Assignee: Scios, Inc.

Location: Fremont, CA
No. of patents: 24

Number	Title	Issue Date
7488744	Indole-type derivatives as inhibitors of p38 kinase The invention is directed to methods to inhibit p38-α kinase using compounds comprising a phenyl or thienyl coupled through a piperidine or piperazine nucleus to an indole residue wherein the indole residue mandatorily has a substituent on the ring nitrogen which i...	02/10/2009
7268139	Methods of promoting osteogenesis The invention is directed to methods of bone healing by administering a p38 MAP kinase inhibitor. The invention is directed to methods of treating bone fractures, bone diseases, bone grafting, especially enhancing bone healing following facial reconstruction, maxill...	09/11/2007
7244441	Stents and intra-luminal prostheses containing map kinase inhibitors A coated stent or intra-luminal prosthesis containing a MAP kinase inhibitor controls, reduces, or prevents restenosis, inflammation, and complications associated with stent or intra-luminal prosthesis implantation and/or cardiovascular disease. ...	07/17/2007
7223766	Bi-cyclic pyrimidine inhibitors of TGFβ Compounds in which a pyrimidine nucleus is bridged at the 5 and 6 position and are further substituted at positions 2 and 4 with substituents comprising aromatic moieties are useful in treating subjects with rheumatoid arthritis ameliorated by inhibition of TGFβ ac...	05/29/2007
7202344	Secreted factors The invention concerns new secreted factors encoded by clones P00184_D11 (SEQ ID NO: 1), P00185_D11 (SEQ ID NO: 3), P00188_D12 (SEQ ID NO: 5), P00188_E01 (SEQ ID NO: 7), P00194_G01 (SEQ ID NO: 9), P00194_G05 (SEQ ID NO: 11), P00194_H10 (SEQ ID NO: 13), P00199_D08 (S...	04/10/2007
7189739	Compounds and methods to treat cardiac failure and other disorders The invention is directed to compounds of the formula and the pharmaceutically acceptable salts thereof wherein Ar1 is indole, benzimidazole, or benzotriazole, optionally substituted with ...	03/13/2007
7189726	Benzofuran derivatives as inhibitors of p38-α kinase The invention is directed to methods to inhibit p38-α kinase using compounds which contain an aromatic residue coupled to an benzofuran moiety through a piperidine. ...	03/13/2007
7186526	Recombinant fibroblast growth factor analogs The DNA sequences encoding analogs of human acidic and basic fibroblast growth factors (FGF) can be recombinantly expressed to obtain practical amounts of proteins useful in effecting both pathologies related to persistent angiogenesis and wound healing and related ...	03/06/2007
7183070	Inhibition of Aβ production by β-secretase BACE2 The present invention is based on the findings that BACE2, a homolog of β-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of Aβ. Accordingly, the present invention provides methods and means for ...	02/27/2007
7179790	Brain natriuretic peptide Peptides comprising the effective portion of human brain natriuretic peptide are provided in pharmaceutical compositions and methods to effect vasodilation and/or natriuresis. ...	02/20/2007
7033812	β-secretase and modulation of β-secretase activity The invention concerns a novel β-secretase, a method of partially purifying this novel β-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel β-secretase has an estimated m...	04/25/2006
7030083	Treatment of eclampsia and preeclampsia The invention concerns the prevention and treatment of endothelial injury and the injury of tissues containing injured blood vessels by administration of angiogenic factors, such as vascular endothelial cell growth factor (VEGF). ...	04/18/2006
7018799	Methods for identifying inhibitors of neuronal degeneration Disclosed herein are methods for identifying inhibitors of neuronal degeneration, and their use in the treatment of neurodegenerative disorders. In particular methods methods are disclosed for identifying inhibitors of neuronal degeneration or cell death by taking a...	03/28/2006
6903096	Quinazoline derivatives as medicaments The invention is directed to methods to inhibit TGF-β and/or p38-α kinase using compounds of the formula or the pharmaceutically acceptable salts thereof wherein R3 is a ...	06/07/2005
6897030	Immunoassays for human brain natriuretic peptide Immunoassays and antibodies useful in conducting them for human and canine brain natriuretic peptide are described. ...	05/24/2005
6890938	Indole-type inhibitors of p38 kinase Compound with an indole linked through an aliphatic ring system to an aromatic moiety are useful in treating conditions associated with enhanced P38α kinase activity. ...	05/10/2005
6887848	Vascular endothelial growth factor variants The invention is directed to a method of enhancing the biological activity of vascular endothelial growth factors (VEGF). The invention further concerns certain VEGF variants having enhanced biological activity, methods and means for preparing these variants, and ph...	05/03/2005
6867209	Indole-type derivatives as inhibitors of p38 kinase The invention is directed to methods to inhibit p38-α kinase using compounds of the formula and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wherein	03/15/2005
6864260	Indole-type derivatives as inhibitors of p38 kinase The invention is directed to methods to inhibit p38-α kinase using compounds which contain a phenyl group linked through a piperazine ring to a substituted indole. ...	03/08/2005
6828303	Prolonged delivery of peptides There are disclosed methods for the treatment of non-insulin dependent diabetes mellitus in a mammal comprising the prolonged administration of GLP-1 (7-37), and related peptides. Also disclosed are compositions to prolong the administration of the peptides. ...	12/07/2004
6821966	Inhibitors of p38 kinase The invention is directed to methods to inhibit p38-α kinase using compounds of the formula and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wherein	11/23/2004
6713276	Modulation of Aβ levels by β-secretase BACE2 The present invention is based on the findings that BACE 2, a homolog of β-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of Aβ. Accordingly, the present invention provides methods and means for...	03/30/2004
6709855	Methods for detection and use of differentially expressed genes in disease states The present invention relates to methods and compositions for the detection, diagnosis, prevention and treatment of a disease, specifically cardiac, kidney or inflammatory disease, and related disorders. The present invention also relates to compositions and methods...	03/23/2004
6696443	Piperidine/piperazine-type inhibitors of p38 kinase Certain compounds which contain a piperidine moiety flanked by aryl groups are inhibitors of p38-଱ kinase and thus useful in the treatment of a variety of conditions characterized by inappropriate p38-଱ kinase activity....	02/24/2004

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Assignee: Scios, Inc.