nonpeptides having bradykinin antagonist activity of the formulae (I) and (II) ##STR1## or a pharmaceutically acceptable salt thereof therefor.... | 11/26/1996 |
| 5578623 | Saccharin derivative proteolytic enzyme inhibitors Compounds having the structural formula ##STR1## wherein L is O; L-R1 is a leaving group, H-L-R1 is the conjugate acid thereof and H-L-R1 has a pKa value less than or equal to to 8; R2 is primary or s... | 11/26/1996 |
| 5576427 | Acyclic nucleoside analogs and oligonucleotide sequences containing them Compounds of formula I; ##STR1## wherein R1 is hydrogen, or a blocking group that is compatible with oligonucleotide synthesis; R2 is hydrogen, nitro, lower alkyl amino, diloweralkyl amino or methyl; R3 is hydrogen or... | 11/19/1996 |
| 5573514 | Holder for cartridge-needle unit This invention relates to a holder for use in combination with a pre-filled cartridge-needle unit, the holder comprising a hollow body sized for housing the cartridge-needle unit therein, and means for permitting the body to move axially relative to the c... | 11/12/1996 |
| 5569655 | Substituted heterocyclylisoquinolinium salts and compositions and method of use thereof Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.... | 10/29/1996 |
| 5567717 | Heterocycle substituted phenoxyalkylheterocycles and their use as antiviral agents A compound of the formula ##STR1## wherein Y, R1, R2, R3, R4 and R5 are as defined in the specification.... | 10/22/1996 |
| 5567719 | Thiadiazoles and their use as antipicornaviral agents The invention pertains to heterocycle substituted phenoxyalkylheterocycles of the formula ##STR1## wherein Thi, Y, R1, R2 and R3 are as defined in the specification, or a pharmaceutically acceptable salt thereof which... | 10/22/1996 |
| 5565430 | Azaaspartic acid analogs as interleukin-1ଲ converting enzyme inhibitors Disclosed are compounds, compositions and methods for inhibiting interleukinprotease activity. The compounds, -substituted acetamides a ##STR1## wherein: R2 =H or alkyl; R3 =halo, O(CO)0-1 aryl, OPOR4 | 10/15/1996 |
| 5563163 | 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof 4-R4 -R5 -2-Saccharinylmethyl heterocyclic carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R4 -R5 -2-halomethylsaccharin with either a heterocyclic carboxylic acid in... | 10/08/1996 |
| 5554620 | Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts and compositions and methods of use thereof Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment of neurodegenerative disorders or neurotoxic injuries utilizing them, wherein the substituted 6,11-ethano-6,11-dihy... | 09/10/1996 |
| 5552420 | Therapeutic phenoxyalkylazoles and phenoxyalkylazines Compounds of the formula ##STR1## wherein Azo is alkyltetrazolyl, oxadiazolyl, imidazolyl, pyrazolyl, triazolyl, oxazolyl, triazinyl, thiazolyl, isothiazolyl; Y is an alkylene bridge of 3-9 carbon atoms; R3 is alkoxycarbonyl, alkyltetrazolyl, p... | 09/03/1996 |
| 5552400 | Fused-bicyclic lactams as interleukin-1ଲ converting enzyme inhibitors Disclosed are compounds, compositions and methods for inhibiting interleukin-1ଲ protease activity. The compounds, bicyclic derivatives of aldehydes and -substituted methyl ketones, have the formula (A) set out herein.... | 09/03/1996 |
| 5543132 | X-ray contrast compositions containing a barium salt and a cellulose derivative Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a barium salt in a pharmaceutically acceptable carrier comprising a cellulose derivative; and methods for their use in diagnostic radiolo... | 08/06/1996 |
| 5541168 | Substituted 2-(phosphinyloxymethyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof Substituted 2-(phosphinyloxymethyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxides, pharmaceutical compositions containing them and methods for the treatment of degenerative diseases utilizing them.... | 07/30/1996 |
| 5535746 | Prefilled syringe for use with power injector A plastic syringe adapted for use with power injector systems comprises a cylindrical barrel for receiving a liquid, a plunger axially reciprocable within the barrel for discharging the liquid therefrom, a discharge extension at the distal end of the barr... | 07/16/1996 |
| 5531979 | Compositions of iodophenoxy alkanes and iodophenyl ethers and pharmaceutically acceptable clays for visualization of the gastrointestinal tract Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkanes and iodophenyl ethers as the x-ray producing agents in combination with a pharmaceutically acceptable clay in a pharm... | 07/02/1996 |
| 5532150 | Low diol polyalkylene oxide biologically active proteinaceous substances Disclosed are pharmaceutical compositions containing low diol polyethylene glycol, covalently attached to superoxide and dismutase process of making the compositions. Also disclosed is a method of treatment of disease processes associated with the adverse... | 07/02/1996 |
| 5532263 | Benzothiopyranoindazole antitumor agents Novel 2H-[1]benzothiopyrano[4,3,2-cd]indazoles are disclosed as antitumor agents. Compositions containing the benzothiopyranoindazoles and methods of treating tumors and cancer in mammals with benzothiopyranoindazoles are also disclosed.... | 07/02/1996 |
| 5531711 | Safety cannula A coupling system for transferring fluids from a medicament-containing cartridge to an injection site comprises a fluid flow channel, a blunt cannula defining the distal end of the fluid flow channel, a needle cannula defining the proximal end of the flui... | 07/02/1996 |
