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Assignee: Sonus Pharmaceuticals, Inc.


Location: Bothell, WA
No. of patents: 30

NumberTitleIssue Date
7786164Lipophilic di(anticancer drug) compounds, compositions, and related methods
Lipophilic di(anticancer drug) compounds, compositions that include the compounds, and methods for treating a cell proliferative disease using the compounds. ...
08/31/2010
7786134Lipophilic anticancer drug compounds, compositions and related methods
Lipophilic anticancer drug compounds, compositions that include the compounds, and methods for treating a cell proliferative disease using the compounds. ...
08/31/2010
7268245Multinuclear platinum compounds
Multinuclear platinum compounds, compositions that include the platinum compounds, methods for making the platinum compounds, and methods for treating cellular proliferative diseases by administering the platinum compounds. ...
09/11/2007
7232919Platinum compounds
Platinum compounds, pharmaceutically acceptable salts, and prodrugs thereof. Compositions that include the platinum compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier. Methods for usin...
06/19/2007
7223770Tocopherol-modified therapeutic drug compounds
Tocopherol-modified therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds; methods for making the compounds and formulations; methods for administering the compounds and formulations; and methods for treating condit...
05/29/2007
7129368Platinum carboxylate anticancer compounds
Platinum carboxylate anticancer compounds, pharmaceutical compositions that include the platinum carboxylate compounds, and methods for treating cellular proliferative diseases by administering the platinum carboxylate compounds. ...
10/31/2006
7091374Fluorinated compounds
Fluorinated compounds and emulsions including the compounds. The compositions are useful as oxygen carriers and surfactants. In one embodiment, the fluorinated compound is pH sensitive. In one embodiment, the fluorinated compound is a vitamin E derivative. In one em...
08/15/2006
7038071Platinum compounds
Platinum compounds, pharmaceutically acceptable salts, and prodrugs thereof. Compositions that include the platinum compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier. Methods for usin...
05/02/2006
7030155Emulsion vehicle for poorly soluble drugs
A method of making an emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various rou...
04/18/2006
6982282Emulsion vehicle for poorly soluble drugs
An emulsion of α-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans via various routes is disclosed. Also included in the emulsio...
01/03/2006
6864386Fluorinated compounds
Fluorinated compounds and emulsions including the compounds. The compositions are useful as oxygen carriers and surfactants. In one embodiment, the fluorinated compound is pH sensitive. In one embodiment, the fluorinated compound is a vitamin E derivative. In one em...
03/08/2005
6858227Vitamin E conjugates
Vitamin E conjugates, methods for their preparation, and compositions that include the conjugates. The vitamin E conjugates include a tocopherol moiety covalently coupled through a linker moiety to either a pyroglutamate moiety, a pyrrolidinone moiety, or a gentisic...
02/22/2005
6727280Method for treating colorectal carcinoma using a taxane/tocopherol formulation
The present invention provides methods for administering a taxane composition for the treatment of cancer. In one aspect, the compositions are not diluted prior to administration. Some embodiments provide methods for administering a taxane as a bolus injection or an...
04/27/2004
6683194Tocopherol derivatives
Tocopherol derivatives are provided. In one embodiment, the tocopherol derivative includes a tocopherol moiety covalently coupled to branched hydrophilic moiety. In another embodiment, the tocopherol derivative includes a first tocopherol moiety covalentl...
01/27/2004
6667048Emulsion vehicle for poorly soluble drugs
An emulsion of ଱-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans various routes is disclosed. Also included in...
12/23/2003
6660286Emulsion vehicle for poorly soluble drugs
An emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various routes is d...
12/09/2003
6458373Emulsion vehicle for poorly soluble drugs
An emulsion of ଱-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans various routes is disclosed. Also included in...
10/01/2002
6245319Colloidal dispersions of perfluoropentane
Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a liquid having a boiling point below the tempera...
06/12/2001
6156292Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and ma...
12/05/2000
5897851Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
A method of activating an ultrasound contrast agent such that an increased number of microbubbles are produced and subsequent ultrasound images using the activated agent is enhanced. Hypobaric methods are disclosed which provide significant increases in b...
04/27/1999
5876696Composition comprising a fluorine containing surfactant and perfluoropentane for ultrasound
Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a high vapor pressure chemical which undergoes a ...
03/02/1999
5707606Phase shift colloids as ultrasound contrast agents
Disclosed herein are agents for enhancing the contrast in a diagnostic ultrasound procedure. These agents comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase has a boiling poi...
01/13/1998
5707607Phase shift colloids as ultrasound contrast agents
Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a high vapor pressure chemical which undergoes a ...
01/13/1998
5595723Method for preparing storage stable colloids
Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a high vapor pressure chemical which undergoes a ...
01/21/1997
5573751Persistent gaseous bubbles as ultrasound contrast media
Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and ma...
11/12/1996
5558853Phase shift colloids as ultrasound contrast agents
Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a liquid having a boiling point below the tempera...
09/24/1996
5558854Ultrasound contrast media comprising perfluoropentane and perfluorohexane gas
Ultrasound contrast media comprising gaseous perfluoropentane and gaseous perfluorohexane are disclosed....
09/24/1996
5558094Methods for using persistent gases as ultrasound contrast media
Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and ma...
09/24/1996
5558855Phase shift colloids as ultrasound contrast agents
Disclosed herein are agents for enhancing the contrast in a diagnostic ultrasound procedure. These agents comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase has a boiling poi...
09/24/1996
5409688Gaseous ultrasound contrast media
Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and ma...
04/25/1995
 
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