Assignee: Seattle Genetics, Inc.

Location: Bothell, WA
No. of patents: 30

Number	Title	Issue Date
8163551	Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation. ...	04/24/2012
8067546	Humanized anti-CD70 binding agents and uses thereof Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragmen...	11/29/2011
8039273	β-glucuronide-linker drug conjugates Ligand Drug conjugate compounds comprising a β-glucuronide-based linker and methods of using such compounds are provided. ...	10/18/2011
7994135	Monomethylvaline compounds capable of conjugation to ligands Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro an...	08/09/2011
7989434	Heterocyclic self-immolative linkers and conjugates The present invention provides heterocyclic linker compounds useful for linking drug moieties to ligands. The compounds also include drug-ligand conjugates comprising a ligand capable of targeting a selected cell population, and a drug connected to the ligand by a h...	08/02/2011
7968687	CD19 binding agents and uses thereof This invention relates to CD 19 binding agents and methods of using such CD 19 binding agents for treating disease. ...	06/28/2011
7964567	Monomethylvaline compounds capable of conjugation to ligands Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro an...	06/21/2011
7964566	Monomethylvaline compounds capable of conjugation to ligands Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro an...	06/21/2011
7837980	Partially loaded antibodies and methods of their conjugation A protein containing one or more activatable groups, e.g., an antibody, is subjected to partial or complete reduction of one or more such bonds to form reactive groups; the resulting protein is reacted with a drug which is reactive with some of the reactive groups, ...	11/23/2010
7824683	Methods for augmenting an immune response using anti-CD40 antibodies The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiate...	11/02/2010
7754681	Heterocyclic self-immolative linkers and conjugates The present invention provides heterocyclic linker compounds useful for linking drug moieties to ligands. The compounds also include drug-ligand conjugates comprising a ligand capable of targeting a selected cell population, and a drug connected to the ligand by a h...	07/13/2010
7750116	Antibody drug conjugate metabolites Methods of treating a refractory or drug resistant cancer, cell proliferative disorder and tumor cells are provided. Also provided are antibody drug conjugate metabolites. ...	07/06/2010
7745394	Monomethylvaline compounds capable of conjugation to ligands Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro an...	06/29/2010
7695716	Methods of treating neoplastic, autoimmune and inflammatory diseases Methods of treating cancer and autoimmune and inflammatory diseases are provided. ...	04/13/2010
7666422	Methods for the treatment of cancer using anti-CD40 antibodies The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiate...	02/23/2010
7659241	Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease Compounds and compositions are disclosed in which a Drug unit (D) is linked to a Ligand unit (L). In an exemplary embodiment, the compound is of the formula LAa-Ww-Yy-D)p Ia or a pharmaceutically acceptable sa...	02/09/2010
7641903	Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunomodulatory without conjugation to a therapeutic agents as well as pharmaceutical compositions and kits comprising the antibody or derivative...	01/05/2010
7553816	-amidobenzylethers in drug delivery agents Compounds of the formulas LAn-Z-X—WwD and BZ-X—WwD wherein: D is a drug moiety; L is a ligand; B is a blocking group; A is an optional acyl unit; Z is an amino acid or a peptide; X is an aminobenzyl ether self...	06/30/2009
7510711	Methods for the treatment of cancer using anti-CD40 antibodies The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiate...	03/31/2009
7498298	Monomethylvaline compounds capable of conjugation to ligands Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro an...	03/03/2009
7491390	Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunosuppressive without conjugation to a therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody or derivati...	02/17/2009
7423116	Pentapeptide compounds and uses related thereto Pentapeptide compounds are disclosed. The compounds have biological activity, e.g., cytotoxicity. Prodrugs having targeting groups and pentapeptide moieties, as well as precursors thereof are also disclosed. For example, precursors having a reactive linker that can ...	09/09/2008
7256257	Pentapeptide compounds and uses related thereto Pentapeptide compounds are disclosed. The compounds have biological activity, e.g., cytotoxicity. Prodrugs having targeting groups and pentapeptide moieities, as well as precursors thereof are also disclosed. For example, precursors having a reactive linker that can...	08/14/2007
7098308	Pentapeptide compounds and uses related thereto Pentapeptide compounds are disclosed. The compounds have biological activity, e.g., cytotoxicity. Prodrugs having targeting groups and pentapeptide moieities, as well as precursors thereof are also disclosed. For example, precursors having a reactive linker that can...	08/29/2006
7091186	-Amidobenzylethers in drug delivery agents Compounds of the formulae LAn-Z-X—WwD and BZ-X—WwD wherein: D is a drug moiety; L is a ligand; B is a blocking group; A is an optional acyl unit; Z is an amino acid ...	08/15/2006
7090843	Recombinant anti-CD30 antibodies and uses thereof The present invention relates to methods and compositions for the treatment of Hodgkin's Disease, comprising administering proteins characterized by their ability to bind to CD30, or compete with monoclonal antibodies AC10 or HeFi-1 for binding to CD30, and exert a ...	08/15/2006
6946129	Recombinant anti-CD40 antibody and uses thereof The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiate...	09/20/2005
6884869	Pentapeptide compounds and uses related thereto Pentapeptide compounds are disclosed. The compounds have biological activity, e.g., cytotoxicity. Prodrugs having targeting groups and pentapeptide moieities, as well as precursors thereof are also disclosed. For example, precursors having a reactive linker that can...	04/26/2005
6843989	Methods for the treatment and prevention of cancer using anti-CD40 antibodies The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiate...	01/18/2005
6838261	Nucleic acids encoding anti-CD40 proteins and methods of producing recombinant anti-CD40 proteins The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiate...	01/04/2005

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Assignee: Seattle Genetics, Inc.