Assignee: Smithkline Beckman Corporation

Location: Philadelphia, PA
No. of patents: 34

Browse patents
Browse applications

Number	Title	Issue Date
5110906	Derivatives of soluble T-4 This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide com...	05/05/1992
5110959	Process for preparation of epoxy esters and intermediates prepared thereby This invention relates to a process for preparing epoxy esters, and intermediates prepared by this process, in particular, to a process which produces non-racemic epoxy esters which are of use as intermediates in the preparation of pharmaceutical compound...	05/05/1992
4876243	Vasopressin compounds Vasopressin-like peptide whose structures have been modified by an alpha-methyl amino acid at the 4 or 7 position are set forth. These compounds have potent vasopressin antagonist activities....	10/24/1989
4874792	Thiophenyl Alkanoic acids useful as leukotriene antagonists This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to treating diseases in which leukotri...	10/17/1989
4840892	Polynucleotide hybridization probes Polynucleotide hybridization probes are labeled in non-probe regions but not in probe regions by selectively protecting probe regions prior to modification of the polynucleotide....	06/20/1989
4786735	Process for preparing cimetidine polymorph B A novel process for preparing cimetidine polymorph "B" comprises precipitating cimetidine from an aqueous-alcoholic solution of an acid addition salt. The precipitation is conducted at a temperature of above 15° C....	11/22/1988
4778846	Affinity chromatography sorbent A novel process for the isolation and purification of vancomycin class antibiotics which utilized affinity chromatography by the formation of a sorption complex between the antibiotic and an immobilizing ligand selected from -D-alanyl-D-alanine or -X-D-al...	10/18/1988
4769386	Imidazolylthioalkenoic acids and -alkenols and leukotriene antagonistic composition containing them The imidazolylthio substituted alkanoic acids represented by the formula (I) or (IA) as defined herein have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma....	09/06/1988
4760052	1,6-dicarba-vasopressin compounds New compounds which have potent V2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by a Pas1,6 or Tas1,6 cyclized unit. A...	07/26/1988
4749782	Vasopressin compounds Certain vasopressin-like compounds whose structures have a ଲ,ଲ-diethyl-ଲ-mercaptopropionic acid at position 1 have unexpectedly potent V2 -antagonist activity. A species of the group is [1-ଲ,ଲ-diethyl-ଲ-merca...	06/07/1988
4742154	GLN- or ASN-vasopressin compounds Peptides whose structures resemble those of vasopressin antagonists but have both a carboxamido amino acid unit and a basic amino acid unit in the side chain have good antagonist activity. A species of the invention is [1-(ଲ-mercapto-ଲ,ଲ...	05/03/1988
4724229	Arg-arg-arg-vasopressin antagonists Vasopressin antagonists which have a tripeptide side chain comprised of three basic amino acids, such as arginine, lysine or ornithine, demonstrate potent V1 and V2 -antagonist activity. A species of the invention, which is prepared ...	02/09/1988
4719199	Diuretic compositions and methods of producing diuresis 2- or 3-ଲ-Indolylalanyl and ଲ-indolylglycyl vasopressins are prepared by standard peptide synthetic methods. These 2- or 3-TRP vasopressins have vasopressin antagonist activity....	01/12/1988
4716230	Certain bis(di-2 or 4-pyridyl-phosphino) alkanes #10 having anti-tumor properties Heterocyclic phosphine compounds, pharmaceutical compositions containing an effective, tumor cell growth-inhibiting amount of such a compound, and a method for treating tumor cells sensitive to such a compound which comprises administering a tumor cell gr...	12/29/1987
4707485	Substituted te[1]trahydroisoquinoline derivatives having ଲ-adrenergic receptor activity Compounds having the formula ##STR1## are ଲ-adrenergic receptor antagonists. Also disclosed are pharmaceutical compositions and methods for producing ଲ-adrenergic receptor antagonistic activity in animals including man....	11/17/1987
4707488	Dopamine-ଲ-hydroxylase inhibitors and use thereof The compounds of this invention are 1-phenylalkyl-2-mercaptotetrazole compounds which are dopamine-ଲ-hydroxylase inhibitors....	11/17/1987
4707470	Polyene antibiotic emulsion formulation A polyene antibiotic emulsion formulation comprising a therapeutically effective amount of the antibiotic incorporated into an oil-in-water emulsion, and a method of treating an active infection in an animal caused by a microorganism with sterols in its c...	11/17/1987
4707483	1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders 1-Phenyl-3-benzazepine compounds are useful in treating gastrointestinal motility disorders. A particular compound of this invention is 8-hydroxy-3-methyl-1-phenyl-7-phenylthio-2,3,4,5-tetrahydro-1H-3-benzazepi ne....	11/17/1987
4634711	Pyridylalkyl imidazole-2-thiols Potent dopamine-ଲ-hydroxylase inhibitors having the formula: ##STR1## which are useful to inhibit dopamine-ଲ-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit do...	01/06/1987
4628059	Dopamine-ଲ-hydroxylase inhibitors Potent dopamine-ଲ-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-ଲ-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopa...	12/09/1986
4554284	7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones Certain aminoethyl substituted 1,3-benzthiazol- and 1,3-benzoxazol-2(3H)-ones are D2 -dopamine agonists. These compounds are prepared by reacting an appropriate o-aminophenol or thiophenol with phosgene....	11/19/1985
4554287	Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones 7-[2-Dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones are prepared by oxidative cyclization of a urea, followed by removal of protective groups. The compounds are D2 -agonists and, thereby, have anti-hypertensive activity. A species of the...	11/19/1985
4542124	Octapeptide vasopressin antagonists Certain octapeptides, which have structures characterized by being a six unit cyclic peptide ring with a dipeptide tail which lacks a glycine unit at position 9, have potent vasopressin antagonist activity. The compounds here claimed are in general charac...	09/17/1985
4532331	1-Benzyl-2-aminomethyl imidazole derivatives Potent DBH inhibitors having the formula: ##STR1## wherein R is --CO2 H or --CH2 NHR1 can be used to inhibit DBH activity in mammals....	07/30/1985
4514394	Anti-hypertensive use of 1-(4'-branched alkylsulfonylphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benz azepines 6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures have an isopropylsulfonyl, isopropylthio, isobutylsulfonyl or isobutylthio group substituted at the 4-position of the 1-phenyl substituent have potent renal dopaminergic...	04/30/1985
4514414	N-Substituted pyrrolidineacetic acids and their esters N-Substituted pyrrolidineacetic acids and their esters, useful as inhibitors of GABA uptake, are prepared by reacting an appropriate N-alkylating derivative with an esters of an N-unsubstituted pyrrolidineacetic acid followed by hydrolysis of the ester....	04/30/1985
4507288	ଲ-Glycerophosphate salts of antimalarial phenanthrenemethanol compounds The compounds of formula (I) ##STR1## wherein R1 is hydrogen or an alkyl radical containing one to six carbon atoms and R2 is an alkyl radical containing one to six carbon atoms possess markedly increased activity against malari...	03/26/1985
4507320	Dopaminergic agonist N,N-di-n-propyl-4-hydroxy-3-methanesulfonamidophenethylamine N,N-Di-n-propyl-4-hydroxy-3-methanesulfonamidophenethylamine is a potent, selective presynaptic dopaminergic agonist. The compound is prepared by N-sulfonylation of an optionally O-protected derivative of 3-amino-4-hydroxy-N,N-di-n-propylphenethylamine, f...	03/26/1985
4496558	Pharmaceutical compositions and methods for producing alpha antagonism Pharmaceutical compositions and methods for producing alpha2 antagonism utilize, as active ingredients, 6-halo-N-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines. These compositions are particularly useful for lowering intraocular pressure and ...	01/29/1985
4476227	Cosmid cloning vectors Small cosmid cloning vectors having two antibiotic resistance markers, selected from chloramphemicol resistance, streptomycin and spectinomycin resistance and tetracycline resistance markers, at least one having a unique restriction site....	10/09/1984
4465677	Pharmaceutical compositions and method of producing alpha₂ antagonism Pharmaceutical compositions and method of producing alpha2 antagonism by administering N-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines....	08/14/1984
4452808	4-Aminoalkyl-2(3H)-indolones A series of new chemical compounds which are 4-aminoalkyl-2(3H)-indolones has been demonstrated to be D2 -agonists useful for treating hypertension. A representative compound of the series is 4-di-n-propylaminoethyl-2(3H)-indolone....	06/05/1984
4383999	Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters N-Substituted azaheterocyclic carboxylic acids and their esters, useful as inhibitors of GABA uptake, are prepared by reacting an appropriate N-alkylating derivative with an ester of an N-unsubstituted azaheterocyclic carboxylic acid followed by hydrolysi...	05/17/1983
4352933	Chemical methods and intermediates for preparing substituted pyrimidinones A series of chemical reactions starting from the condensation of uracil with an acid stable heterocyclic aldehyde in an acid medium produces biologically active end products which are 2-heterocyclylmethylthioethylamino-5-heterocyclylmethyl-4-pyrimidinones...	10/05/1982

PatentStorm

Bizarre Patents

PatentStorm News

Assignee: Smithkline Beckman Corporation