Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 8017351 | Amylases for pharmaceutical use The pharmaceutical use of amylases related to Bacillus alpha-amylases of SEQ ID NOs: 1-3, optionally in combination with a lipase and/or a protease. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI)... | 09/13/2011 |
| 7820690 | Method of treating or inhibiting a non-digestive tract derived abdominal disorder associated with pain using a 5-HT, receptor antagonist A method of treating or inhibiting non-digestive tract derived abdominal disorders associated with pain, in particular interstitial cystitis, chronic pelvic pain syndrome and/or abdominal pain associated with endometriosis, in a patient in need thereof, by administe... | 10/26/2010 |
| 7816347 | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and HMG CoA reductase inhibitors A combination therapy is disclosed for treating or inhibiting cardiovascular or metabolic diseases or conditions through a combination of at least one inhibitor of neutral endopeptidase (=NEP), at least one inhibitor of the endogenous endothelin producing system and... | 10/19/2010 |
| 7772225 | N-sulfamoyl-piperidineamides for the treatment or inhibition of obesity and related conditions The present invention relates to novel N-sulfamoyl-piperidineamides of Formula I and their physiologically acceptable acid addition salts, to pharmaceutical compositions comprising them, processes for their preparation, and their use for the treatment of obesity and... | 08/10/2010 |
| 7767692 | 1-amidomethylcarbonyl-piperidine compounds, methods and intermediate products for the production thereof and pharmaceutical formulations containing said compounds 4-substituted 1-amidomethylcarbonyl-piperidine compounds having motilin-agonistic properties and their acid addition salts, pharmaceutical compositions containing these compounds, processes and intermediate products for the preparation of these compounds, and method... | 08/03/2010 |
| 7763607 | Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators Described herein are pharmaceutical compositions comprising therapeutically effective quantities of (i) a KATP channel modulator; and (ii) a CBx modulator. Also described herein are methods of making and using these compositions. ... | 07/27/2010 |
| 7714150 | Aminoalkyl-amidomethyl-substituted 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2-chroman-6-yl derivatives Compounds corresponding to formula I, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n have the meanings giv... | 05/11/2010 |
| 7592344 | NK1 and NK2-antagonists and compositions and methods of using the same 3-cyanonaphthalene-1-carboxylic acid perhydroxyalkylmethyl-piperazine compounds of formula I which are antagonistic to tachykinin receptors, pharmaceutical compositions containing such compounds, methods of using such compo... | 09/22/2009 |
| 7534903 | Use of amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2-chromen-6-yl-compounds in the treatment of cardiac arrhythmia and other disease states The use of compounds corresponding to formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the description for treating cardiac arrhythmi... | 05/19/2009 |
| 7524853 | Compounds and their use in therapy Thiophenepyrimidinone compounds and their use in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring inhibition of 17β-hydroxysteroid ... | 04/28/2009 |
| 7524833 | Method and apparatus for concentrating and stabilizing conjugated estrogens from mare urine A method and apparatus for concentrating and stabilizing conjugated estrogens from pregnant mare urine on solid adsorbent supports to obtain a starting material for pharmaceuticals that contain a natural mixture of conjugated estrogen mixtures on cartridges in the v... | 04/28/2009 |
| 7479378 | Method of analyzing enzyme compositions with lipolytic, proteolytic and amylolytic activity A method for analyzing the identity, protein and/or peptide pattern and also the stability of samples containing physiologically acceptable enzyme mixtures with lipolytic, proteolytic and amylolytic activity, particularly mixtures of digestive enzymes such as pancre... | 01/20/2009 |
| 7452875 | Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them Compounds having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity corresponding to the formula I, wherein the substituents R1, R2, R3 and R4 | 11/18/2008 |
| 7439235 | Method for obtaining estrogens from mare's urine A method for obtaining an extract from a natural mixture of conjugated estrogens from the urine of pregnant mares (PMU) by solid-phase extraction on semipolar adsorption resins in which the resulting extract meets the pharmaceutical specifications for conjugated est... | 10/21/2008 |
| 7427611 | Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them Compounds having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity corresponding to the formula I, wherein the substituents R1, R2, R3 and R4 | 09/23/2008 |
| 7410962 | Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them Compounds having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity corresponding to the formula I, wherein the substituents R1, R2, R3 and R4 | 08/12/2008 |
| 7368582 | Amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl compounds, a process and intermediates for their production, and pharmaceutical compositions containing them Compounds corresponding to formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the description; a process for the preparation of these c... | 05/06/2008 |
| 7309706 | Method for the treatment of diseases requiring inhibition or a reduction in the activity of pH value-regulating bicarbonate transporter proteins The use of selective imidazoline receptor agonists, such as moxonidine, rilmenidine, LNP-509, S-23515, PMS-812, PMS-847 and BU-98008, and their physiologically compatible acid addition salts in pharmaceutical preparations for the treatment and/or inhibition of funct... | 12/18/2007 |
| 7282325 | Method of preparing pharmaceutical compositions A method for the discovery of compounds suitable for the treatment and/or prophylaxis of obesity, in which the ability of the test compounds to inhibit de novo lipogenesis in mammals and/or man is determined. The use of compounds which are capable of inhibiting de n... | 10/16/2007 |
| 7273860 | Method and pharmaceutical compositions for treating or inhibiting renal dysfunctions, diseases or disorders, particularly in diabetic patients Treatment and/or inhibition of renal dysfunction, disease or disorder in larger mammals, and particularly in humans, especially in human patients suffering from diabetes, using benzazepine-N-acetic acid derivatives which contain an oxo-group in the α-position to th... | 09/25/2007 |
| 7262184 | Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them Compounds having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity corresponding to the formula 1, wherein the substituents R1, R2, R3 and ... | 08/28/2007 |
| 7244743 | Non-peptidic BRS-3 agonists Selectively BRS-3-agonistic compounds of formula I wherein A1, A2, A3, R1, R2, R3, Ar1, Ar2, Ar3, m and n have th... | 07/17/2007 |
| 7241770 | Hydronopol derivatives as agonists on human ORL1 receptors The invention relates to a group of hydronopol derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at le... | 07/10/2007 |
| 7238470 | Method of treating or inhibiting obesity A method for the discovery of compounds suitable for the treatment and/or prophylaxis of obesity, in which the ability of the test compounds to inhibit de novo lipogenesis in mammals and/or man is determined. The use of compounds which are capable of inhibiting de n... | 07/03/2007 |
| 7220733 | Separation of cresol from mares' urine A method of separating cresol from mares' urine by pervaporation using pore-free polymeric silicone membranes in which starting urine solutions containing high-quality and -quantity conjugated estrogens with a reduced or substantially removed cresol content are prov... | 05/22/2007 |
| 7189709 | Method and pharmaceutical compositions for treating or inhibiting renal dysfunctions, diseases or disorders, particularly in diabetic patients Treatment and/or inhibition of renal dysfunction, disease or disorder in larger mammals, and particularly in humans, especially in human patients suffering from diabetes, using benzazepine-N-acetic acid derivatives which contain an oxo-group in the α-position to th... | 03/13/2007 |
| 7121069 | Net blanket for use as a holding harness for urine collecting devices for horses A net blanket for a horse for use as an easy-to-handle holding harness for flexible and easily replaceable attachment of a urine collecting device to the horse, which net blanket comprises a net (1) for covering the predominant part of the horse's rump, the n... | 10/17/2006 |
| 7122357 | Method for the treatment of diabetes The use of physiologically acceptable enzyme mixtures having lipolytic, proteolytica and amylolytic activity, of microbial or animal origin, preferably digestive enzyme mixtures such as pancreatin or digestive enzyme mixtures containing pancreatin, for the treatment... | 10/17/2006 |
| 7087620 | Liquid pharmaceutical formulations containing 3,7-diazabicyclo[3,3,1]nonane compounds and methods of treatment relating to anti-arrhythmic events The present invention relates to the use of 3,7-diazabicyclo[3,3,1]nonane compounds, preferably of 9,9-alkylene-3,7-diazabicyclo[3,3,1]nonane compounds, and most preferably to the use of tedisamil, and the physiologically acceptable acid addition salts and/or solvat... | 08/08/2006 |
| 7081451 | Method and apparatus for concentrating and stabilizing conjugated estrogens from mare urine A method and apparatus for concentrating and stabilizing conjugated estrogens from pregnant mare urine on solid adsorbent supports to obtain a starting material for pharmaceuticals that contain a natural mixture of conjugated estrogens as active ingredient. The appa... | 07/25/2006 |
| 7074325 | Device for concentrating and stabilizing conjugated estrogens from mare urine An apparatus for concentrating and stabilizing conjugated estrogens from pregnant mare urine on solid adsorbent supports to obtain a starting material for pharmaceuticals that contain a natural mixture of conjugated estrogens as active ingredient. The apparatus is s... | 07/11/2006 |
| 7074822 | Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them Substituted β-lactones (oxetanones) corresponding to the formula I, wherein R1, R2 and n have the meanings given in the specification, and pharmaceutical compositions which contain these co... | 07/11/2006 |
| 7041303 | Use of moxonidine for postmyocardial infarction treatment A method of treating myocardial damage secondary to myocardial infarction using moxonidine or a physiologically compatible salt thereof. Pharmaceutical preparations containing moxonidine and its physiologically compatible acid addition salts are suitable for use in ... | 05/09/2006 |
| 6946243 | Method of identifying compounds suitable for treatment and/or prophylaxis of obesity A method for the discovery of compounds suitable for the treatment and/or prophylaxis of obesity, in which the ability of the test compounds to inhibit de novo lipogenesis in mammals and/or man is determined. The use of compounds which are capable of inhibiting de n... | 09/20/2005 |
| 6930207 | Trifluoroacetylalkyl-substituted phenyl, phenol and benzoyl compounds and related methods of treatment Novel and known trifluoroacetyl-substituted phenyl, phenol and benzoyl compounds for the treatment and/or inhibition of obesity and of concomitant and/or secondary diseases involved therewith, in particular metabolic syndrome and cardiovascular diseases. Novel trifl... | 08/16/2005 |
| 6906059 | Pharmaceutical composition with protective action against oxidative/toxic substances, especially cardiotoxic substances The use of benzazepin-N-acetic acid derivatives which contain an oxo group in the a position to the nitrogen atom and are substituted in the 3 position by a 1-(carboxyalkyl)-cyclopentyl-carbonyl-amino radical, and of their salts and biolabile esters, for the prophyl... | 06/14/2005 |
| 6900322 | Method for stereochemically controlled production of isomerically pure highly substituted azacyclic compounds A method for stereochemically controlled production of azacyclic compounds of general formula (I) in which the substituents have the meanings given in the specification. The invention also relates to intermediate produ... | 05/31/2005 |
| 6854427 | Urine collection device with a detachable head part A urine collecting device for horses, especially mares, suitable for attachment to a special holding harness and a special head part therefor, which is advantageously suitable for collecting pregnant mares' urine for obtaining natural mixtures of conjugated estrogen... | 02/15/2005 |
| 6770649 | 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]-piperazine compounds, process for their preparation and pharmaceutical compositions containing them Novel 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]-piperazine compounds which are antagonistic to tachykinin receptors, of the general formula I, wherein R6, R7, A and Z have the meanings given in the... | 08/03/2004 |
| 6666171 | Holding harness with urine collecting device A holding harness with a urine collecting device for horses, as well as a urine collecting device suitable for the holding harness and a special head part for such a urine collecting device, which is advantageously suitable for collecting urine from pregn... | 12/23/2003 |
