Assignee: Siemens Healthcare Diagnostics Inc.

Location: Tarrytown, NY
No. of patents: 46

Number	Title	Issue Date
8148061	Endometriosis-related markers and uses thereof The present invention relates to markers of endometriosis which are differentially expressed in the endometrial cells of females with endometriosis compared to endometriosis-free females. The invention also relates to methods for determining likelihood of endometrio...	04/03/2012
8131035	Cell analysis using isoperimetric graph partitioning A computer implemented method for differentiating between elements of an image and a background includes inputting an image comprising pixels forming a view of the elements and a background, providing a model for assigning a probability of belonging to a predefined ...	03/06/2012
8119422	Stable acridinium esters with fast light emission Chemiluminescent acridinium esters are provided which are fast light emitting and hydrolytically stable. The chemiluminescent acridinium esters are useful labels in assays for detecting or quantifying analytes. ...	02/21/2012
8101429	Native analyte as a reference in lateral flow assays This invention is directed to a lateral flow assay for detecting the presence of an analyte in a liquid test sample. The lateral flow assay represents an improvement in the ability to accurately and with high fidelity to detect the presence or absence of a target an...	01/24/2012
D650089	Universal cap	12/06/2011
8063196	Highly orthogonal universal sequences for use in nucleic acid assays The invention provides a set of highly orthogonal six-code universal sequences for use in bDNA singleplex and multiplex nucleic acid hybridization assays. The six-code orthogonal sequences do not cross-hybridize and thus, minimize or eliminate the 3-mer cross-hybrid...	11/22/2011
8030007	Method for the detection of endometriosis using an ME-2 antigen A method for diagnosing endometriosis in a human subject comprising the steps of detecting a test amount of an antibody that specifically binds to SEQ ID NO: 6 polypeptide or a truncated peptide comprising an epitope of SEQ ID NO: 6 in a sample from the subject; and...	10/04/2011
8017573	Adiponectin receptor fragments and methods of use Methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using C-terminal fragments of adiponectin receptor R1. Methods of causing the secretion of insulin in healthy and diabetic patients using C-terminal fragments of adiponec...	09/13/2011
7993838	Nucleic acid primers and probes for detecting human and avian influenza viruses Provided are nucleic acid sequences that are used to prepare primers and probes that are used in a kinetic polymerase chain reaction (kPCR) assay to detect influenza viruses in a human or animal subject. The starting material for the kPCR assays may be DNA or RNA an...	08/09/2011
7981626	Method of detecting endometriosis in human subjects using SEQ ID No. 9 or an epitope thereof A method for diagnosing endometriosis in a human subject comprising the steps of detecting a test amount of an antibody that specifically binds to SEQ ID NO:9 polypeptide or a truncated peptide comprising an epitope of SEQ ID NO: 9, in a sample from the subject; and...	07/19/2011
7951329	Rotary luminometer A rotary luminometer subsystem presents test vessels to a detection mechanism to be read as part of the automated immunoassay analyzer system. The rotary luminometer provides a read station separate from that of the transportation element of the luminometer. Within ...	05/31/2011
7847946	Verification apparatus and methods for optical inspection machine Apparatus and methods are disclosed for verifying one or more operational conditions of an optical inspection machine. A row of grooves (1-5) that simulate a reagent pad containing a specific type of analytes at known concentrations can be used for ver...	12/07/2010
7847087	Methods and primers for evaluating HIV-1 mutations Primer sequences and a method of using such sequences for the genotyping of HIV-1-containing samples, particularly those which have failed genotyping analysis are provided using primer sequences designed for analysis of Group B subtype of the Group M type virus. For...	12/07/2010
7879562	Methods of diagnosing endometriosis in human subjects using the ME-5 polypeptide A method for diagnosing endometriosis in a human subject comprising the steps of detecting a test amount of an antibody that specifically binds to ME-5 (SEQ ID NO:3) polypeptide or a peptide comprising an epitope of ME-5 in a sample from the subject; and comparing t...	02/01/2011
7875467	Applications of acridinium compounds and derivatives in homogeneous assays Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent acridinium compounds include acridinium esters with electron donating fun...	01/25/2011
7858031	Vial presence indicator for vial-bearing rack An indicator for enabling an analytical instrument to positively detect the presence of a vial in respective vial-receiving rack position regardless of whether the vial is oriented in a manner necessary for a code reader to read a code printed on the vial. Translati...	12/28/2010
7790386	specific oligonucleotide sequences The present invention relates to oligonucleotide sequences for amplification primers and detection probes and their use in nucleic acid amplification methods for the selective and specific detection of Neisseria gonorrhoeae in biological samples. The inventio...	09/07/2010
7785904	High quantum yield acridinium compounds and their uses in improving assay sensitivity The present invention relates to hydrophilic, high quantum yield acridinium compounds. It has been discovered that the placement of electron-donating groups in the acridinium ring system increases the amount of light that is emitted by the corresponding acridinium c...	08/31/2010
7768645	Miniature optical readhead and colorimeter for analysis media A miniature readhead is provided for photometric color detection using ambient light. The readhead is hand-held, including a superposed plate and tray. The tray receives sample media configured to react and to change color according to an amount of analyte in a samp...	08/03/2010
7745219	Reagent composition for the analysis of residual white blood cells in leuko-reduced blood banking products The enumeration and analysis of residual white blood cells in a sample of leukocyte-reduced blood products is conducted by forming a suspension of the leukocyte-reduced blood products with a sufficient amount of a lysing reagent. The lysing reagent comprises a buffe...	06/29/2010
7732159	Assays for cancer patient monitoring based on levels of analyte components of the plasminogen activator system in body fluid samples The present invention describes clinically and medically important methods of examining, screening over time, and monitoring the outcome of a cancer patient who is undergoing treatment or therapy for his or her disease. More specifically, the invention provides a me...	06/08/2010
7723064	Methods for monitoring patients for efficacy of an antiplatelet therapy regimen Methods are disclosed for monitoring patients utilizing Mean Platelet Component values during therapeutic intervention. ...	05/25/2010
D616564	Reagent card	05/25/2010
7713474	Liquid permeable composition in dry reagent devices A device for detecting an analyte in a fluid sample includes a liquid permeable composition for making a physical separation between compositions of the sample or for reacting with components. The liquid permeable composition has adhesive properties and can be used ...	05/11/2010
7687034	Valve sealing system for a reagent package The valve sealing system for a reagent package includes an annular cylindrical gasket seated in a channel formed in the package. A rocker valve on the package pivots relative to the annular cylindrical gasket which surrounds an opening to the chamber of the reagent ...	03/30/2010
7670798	Automated method and reagent therefor assaying body fluid samples such as cerebrospinal fluid (CSF) The present invention describes semi- and fully-automated methods and reagents therefor for the assay and analysis of body fluid samples, particularly non-blood samples. The methods and reagents are especially useful for the assay and analysis of cerebrospinal fluid...	03/02/2010
7670553	Carousel system for automated chemical or biological analyzers employing linear racks An automated chemical or biological sample analyzer includes a plurality of linear sample carrying racks that are moved to a processing station for conducting an analysis using one or more carousel devices. Under computer control, rotational movements of the carouse...	03/02/2010
7668661	Liver disease-related methods and systems The invention provides diagnostic methods, kits, and systems, and related computer-readable media, which use multiple blood marker values, including serum and plasma marker values, to aid in the diagnosis of the status or progress of a liver disease in a patient.	02/23/2010
7621181	Fluid level detector and analyzer An electronic technique is used for identifying a fluid and determining its level in a container. Specifically, impedance spectroscopy is applied to fluid handling probes such as those employed by automated chemical and immunoassay analyzers to provide superior sens...	11/24/2009
7611909	Near infrared chemiluminescent acridinium compounds and uses thereof A method for the detection or quantitation of unlabeled target analyte in a biological sample, the method comprising labeling a target analyte for a biological sample suspected of containing unlabeled target analyte with an acridinium compound to form a labeled targ...	11/03/2009
7611845	Serum levels of HER2/neu as an indicator of clinical state and prognosis of prostate cancer The present invention relates to methods of diagnosing prostate cancer, predicting disease progression of prostate cancer, prognosing the stage and state of prostate cancer, and identifying appropriate treatment indication for prostate cancer patients. Methods encom...	11/03/2009
7601544	Method and apparatus for using infrared readings to detect misidentification of a diagnostic test strip in a reflectance spectrometer A method and apparatus for using an infrared reading to detect the misidentification of a diagnostic test strip disposed on a feed table comprising the steps of determining if the test strip possesses specified reagents, reading the infrared reflectances from the re...	10/13/2009
7561272	Precision correction of reflectance measurements A system and method of correcting reflectance comprises determining a reflectance constant for a test product at a first wavelength for which reflectance does not substantially change with the presence of a test substance, with the test product loaded with the test ...	07/14/2009
RE40768	Optical inspection apparatus with removable inserts An apparatus in accordance with the invention is directed to an optical inspection apparatus (10) adapted to inspect a liquid sample. The apparatus includes a tray (20) that is adapted to be physically coupled to a first liquid sample carrier (22	06/23/2009
7538336	Automatic identification of reagent test strips using reflectance values Identifying a test product having a test region includes impinging on the test region a set of test signals at known test wavelengths. An image of the test region is generated from the reflected signals. The image is comprised of a set of reflectance values that are...	05/26/2009
7499154	Readhead for optical inspection apparatus A readhead for illuminating a sample carrier and receiving light from the sample carrier, including a housing for receiving a sample carrier, an array of light sources mounted within the housing in a fixed position relative to the sample carrier, and including first...	03/03/2009
7473534	Assays for cancer patient monitoring based on levels of epidermal growth factor receptor (EGFR) extracellular domain (ECD) analyte, alone or in combination with other analytes, in body fluid samples The present invention describes clinically and medically important methods of monitoring the outcome of a cancer patient who is suffering from disease or who is undergoing treatment or therapy for his or her disease. More specifically, the invention provides a metho...	01/06/2009
7459284	Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows: Lumi-M-P Formula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attac...	12/02/2008
7459127	Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces A micro-liter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved through one or more sample wells arrayed within a small flat chip via interconnecting capillary passageways. The pa...	12/02/2008
7452727	Method for increasing clinical specificity when detecting tumors and their precursor stages by simultaneously measuring at least two different molecular markers The present invention relates to an automatable method for the improved diagnosis of pathologically altered cells by simultaneously staining at least two different molecular markers, which exhibit a change in gene expression which is disease-associated, in a cell or...	11/18/2008

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Assignee: Siemens Healthcare Diagnostics Inc.