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| Number | Title | Issue Date |
| 6251948 | Tri-and tetra-substituted guanidines and their use as excitatory amino acid antagonists Tri- and tetra-substituted guanidines which exhibit a high binding affinity to phencyclidine (PCP) receptors and, more preferably, low affinity to the brain sigma receptors. These guanidine derivatives act as non-competitive inhibitors of glutamate induce... | 06/26/2001 |
| 6017910 | PCP receptor ligands and the use thereof The invention relates to 5-(iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives thereof. The invention also relates to the use of such compounds for the treatment or prevention of neuronal loss in ischemia, hypoxia, brain or spina... | 01/25/2000 |
| 5853686 | Calcium carbonates of altered crystal habit or morphology and methods for producing same Methods are disclosed in which first and second reactant salts and, optionally, a complexing agent are added to a non-aqueous reaction solvent to form a reaction system. The reactant salts, which are substantially soluble and reactive with each other in w... | 12/29/1998 |
| 5853691 | Silver halides of altered crystal habit or morphology and methods for producing same Methods are disclosed in which first and second reactant salts and a complexing agent are added to a non-aqueous reaction solvent in which the complexing agent is soluble. The complexing agent is a crown ether or other cyclic or acyclic polydentate chelat... | 12/29/1998 |
| 5798390 | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists Tri- and tetra-substituted guanidines which exhibit a high binding affinity to phencyclidine (PCP) receptors and, more preferably, low affinity to the brain sigma receptors. These guanidine derivatives act as non-competitive inhibitors of glutamate induce... | 08/25/1998 |
| 5767162 | Tri-and tetra-substituted guanidines and their use as excitatory amino acid antagonists Tri- and tetra-substituted guanidines which exhibit a high binding affinity to phencyclidine (PCP) receptors and, more preferably, low affinity to the brain sigma receptors. These guanidine derivatives act as non-competitive inhibitors of glutamate induce... | 06/16/1998 |
| 5688789 | PCP receptor ligands and the use thereof The invention relates to 5-(iminomethano)-10,11-dihydro-5H-dibenzoa,d!cycloheptene and derivatives thereof. The invention also relates to the use of such compounds for the treatment or prevention of neuronal loss in ischemia, hypoxia, brain or spin... | 11/18/1997 |
| 5652368 | 1,2,3,4-tetrahydroquinoline 2,3,4-trione-3 or 4-oximes Disclosed herein are substituted or unsubstituted 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes or pharmaceutically acceptable salts thereof that have high binding to the glycine receptor and are usefully administered to animals for the treatment... | 07/29/1997 |
| 5631373 | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia, and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, and... | 05/20/1997 |
| 5622965 | 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-ones and the use thereof as excitatory amino acid and glycine receptor antagonists Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and D... | 04/22/1997 |
| 5622952 | Glycine receptor antagonists and the use thereof Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and D... | 04/22/1997 |
| 5620978 | 8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/NMDA receptor Disclosed is a method of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma or hypoglycemia. The method comprises administering to an animal a compound of the formula: ##STR1## or a pharmaceutically acceptable salt ther... | 04/15/1997 |
| 5574070 | Substituted guanidines having high binding to the sigma receptor and the use thereof The invention relates to a method for the treatment or prophylaxis of psychosis, depression, hypertension, or anxiety in an animal by administering an effective amount of an N,N'-disubstituted guanidine or 2-iminoimadazolidine having an affinity for the s... | 11/12/1996 |
| 5476933 | Azepine synthesis via a diels-alder reaction Disclosed are methods of preparing azepines by a multistep synthesis including a Diels-Alder reaction. Also disclosed are methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as tr... | 12/19/1995 |
| 5475007 | 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the use thereof Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and D... | 12/12/1995 |
| 5385946 | Method for treating hypertension with disubstituted granidine compounds N,N-disubstituted-guanidines, e.g., of the formula ##STR1## wherein R and R' are substituted or unsubstituted hydrocarbon groups. Methods are provided for the treatment of psychosis and hypertension by administering an effective amount of an N,N'-dis... | 01/31/1995 |
| 5364475 | Process for removing chemical preservatives from wood using supercritical fluid extraction The process of the present invention is directed to the remediation of wood that has been treated with a preservative, such as pentachlorophenol or other non-ionic organic biocides, using supercritical fluids, with or without the addition of modifiers.... | 11/15/1994 |
| 5356867 | Method and composition comprising vinyl or vinylidene halide polymers for controlling water loss in plants A liquid composition is applied to a plant to provide a barrier to water vapor transmission. The composition dries to form a film on the surface of the plant. The film inhibits water loss and thereby increases the survival likelihood and quality of the pl... | 10/18/1994 |
| 5344265 | Securement system for a rollable mobility aid A securement system is provided for a rollable mobility aid with a frame and rollers, which aid is located adjacent surrounding structure such as the interior of a vehicle. The system includes protruding structure attached to such frame, with a substantia... | 09/06/1994 |
| 5336689 | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists Tri- and tetra-substituted guanidines which exhibit a high binding affinity to phencyclidine (PCP) receptors and, more preferably, low affinity to the brain sigma receptors. These guanidine derivatives act as non-competitive inhibitors of glutamate induce... | 08/09/1994 |
| 5276637 | Swept-carrier frequency selective optical memory and method Data storage methods and apparatus are disclosed that utilize a swept-carrier optical approach with an inhomogeneously broadened absorber material having multiple special storage cells. Data are encoded on a data pulse by appropriately modulating the data... | 01/04/1994 |
| 5212904 | Fertilizing apparatus The fertilizing apparatus comprises a diffusion member having a porous member associated with it to retain fertilizer inside a compartment defined by the diffusion member. The diffusion member provides a diffusion pathway that is protected from gravitatio... | 05/25/1993 |
| 5202891 | Nonlinear optical material Nonlinear optical materials having the general formula Ca1.40-X MX V0.98&#b1;0.05 O4.00&#b1;0.08 wherein X is 0.07 to 0.43 and M is selected from the group consisting of Bi, La, Ce, Y, Pm, Pr, Nd, Sm, Eu, Gd, Tb... | 04/13/1993 |
| 5190976 | N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists N,N'-disubstituted guanidines exhibiting a high binding affinity to phencyclidine (PCP) receptors are disclosed. These N,N'-disubstituted guanidine derivatives act as non-competitive inhibitors or glutamate-induced responses generated via the NMDA recepto... | 03/02/1993 |
| 5117581 | Pallet system for container-grown plants The system includes an efficient, closed irrigation system in conjunction with insulating components for minimizing the harmful effects of extreme changes in ambient temperature, moisture and chemical concentrations in plant containers. Mechanisms are pro... | 06/02/1992 |
| 5059431 | Process for deacidifying wine A method is disclosed for deacidifying wine using malolactic fermentation (MLF) under conditions inhibitory for spoillage lactic acid bacteria (LAB), making possible a "pure culture" MLF in which a winemaker is provided with a way to control the timing of... | 10/22/1991 |
| 4982147 | Power factor motor control system A device and associated method to control the electromechanical energy conversion process of a variable speed drive utilizing a doubly fed machine, which provides the mechanical energy as demanded by some mechanical load. Alternatively, a device and assoc... | 01/01/1991 |
| 4935529 | Cytoxic substances from the marine cyanophyte hormothamnion enteromorphoides grunow Several new, biologically active substances have been isolated from Hormothamnion enteromorphoides, a somewhat rare cyanophyte from Puerto Rico. Hormothamnion, a lipophilic metabolite from this alga, has the styrylchromone structure: ##STR1## Ho... | 06/19/1990 |
| 4571384 | Methane production Methane is produced by dissolving mineral carbonate in water to produce dissolved carbon dioxide which is converted to methane by anaerobic methanogenic bacteria in the presence of hydrogen gas supplied to the water. Preferably, the mineral carbonate is i... | 02/18/1986 |
