...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 7786164 | Lipophilic di(anticancer drug) compounds, compositions, and related methods Lipophilic di(anticancer drug) compounds, compositions that include the compounds, and methods for treating a cell proliferative disease using the compounds. ... | 08/31/2010 |
| 7786134 | Lipophilic anticancer drug compounds, compositions and related methods Lipophilic anticancer drug compounds, compositions that include the compounds, and methods for treating a cell proliferative disease using the compounds. ... | 08/31/2010 |
| 7268245 | Multinuclear platinum compounds Multinuclear platinum compounds, compositions that include the platinum compounds, methods for making the platinum compounds, and methods for treating cellular proliferative diseases by administering the platinum compounds. ... | 09/11/2007 |
| 7232919 | Platinum compounds Platinum compounds, pharmaceutically acceptable salts, and prodrugs thereof. Compositions that include the platinum compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier. Methods for usin... | 06/19/2007 |
| 7223770 | Tocopherol-modified therapeutic drug compounds Tocopherol-modified therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds; methods for making the compounds and formulations; methods for administering the compounds and formulations; and methods for treating condit... | 05/29/2007 |
| 7129368 | Platinum carboxylate anticancer compounds Platinum carboxylate anticancer compounds, pharmaceutical compositions that include the platinum carboxylate compounds, and methods for treating cellular proliferative diseases by administering the platinum carboxylate compounds. ... | 10/31/2006 |
| 7091374 | Fluorinated compounds Fluorinated compounds and emulsions including the compounds. The compositions are useful as oxygen carriers and surfactants. In one embodiment, the fluorinated compound is pH sensitive. In one embodiment, the fluorinated compound is a vitamin E derivative. In one em... | 08/15/2006 |
| 7038071 | Platinum compounds Platinum compounds, pharmaceutically acceptable salts, and prodrugs thereof. Compositions that include the platinum compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier. Methods for usin... | 05/02/2006 |
| 7030155 | Emulsion vehicle for poorly soluble drugs A method of making an emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various rou... | 04/18/2006 |
| 6982282 | Emulsion vehicle for poorly soluble drugs An emulsion of α-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans via various routes is disclosed. Also included in the emulsio... | 01/03/2006 |
| 6864386 | Fluorinated compounds Fluorinated compounds and emulsions including the compounds. The compositions are useful as oxygen carriers and surfactants. In one embodiment, the fluorinated compound is pH sensitive. In one embodiment, the fluorinated compound is a vitamin E derivative. In one em... | 03/08/2005 |
| 6858227 | Vitamin E conjugates Vitamin E conjugates, methods for their preparation, and compositions that include the conjugates. The vitamin E conjugates include a tocopherol moiety covalently coupled through a linker moiety to either a pyroglutamate moiety, a pyrrolidinone moiety, or a gentisic... | 02/22/2005 |
| 6727280 | Method for treating colorectal carcinoma using a taxane/tocopherol formulation The present invention provides methods for administering a taxane composition for the treatment of cancer. In one aspect, the compositions are not diluted prior to administration. Some embodiments provide methods for administering a taxane as a bolus injection or an... | 04/27/2004 |
| 6683194 | Tocopherol derivatives Tocopherol derivatives are provided. In one embodiment, the tocopherol derivative includes a tocopherol moiety covalently coupled to branched hydrophilic moiety. In another embodiment, the tocopherol derivative includes a first tocopherol moiety covalentl... | 01/27/2004 |
| 6667048 | Emulsion vehicle for poorly soluble drugs An emulsion of -tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans various routes is disclosed. Also included in... | 12/23/2003 |
| 6660286 | Emulsion vehicle for poorly soluble drugs An emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various routes is d... | 12/09/2003 |
| 6458373 | Emulsion vehicle for poorly soluble drugs An emulsion of -tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans various routes is disclosed. Also included in... | 10/01/2002 |
| 6245319 | Colloidal dispersions of perfluoropentane Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a liquid having a boiling point below the tempera... | 06/12/2001 |
| 6156292 | Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and ma... | 12/05/2000 |
| 5897851 | Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging A method of activating an ultrasound contrast agent such that an increased number of microbubbles are produced and subsequent ultrasound images using the activated agent is enhanced. Hypobaric methods are disclosed which provide significant increases in b... | 04/27/1999 |
| 5876696 | Composition comprising a fluorine containing surfactant and perfluoropentane for ultrasound Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a high vapor pressure chemical which undergoes a ... | 03/02/1999 |
| 5707606 | Phase shift colloids as ultrasound contrast agents Disclosed herein are agents for enhancing the contrast in a diagnostic ultrasound procedure. These agents comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase has a boiling poi... | 01/13/1998 |
| 5707607 | Phase shift colloids as ultrasound contrast agents Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a high vapor pressure chemical which undergoes a ... | 01/13/1998 |
| 5595723 | Method for preparing storage stable colloids Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a high vapor pressure chemical which undergoes a ... | 01/21/1997 |
| 5573751 | Persistent gaseous bubbles as ultrasound contrast media Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and ma... | 11/12/1996 |
| 5558853 | Phase shift colloids as ultrasound contrast agents Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a liquid having a boiling point below the tempera... | 09/24/1996 |
| 5558854 | Ultrasound contrast media comprising perfluoropentane and perfluorohexane gas Ultrasound contrast media comprising gaseous perfluoropentane and gaseous perfluorohexane are disclosed.... | 09/24/1996 |
| 5558094 | Methods for using persistent gases as ultrasound contrast media Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and ma... | 09/24/1996 |
| 5558855 | Phase shift colloids as ultrasound contrast agents Disclosed herein are agents for enhancing the contrast in a diagnostic ultrasound procedure. These agents comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase has a boiling poi... | 09/24/1996 |
| 5409688 | Gaseous ultrasound contrast media Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and ma... | 04/25/1995 |