Assignee: SmithKline Beecham Corporation

Location: Philadelphia, PA
No. of patents: 1613

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Number	Title	Issue Date
8122849	Apparatus and method for producing a pharmaceutical product An apparatus and method are provided for producing pharmaceutical and pharmaceutical-like products. The apparatus and method provide real-time monitoring of the pharmaceutical product and can provide real-time control. The apparatus and method can monitor the dosage...	02/28/2012
8101244	Apparatus and method for producing or processing a product or sample An apparatus and method are provided for producing a plurality of products or processing a plurality of samples via dispensing. The apparatus and method provide real-time monitoring of the products/samples and can provide real-time control. The apparatus and method ...	01/24/2012
8022032	Method for customized dispensing of variable dose drug combination products for individualizing of therapies The method set out herein involves identifying the concentration of each of two or more active therapeutics tailored to treat a particular patient's unique metabolism and one or more diseases, communicating that information to a producer who has multiple fixed or va...	09/20/2011
7910321	Methods of determining the level of human tumor necrosis factor receptor-like 2 The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, ...	03/22/2011
7858319	Method of screening for drug hypersensitivity reaction Methods of assessing the risk of clinical signs of hypersensitivity reaction to nucleoside antiviral compounds, including abacavir, are described. The methods include genotyping subjects for polymorphisms in the TNFα gene, the class 1 HLA genes, or a combination of...	12/28/2010
7812016	Naphthyridine integrase inhibitors The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC. ...	10/12/2010
7668662	Patient-specific dosimetry A patient-specific optimally effective radiation dose for administration of a radiopharmaceutical to a patient for treatment of a disease may be established by basing the calculation of the appropriate therapeutic dose on factors such as the desired total body dose,...	02/23/2010
D609094	Container	02/02/2010
7651988	Cleanser compositions comprising a gasified candy as a sensory signal A cleanser composition suitable for use with oral appliances, which provides a sensory signal to the user. The sensory signal is such that the user believes the signal to indicate that cleansing of the oral device if occurring or, alternatively, that cleansing actio...	01/26/2010
7642276	Fused heteroaryl derivatives for use as P38 kinase inhibitors Compounds of formula (I): wherein A is a 5-membered heteroaryl ring are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38, such as rheumat...	01/05/2010
D606861	Compliance dose indicator	12/29/2009
7629477	Compounds, compositions and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ...	12/08/2009
7629462	Tetrasubstituted pyrimidine compounds as chemical intermediates Novel substituted pyrimido[4,5-d]pyrimidin-2-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors. ...	12/08/2009
7629350	Compounds Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors. ...	12/08/2009
7629340	N-(6-membered aromatic ring)-amido anti-viral compounds Disclosed are compounds having Formula (I) and the compositions and methods relating to these compounds, for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T,...	12/08/2009
7629328	Nucleoside derivatives for treating hepatitis C virus infection Disclosed are methods for treating hepatitis C viral infections using deaza-purine compounds of Formula I: wherein W, W1, W2, Y, R1, Z, Y′ and R are as defined herein. ...	12/08/2009
7629320	Nucleoside derivatives for treating hepatitis C virus infection Disclosed are β-D-ribofuranosyl-pyrazolo[3,4-d]pyrimidine compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. Representative compounds include those having the general formula.	12/08/2009
7626055	Biphenyl-carboxamide derivatives and their use as p38 kinase inhibitors Compounds of formula (I) or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ...	12/01/2009
7625904	Methods for the treatment of sleep disorders The invention relates to methods for the treatment of a sleep disorder in a mammal comprising administering to said mammal an effective amount of a compound of formula (I): wherein all variables are as defined herein. ...	12/01/2009
7625903	Anthranilamide inhibitors of Aurora kinase The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; where R1, R2, R3, R4, r and s are as ...	12/01/2009
7622494	Chemical compounds The present invention relates to compounds that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds. ...	11/24/2009
7618981	Imidazopyridinyl-benzamide anti-cancer agents Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders. ...	11/17/2009
RE40988	Ligands of the neuropeptide receptor HFGAN72 Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, method...	11/17/2009
7615643	Benzimidazole thiophene compounds The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. ...	11/10/2009
7598251	Aminopyrazine derivatives and compositions The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such aminopyrazine derivatives are useful in the treatment...	10/06/2009
7595398	N-(5-membered aromatic ring)-amido anti-viral compounds Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R1, Y,...	09/29/2009
7595330	Benzimidazole thiophene compounds The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. ...	09/29/2009
7595039	Methods of healing wounds by administering human IL-18 The present invention relates generally to the use of human IL-18, also known as interferon-γ-inducing factor (IGIF), in the treatment of skin wounds, surgical wounds, leg ulcers, diabetic ulcers, gastrointestinal mucositis, oral mucositis, and lung injury. ...	09/29/2009
7592357	Compounds Novel Inhibitors of Rho-kinases are disclosed. ...	09/22/2009
7592352	Substituted thieno and furo-pyridines This invention relates to newly identified compounds for treating and preventing tumors and cancers, and methods for treating proliferative diseases associated with the imbalance or inappropriate activity of tyrosine kinases implicated in proliferative diseases....	09/22/2009
7592342	Quinoxaline derivatives as PI3 kinase inhibitors Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenera...	09/22/2009
7589207	Cyclohexyl compounds as CCR5 antagonists The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an...	09/15/2009
7589204	Indane compounds as CCR5 antagonists The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an...	09/15/2009
7582668	Imidazoyl-benzamide anti-cancer agents Provided are compounds of Formula I and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders. ...	09/01/2009
7582630	Pyradazine compounds as GSK-3 inhibitors The present invention relates to pyrazaolpyradazine derivatives that inhibit GSK3 (glycogen synthase kinase), pharmaceutical compositions containing these derivatives, and methods for their use in the treatment of disorder characterized by misregulation of GSK3....	09/01/2009
D598738	Container	08/25/2009
7572820	Chemical compounds This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds. ...	08/11/2009
7572790	Biphenyl carboxylic amide p38 kinase inhibitors Compound of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ...	08/11/2009
7569601	Cycloalkylidene compounds as modulators of estrogen receptor The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation. ...	08/04/2009
7569579	Cyclopropyl compounds as ccr5 antagonists The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an...	08/04/2009

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Assignee: SmithKline Beecham Corporation