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| Number | Title | Issue Date |
| 8148389 | Pharmaceutical comprising PPAR agonist An object of the present invention is to provide an agent for promoting proliferation of a meibomian gland epithelial cell and a corneal epithelial cell, as well as provide an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dr... | 04/03/2012 |
| 8129431 | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid An aqueous liquid preparation of the present invention containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid or its pharmacologically acceptable salt or a hydrate thereof, an alkyl aryl polyether alcohol type polymer such as tyloxapol, or a polyethylene glycol fatt... | 03/06/2012 |
| 8101654 | Percutaneously absorptive ophthalmic preparation comprising olopatadine The present invention provides a percutaneously absorptive preparation for preventing or treating allergic eye disease, which comprises olopatadine or a salt thereof as an active ingredient. In addition, the present invention provides a method for preventing or trea... | 01/24/2012 |
| 7956072 | Agent for repairing corneal sensitivity containing amide compound The amide compound of the formula (I) [each symbol is as defined in the description] has a promoting action on neuritogenesis of trigeminal nerve cells, and the compound is useful as a corneal neuritogenesis promoter, an agent for recovering corneal sensitivity by p... | 06/07/2011 |
| 7939511 | Ophthalmic composition containing xanthan gum and amino acid The present invention provides an ophthalmic composition containing xanthan gum, or xanthan gum and an amino acid, which has a superior corneal epithelial disorder-treating effect and a superior corneal epithelial cell-protecting effect. ... | 05/10/2011 |
| 7875271 | Ophthalmic composition comprising xanthan gum and glucose The present invention provides an ophthalmic composition containing xanthan gum and glucose, which has a superior corneal epithelial disorder-treating effect. ... | 01/25/2011 |
| 7850993 | Drug-releasing system of biodegradable polymer type A method for producing compression-melt molded product using polylactic acid powder is described. The method comprises the steps of: 1) heat-melting polylactic acid having a weight-average molecular weight of 3,000-40,000 at 140-220° C., 2) allowing the melted poly... | 12/14/2010 |
| 7829544 | Aqueous solution preparation containing aminoglycoside antibiotic and bromfenac Stable and clear aqueous solution preparations comprising an aminoglycoside antibiotic or a pharmacologically acceptable salt thereof and bromfenac being a nonsteroidal antiinflammatory agent or a pharmacologically acceptable salt thereof. ... | 11/09/2010 |
| 7700080 | Method of suppressing melanin production by metal chelates of lipoyl amino acid derivatives A novel α-lipoic acid derivative represented by the following formula (I). It has a tyrosinase inhibiting activity, melanin production inhibitory activity, and elastase inhibiting activity. (I) (In the formula, M represents a metal and A denotes an amino acid resid... | 04/20/2010 |
| 7696194 | Visual function disorder improving agents The present invention provides a visual function disorder improving agent containing a compound having Rho kinase inhibitory activity, particularly (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide, as an effective component. This agent has axon of... | 04/13/2010 |
| 7572833 | Drug composition comprising dipeptidyl aldehyde derivative The present invention provides a preparation containing a compound of the formula (I) wherein R1 is an alkyl group having 1 to 4 carbon atoms or an optionally substituted aryl group having 6 to 10 carbon atoms; R... | 08/11/2009 |
| 7491705 | Alpha-ketoamide derivative, and production method and use thereof The present invention provides a compound represented by the formula (I): (wherein R1 is a lower alkyl substituted by a lower alkoxy or a heterocyclic group, or a heterocyclic g... | 02/17/2009 |
| 7485654 | Corneal perception recovery drug containing amide compound The amide compound of the formula (I) [each symbol is as defined in the description] has a promoting action on neuritogenesis of trigeminal nerve cells, and the compound is useful as a corneal neuritogenesis promoter, an agent for recovering corneal sensitivity by p... | 02/03/2009 |
| 7347324 | Packaged container containing ocular perfusion/washing solution and process for producing the same The present invention provides an improved packaged container containing an ocular perfusion/washing solution, the solution being securely prevented from generating gas bubbles that impede operation when used as an ocular perfusion/washing solution in cataract surge... | 03/25/2008 |
| 7320985 | Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid A method for stabilizing an arylcarboxylic acid, which comprises adding a heterocyclic base to the arylcarboxylic acid or a pharmacologically acceptable salt thereof, a stabilizer thereof and an aqueous solution containing a stabilized arylcarboxylic acid. According... | 01/22/2008 |
| 7223755 | Hydroxymorpholinone derivative and medicinal use thereof A compound represented by the following formula (I) wherein R1 and R2 are each a lower alkyl group optionally having substituents, which has a calpain inhibitory activity, or a salt thereof ... | 05/29/2007 |
| 7202274 | Cyclic hemiacetal derivative and use thereof A compound represented by the following formula (I) wherein R1 is a lower alkyl group, R2 is a hydrogen, a halogen, a cyano group, a lower alkyl group or a lower alkoxy group, and n is 0 or ... | 04/10/2007 |
| 7109208 | Visual function disorder improving agents The present invention provides a visual function disorder improving agent containing a compound having Rho kinase inhibitory activity, particularly (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide, as an effective component. This agent has axon of... | 09/19/2006 |
| 7047708 | Method of packaging ocular irrigating solution A packaged ocular irrigating solution bag, which comprises a gas-permeable plastic multiple compartment bag and a gas-impermeable plastic packaging member for packaging the bag and in which an oxiglutatione-containing solution or solid preparation is enclosed in one... | 05/23/2006 |
| 7022738 | α-ketoamide derivative and use thereof The present invention provides a compound represented by the formula (I): wherein R1, R2 and R3 each represents a lower alkyl group. ... | 04/04/2006 |
| 6919365 | Imidazolidinedione derivatives and use thereof as drugs The present invention is to provide an imidazolidinedione derivative and oxazolidinedione derivative represented by the following general Formula (I) having the chymase and/or tryptase inhibition activity [wherein R | 07/19/2005 |
| 6828348 | L-ascorbic acid-2-o-maleic acid-a-tocopherol diester 1-propanol adduct and process for producing the same L-Ascorbic acid-2-O-maleic acid-α-tocopherol diester.1-propanol adduct or its pharmacologically acceptable salt; cosmetic components, antioxidants, radical scavengers, anti-inflammatory agents and elastase inhibitors containing the same as the active ingredient; an... | 12/07/2004 |
| 6764481 | Packaged ophthalmic perfusate and cleaning fluid bag A packaged ocular irrigating solution bag, which comprises a gas-permeable plastic multiple compartment bag and a gas-impermeable plastic packaging member for packaging the bag and in which an oxiglutatione-containing solution or solid preparation is enclosed in one... | 07/20/2004 |
| 6683070 | Aqueous suspension with good redispersibility The aqueous suspension can be prepared by incorporating, in an aqueous suspension of a hardly soluble drug, a water-soluble polymer within the concentration range from the concentration at which the surface tension of the aqueous suspension of the drug be... | 01/27/2004 |
| 6673812 | Preventives/remedies for glaucoma An agent for the prophylaxis and treatment of glaucoma, which contains a compound having a Rho kinase inhibitory activity, particularly an agent for the prophylaxis and treatment of glaucoma, which contains a compound of the formula (I) ##STR1## wher... | 01/06/2004 |
| 6649625 | Agent for prophylaxis and treatment of glaucoma An agent for the prophylaxis and treatment of glaucoma, which contains a compound having a Rho kinase inhibitory activity, particularly an agent for the prophylaxis and treatment of glaucoma, which contains a compound of the formula (I) ##STR1## wher... | 11/18/2003 |
| 6645963 | Prolonged-action eye drop Eye drops containing a ଲ-blocker such as cartelol hydrochloride are improved in the penetration of the ଲ-blocker into the eye and the retention thereof in the eye tissues by the incorporation of a C3-7 fatty acid such as sorbic acid... | 11/11/2003 |
| 6630473 | Anti-inflammatory agents and inhibitors against increase in ocular tension caused by irradiation with lasers, containing 1,4-dihydropyridine derivatives The present invention provides an anti-inflammatory medicament and an inhibitor of intraocular pressure rise due to laser irradiation, which contains 1,4-dihydropyridine derivative of the formula (I) ##STR1## wherein X1 and X2 are th... | 10/07/2003 |
| 6582932 | Calpain and DNA encoding the same A calpain protein which is specific for the retina in eye tissues containing a protein having an amino acid sequence represented by SEQ ID NO: 1 in Sequence Listing; a DNA represented by SEQ ID NO: 2 in Sequence Listing which encodes the above protein; a ... | 06/24/2003 |
| 6551999 | Angiogenesis inhibitor An angiogenesis inhibitor comprising a cysteine protease inhibitory compound. As the preferable cysteine protease inhibitory compound, epoxysuccinic acid compounds, peptide halohydrazide compounds, calpain inhibitory compounds, compounds of the formula (I... | 04/22/2003 |
| 6545058 | Ophthalmic compositions for soft contact lens, method of enhancing wettability of soft contact lens, and method of inhibiting terpenoid adsorption The present invention provides an ophthalmic composition for soft contact lenses (SCL), which contains a terpenoid as an active ingredient, an ophthalmic composition for SCL, which contains polyoxyethylene sorbitan ester, a method of enhancing the wettabi... | 04/08/2003 |
| 6479556 | Ophthalmic compositions for soft contact lens, method of enhancing wettability of soft contact lens and method of inhibiting terpenoid adsorption The present invention provides an ophthalmic composition for soft contact lenses (SCL), which contains a terpenoid as an active ingredient, an ophthalmic composition for SCL, which contains polyoxyethylene sorbitan ester, a method of enhancing the wettabi... | 11/12/2002 |
| 6451799 | Drugs for ameliorating ocular circulatory disorders An agent for ameliorating ocular circulatory disorder containing a 1,4-dihydropyridine derivative of the formula (I) ##STR1## wherein each symbol is as defined in the specification, or an acid addition salt thereof as an active ingredient. The agent for a... | 09/17/2002 |
| 6448296 | Aqueous suspension with good redispersibility The aqueous suspension can be prepared by incorporating, in an aqueous suspension of a hardly soluble drug, a water-soluble polymer within the concentration range from the concentration at which the surface tension of the aqueous suspension of the drug be... | 09/10/2002 |
| 6432893 | Method for removal of protein from contact lenses The present invention provides an agent for contact lenses, which contains an oxo-acid compound and/or a polyacid compound. The agent for contact lenses of the present invention can remove protein as, for example, a protein remover, irrespective of the ki... | 08/13/2002 |
| 6423691 | Pharmaceutical composition for prophylaxis and therapy of diseases associated with ocular fundus tissue cytography A pharmaceutical composition for the prophylaxis and therapy of a disease arising from ocular fundus tissue cytopathy such as retinochoroidal disease, glaucoma, and posterior complication arising form photocoagulation, which contains, as an active ingredi... | 07/23/2002 |
| 6387882 | Vitamin E derivatives The present invention provides novel vitamin E derivatives represented by the following formula (I) wherein: R1 and R2 are the same or different and each denotes hydrogen or methyl, R3 denotes an S-linked SH compound (glut... | 05/14/2002 |
| 6379688 | Preservative for emulsion and emulsion containing same A preservative for emulsion, comprising sorbic acid or a pharmaceutically acceptable salt thereof, and, where necessary, sodium edetate and boric acid; an emulsion comprising sorbic acid or a pharmaceutically acceptable salt thereof, and, where necessary,... | 04/30/2002 |
| 6368616 | Aqueous suspension for nasal administration of loteprednol An aqueous suspension for nasal administration which contains loteprednol etabonate and microcrystalline cellulose carmellose sodium. This aqueous suspension can be administered to nasal mucosa to treat inflammation or allergy.... | 04/09/2002 |
| 6342531 | Pharmaceutical composition containing a cysteine protease inhibitor for prophylaxis and therapy of brain tissue impairment A pharmaceutical composition for the prophylaxis and therapy of brain tissue impairment, which contains, as an active ingredient, a compound of the following formula (I) ##STR1## wherein R1 represents an alkyl group having 1-4 carbon atoms or a... | 01/29/2002 |
