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| Number | Title | Issue Date |
| 7456253 | Growth hormone releasing peptides Disclosed are peptide and peptidomimetic compounds generally according to formula (I), and pharmaceutically acceptable salts thereof, that are useful as GHRP analogs: R1-A2-A3-A4-A5-R2 (I) or a pharma... | 11/25/2008 |
| 7410948 | Analogs of parathyroid hormone The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pha... | 08/12/2008 |
| 7385024 | Heterocarpine, a human GHRH-binding protein The invention relates to a human GHRH-binding protein (human Growth Hormone-releasing hormone). Said protein, which is obtained from the Pilocarpus Heterophyllus plant, can be used to prepare medicaments intended to antagonise the effects of GHRH and to treat... | 06/10/2008 |
| 7368427 | GLP-1 analogues The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues. ... | 05/06/2008 |
| 7361656 | Prenyl transferase inhibitors A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH | 04/22/2008 |
| 7355052 | Benzimidazole and imidazopyridine derivatives and use thereof as a medicament A compound of the formula wherein the substituents are as defined in the specification and pharmaceutical salts thereof having a good affinity for sub-types of melanocortin receptors making them useful for treating diseases... | 04/08/2008 |
| 7345066 | Use of thiazole derivatives for preparing a medicine for protecting mitochondria The invention concerns compounds of general formula (I), wherein: A represents one of the radicals in which R5 represents independently a hydrogen atom, or alkyl; R6, R7 and R8 independently represent a hydrogen atom, alky... | 03/18/2008 |
| 7323484 | Farnesyl transferase inhibitors The present invention is directed to compounds of the formula wherein the variables are as defined in the specification. The compounds are useful for inhibiting farnesyl transferase and for the treatment of tumor... | 01/29/2008 |
| 7291641 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments Thiaxozle, oxazole, imidazole, isoxazole and isoxazoline compounds of the formula wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is selected from the various... | 11/06/2007 |
| 7279467 | Benzothiazole-and benzoxazole-4, 7-dione derivatives and their use as dcd25 phosphatase inhibitors The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in ... | 10/09/2007 |
| 7268213 | Analogues of GLP-1 The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues. ... | 09/11/2007 |
| 7256174 | Somatostatin and somatostatin agonists for treating insulin insensitivity and Syndrome X The present invention relates to a method of treating insulin resistance or Syndrome X by administering a therapeutically effective amount of a somatostatin agonist or a pharmaceutical composition comprised of a somatostatin agonist to a patient suffering from insul... | 08/14/2007 |
| 7241737 | Urotensin-II agonists and antagonists The present invention is directed to a novel class of cyclic polypeptides of the formula: (R1)a-AA1-cyclo[AA2-AA3-AA4-AA5-AA6-Cys]-AA7-R2, pharmaceutically ... | 07/10/2007 |
| 7238695 | Imidazolyl derivatives The present invention is directed to imidazolyl derivatives or pharmaceutically acceptable salts thereof which are useful as agonists or antagonists of somatostatin receptors, having the following formula (I), wh... | 07/03/2007 |
| 7238666 | Method of inhibiting fibrosis with a somatostatin agonist The present invention relates to a method of inhibiting fibrosis in a patient. The method comprises administering a therapeutically effective amount of a somatostatin, a somatostatin agonist or apharmaceutically acceptable salt thereof to said patent. ... | 07/03/2007 |
| 7235628 | Analogues of GLP-1 The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful thereof comprising said analogues. ... | 06/26/2007 |
| 7208166 | Use of botuline toxin to obtain a product to be used in articular pathologies, particularly coxarthrosis, epicondylitis and rotator muscle cap pathology Use of botulin toxin to obtain a product intended to be administered intramuscular with lissive effect in treating articular pathologies, particularly coxarthrosis, or arthrosis of the hip, epicondylitis of the elbow and rotator muscle cap pathology of the shoulder.... | 04/24/2007 |
| 7205378 | Lactone bearing absorbable polymers The present invention pertains to biodegradable polymers comprising a non-polymerizable lactone, biodegradable compositions comprising the polymer and a therapeutic agent, the use of the compositions for the sustained release of therapeutic agents, wherein the thera... | 04/17/2007 |
| 7169729 | Use of zinc derivatives as cyclic ester polymerization catalysts The invention concerns the use of zinc derivatives of general formula (I) wherein: L1 represents a group of formula: —E14(R14)(R′14)(R″14), —E15(R15) (R′15) or —E | 01/30/2007 |
| 7144859 | Somatostatin agonists The present invention is directed to cyclic peptides of formula (I): X-A1-cyclo(D-Cys-A3-A4-Lys-A6-A7)-A8-Y, or a pharmaceutically acceptable salt thereof. The peptides bind selectively to the somatos... | 12/05/2006 |
| 7078434 | Use of Ginkgo extract The present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated Ginkgolide B (GKB), a component of the extract of Ginkgo biloba leaves in a method for decreasing the expression of peripheral-type benzodiazepine receptor ... | 07/18/2006 |
| 6896893 | Needle-less parenteral introduction device A needle-less device for the parenteral administration of a medicament is disclosed. The medicament has the shape of one end of a toothpick. It is placed in the bore of a barrel with the barrel having the shape of a nose cone at one end. A plunger is inserted into t... | 05/24/2005 |
| 6780887 | Anti-ischemic compounds The present invention is related to a compound of formula (I), salts and pro-drugs of the compound (I) and methods for treating and/or preventing partial or total ischemia, methods for treating and/or preventing pathologies associated with ischemia or with mitochond... | 08/24/2004 |
| 6762301 | Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them A process for the preparation of a compound of the formula wherein the substituents are defined as set forth in the specification comprising reacting a compound of the formula | 07/13/2004 |
| 6613076 | Implantable intraluminal device A device implantable in the vascular ducts. The device includes an elongated intraluminal element that occupies a section of the vascular lumen so as to increase the speed at the vascular wall at the level of the element without decreasing the blood flow ... | 09/02/2003 |
| 6349850 | Method for preparing an injectable preparation and device for implementing same A method comprising the following steps: preparing in a vacuum a dry form (18) of an active principle, as well as a liquid (22), and drawing this liquid into the dry form, by the action of the vacuum to obtain an injectable preparation. The device compris... | 02/26/2002 |
| 6342479 | Prolonging survival of transplanted pancreatic cells A method of prolonging the survival of pancreatic cells transplanted in a patient. The method includes the step of administering a therapeutically effective amount of somatostatin or a somatostatin agonist to the patient.... | 01/29/2002 |
| 5980945 | Sustained release drug formulations A sustained release drug formulation including: a drug; a biodegradable polymer which is insoluble in water; and an oil vehicle in which both the drug and the polymer are dissolved. The oil vehicle contains 10-100% by volume a pharmaceutically acceptable ... | 11/09/1999 |
| 5695463 | Safety injection device An injection device for intramuscular or subcutaneous injection of solid or semi-solid medicaments is disclosed. The device includes main body member having a needle attached thereto. A protective sleeve covers the needle and retracts into the main body m... | 12/09/1997 |
| 5660846 | Methods and apparatus for the delivery of solid drug compositions The invention features an implantable device for the automatic delivery of an active ingredient according to an adjustable delivery profile. The device includes a housing; a reservoir operatively connected to the housing and arranged to store a solid comp... | 08/26/1997 |
| 5147856 | Method for inhibiting blood vessel blockage using octapeptide compositions A method for inhibiting blood vessel blockage in a mammal particularly after a procedure such as angioplasty, an arterial bypass operation or an allograft transplant operation which comprises: administering to a mammal before, during and/or after the proc... | 09/15/1992 |
| 5112811 | SDK peptides and therapeutic compositions containing them The invention relates to peptides having the general formula H2 N - W - Ser - Asp - Lys - X - OH wherein X represents a Pro or Lys residue or a valence bond and W represents a Thr or Pro residue or a valence bond with the proviso that if X represent... | 05/12/1992 |
| 4735950 | Furo-(3,4-C)-pyridine derivatives and therapeutic composition containing the same This invention relates to 1,3-dihydro-6-methyl-7-hydroxy-furo-(3,4-c)-pyridine derivatives of the general formula I ##STR1## wherein each of A1 and A2 independently represents various hydrocarbon groups and therapeutically ... | 04/05/1988 |
| 4720487 | Bornane derivatives, their preparation and therapeutic compositions containing the same This invention relates to bornane derivatives of the formula: ##STR1## wherein Z stands for: ##STR2## and Y stands for an arabinose, xylose or ribose rest, the acetylated form of the same, with either a pyrane or furane configuration and bound t... | 01/19/1988 |
| 4704454 | Pyranoderivatives, their preparation and therapeutic compositions containing the same This invention relates to new pyranoderivatives of the formula: ##STR1## wherein X1 is H, Cl or Br and Z stands for: ##STR2## wherein X2 is H, Cl or Br, T is O or S and Y stands for an arabinose, xylose or ribose moiety, th... | 11/03/1987 |
| 4703045 | Therapeutic compositions for the treatment of hangover This invention relates to therapeutic compositions containing betaine salts for the treatment of hangover and for the lowering of alcohol content in blood in human. Daily dose comprises oral administration of 1 to 30 g, associated with appropriate carrier... | 10/27/1987 |
| 4699919 | Lipoxygenase and cyclogenase inhibiting thiachromen and thiepan derivatives and pharmaceutical compositions therefor This invention relates to bicyclic catechol derivatives having the general formulae I and II ##STR1## wherein R1, R2, R3 and Z represent various substituents, to a preparation process of the same comprising reacting a... | 10/13/1987 |
| 4681888 | Thienopyridine derivatives and anti-thrombotic compositions containing the same This invention relates to new derivatives of 5-(ω-phenethylamino-alkyl) -4,5,6,7-tetrahydro-thieno-(3,2-c)-pyridine of the formula ##STR1## wherein n is an integer of from 2 to 5, R1 represents a hydrogen atom or a 3,4-dimethoxypheny... | 07/21/1987 |
| 4659719 | 6-phenethylaminoalkyl-furo-(3,4-c)-pyridine derivatives and therapeutic compositions containing the same This invention relates to new 1,3-dihydro-6-[1-cyano-1-isopropyl-N-phenethyl-N-methyl-ω-aminoalkyl ]-7-hydroxy-furo-(3,4-c)-pyridine derivatives of the general formula ##STR1## wherein each of A1 and A2 independently represents ... | 04/21/1987 |
| 4610990 | 5-(1-cyano-1-alkyl-N-methyl-N-methoxy-phenethyl)-alkylamino-2,2,8-trimeth yl-4H-dioxino-(4,5-c)-pyridine derivatives, and their use as calcium antagonistic agents The invention relates to new 5-(1-cyano-1-alkyl-N-methyl-N-methoxy-phenethyl)-alkylamino-2,2,8-trimethy l-4H-dioxino-(4,5-c)-pyridine derivatives of the formula ##STR1## and therapeutically acceptable salts of these compounds, to a preparation pr... | 09/09/1986 |
