Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 5420135 | Substituted quinoline derivatives Substituted quinoline derivatives are described as inhibitors bone resorption with in particular, the compound 1-(2-methylphenyl)imidazo[4,5-c]quinoline hydrochloride.... | 05/30/1995 |
| 5326781 | Medicaments Benzylimidazole derivatives are described as anxiolytic agents.... | 07/05/1994 |
| 5280043 | Sulphonamido containing phenylalkanoic acids as thromboxane A2 antagonists Phenylalkanoic acids containing a sulphonamido group, and their use in a method of treatment of thromboxane-A2 mediated diseases are disclosed. A compound of the invention is 4-[4-(phenyl-sulphonamido)phenyl]butyric acid.... | 01/18/1994 |
| 5275823 | Pharmaceutical compositions Chewable tablets containing unpleasant tasting medicaments such as cimetidine are provided. The palatability of the tablets is improved by including certain hygroscopic water-insoluble substances as extragranular excipients in amounts corresponding to 5% ... | 01/04/1994 |
| 5254571 | Chemical compounds This invention relates to phenylpyridone derivatives which have bronchodilator and anti-allergic activities. A compound of the invention is 6-(2-propoxyphenyl)-1,2-dihydro-2-oxopyridine-3-carboxamide.... | 10/19/1993 |
| 5246928 | Thiadiazinones for stimulating cardiac activity This invention relates to N-phenylpyridone derivatives which have inotropic, vasodilator and bronchodilator activity. A compound of the invention is 5-methyl-6-[4-(4-oxo-1,4-dihydropyridin-1-yl)phenyl]-4,5-dihydro-3(2H)pyri dazinone.... | 09/21/1993 |
| 5230885 | Polystyrene anion exchange polymer pharmaceutical composition Polystyrene polymers having a quaternised ammonium group and their use in a method of treatment of hypercholesterolaemia. A particular compound of the invention is (N,N-dimethyl-N-dodecyl-ammoniomethylstyrene-ethyl methacrylate-divinylbenzene co-polymer, ... | 07/27/1993 |
| 5169640 | Pharmaceutical compositions The invention provides a solid pharmaceutical dosage form comprising: (i) cimetidine; and (ii) antacid, wherein at least part of the antacid is in the form of granules comprising a freely water-soluble solid diluent, the antacid, and a rapidly swellable water-... | 12/08/1992 |
| 5162316 | Pyrimido[4,5-d]pyrimidine derivatives for use as bronchodilators This invention relates to pyrimidopyrimidine derivatives which have bronchodilator and anti-allergic activities. A compound of the invention is 7-cyclopropylamino-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d] pyrimidine.... | 11/10/1992 |
| 5118686 | Phenylpyrimidones This invention relates to phenylpyrimidone derivatives which have bronchodilator activity. A compound of the invention is 4-cyano-6-hydroxy-2-(2-propoxyphenyl)pyrimidine.... | 06/02/1992 |
| 5112922 | Polystyrene anion exchange polymers Polymers bearing a quaternary ammonium group are disclosed as being useful in lowering serum cholesterol levels in man. A compound of the invention is N,N-dimethyl-N-(2-(N,N-dimethylcarbamoyl)ethyl)-ammoniomethyl-substitut ed polystyrene, chloride salt.... | 05/12/1992 |
| 5110875 | Polystyrene anion exchange polymers Polymers bearing a quaternary ammonium group are disclosed as being useful in lowering serum cholesterol levels in man. A compound of the invention is N-(2-N,N-dimethylamino)ethyl)-N,N-dimethylammoniomethyl-substituted polystyrene, chloride salt.... | 05/05/1992 |
| 5082848 | Substituted 4-aminoquinoline derivatives as gastric acid secretion inhibitors Substituted 4-aminoquinoline derivatives of the formula: ##STR1## wherein R1 is hydrogen, C1-6 alkyl, C1-6 alkoxyC1-6 alkyl; C3-6 cycloalkyl, C3-6 cycloalkyl-C1-6 alkyl, phenyl ... | 01/21/1992 |
| 5082651 | Pharmaceutical compositions Pharmaceutical compositions suitable for intra-rectal administration in the form of a foam are described which comprise a therapeutically effective amount of 5-aminosalicylic acid, a pharmaceutically acceptable aqueous carrier therefor, and means for gene... | 01/21/1992 |
| 5075310 | Pyrimidone derivatives as bronchodilators This invention relates to fused pyrimidine derivatives which have bronchodilator activity. A compound of this invention is 2-(2-propoxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one.... | 12/24/1991 |
| 5073559 | 2-Substituted purinone having phosphodiesterase inhibitory activity This invention relates to phenylpurinone derivatives which have bronchodilator and anti-allergic activities. A compound of the invention is 2-(2-propoxy-5-chlorophenyl)purin-6-one.... | 12/17/1991 |
| 5066653 | Chemical compounds Phosphodiesterase (type III) inhibitors having the formula: ##STR1## wherein R4 is hydrogen and A is a dihydro-1,2,4-triazin-3-one group or a dihydro-1,2,4-triazin-6-one group which are useful in stimulating cardiac activity and in treatin... | 11/19/1991 |
| 5061798 | Benzyl pyridyl and pyridazinyl compounds This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3'-[6-oxo-3)1H)-pyridazinylmethyl)-thyronine.... | 10/29/1991 |
| 5047404 | Chemical compounds This invention relates to fused pyrimidine derivatives which have bronchodilator and anti-allergic activities. A compound of the invention is 2-(2-propoxyphenyl)pyrido[2,3-d]pyrimid-4(3H)-one.... | 09/10/1991 |
| 5047418 | Method of stimulating histamine H3 -receptors A pharmaceutical composition is described which comprises a pharmaceutically acceptable carrier and a compound of the formula (1): ##STR1## or a pharmaceutically acceptable salt thereof wherein X is CH2 or S, in an amount sufficient to sti... | 09/10/1991 |
| 5006535 | Substituted heterocylic 4-aminoquinoline derivatives as gastric acid secretion inhibitors Substituted 4-aminoquinazoline derivatives which are inhibitors of gastric acid secretion. A compound of the invention is ethyl 8-methoxy-4-(4-methyl-3-thienyl-amino)quinoline-3-carboxylate.... | 04/09/1991 |
| 4997847 | Biologically active compounds The invention relates to phenylsulphonamidolkanoic acids which have thromboxane A2 receptor antagonist activity.... | 03/05/1991 |
| 4997954 | Process for preparing substituted isoindolinone derivatives This invention relates to an improved process for the preparation of substituted indolinone derivatives using reductive cyclization conditions.... | 03/05/1991 |
| 4996222 | Pharmaceutical formulations The invention provides pharmaceutical suspension compositions of cimetidine wherein substantially all of the cimetidine is in the polymorph B crystalline form.... | 02/26/1991 |
| 4988695 | Pyrrolocinnolines for use as inhibitors of gastric acid secretion Pyrrolo- and dihydropyrrolocinnolines, and their use as inhibitors of gastric acid secretion. A compound of the invention is 1-(2-methylphenyl)-2,3-dihydropyrrolo-[3,2-c]-cinnoline.... | 01/29/1991 |
| 4962110 | Pyridazinone derivatives The invention relates to 2-aminopyrimidinone derivatives that have utility as cardiac stimulants. A compound of the invention is 6-[4-(1,4-dihydro-4-oxo-2-pyrimidinylamino)phenyl]-5-methyl-4,5-dihydro-3( 2H)-pyridazinone.... | 10/09/1990 |
| 4954339 | Novel polystyrene anion exchange polymers Polystyrene polymers having a quaternized ammonium group and their use in a method of treatment of hypercholesterolaemia. A particular compound of the invention is N,N-dimethyl-N-dodecylammoniomethyl-substituted polystyrene.... | 09/04/1990 |
| 4952589 | Pyridine compounds This invention relates to aminoalkylphenoxyalkyl substituted heterocycles. These compounds antagonize the action of histamine on histamine H2 -receptors in the brain. A compound of the invention is 2-[3-[3-(piperidinomethyl)phenoxy]propylamino]... | 08/28/1990 |
| 4950765 | Process This invention relates to a catalytic transfer hydrogenation process using water as a solvent in the preparation of substituted indolinone derivatives.... | 08/21/1990 |
| 4946842 | Novel guanidino pyridazinones as cardiac stimulants The invention relates to phenyl dihydropyridazinone derivatives that have utility as cardiac stimulants. A compound of the invention is 6-[4-(N3 -benzyl-N2 -cyanoguanidino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone.... | 08/07/1990 |
| 4912126 | Producing anxiolytic activity and treating depression with 3(H)-indolones The present invention relates to the use of certain indolone derivatives in particular, 4-(2-di-n-propyl-aminoethyl)-2-(3H)-indolone in a method of treatment of Parkinsons disease.... | 03/27/1990 |
| 4910305 | Pyridyl and pyridazinyl substituted thyronine compounds This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3'-[6-oxo-3(1H)-pyridazinylmethyl]-thyronine.... | 03/20/1990 |
| 4906628 | N-phenylpyridone type III phosphodiesterases Phosphodiesterase (type III) inhibitors having the formula: ##STR1## which are useful in stimulating cardiac activity and in treating congestive heart failure and bronchoconstriction, pharmaceutical compositions including these inhibitors, and method... | 03/06/1990 |
| 4904664 | Benzene compounds having two pyridazinone substituents The invention relates to pyridazinone derivatives which have inotropic, vasodilator and bronchodilator activity. The compounds of the invention are described by formula (I): ##STR1## wherein: R1 is hydrogen or methyl; R2 is hydr... | 02/27/1990 |
| 4902698 | Benzenesulphonamidopyridyl compounds which are useful as thromboxane A.sub. 2 The invention provides a class of alkanoic acids substituted with a benzenesulphonamidopyridyl group. The compounds have activity as thromboxane A2 -antagonists.... | 02/20/1990 |
| 4894372 | Pyridine compounds which have useful histamine-H2 antagonist activity This invention relates to 2-pyridine derivatives substituted in the 4-position with a dialkylamino- or piperidinyl- or pyrrolidinylalkyl group. The compounds have histamine H2 -antagonist activity.... | 01/16/1990 |
| 4885301 | Purinone derivatives which have bronchodilator, vasodilator and anti-allergic activities This invention relates to purinone derivatives which have bronchodilator, vasodilator and anti-allergic activities. A compound of the invention is 2-(2-propoxyphenyl)-6-purinone.... | 12/05/1989 |
| 4866076 | Biologically active compounds The invention provides a class of sulphonamide-containing tetrahydroisoquinolinyl compounds having thromboxane antagonist activity.... | 09/12/1989 |
| 4863933 | 3-hydroxypyridines The disclosure relates to a class of 2-(pyridylalkylamino)-3-hydroxypyridines which are active as histamine H1 -antagonists.... | 09/05/1989 |
| 4863936 | 3,5-Substituted-2-pyridyl-alkylaminocyclobutenediones having histamine h1 -antagonist activity Various substituted aminoalkylamino-2-pyridine derivatives are disclosed which are useful as histamine H1 -antagonists.... | 09/05/1989 |
