Assignee: Southern Research Institute

Location: Birmingham, AL
No. of patents: 110

Number	Title	Issue Date
8178510	Preparation of thioarabinofuranosyl compounds and use thereof Patients suffering from cancer are treated by being administered a compound represented by the following formula: wherein each R individually is H or an aliphatic or aromatic acyl group; ...	05/15/2012
8129406	Nonpeptide inhibitors of matrix metalloproteinases Disclosed are selective inhibitors of matrix metalloproteinases represented by the following formula (I). wherein X is (CH2)nO, (CH2)nS, (CH2)nNR1...	03/06/2012
8044048	Derivatives of sulindac, use thereof and preparation thereof Derivatives of sulindac are provided along with pharmaceutical compositions containing them and use for precancerous conditions and treating cancer. Derivatives of sulindac are also suitable for treating chronic inflammatory conditions. A method for preparing the de...	10/25/2011
8007688	Process for decontaminating syngas Disclosed herein is an apparatus and methods for decontaminating syngas generated in a fluidized-bed gasifier wherein metal contaminants, inter alia, alkali metals, halogens, particulates, and transition metals and sulfur containing contaminants are removed prior to...	08/30/2011
7951817	Pyridomorphinans, pyridazinomorphinans and use thereof Compounds represented by the formula: wherein R is C1-6 alkyl; C4-6 cycloalkylalkyl; or C3-6 alkenyl; R′ is H or C1-6 alkyl; X is H or OH; Y is alkyl, cycloalkyl, aryl, h...	05/31/2011
7838508	4′-thio-L-xyloy furanosyl nucleosides, precursors thereof, preparation and use thereof Compounds represented by the formula 1: A is selected from the group consisting of wherein each R ...	11/23/2010
7718651	Inhibitors of FtsZ and uses thereof The invention relates to inhibitors of FtsZ polymerization and uses thereof. ...	05/18/2010
7691820	Preparation of thioarabinofuranosyl compounds and use thereof Patients suffering from cancer are treated by being administered a compound represented by the following formula: wherein each R individually is H or an aliphatic or aromatic acyl group; ...	04/06/2010
7541364	Pyridomorphinans, pyridazinomorphinans and use thereof Compounds represented by the formula: wherein R is C1-6 alkyl; C4-6 cycloalkylalkyl; or C3-6 alkenyl; R′ is H or C1-6 alkyl; X is H or OH; Y is alkyl, cycloalkyl, aryl, heteroar...	06/02/2009
7534799	Pyridomorphinans, thienomorphinans and use thereof Compounds represented by the formulae: wherein each of Y, X and R individually is selected from the group consisting of hydrogen, hydroxy, halo, CF3, NO2, CN, NH2, COR1 and CO	05/19/2009
7488598	Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof A host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside cleavage enzymes is provided. The transformed or transfected host cell can be used in combination with a purine substrate to treat tumor cells an...	02/10/2009
7470784	Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)--purin-6-amine 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofiranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy...	12/30/2008
7148223	4′-thio-L-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or...	12/12/2006
7138385	Thioarabinofuranosyl compounds and use thereof Patients suffering from cancer are treated by being administered a compound represented by the following formula: wherein each R individually is H or an aliphatic or aromatic acyl group;	11/21/2006
7122563	Derivatives of 4-demethylpenclomedine, use thereof and preparation thereof Thiocarbonate and thiocarbamate derivatives of 4-demethylpenclomedine are provided along with pharmaceutical compositions containing them and use for treating cancer. A method for preparing the derivatives is also provided. ...	10/17/2006
7105675	Pyridomorphinans, thienomorphinans and use thereof Compounds represented by the formulae: wherein each of Y, X and R individually is selected from the group consisting of hydrogen, hydroxy, halo, CF3, NO2, CN, NH2, COR1	09/12/2006
7037718	Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combin...	05/02/2006
7015326	Pyridomorphinans, thienomorphinans and use thereof Compounds represented by the formulae: wherein each of Y, X and R individually is selected from the group consisting of hydrogen hydroxy, halo, CF3, NO2, CN, NH2, COR1 and CO	03/21/2006
6958318	Recombinant bacterial cells for delivery of PNP to tumor cells The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combination w...	10/25/2005
6949640	Method for synthesizing 2-chloro-9-(2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-9-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofuranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy...	09/27/2005
6914061	4′-thio-L-xylofuranosyl nucleosides, precursors thereof, preparation and use thereof Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or acyl, Y is X, N3,...	07/05/2005
6911998	Automatic conformal window sizing in a video imaging system An apparatus and method for generating a conformal window in a video tracking system. Each of the lines within the conformal window comprises a sub-window which is resized for each frame of video signal. The composite window comprising all the sub-windows is also re...	06/28/2005
6870052	Preparation of thioarabinofuranosyl compounds and use thereof Patients suffering from cancer are treated by being administered a compound represented by the following formula: wherein each R individually is H or an aliphatic or aromatic acyl group; ...	03/22/2005
6685759	Cascade impactor and jet plate for same A sampling system and method for sampling particulate matter from a high-temperature, high-pressure gas stream. A cyclone sampler for use at high temperatures and pressures, and having threadless sacrificial connectors is disclosed. Also disclosed is an i...	02/03/2004
6656254	Full flow mechanical failsafe A full-flow mechanical failsafe (100) is composed of a cylindrical shell (101) having a movable sealing plug (105) therein, for attachment to a filter element (110) of a fluid filtering system, such as a gas clean up system in a power plant. The sealing p...	12/02/2003
6655259	Full flow mechanical fail safe A full-flow mechanical failsafe is composed of a cylindrical shell having a movable sealing plug therein, for attachment to a reaction tube of a fluid treatment system, such as a gas clean up system in a power plant. The sealing plug rests on locking sphe...	12/02/2003
6605139	Apparatus and method for improved pulse-jet cleaning of industrial filters An improved apparatus and method for pulse-jet cleaning of filter bags in a baghouse using pulsed, high-pressure/low-volume, intermediate-pressure/intermediate-volume, or low-pressure/high-volume pulsed air flow. Relative movement between a first tubular ...	08/12/2003
6576621	Preparation of thioarabinofuranosyl compounds and use thereof Patients suffering from cancer are treated by being administered a compound represented by the following formula: ##STR1## wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of ##STR2## wherein...	06/10/2003
6565875	Microcapsules for administration of neuroactive agents The present invention relates to polymeric microspheres as injectable, drug-delivery vehicles for use to deliver bioactive agents to sites within the central nervous system, and for the stimulation of nerve fiber growth by implanting such microspheres wit...	05/20/2003
6559295	Mycobacterium fol A gene that encodes for the enzyme dihydrofolate reductase The invention relates to the nucleic acid sequence and amino acid sequence of dihydrofolate reductase (DHFR) from mycobacteria and to expression of recombinant DHFR protein. Utilizing the recombinant protein, novel therapies and diagnostic strategies can ...	05/06/2003
6517859	Microcapsules for administration of neuroactive agents The present invention relates to polymeric microspheres as injectable, drug-delivery vehicles for use to deliver bioactive agents to sites within the central nervous system, and for the stimulation of nerve fiber growth by implanting such microspheres wit...	02/11/2003
6503948	Method for prevention or treatment of acute allograft rejection and a pharmaceutical composition therefor A method for treating an organ donor prior to harvesting organ to reduce graft rejection in a recipient. An amount effective to reduce graft rejection of at least one compound selected from the group consisting of compounds having formulas I, II, III, IV,...	01/07/2003
6495571	Pyridine compounds, use and preparation thereof New pyridine compounds are provided along with their method of preparation. The compounds are useful as intermediates in preparing new anticancer agents. A few of the pyridine compounds are also useful for treating cancer....	12/17/2002
6495155	Injectable opioid partial agonist or opioid antagonist microparticle compositions and their use in reducing consumption of abused substances An injectable slow-release partial opioid agonist or opioid antagonist formulation is provided comprising a partial opioid agonist or opioid antagonist in a poly(D,L-lactide) excipient with a small amount of residual ethyl acetate. Upon intramuscular inje...	12/17/2002
6491905	Recombinant bacterial cells for delivery of PNP to tumor cells The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in co...	12/10/2002
6479241	High throughput screening of the effects of anti-cancer agents on expression of cancer related genes in various cell lines A high-throughput method for screening compounds for anticancer activity involves cultivating cells capable of expressing cancer genes in cell culture in microtiter plate wells in the presence of test compounds and detecting the level of gene expression b...	11/12/2002
6465479	Pyridomorphinans and use thereof Compounds represented by the formula: ##STR1## wherein each of Y, X and R individually is H, OH, alkyl, alkoxy, aryl, halo, CF3 and NO2, provided that at least one of Y, X and R is other than H; and pharmaceutically acceptable salts ...	10/15/2002
6391893	Pyridine compounds use and preparation thereof New pyridine compounds are provided along with their method of preparation. The compounds are useful as intermediates in preparing new anticancer agents. A few of the pyridine compounds are also useful for treating cancer....	05/21/2002
6376518	Acyl derivatives of 4-demethylpenclomedine, use thereof and preparation thereof Acyl derivatives of 4-demethylpenclomedine are provided along with pharmaceutical compositions containing them and use for treating cancer. A method for preparing the derivatives is also provided....	04/23/2002
6323205	Combinations of 10-propargyl-10-deazaaminopterin and taxols and methods of using same in the treatment of tumors Preliminary clinical studies in humans have now been done which show both the efficacy of 10-propargyl-10dAM and a preferred dosage schedule for such treatments. In addition, it has now been determined that combinations of 10-propargyl-10-deazaaminopterin...	11/27/2001

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Assignee: Southern Research Institute