Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 7452906 | Pyridine derivatives as Raf kinase inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. ... | 11/18/2008 |
| 7446106 | Pyridylfurans and pyrroles as Raf kinase inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. ... | 11/04/2008 |
| 7432270 | N-aroyl cyclic amines This invention relates to N-aroyl cyclic amine derivatives and their use as orexin antagonists wherein: Y represents a bond, oxygen, or a group (CH2)n, wherein n represents 1, 2 or 3;... | 10/07/2008 |
| 7429579 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) The invention provides compounds of formula (I): wherein: R2 and R3 independently represent various substituents; R1 and R4 independently represent H, F, Cl, Br, C1-2alkyl, C1alkoxy, OH, CN, or NO | 09/30/2008 |
| 7423052 | Piperidine compounds for use as orexin receptor antagoinst A invention relates to N aroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists. ... | 09/09/2008 |
| 7416853 | Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds. ... | 08/26/2008 |
| 7405217 | N-aroyl piperazine derivatives as orexin receptor antagonists This invention relates to N-aroyl cyclic amino derivatives and their use as pharmaceuticals. ... | 07/29/2008 |
| 7405209 | Protease inhibitors The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such co... | 07/29/2008 |
| 7399837 | Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided. ... | 07/15/2008 |
| 7375105 | Pyridine substituted furan derivatives as Raf kinase inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. Wherein X is O, CH2 CO, S or NH, or the moiety X—R | 05/20/2008 |
| 7368574 | Substituted thiazolidinedione derivative, process for its preparation and its pharmaceutical use A hydrate of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt., characterized in that it: (i) comprises water in the range of from 0.3 to 0.6 molar equivalents; and (ii) provides an infra red spect... | 05/06/2008 |
| 7365077 | Piperazine bis-amide derivatives and their use as antagonists of the orexin receptor Disclosed are piperazine bis-amide derivatives useful as antagonists of the orexin receptor and pharmaceutical compositions containing the same. ... | 04/29/2008 |
| 7358366 | Thiazolidinedione derivative and its use as antidiabetic A polymorphic form of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt (the “Polymorph”) characterised in that it provides: (i) an infra red spectrum containing peaks at 1752, 1546, 1154, 621, and 602 cm−1;... | 04/15/2008 |
| 7351832 | Process for the preparation of thiazolidinedione derivatives A process for preparing a compound of formula (I): or a tautomeric form thereof or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein: A1 represents... | 04/01/2008 |
| 7344869 | Isolated DNA comprising one or more genes specific for 5S clavam biosynthesis, vectors comprising such DNA and hosts capable of improved clavulanic acid production Novel bacterial genes, microorganisms and processes for improving the manufacture of 5R clavams, eg. clavulanic acid. ... | 03/18/2008 |
| 7291740 | 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione Mesylate salt Disclosed are 5-[4-[2-(N-Methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione mesylate salts, or solvates thereof; processes for preparing such compounds, compositions comprising such compounds and the use of such compounds in medicine. ... | 11/06/2007 |
| 7285557 | Pyrimidinones as melanin concentrating hormone receptor 1 A compound of formula (Ia) comprising a pharmaceutically acceptable salt or solvate thereof, formulations, processes of preparing, and methods of administering to mammals are provided ... | 10/23/2007 |
| 7279152 | Use of polyphosphate as a tooth erosion inhibitors in acidic compositions The use of polyphosphate in acidic oral compositions, especially acid beverages with a pH between 2.2 and 5.5, to alleviate or prevent the tooth damage associated with the consumption of acid. The invention may be practiced using polyphosphate alone or in combinatio... | 10/09/2007 |
| 7276229 | Oral compositions comprising a viscosity modifier for reduction of tooth erosion The use of viscosity modifying polymer materials, commonly used as stabilisers, thickeners and emulsifiers, as tooth erosion inhibitors in acidic compositions for oral administration, especially in acidic beverages such as fruit drinks and oral healthcare products s... | 10/02/2007 |
| 7241579 | Method of screening for GPR40 ligands Methods of screening for ligands of the GPR40 receptor are provided, including methods utilizing fatty acid GPR40 ligands. ... | 07/10/2007 |
| 7235658 | Imidazol derivatives as Raf kinase inhibitors Compounds of formula (I): wherein X is O, CH2, S or NH, or the moiety X—R1 is hydrogen; V is CH or N; R1 is ... | 06/26/2007 |
| 7230109 | 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical A hydrate of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt, characterized in that it: (i) comprises water in the range of from 0.4 to 2.5% w/w; and (ii) provides an infra red spectrum containing peaks at 1749, 1703, 1645... | 06/12/2007 |
| 7220777 | Lactam derivatives as antagonists for human 11cby receptors The invention provides compounds of formula (I) a salt, or solvate thereof. ... | 05/22/2007 |
| 7217535 | Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds. ... | 05/15/2007 |
| 7214389 | Process A wet granulation process in which a pharmaceutical substance is granulated using a granulating fluid which is a halogenated hydrocarbon which has a normal boiling point below ambient temperature, for example 1,1,1,2-tetraflouroethane, under a pressure sufficient to... | 05/08/2007 |
| 7199137 | Imidazole derivatives as Raf kinase inhibitors Novel compounds (I) and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy wherein Ar is a group of formula a) or b). ... | 04/03/2007 |
| 6696457 | Morphinoid compounds Heterocycle condensed morphinoid derivatives of formula (I) have therapeutic utility as analgesics, in collagen disease, as anti-allergic and anti-inflammatory agents, brain cell protectants, in gastritis, diarrhoea, cardiovascular and respiratory disease... | 02/24/2004 |
| 6235753 | Inhibitors of the production of S-CD23 and the secretion of TNF Inhibitors of the Production of s-CD23 and the secretion of TNF are provided.... | 05/22/2001 |
| 6046210 | Tetrahydroisoquinoline derivatives as modulators of dopamine D3 receptors This invention relates to compounds of formula (I): ##STR1## which are useful as modulators of D3 receptors, in particular in the treatment of psychoses.... | 04/04/2000 |
| 6047109 | Methods and systems for re-evaluating assembly consensus sequences A computational method maximizing open reading frame length in an assembly consensus sequence is provided. Systems employing the method are also provided.... | 04/04/2000 |
| 5962501 | Enantiomer of carbazole derivative as 5-HT1-like agonists A (+) or (-) enantiomer of a compound of formula (I) wherein R4 is methyl or ethyl, or a salt, solvate, or hydtrate thereof, processes for preparing said compounds and pharmaceutical compostions containing them. Compounds of formula (+) are 5-H... | 10/05/1999 |
