Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 7893098 | Pyrrole and pyrazole DAAO inhibitors Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia or neuropathic pain, or preventing loss ... | 02/22/2011 |
| 7884124 | Fluoro-substituted inhibitors of D-amino acid oxidase This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. The invention also provides methods for the treatment and prevention of neurological disorders, such as neuro... | 02/08/2011 |
| 7816375 | Ligands for monoamine receptors and transporters, and methods of use thereof One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine tra... | 10/19/2010 |
| 7812035 | 4-substituted piperidines, and methods of use thereof One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine tra... | 10/12/2010 |
| 7790772 | Treatment of CNS disorders with 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-n... | 09/07/2010 |
| 7776858 | Methods of treatment of chronic pain using eszopiclone The invention relates to the use of eszopiclone for the treatment of low-level, chronic pain and fatigue associated with pain. ... | 08/17/2010 |
| 7732641 | Formoterol tartrate process and polymorph A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph. ... | 06/08/2010 |
| 7718822 | Carbamate Stereoisomer The compound of formula (I) is a water-stable, long acting β2-selective adrenoceptor agonist useful as a bronchodilator in the treatment of bronchoconstriction associated with reversible obstructive airways dise... | 05/18/2010 |
| 7714023 | Treatment or prophylaxis of migraine or headache disorders using citalopram, escitalopram or citalopram metabolites Methods for prophylaxis of or treating or preventing migraine or migraine headaches, or other headache disorders include administering to a subject in need of treatment a therapeutically effective amount of citalopram, escitalopram, or a racemic or optically pure ci... | 05/11/2010 |
| 7692019 | Methods for the stereoselective synthesis of substituted piperidines One aspect of the present invention relates to methods of synthesizing substituted piperidines. A second aspect of the present invention relates to stereoselective methods of synthesizing substituted piperidines. The methods of the present invention will find use in... | 04/06/2010 |
| 7671087 | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof One aspect of the present invention relates to amines. A second aspect of the present invention relates to the use of the amines as inhibitors of a mammalian anandamide transporter. The compounds of the present invention will also find use in the treatment of numero... | 03/02/2010 |
| 7615572 | Pyrrole and pyrazole DAAO inhibitors Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia or neuropathic pain, or preventing loss ... | 11/10/2009 |
| 7589237 | Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-n... | 09/15/2009 |
| 7579370 | Fused heterocycles This invention provides fused heterocycles having the formula: in which R1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylal... | 08/25/2009 |
| 7566725 | Imidazo[1,2-A] pyridine anxiolytics Imidazo[1,2-a]pyridines of the formulae I and II: are disclosed. The compounds are useful to treat anxiety and insomnia. Pharmaceutical compositions and methods are also disclosed. A representative compound of the invention... | 07/28/2009 |
| 7517892 | Ligands for monoamine receptors and transporters, and methods of use thereof One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine tra... | 04/14/2009 |
| 7488747 | Pyrrole and pyrazole DAAO inhibitors Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia or neuropathic pain, or preventing loss ... | 02/10/2009 |
| 7479572 | Formoterol tartrate process and polymorph A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph. ... | 01/20/2009 |
| 7468362 | Carbonate and carbamate modified forms of glucocorticoids in combination with βadrenergic agonists Compositions containing β2 adrenergic agonists in combination with carbonates and carbonates of the formula and in combination with related steroid carbonates and carbonates are disclosed. The compositions are u... | 12/23/2008 |
| 7465729 | Methods of treatment of menopause and perimenopause using eszopiclone The invention relates to the use of eszopiclone for the treatment of symptoms accompanying perimenopause or menopause. ... | 12/16/2008 |
| 7456173 | Compositions comprising zopiclone derivatives and methods of making and using the same The invention is directed to racemic and stereomerically pure compounds of Formula 3: and to pharmaceutical compositions comprising them, methods of their use, and methods of their preparation. ... | 11/25/2008 |
| 7446115 | Peptidomimetic ligands for cellular receptors and ion channels One aspect of the present invention relates to novel peptidomometic compounds. A second aspect of the present invention relates to the use of the novel peptidomimetic compounds as ligands—agonists or antagonists—for various cellular receptors, e.g., G-protein-co... | 11/04/2008 |
| 7423179 | Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-... | 09/09/2008 |
| 7390796 | Fatty acid modified forms of glucocorticoids Compounds are disclosed of the formula in which R3 is C8 to C24 hydrocarbon or the residue of misoprostol. The compounds are useful for treating rhinitis and asthma, particularly by inhalati... | 06/24/2008 |
| 7381724 | Optically active 5H-pyrrolo[3,4-b]pyrazine derivative, its preparation and pharmaceutical compositions containing same Dextrorotatory isomer of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine, its preparation and pharmaceutical compositions containing it which are usable as tranquillisers and hypnotics. ... | 06/03/2008 |
| 7368120 | Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol A method and composition are disclosed utilizing the pure (R,R) isomer of formoterol, which is a potent bronchodilator with reduced adverse effects, a low incidence of the development of tolerance and an increased duration of action, as compared to racemic formotero... | 05/06/2008 |
| 7361666 | Heterocyclic analgesic compounds and methods of use thereof One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-protein-couple... | 04/22/2008 |
| 7342132 | Formoterol tartrate process and polymorph A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph. ... | 03/11/2008 |
| 7294637 | Method of treating addiction or dependence using a ligand for a monamine receptor or transporter One aspect of the present invention relates to a method of treating of drug addiction or drug dependence in a mammal, comprising the step of administering to a mammal in need thereof a therapuetically effective amount of a heterocyclic compound, e.g., a 3-substitute... | 11/13/2007 |
| 7256310 | Levalbuterol salt Levalbuterol L-tartrate affords crystals possessing properties desirable for use in a metered dose inhaler. ... | 08/14/2007 |
| 7253156 | Carbonate and carbamate modified forms of glucocorticoids in combination with Badrenergic agonists Compositions containing β2 adrenergic agonists in combination with carbonates and carbamates of the formula and in combination with related steroid carbonates and carbamates are disclosed. The composi... | 08/07/2007 |
| 7217823 | 4,4-Disubstituted piperidines, and methods of use thereof One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine transporters. The compounds of th... | 05/15/2007 |
| 7214684 | Methods for the treatment of allergic rhinitis Methods are disclosed utilizing DCL, a metabolic derivative of loratadine, for the treatment of allergic rhinitis, and other disorders, while avoiding the concomitant liability of adverse side-effects associated with other non-sedating antihistamines. ... | 05/08/2007 |
| 7214683 | Compositions of descarboethoxyloratadine Methods are disclosed utilizing DCL, a metabolic derivative of loratadine, for the treatment of allergic rhinitis, and other disorders, while avoiding the concomitant liability of adverse side-effects associated with other non-sedating antihistamines. ... | 05/08/2007 |
| 7211582 | Methods for treating urticaria using descarboethoxyloratadine Methods are disclosed utilizing DCL, a metabolic derivative of loratadine, for the treatment of allergic rhinitis, and other disorders, while avoiding the concomitant liability of adverse side-effects associated with other non-sedating antihistamines. ... | 05/01/2007 |
| 7189715 | Compositions comprising zopiclone derivatives and methods of making and using the same The invention is directed to racemic and stereomerically pure compounds of Formula 3: and to pharmaceutical compositions comprising them, methods of their use, and methods of their preparation. ... | 03/13/2007 |
| 7166725 | Benzo[d]isoxazol-3-ol DAAO inhibitors Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia, or neuropathic pain, or preventing loss... | 01/23/2007 |
| 7148353 | Imidazo[1,2-a] pyridine anxiolytics Imidazo[1,2-a]pyridines of the formulae I and II: are disclosed. The compounds are useful to treat anxiety and insomnia. Pharmaceutical compositions and methods are also disclosed. A representative compound of th... | 12/12/2006 |
| 7145036 | Formoterol tartrate polymorph A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph. ... | 12/05/2006 |
| 7132551 | Ligands for monoamine receptors and transporters, and methods of use thereof One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine tra... | 11/07/2006 |
