Assignee: Sigma-Aldrich Co.

Location: St. Louis, MO
No. of patents: 40

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Number	Title	Issue Date
7972828	Stabilized compositions of thermostable DNA polymerase and anionic or zwitterionic detergent The present invention provides compositions, methods, and kits for protecting thermostable DNA polymerase during amplification reactions conducted at a temperature ranging from about 40° C. to greater than 100° C. The composition comprises a thermostable DNA polym...	07/05/2011
7927661	Methods of depositing a metal oxide layer or film using a rare earth metal precursor Methods of depositing a single or mixed metal oxide layer or film are described herein. The methods use a rare earth metal precursor are described herein. The rare earth metal precursors have a general formula M[OCR1(R2)(CH2)X]3...	04/19/2011
7919322	Targeted deletions using retroelement-mediated placement of recombination sites The present invention provides methods, nucleic acid constructs, and kits for selectively deleting a region of a nucleic acid sequence. Specifically, it utilizes retargeting retroelements to place site-specific recombination sites at targeted locations in the nuclei...	04/05/2011
7897758	Activators for oligonucleotide and phosphoramidite synthesis The present invention discloses novel methods for the synthesis of oligonucleotides and nucleoside phosphoramidites. The methods are based on employing aryl-substituted 5-phenyl-1H-tetrazoles with perfluoroalkyl groups on the aromatic ring as activators. In one aspe...	03/01/2011
7897376	Method for extracting a target product from a host cell employing zwitterionic detergent combinations The present invention provides lysis reagents, containers, methods and kits relating to the extraction or the extraction and isolation of a cellular component from a host cell. More specifically, the invention provides combinations of zwitterionic compounds that may...	03/01/2011
7875738	Polysilazane thermosetting polymers for use in chromatographic systems and applications This invention relates to an amorphous non-glassy ceramic composition that may be prepared by curing, calcining and/or pyrolyzing a precursor material comprising silicon, a Group III metal, a Group IVA metal, and/or a Group IVB metal. ...	01/25/2011
7815864	Polysilazane thermosetting polymers for use in chromatographic systems and applications This invention relates to an amorphous non-glassy ceramic composition that may be prepared by curing, calcining and/or pyrolyzing a precursor material comprising silicon, a Group III metal, a Group IVA metal, and/or a Group IVB metal. ...	10/19/2010
7794674	Consolidated vacuum sublimation module A consolidated vacuum sublimation module (VSM) can comprise an upper body portion, a middle body portion, a lower body portion, a bushing, and a seal. A vapor director cartridge can be loaded with a crude material and manually inserted into a cartridge-holding membe...	09/14/2010
7776582	Optically enhanced chiral ionic liquids The invention relates to the use of optically enhanced chiral ionic liquids, particularly for gas chromatography and as a reaction solvent. Specific optically enhanced chiral cationic liquids are described as is a class of optically enhanced chiral anionic liquids.	08/17/2010
7767833	Stabilized borane-tetrahydrofuran complex A stabilized borane-tetrahydrofuran complex is disclosed. Also disclosed are processes for the preparation of the borane-tetrahydrofuran complex and methods of storing and transporting the prepared complex. The borane-tetrahydrofuran complexes exhibit enhanced shelf...	08/03/2010
7750168	Stabilized deuteroborane-tetrahydrofuran complex A stabilized deuteroborane-tetrahydrofuran complex is disclosed. Also disclosed are processes for the preparation of the deuteroborane-tetrahydrofuran complex and methods of storing and transporting the prepared complex. The deuteroborane-tetrahydrofuran complexes e...	07/06/2010
7741053	Processes for purification of recombinant proteins Processes for the detection and purification of peptides and proteins comprising a metal ion-affinity peptide having a high affinity for coordinated metals and also being highly antigenic are described. Antibodies for use in the processes are also described. ...	06/22/2010
7709612	Metal chelating compositions for protein purification, detection or binding A metal chelating composition having the formula: wherein Q is a carrier; S1 is a spacer; L is -A-T-CH(X)— or —C(═O)—;	05/04/2010
7615629	Methods and compositions for the tandem synthesis of two or more oligonucleotides on the same solid support The present invention relates to novel methods and novel solid support materials for the tandem synthesis of two or more different oligonucleotides on the same solid support in one synthetic run. The methods involve novel support preparations comprised of two or mor...	11/10/2009
7531308	Process for the reduction of endotoxins in a plasmid preparation using a carbohydrate non-ionic detergent with silica chromatography The present invention provides methods for the reduction of endotoxins in a plasmid preparation using a carbohydrate non-ionic detergent with silica chromatography. ...	05/12/2009
7520657	Magnetic stirrer A magnetic stirring system includes a stir-mantle and a magnetic stirring apparatus used for stirring/mixing materials in a flask. A rare-earth magnet is mounted on the magnetic stirring apparatus and is driven in rotation by a pneumatic motor. The rare-earth magnet...	04/21/2009
7504238	Processes for directionally ligating double stranded nucleic acids Amplification mixtures, kits, amplicons, kits and processes are provided for amplifying a nucleic acid. In particular, provided are processes which utilize an amplification mixture comprising a polymerase, a deoxynucleotidetriphosphate (dNTP) mixture which contains ...	03/17/2009
7438806	Affinity matrices with enhanced visibility for molecular pull-down and immunoprecipitation applications An affinity matrix for use in affinity based molecular pull down and immunoprecipitation procedures. The affinity matrix comprises a polymeric support, a dye attached to a fraction of the polymeric support to enable optical detection of the polymeric support, and an...	10/21/2008
7431049	Valve for withdrawal of a substance from a container A valve has a housing defining a bore. Two bottom ports and two side ports in the housing communicate with the bore. Two annular grooves are in the outer surface of a spool received in the bore. A bypass extends within the spool from an annular groove to a bypass po...	10/07/2008
7427678	Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method This invention discloses a novel method for immobilizing molecules to a support. Specifically, this invention discloses a method of immobilizing derivatized biomolecules, such as oligonucleotides, using cycloaddition reactions, such as the Diels-Alder reaction. Incl...	09/23/2008
7419698	Precursors for chemical vapor deposition Ti, Zr Hf and La precursors for use in MOCVD techniques have a ligand of the general formula OCR1(R2)CH2X, wherein R1 is H or an alkyl group, R2 is an optionally substituted alkyl group and X is selected from OR...	09/02/2008
7399620	Polypeptides and bacterial strains for increased protein production The invention provides polypeptides, nucleic acid sequences, bacterial strains, methods and kits for producing exogenous protein. More specifically, the invention provides RNase E polypeptides that posses impaired mRNA degrading activity and efficient rRNA and tRNA ...	07/15/2008
7329515	Solid support for the synthesis of 3′-amino oligonucleotides The present invention discloses novel methods and solid supports for the synthesis of 3′-amino oligonucleotides. The novel supports are based on an unsubstituted or ring-substituted hydroxymethylbenzoyl linker element wherein the hydroxymethyl group is esterified ...	02/12/2008
7317070	Process for the preparation of polyamino acids Among the various aspects of the present invention is an improved process for the preparation of polyamino acids generally, and more specifically, polyglutamic acid and polyaspartic acid. Another aspect is a process for the large scale (i.e. >1 kg) preparation of po...	01/08/2008
7294719	Synthesis of amino acid, N-carboxyanhydrides A process for producing N-carboxyanhydrides is disclosed. The process produces N-carboxyanhydrides as a product and HCl as a by-product. The HCl by-product is purged from the reaction mixture by passing a purge gas through the reaction mixture as a carbonylation rea...	11/13/2007
7282475	Compositions and methods employing zwitterionic detergent combinations The present invention provides lysis reagents, containers, methods and kits relating to the extraction or the extraction and isolation of a cellular component from a host cell. More specifically, the invention provides combinations of zwitterionic compounds that may...	10/16/2007
7282119	Process and apparatus for the isolation of pure, or substantially pure, organometallic compounds A process and apparatus to enable the continuous isolation of an organometallic compound, such as trimethylindium from a liquid feedstock. The liquid feedstock is delivered to a distillation column having two heating zones to effect dissociation of the feed stock th...	10/16/2007
7276598	Phosphorylation reagents for improved processes to convert terminal hydroxyl groups of oligonucleotides into phosphate monoesters The present invention discloses novel phosphoramidite reagents for use in oligonucleotide synthesis. The present invention further discloses novel methods for the conversion of terminal hydroxyl groups of oligonucleotides into phosphate monoesters. By employing nove...	10/02/2007
7214484	Compositions and methods for nucleic acid extraction from biological samples Methods and compositions for extracting nucleic acids from a biological sample are provided. The extraction compositions contain a protease enzyme such as proteinase K at alkaline pH with little or no surfactant present. Extraction can be efficiently performed in 60...	05/08/2007
7169584	Tracer reagents that enhance reaction-product analysis A composition suitable for formulation of an enzymatic reaction mixture, the composition comprising a reaction component essential for an ex-vivo non-polymerase enzymatic reaction in which a substrate is catalyzed by an enzyme in a reaction mixture to form a product...	01/30/2007
7163633	Affinity matrices with enhanced visibility for molecular pull-down and immunoprecipitation applications An affinity matrix for use in affinity based molecular pull down and immunoprecipitation procedures. The affinity matrix comprises a polymeric support, a dye attached to a fraction of the polymeric support to enable optical detection of the polymeric support, and an...	01/16/2007
7098326	Methods for the integrated synthesis and purification of oligonucleotides The present invention discloses novel methods for the integrated synthesis and purification of oligonucleotides. The methods employ novel capping reagents carrying two functional groups. The first functional group provides for a smooth and efficient capping process ...	08/29/2006
7077017	Container with a frangible seal A container for receiving fluids comprises a body having opposite ends and at least one wall defining an interior space. At least one seal defines a sealed chamber within the interior space of the body. Each seal is recessed from one of the ends of the body and has ...	07/18/2006
6887377	Affinity matrices with enhanced visibility for molecular pull-down and immunoprecipitation applications An affinity matrix for use in affinity based molecular pull down and immunoprecipitation procedures. The affinity matrix comprises a polymeric support, a dye attached to a fraction of the polymeric support to enable optical detection of the polymeric support, and an...	05/03/2005
6713299	Apparatus for separating biological materials A method and apparatus are provided for the separation of biological materials from one another. The device includes a separation column that is in flow communication with a collection chamber in a reservoir that includes a collection container and a lid. The separa...	03/30/2004
5819956	Rack for electrical equipment A rack for electrical equipment is constructed for resistance to failure in earthquake conditions. The rack has a base and two legs extending upwardly from the base. A cross member spans between and interconnects the legs near their tops. A reinforcing st...	10/13/1998
5816542	Support system for data transmission lines A support system for data transmission lines and the like, comprising a rail section supported generally horizontally, a splice for connecting the rail section and another structure, and a fastener for securing the splice to the rail section. Each rail se...	10/06/1998
5792993	Wireway sealing device The disclosure describes a sealing device for sealing two adjacent wireway sections positioned in an end-to-end relation. Each wireway section has a lower channel portion for receiving cable and a cover movable between an open position for placing cable i...	08/11/1998
5782439	Support system for transmission lines and cable A support system for data transmission lines and the like includes a plurality of rail sections and a hub having a horizontal peripheral rim. A plurality of vertical holes are spaced at intervals around the rim for connecting the rail sections to the hub ...	07/21/1998
5720567	Cable tray system A splice system having two rails to be connected end to end and splice member having a center part and a pair of end parts sized for insertion in open ends of the two rails. The rails to be connected end to end having first and second opposing walls and a...	02/24/1998

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Assignee: Sigma-Aldrich Co.