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| Number | Title | Issue Date |
| 8148415 | Sulfamic acid ester compounds useful in the inhibition of steroid sulphatase activity and aromatase activity The present invention relates to steroid sulphatase and/or aromatase inhibitors of Formula III or Formula IV, wherein A is selected from H, OH, halogen and hydrocarbyl; D, E and F are each independently of each other an optional linker group; P, Q and R are independ... | 04/03/2012 |
| 8124614 | Steroidal compounds for inhibiting steroid sulphatase There is provided a compound having Formula (I) wherein G is H or a substituent, and wherein R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group, capable of inhibiting steroid sulph... | 02/28/2012 |
| 8119627 | Heterocyclic compounds as inhibitors of 17beta-HSD3 There is provided a compound having Formula (I) wherein each of rings A and B is selected from five or six membered carbon rings optionally containing one or more hetero atoms selected from N, S, and O and optionally having... | 02/21/2012 |
| 8026229 | Antitumor-active 2-alkoxyestradiol sulfamates The present invention relates to the use of 2-alkoxyestrogen sulfamates of general formula I wherein R1 and R2 independently represent H, methyl, C1-C4 acyl, benzoyl | 09/27/2011 |
| RE42132 | Antitumoral D-homoestra-1,3,5(10)-trien-3-yl 2-substituted sulfamates This invention relates to 2-substituted D-homo-estra-1,3,5(10)-trien-3-yl sulfamates of general formula I (I), in which R3 means a C1-C5-alkyl or C1-C5-alkyloxy group as well as their use for the production of a pharmaceutical agent for treating tumor diseases, whic... | 02/08/2011 |
| 7846965 | Compound A compound is described. In particular, a non-steroidal sulphamate compound is described. The compound is suitable for use as an inhibitor of oestrone sulphatase. The compound is of general Formula (A), wherein R1 | 12/07/2010 |
| 7745472 | Compound There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the v... | 06/29/2010 |
| 7427610 | 2-substituted estra-1,3,5(10)-triene-3-yl sulfamate with an anti-tumour action Disclosed are compounds of formula I and use thereof in a method of treating a tumor disease that can be influenced positively by the inhibition of tubulin polymerization. ... | 09/23/2008 |
| 7335650 | Composition There is provided a pharmaceutical composition comprising (i) a compound of the formula wherein: X is a hydrocarbyl ring having at least 4 atoms in the ring; K is a hydrocarbyl group; Rs is a sulphamate group; (ii) optional... | 02/26/2008 |
| 7244762 | Antitumoral d-homoestra-1,3,5 (10)-trien-3-yl 2-substituted sulfamates This invention relates to 2-substituted D-homo-estra-1,3,5(10)-trien-3-yl sulfamates of general formula I (I), in which R3 means a C1-C5-alkyl or C1-C5-alkyloxy group as well as their use for the production of a pharmaceutical agent for treating tumor diseases, whic... | 07/17/2007 |
| 7230020 | 11β-hydroxysteroid dehydrogenase inhibitors A compound having Formula I R1—Z—R2Formula I wherein R1 is an optionally substituted phenyl ring; R2 is or comprises an optionally substituted aromatic ring; and Z is —X—Y—L— or —Y—X—L... | 06/12/2007 |
| 7211246 | Compositions comprising oestrone-3-0-sulphamate and trail (TNF-related apoptosis inducing ligand) The present invention provides a composition comprising (i) a compound comprising a sulphamate group (“a sulphamate compound”); and (ii) an apoptosis inducer. ... | 05/01/2007 |
| 7119081 | Oestrogen-17-sulphamates as inhibitors of steroid sulphatase There is provided a compound of Formula I wherein X is a ring system; R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R | 10/10/2006 |
| 7098218 | Steroidal compounds for inhibiting steroid sulphatase There is provided a compound having Formula (I) wherein G is H or a substituent, and wherein R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group, capable of inhibiting steroid sulph... | 08/29/2006 |
| 7098199 | Steroid sulphatase inhibitors A method of inhibiting steroid sulphatase activity in a subject in need of same is described. The method comprises administering to said subject a steroid sulphatase inhibiting amount of a ring system compound; which ring system compound comprises a ring to w... | 08/29/2006 |
| 7067503 | 17-aryl linker derivatised estrogen 3-sulphamates as inhibitors of steroid sulphatase There is provided a compound comprising a steroidal ring system and a group R1 selected from any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring of the steroidal ring ... | 06/27/2006 |
