Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

Location: Rome, IT
No. of patents: 232

Number	Title	Issue Date
7935346	Medicament for the two-step perioperative therapy of solid tumours The present invention describes the use of an agent endowed with tumour tropism in combination with another agent with anticancer activity and with an affinity for the first agent for the preparation of a medicament useful for the two-step perioperative therapy of s...	05/03/2011
7932291	Use of L-carnitine and its alkanoyl derivatives as osmotic agents in solutions for medical use The use of L-carnitine and its alkanoyl derivatives, optionally in the form of a pharmaceutically acceptable salt, as osmotic agents in the preparation of solutions for medical use, particularly for peritoneal dialysis, is described. ...	04/26/2011
7897641	Composition for the prevention and/or treatment of the cytotoxic effects induced by the use of immunosuppressive agents A composition is disclosed which is suitable for the prevention and/or treatment of cell and tissue abnormalities of exogenous, toxic or metabolic origin and suitable for reducing the toxic effects of cyclosporin-A and other immunosuppressive agents, which may take ...	03/01/2011
7888368	Treatment of drug-resistant tumors A subclass of camptothecin derivatives is disclosed to be useful for the preparation of a medicament for the treatment of drug-resistant tumors and/or for the administration to patients who show polymorphisms in the gene coding for DNA topoisomerase I. ...	02/15/2011
7883889	Antigen presenting cells, method for their preparation and their use for cancer vaccines The present invention discloses a method of generation of antigen presenting cells, comprising: a collecting said cells from a subject, b. activating said collected cells; c. culturing and optionally expanding ex vivo said activated cells; d. treating said cultured ...	02/08/2011
7879908	Use of L-carnitine for the treatment of cardiovascular diseases The use of L-carnitine, or one of its pharmaceutically acceptable salts, is described in combination with glucose for the preparation of a medicament useful for diminishing the number of deaths caused by acute myocardial infarction, for reducing the number of days i...	02/01/2011
7867503	Chimeric recombinant antigens of A method for treatment or prevention of Toxoplasma gondii infections pharmaceutical composition comprising an antigen fragments of Toxoplasma gondii in the form of a chimeric fusion product or a nucleotide sequence coding for the chimeric fusion produc...	01/11/2011
7858820	Solid compositions suitable for oral administration containing non-hygroscopic salts of L-carnitine and the alkanoyl L-carnitines with taurine chloride and glycine chloride Described herein are both non-hygroscopic salts of L-carnitine and alkanoyl L-carnitine with taurine chloride (2-aminoethane-sulphonic chloride) and non-hygroscopic salts of L-carnitine and alkanoyl L-carnitine with glycine chloride which lend themselves favorably t...	12/28/2010
7858577	Use of the long pentraxin PTX3 for the treatment of diseases caused by an altered activation of the growth factor FGF-2 The use of the long pentraxin PTX3 (PTX3) or one of its functional derivatives is described for the preparation of medicament which inhibits the biological activity of the growth factor FGF-2, useful for the prevention and treatment of diseases brought about by an a...	12/28/2010
7854939	Gel useful for the delivery of cosmetic active ingredients A gel, for cosmetic use, composed of a mixture of a polymer which forms a gel, a surfactant, and propionyl L-carnitine glycinate hydrochloride, useful for treating disturbances of the skin such as cellulite and wrinkles is described. ...	12/21/2010
7851621	Synthesis of deoxybiotinyl hexamethylenediamine-dota A process for the synthesis of deoxybiotinyl hexamethylenediamine0-DOTA is herein described. Said process comprises reacting biotinyl hexamithylenediamine with tri-t-butyl DOTA in the presence of benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate, as...	12/14/2010
7851142	Method of reducing glycolysis in platelet concentrates using L-carnitine, alkanoyl carnitines and salts thereof Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond cu...	12/14/2010
7842023	Container for vial of radiopharmaceutical and set for its infusion in a patient or for its transfer elsewhere A container for a vial of radiopharmaceutical, made of polymethyl methacrylate consists of a receptacle, with a cavity capable of containing the vial of radiopharmaceutical, and of a lid screwed onto the receptacle for closing the container, said lid presenting a ce...	11/30/2010
7833981	Deglycosylated and desialidated long pentraxin PTX3 Deglycosylated long pentraxin PTX3 and desialidated long pentraxin PTX3 are disclosed, as well as processes for their preparation, pharmacological compositions containing them, and their use for the preparation of a medicament for the treatment of diseases in which ...	11/16/2010
7833977	Use of L-Carnitine as stabilizing agent of proteins The present invention relates to the technical field of stabilizing proteins, in particular to the therapeutic aspects of protein stabilization. L-carnitine is a useful agent for stabilizing proteins, and in a particularly favourable aspect in proteins used in the m...	11/16/2010
7816388	Biotin diaminoderivatives and their conjugates with macrocyclic chelating agents Formula (I) compounds are described: Formula (I) where the radicals are as defined in the description, processes for their preparation, and their uses for the preparation of conjugates with radionuclides for use in human and animal therapy and diagnostics, particula...	10/19/2010
7816386	Cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumor agents Cinnamic and phenylpropiolic acid derivatives of formula (I) having antitumour and chemo sensitizing activity are described. Also described are pharmaceutical compositions containing the above-mentioned compounds, for the treatment of tumours. ...	10/19/2010
7816073	Method for inhibiting bacterial growth in a leuko-reduced platelet concentrate by adding L-carnitine Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond cu...	10/19/2010
7807133	Avidin dimers effective in increasing the concentration of radioactive biotin in pretargeted radioimmunotherapy Dimers of avidin and streptavidins (diavidins) are described wherein the linker is suberate, which in turn, is bound to different functional groups (—NH2 o-COOH) of avidin. As compared to avidin, the diavidins have shown the ability to increase the amount of label...	10/05/2010
7799921	Stereoselective process and crystalline forms of a camptothecin A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystal...	09/21/2010
7790700	Derivatives of partially desulphated glycosaminoglycans endowed with antiangiogenic activity and devoid of anticoagulating effect Partially desulfated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the description. The...	09/07/2010
7776913	Carnitines for treating or preventing disorders caused by andropause L-carnitine, propionyl L-carnitine and/or acetyl L-carnitine are used to prevent or treat disorders of male andropause caused by ageing or by chemical or surgical castration. ...	08/17/2010
7728039	Biphenyl and Naphthyl-Phenyl Hydroxamic Acid Derivatives Biphenyl and phenyl-naphthyl compounds bearing a hydroxamic group, which are endowed with antitumor, and anti-angiogenic activity These compounds are therefore particularly useful for the treatment of drug-resistant tumors. ...	06/01/2010
7728037	Alpha-ketoglutarates of active ingredients and compositions containing same Novel stable and pharmacologically acceptable salts of L-carnitine and lower alkanoyl L-carnitines with alpha-ketoglutaric acid are disclosed as well as the compositions useful as dietary and dietetic supplements, nutraceuticals or drugs containing same. ...	06/01/2010
7713956	Dealkylated derivatives of pyrrolo[2,1-b]benzothiazepines with atypical antipsychotic activity Derivatives of pyrrolo[2,1-b]benzothiazepines with formula (I) where A is CH—CH2C═CH; R is hydrogen, halogen, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkyl, C5-C6 cyc...	05/11/2010
7705012	Camptothecins conjugated in position 7 to cyclic peptides as cytostatic agents Compounds of Formula (I) are described in which the R1 group is as defined in the specification and includes the condensation of the camptothecin molecule in position 7 with a cyclopeptide containing the RGD sequ...	04/27/2010
RE41226	Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-t...	04/13/2010
7683032	Deglycosylated and desialidated long pentraxin PTX3 Deglycosylated long pentraxin PTX3 and desialidated long pentraxin PTX3 are disclosed, as well as processes for their preparation, pharmacological compositions containing them, and their use for the preparation of a medicament for the treatment of diseases in which ...	03/23/2010
7655698	Use of L-carnitine or of alkanoyl L-carnitines for the preparation of a physiological supplement or medicament for opthalmic use in the form of eye drops Use of L-carnitine and/or of one or more alkanoyl L-carnitines or one of their pharmaceutically acceptable salts for the preparation of an ophthalmic physiological supplement or medicament in the form of eye-drops, for the treatment of corneal diseases. ...	02/02/2010
7635719	Use of adamatyl methoxydiphenyl propenoic acid for the treatment of acne The use of a substance belonging to the class of atypical retinoids for the topical treatment of acne is described. In particular the effects on an animal model for this skin disease of a pharmaceutical or cosmetic compound for topical use containing adamantyl metho...	12/22/2009
7608289	Food supplemented with a carnitine, suitable for stimulating the biosynthesis of polyunsaturated fatty acids from the saturated fatty acids contained in the food A food selected from the group comprising milk and dairy products derived from milk, comprising a carnitine in an effective amount to stimulate, through the natural fatty acid metabolic processes that take place in a consumer of said food, the synthesis of polyunsat...	10/27/2009
7585896	Composition for the prevention and treatment of kidney dysfunctions and diseases A composition is disclosed which is suitable for the prevention and treatment of kidney dysfunctions and diseases and which can therefore take the form of a food supplement or of an actual medicinal drug comprising a combination of acetyl L-carnitine and propionyl L...	09/08/2009
7585519	Esters of L-carnitine or alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine and alkanoyl L-carnitines of formula (I) are also disclosed wherein the...	09/08/2009
7572778	Fluorocombretastatin and derivatives thereof The present invention is related to new derivatives of Combretastatin, of Formula obtained by total synthesis. The strategy developed for each of the compounds is to i) replace a halogen (i.e. fluorine atom) to hydrogen on ...	08/11/2009
7560439	Method for increasing the gene expression of transfected genes The present invention provides a method of increasing the gene expression of transfected genes which includes the administration of a carnitine. ...	07/14/2009
7452900	Esters in position 20 of camptothecins Formula (I) compounds are described: (I) where the groups are as defined in the description here below, the racemic mixtures, their individual enantiomers, their individual diastereoisomers, their mixtures, and their pharmaceutically acceptable salts. Said compounds...	11/18/2008
7449495	Retinoid derivatives with antiangiogenic, antitumoral and proapoptotic activities Described and claimed are compounds of Formula (I) in which R, R′, R″, A, and D have the meanings described in the text, as useful agents in the cure of pathologies characterized by altered angiogenesis and as antitumorals. ...	11/11/2008
7438908	Anti-human tenascin monoclonal antibody A novel anti-human tenascin ST2146 monoclonal antibody is described endowed with high affinity with the native antigen and high tumor selectivity. The cST2146 hybridoma is stably producing the antibody in high density culture conditions and is suitable for the indus...	10/21/2008
7422844	Solution for the storage and perfusion of organs awaiting transplantation A storage solution to maintain and perfuse organs awaiting transplantation comprising (a) an isotonic balanced solution comprising a physiologically acceptable amount of potassium, mono acidic phosphate, biacidic phosphate, chloride, sodium and bicarbonate ions; (b)...	09/09/2008
7390828	Aminoderivatives of biotin and their conjugates with macrocyclic chelating agents Formula (I) compounds are described where the groups are as defined here below, processes for their preparation, and their uses for the preparation of conjugates with radionuclides for use in human and animal therapy and diagnostics, particularly for the diagnosis a...	06/24/2008

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Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.