Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 8137941 | Chondroitin polymerase and DNA encoding the same A chondroitin polymerase having such properties that it transfers GlcUA and GalNAc alternately to a non-reduced terminal of a sugar chain from a GlcUA donor and a GalNAc donor, respectively, and the like; and a process for producing the chondroitin polymerase. ... | 03/20/2012 |
| 8071756 | Polysaccharide pseudo-sponge A photocrosslinked polysaccharide pseudo-sponge exhibiting a low swelling property and a high degradation ability in vivo while retaining a suitable strength. The polysaccharide pseudo-sponge is produced by a crosslinking reaction of a photoreactive polysaccharide o... | 12/06/2011 |
| 8026090 | Modified chondroitin synthase polypeptide and crystal thereof Disclosed are: (A) a polypeptide consisting of the amino acid sequence of SEQ ID NO:2, or (B) a polypeptide comprising an amino acid sequence of SEQ ID NO:2 including deletion, substitution or addition of one or several amino acid residues and having chondroitin syn... | 09/27/2011 |
| 8003337 | Method for detecting lysosomal storage diseases A method for detecting lysosomal storage diseases including the steps of performing an assay for a single species of glycosaminoglycan contained in a specimen and correlating results of the assay with lysosomal storage diseases. A body fluid such as urine or blood c... | 08/23/2011 |
| 7951936 | Crosslinked polysaccharide sponge A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtain... | 05/31/2011 |
| 7951545 | Method for detecting lysosomal storage diseases A method for detecting lysosomal storage diseases including the steps of performing an assay for a single species of glycosaminoglycan contained in a specimen and correlating results of the assay with lysosomal storage diseases. A body fluid such as urine or blood c... | 05/31/2011 |
| 7939065 | Chondroitin sulfate synthesis promoter The invention provides a chondroitin sulfate synthesis promoter useful for the treatment of diseases such as articular disease and discopathy. The chondroitin sulfate synthesis promoter contains, as an active ingredient, chondroitin sulfate glucuronyltransferase pro... | 05/10/2011 |
| 7927837 | Modified chondroitin synthase polypeptide and crystal thereof Disclosed are: (A) a polypeptide consisting of the amino acid sequence of SEQ ID NO:2, or (B) a polypeptide comprising an amino acid sequence of SEQ ID NO:2 including deletion, substitution or addition of one or several amino acid residues and having chondroitin syn... | 04/19/2011 |
| 7915041 | Hybridoma capable of producing anti-dectin-1 monoclonal antibody A hybridoma capable of producing a monoclonal antibody against dectin-1, and a monoclonal antibody which specifically reacts with dectin-1. ... | 03/29/2011 |
| 7893225 | Crosslinked polysaccharide sponge A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtain... | 02/22/2011 |
| 7879817 | Hyaluronic acid derivative and drug containing the same A hyaluronic acid derivative in which an anti-inflammatory drug is bound to hyaluronic acid through a covalent bond via a spacer having a biodegradable region, and a production process thereof. ... | 02/01/2011 |
| 7867733 | Method for producing factor G derived from horseshoe crab The invention provides a virus harboring a DNA encoding a subunit of limulus-derived factor G, the virus being capable of mass-producing a (1→3)-β-D-glucan assay reagent of satisfactory quality, steadily and at low cost, a cell harboring the virus, and a m... | 01/11/2011 |
| 7867722 | Pretreatment agent for test A pretreatment agent for a sample to be subjected to Limulus assay comprising an alkali metal sulfate and/or an alkaline earth metal sulfate wherein the sulfate(s) has a final concentration of 20 mM or more when the sulfate(s) is allowed to contact with the s... | 01/11/2011 |
| 7851179 | Method of measuring lipoarabinomannan and application thereof A method for measuring LAM and a method for detecting an acid-fast bacterium, which comprise at least a step of allowing a Limulus reagent to contact with a LAM-containing sample, a method for removing reactivity of LAM with a Limulus reagent, which co... | 12/14/2010 |
| 7790773 | Carba-sugar amine derivative and glycolipid metabolic disorder treating agent containing the same as active ingredient A carba-sugar amine derivative represented by the following formula (1) or (2) is used as the active ingredient of a β-galactosidase inhibitor or a glycolipid metabolic disorder treating agent. Wherein each of R1 ... | 09/07/2010 |
| 7790447 | Vector expressing n-deacetylase/n-sulfotransferase 2 An object of the present invention is to provide an expression vector that allows for stable production of N-deacetylase/N-sulfotransferase 2 in large amounts and a process for production of N-deacetylase/N-sulfotransferase 2 using the same. The present invention pr... | 09/07/2010 |
| 7723092 | Chondroitin polymerase and DNA encoding the same A chondroitin polymerase having such properties that it transfers GlcUA and GalNAc alternately to a non-reduced terminal of a sugar chain from a GlcUA donor and a GalNAc donor, respectively, and the like; and a process for producing the chondroitin polymerase. ... | 05/25/2010 |
| 7700747 | Crosslinked polysaccharide sponge A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtain... | 04/20/2010 |
| 7687609 | Galectin-glycosaminoglycan complex and method for controlling galectin activity A complex consisting of galectin-3 and chondroitin oligosaccharide and methods for seperating and detecting the chondroitin oligosaccharide in a sample using the immobilized complex. ... | 03/30/2010 |
| 7678884 | Biologically active peptide and agent containing the same A peptide having any one of the amino acid sequences of SEQ ID NO: 1 or 13, preferably a peptide having any one of the amino acid sequences of SEQ ID NOS: 2 to 9 or a peptide having any one of the amino acid sequences of SEQ ID NOS: 10 and 15 to 17, is used as an ac... | 03/16/2010 |
| 7601488 | Hyaluronic acid oligosaccharide fractions and drugs containing the same A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administe... | 10/13/2009 |
| 7598068 | Chondroitin polymerase and DNA encoding the same A chondroitin polymerase having such properties that it transfers GlcUA and GalNAc alternately to a non-reduced terminal of a sugar chain from a GlcUA donor and a GalNAc donor, respectively, and the like; and a process for producing the chondroitin polymerase. ... | 10/06/2009 |
| 7541162 | Method for producing factor G derived from horseshoe crab The invention provides a virus harboring a DNA encoding a subunit of limulus-derived factor G, the virus being capable of mass-producing a (1→3)-β-D-glucan assay reagent of satisfactory quality, steadily and at low cost, a cell harboring the virus, and a method o... | 06/02/2009 |
| 7507723 | Hyaluronic acid oligosaccharide fractions and drugs containing the same Hyaluronic acid oligosaccharides having a size selected from sizes of 4 to 60 saccharides, fractions containing the hyaluronic acid oligosaccharides and having particular physicochemical properties, and drugs containing the same. The hyaluronic acid oligosaccharides... | 03/24/2009 |
| 7485755 | Acid addition salt of carbasugar amine derivative An acid addition salt of a carba-sugar amine derivative represented by the following formula (1): wherein R1 and R2 each independently represents a hydrogen atom, or an alkyl group, an alkenyl group, a... | 02/03/2009 |
| 7468265 | Stabilizing agent for enzymes The present invention provides a safe and novel stabilizing agent for enzymes; a composition containing an enzyme and the stabilizing agent; and a kit containing the stabilizing agent composition. According to the invention, deactivation or inactivation of the activ... | 12/23/2008 |
| 7452856 | Antibacterial peptide The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or an endotoxin-shock suppressant, each containing the peptide as an acti... | 11/18/2008 |
| 7365059 | Photocrosslinked-polysaccharide composition and production process of the same A process for producing a photocrosslinked-polysaccharide composition, which comprises: freezing a photoreactive polysaccharide-containing solution comprising a photoreactive polysaccharide in which a photoreactive group is bound to a polysaccharide, an aqueous solv... | 04/29/2008 |
| 7150981 | Sulfate transferase and DNA encoding this enzyme A glycosaminoglycan 6-O-sulfotransferase having an activity of transferring sulfate to a hydroxyl at position 6 of a glycosamine residue of a glycosaminoglycan, which has a ratio of relative activities to substrates satisfying completely desulfated N-acetylated (CDS... | 12/19/2006 |
| 7060483 | DNA encoding endo-β-galactosidase A full-length cDNA is obtained by analyzing the partial amino acid sequence of purified endo-β-galactosidase C, constructing primers based thereon, effecting PCR with the use of the genomic DNA of Clostridium perfringens as a template to thereby obtain a fra... | 06/13/2006 |
| 7052882 | Glucan derived from A glucan extracted by oxidation treatment of microorganism cells belonging to the genus Aspergillus under alkaline conditions; a glucan obtained by dissolving an aqueous solvent-insoluble fraction of the glucan in an aprotic polar solvent; a glucan obtained b... | 05/30/2006 |
| 7008626 | Medical composition for protuberance of epithelium A medical composition for protuberance of epithelium, which comprises a solution comprising a polysaccharide or a medically acceptable salt thereof, wherein the solution has a viscosity of: (1) from 50 to 500 mPa·s at a shear rate of from 7.7 to 10.0 s−1 | 03/07/2006 |
| 6903223 | Phenyldiazirine compounds and photoaffinity labeling reagent This invention offers a photoreactive labeling reagent consisting of a novel biotinylated phenyldiazirine compound; a photoaffinity labeling reagent consisting of a saccharide-linked biotinylated phenyldiazirine compound where a saccharide compound is introduced int... | 06/07/2005 |
| 6783966 | Alpha1, 4-galactosyltransferase and DNA encoding thereof The object of the present invention is to provide α1,4-galactosyltransferase to transfer a galactose residue to C4 position of galactose residue of lactosylceramide or galactosylceramide, and DNA coding for the enzyme. What is provided includes the following... | 08/31/2004 |
| 6602859 | Photocurable hyaluronic acid derivative and process for producing the same, and photocured crosslinked-hyaluronic acid derivative and medical material using the same A photocurable hyaluronic acid derivative of the present invention comprises hyaluronic acid and a photoreactive crosslinking group bonded thereto, wherein a 1.0 wt. % aqueous solution of the photocurable hyaluronic acid derivative obtained by dissolving ... | 08/05/2003 |
| 6562954 | Method for producing oligosaccharide, and novel oligosaccharide and pharmaceutical composition containing the same Oligosaccharides including those usable as anti-inflammatory agent or anti-allergy agent, represented by the following general formula (3): ##STR1## wherein R10 and R11 each independently represent a hydrogen atom or --SO3... | 05/13/2003 |
| 6548487 | Agent for treatment of bladder troubles A method for promoting vesical mucosa epithelium dilatation and/or healing vesical mucosa of a patient's bladder, comprising: administering to the inside of the patient's bladder a solution comprising hyaluronic acid and/or a pharmaceutically acceptable s... | 04/15/2003 |
| 6537977 | Anti-inflammatory agent A pharmaceutical composition, which contains glycosaminoglycan having at least one sulfate group or a pharmaceutically acceptable salt thereof, and an immunosuppressant.... | 03/25/2003 |
| 6498246 | Glycosaminoglycan derivatives and processes for preparing same The invention provides novel glycosaminoglycan derivatives having a repeating unit structure of two saccharides of hexosamine and hexuronic acid as a backbone structure, in which the bonds between 2- and 3-positions carbon atoms of hexuronic acid as its c... | 12/24/2002 |
| 6492503 | Glycosaminoglycan and drug compositions containing the same There is provided a glycosaminoglycan having a backbone structure comprising a repetitive disaccharide bearing a uronic acid residue and a glucosamine residue, and having sulfate groups, wherein substantially no sulfate group bound to the hydroxyl group a... | 12/10/2002 |
