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| Number | Title | Issue Date |
| 8183372 | Substituted 9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydor-1H-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazines The present invention is directed to a process for the preparation of a compound of formula 1b which compound is useful as a prodrug of HIV integrase inhibitors and therefore is useful in the inhibition of HIV replication, ... | 05/22/2012 |
| 8178681 | 3-carbamoyl-2-pyridone derivatives The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I): wherein R1 is optionally substituted C1-C8 alkyl and the like; R2 | 05/15/2012 |
| 8173642 | Aminodihydrothiazine derivatives A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; | 05/08/2012 |
| 8168630 | Aminodihydrothiazine derivatives substituted with a cyclic group This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, ... | 05/01/2012 |
| 8153793 | Sulfonamide derivative having PGD2 receptor antagonistic activity The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound... | 04/10/2012 |
| 8148362 | Compound having heterocyclic ring The invention provides a novel oxazolidinone derivative represented by the formula (I): wherein Ring A is optionally substituted or fused and represents (A... | 04/03/2012 |
| 8143285 | Indolecarboxylic acid derivative having PGD2 receptor antagonistic activity The present invention provides an indolecarboxylic acid derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. ... | 03/27/2012 |
| 8133513 | Solid preparation having improved solubility A preparation which can improve the dissolution property of a poorly water soluble drug even when the drug is contained in the preparation at a high content is provided. When an addition amount of nicotinic acid amide and/or urea is 0.1 to 10% by weight in a ... | 03/13/2012 |
| 8129507 | Atopic dermatitis inducer An atopic dermatitis inducer binding to a human own IgE antibody and activating mast cells and basophiles, which includes a purified human secretion fraction, or an antigenic molecule or an antigenic determinant in the purified fraction, and obtained through the fol... | 03/06/2012 |
| 8129385 | Substituted 5-hydroxy-3,4,6,9,9a, 10-hexanhydro-2h-1-oxa04a,8a-diaza-anthracene-6,10-dioness The present invention is directed to a class of substituted 5-hydroxy-3,4,6,9,9a,10-hexahydro-2H-1-oxa-4a,8a-diaza-anthracene-6,10-diones useful as anti-HIV agents. The compounds have the formula: Z═O; R20, R | 03/06/2012 |
| 8124625 | Method of enhancing the expression of apolipoprotein AI using olefin derivatives Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): in which Ar1 and Ar2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic het... | 02/28/2012 |
| 8106051 | Utilities of amide compounds Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments. Compounds of formula (I): in which ring A and Ar1 are independently a monocyclic or bicyclic aro... | 01/31/2012 |
| 8101644 | Pyrrolinone derivative and pharmaceutical composition comprising the same The present invention provides a compound represented by the formula (I): wherein R1, R2, R3, Z1, Z2, Ra, Rb, q, A and n are as defined in the des... | 01/24/2012 |
| 8097610 | Derivative having PPAR agonistic activity A compound of the formula (I): or a pharmaceutically acceptable salt thereof. ... | 01/17/2012 |
| 8097276 | Method for coating particle with lipid film A method for coating an object, i.e. a particle, with two sheets of lipid film having a space formed there between. In the method for coating a particle having a positive electrostatic-charging property with two sheets of lipid film, the particle having a positive e... | 01/17/2012 |
| 8093284 | Process for producing aqueous solution of doripenem A process for producing an aqueous solution of doripenem while decomposition of doripenem by heat is suppressed is found out. It was found out that decomposition of doripenem by heat can be suppressed by continuous heating an aqueous suspension of doripenem, ... | 01/10/2012 |
| 8088924 | Pyridone derivatives having a binding activity to the cannabinoid type 2 receptor It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein R1 is a group represented by the formula: —Y1—Y2—Y | 01/03/2012 |
| 8088777 | Urea derivative Disclosed is a novel compound having an NPY Y5 receptor antagonistic activity. A compound represented by the formula: its pharmaceutically acceptable salt or solvate thereof, wherein X is hydrogen... | 01/03/2012 |
| 8084646 | Process for production of hydroxyadamantaneamine Disclosed is a process for producing 1-hydroxy-4-aminoadamantane. ... | 12/27/2011 |
| 8084460 | 6,7-unsaturated-7-carbamoyl substituted morphinan derivative A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation. A compound represented by the formula (I): wherein R1 and R2 are each independen... | 12/27/2011 |
| 8058409 | Method of serum pre-treatment for glycomic analysis A means for pre-treatment in glycomic analysis of a glycoprotein is provided by the present invention. A salt of the general formula (I): wherein Z, X, R1, R2, M, m and n are the same as describ... | 11/15/2011 |
| 8053445 | Utilities of olefin derivatives Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): in which Ar1 and Ar2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic het... | 11/08/2011 |
| 8029878 | Medical container and medical duplex container A medical container comprising a body for containing a medicament, the body of the medical container being formed of a multilayered film comprising (i) a layer formed of a linear polyolefin and (ii) a layer formed of a cyclic polyolefin adjacent to the layer (i), an... | 10/04/2011 |
| 8017793 | Oxidation of alcohol with use of hydrogen peroxide and tungsten catalyst Disclosed is a method for oxidizing an alcohol in an amide solvent using a mixed reagent containing hydrogen peroxide and a tungsten catalyst. ... | 09/13/2011 |
| 8017638 | Isoxazole derivative and isothiazole derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1 Disclosed is a compound useful as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1. A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein ... | 09/13/2011 |
| 7998992 | Oxazolidinone derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1 Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor. A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, whe... | 08/16/2011 |
| 7935706 | Nitrogen-containing heterocycle derivatives substituted with cyclic group It was found out that the nitrogen-containing heterocyclic derivative represented by the formula (I) specifically binds to a receptor of NR1/NR2B, and is used as a NR2B receptor antagonist. A compound represented by: ... | 05/03/2011 |
| 7932381 | Process for producing carbapenem derivative and intermediate crystal therefor An object of the present invention is to provide a carbapenem synthetic intermediate which is advantageous in an industrial process. There are provided a process for producing Compound (I), or a pharmaceutically acceptable salt, or a solvate, or a crystal thereof, c... | 04/26/2011 |
| 7919623 | Naphthyridine derivatives having inhibitory activity against HIV integrase A compound having HIV Integrase Inhibitory activity of the formula: (wherein: R1 is optionally substituted aralkyl; R2 and R3 are each independently hydrogen, optio... | 04/05/2011 |
| 7858788 | Bicyclic carbamoylpyridone derivative having HIV integrase inhibitory activity Is to provide a novel compound having an anti-viral activity, particularly a HIV integrase inhibitory activity, and an agent, particularly an anti-HIV agent. A compound represented by the formula: (wherein | 12/28/2010 |
| 7842692 | Azaindole derivative having PGD2 receptor antagonistic activity The present invention creates an azaindole derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further providing a therapeutic agent for treating allergic diseases. A c... | 11/30/2010 |
| 7825146 | Sulfonamide derivative having isoxazole ring A compound represented by the general formula (I-A): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R4 | 11/02/2010 |
| 7786140 | Piperidine derivative having NMDA receptor antagonistic activity A piperidine derivative of the formula (I) is found to bind specifically with the NR1/NR2B receptor and usable as an analgesic (pain treatment drug). wherein X is OH or lower alkylsulfonyloxy; Ar is optionally substituted a... | 08/31/2010 |
| 7781469 | Arylacetate derivatives having isoxazole skeleton A compound of the formula (I): pharmaceutically acceptable salt or solvate thereof, wherein Y is a group of the formula: wherein Ring A ... | 08/24/2010 |
| 7767809 | Crystal of intermediate for carbapenem The disclosed invention relates to a solvate of the compound (I) of the formula: or a crystal thereof. ... | 08/03/2010 |
| 7759372 | Nitrogen-containing heteroaryl compounds having inhibitory activity against HIV integrase A compound of the formula (I): wherein Z4, Z5 and Z9 each is independently carbon atom or nitrogen atom; Y is hydroxy, mercapto or amino; RA is a group of the formula: | 07/20/2010 |
| 7745453 | Hydroxypyrimidinone derivatives having inhibitory activity against HIV integrase Compounds of Formula (1), pharmaceuticals containing the same, especially anti-HIV agents having anti viral activity, especially inhibitory activity against HIV integrase, wherein X represents either one of the following gr... | 06/29/2010 |
| 7696354 | Cephem compounds having broad antibacterial spectrum A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substitut... | 04/13/2010 |
| 7662826 | Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same A compound represented by the formula (Ia) (wherein R1a, R2a, and R3 to R5 are the same as defined in the description), a prodrug thereof, a pharmaceutically acceptable salt thereof, or solvate thereof. The compounds are useful in the prevention of or ... | 02/16/2010 |
| 7652141 | Pyridone derivatives having a binding activity to the cannabinoid type 2 receptor It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein R1 is a group represented by the formula: —Y1—Y2—Y | 01/26/2010 |
