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| Number | Title | Issue Date |
| 6376648 | Protease inhibitor peptides Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to and inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compo... | 04/23/2002 |
| 6235884 | Heparin binding mitogen with homology to epidermal growth factor (EGF) Disclosed are heparin binding mitogens which include an epidermal growth factor-homologous segment (HB-EHM). These factors stimulate proliferation of fibroblast cells, epithelial cells, and smooth muscle cells, but not endothelial cells. Also disclosed ar... | 05/22/2001 |
| 5811393 | Heparin binding mitogen with homology to epidermal growth factor (EGF) Disclosed are heparin binding mitogens which include an epidermal growth factor-homologous segment (HB-EHM). These factors stimulate proliferation of fibroblast cells, epithelial cells, and smooth muscle cells, but not endothelial cells. Also disclosed ar... | 09/22/1998 |
| 5646254 | Antibodies for human phospholipase inhibitory protein (hPIP) Antibodies which react with the human phospholipase inhibitory protein/apolipoprotein AIV complex and hPIP are provided.... | 07/08/1997 |
| 5552383 | Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins Pseudopeptide compounds based on a modified bradykinin sequence are potent bradykinin receptor antagonists. All or a portion of the amino acids at postions 2 through 5 of the bradykinin sequence are replaced by 2-pyrrolidinyl and/or amino-alkanoic acid or... | 09/03/1996 |
| 5543496 | Cyclic bradykinin antagonist peptides Cyclic compounds based on a modified bradykinin sequence are potent bradykinin receptor antagonists. Amino acid substitutions are made at postions 2 and 5 or 6 to facilitate the cyclization of the peptide through covalent bonding of the amino acid side ch... | 08/06/1996 |
| 5541286 | Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids Pseudopeptide compounds based on a modified bradykinin sequence are potent bradykinin receptor antagonists. Amino acids at at positions 2 through 5 are replaced by olefinic aminoalkenoyl groups to reduce the peptide nature of the compounds. The analogs pr... | 07/30/1996 |
| 5530157 | Anti-inflammatory benzoic acid derivatives Novel benzoic acid derivatives have the formula: ##STR1## wherein --X-- represents C1 to C6 alkylene, C2 to C6 alkenylene or a divalent moiety having the structure --(CH2)m --Z-- in wh... | 06/25/1996 |
| 5521158 | Pseudopeptide bradykinin receptor antagonists The invention relates to peptides of up to 10 amino acids that are synthesized by substituting at least one of the bradykinin amino acids found in positions 2, 3, 4 and 5 of the bradykinin peptide with a fatty acid amine. The modified bradykinin peptides ... | 05/28/1996 |
| 5519043 | Fluorenyl derivatives The compound having the formula: ##STR1## and a method of treating an inflammatory condition comprising administering to an animal in need of such treatment an effective amount of at least one compound represented by the formula.... | 05/21/1996 |
| 5512455 | Atrial natriuretic peptide receptor protein Purified native Atrial Naturetic Peptide (ANP) receptor protein is provided, as well as synthetic ANP receptor and methods of making and using ANP receptor protein and antibodies.... | 04/30/1996 |
| 5472973 | Fluorenyl derivatives as anti-inflammatory agents The compound having the formula: ##STR1## and a method of treating an inflammatory condition comprising administering to an animal in need of such treatment an effective amount of at least one compound represented by the formula.... | 12/05/1995 |
| 5449662 | Atrial natriuretic peptide clearance inhibitors which resist degradation Compounds with natriuretic, diuretic and/or vasodilation activity which enhance the function of an endogenous ANP are provided. These compounds are capable of both binding to the clearance receptors for ANP and of inhibition of endopeptidase 24.11, an enz... | 09/12/1995 |
| 5446020 | Method of treating diabetes with tissue-selective insulin analogs Human insulin analogs are disclosed. These analogs are tissue-selective. Accordingly, pharmaceutical formulations containing the analogs of the invention provide superior clinical benefits as compared to human insulin when used in the treatment of patient... | 08/29/1995 |
| 5444048 | Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids Pseudopeptide compounds based on a modified bradykinin sequence are potent bradykinin receptor antagonists. Amino acids at postions 2 through 5 are replaced by olefinic aminoalkenoyl groups to reduce the peptidic nature of the compounds. The analogs produ... | 08/22/1995 |
| 5439818 | DNA encoding human recombinant basic fibroblast growth factor Disclosed herein are the DNA sequences encoding human and bovine acidic and basic fibroblast growth factors (FGF). Expression of these sequences results in practical amounts of proteins useful in effecting wound healing.... | 08/08/1995 |
| 5430020 | Recombinant alveolar surfactant protein The complete coding sequences and amino acid sequences for both canine and human 32K alveolar surfactant proteins (ASP) are disclosed; clones encoding variants of the SP-18 and SP-5 forms of human protein are disclosed. Methods and vectors for obtaining t... | 07/04/1995 |
| 5403915 | Isolation and purification of lung surfactant protein Methods are provided for the isolation and purification of recombinant lung surfactant protein. The methods involve a multistep procedure including extraction with a C1 -C4 aliphatic alcohol and chromatographic purification steps whi... | 04/04/1995 |
| 5387746 | Pulmonary hydrophobic surfactant-associated protein of 6,000 daltons molecular weight and multimers thereof A novel hydrophobic surfactant-associated protein mixture, i.e., a SAP-6 proteins, has been isolated from pulmonary animal tissue. A small, novel pulmonary hydrophobic surfactant-associated SAP-6-Val protein having a molecular weight of about 6,000 dalton... | 02/07/1995 |
| 5387742 | Transgenic mice displaying the amyloid-forming pathology of alzheimer's disease Cloned recombinant or synthetic DNA sequences related to the pathology of Alzheimer's disease are injected into fertilized mouse eggs. The injected eggs are implanted in pseudo pregnant females and are grown to term to provide transgenic mice whose cells ... | 02/07/1995 |
| 5385840 | DNA encoding analogs of human alveolar surfactant protein SP-5 Various specific human SP-18 and human SP-5 derived peptides have alveolar surfactant protein (ASP) activity. These peptides are prepared using synthetic methods or by recombinant techniques.... | 01/31/1995 |
| 5385889 | Bradykinin antagonist peptides The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with a D-configuration hydroxyproline ether or thioether converts bradykinin agonists into bradykinin antagonists. The invention f... | 01/31/1995 |
| 5342764 | Recombinant expression system for human anti-inflammatory phospholipase inhibitor protein Cloning and expression of the gene encoding human phospholipase inhibitory protein (hPIP) permits production of an anti-inflammatory protein in practical quantities using recombinant techniques.... | 08/30/1994 |
| 5331095 | Process for purification of basic fibroblast growth factor The invention relates to a method of purifying basic fibroblast growth factor. The method involves the use of strong cation exchange chromatography followed by hydrophobic interaction chromatography and then by weak cation exchange chromatography.... | 07/19/1994 |
| 5322930 | Expression of recombinant polypeptides with improved purification An improved method for expressing peptides as fusion proteins, uses a carrier for a heterologous peptide to provide a fusion protein having a high pI. The high isoelectric point facilitates separation of the fusion protein from all other host cell protein... | 06/21/1994 |
| 5264550 | Human anti-inflammatory phospholipase inhibitor protein Cloning and expression of the gene encoding human phosphlipase inhibitory protein (hPIP) permits production of an anti-inflammatory protein in practical quantities using recombinant techniques.... | 11/23/1993 |
| 5258496 | Isolation and purification of lung surfactant protein Methods are provided for the isolation and purification of recombinant lung surfactant protein. The methods involve a multistep procedure including extraction with a C1 -C4 aliphatic alcohol and chromatographic purification steps whi... | 11/02/1993 |
| 5258368 | Atrial natriuretic/vasodilator peptide compounds Methods, compounds and compositions are provided for inducing natriuresis, diuresis and vasodilatation in mammalian hosts by administering atrial natriuretic/vasodilator peptides to said host. Also provided are methods for producing such peptide compounds... | 11/02/1993 |
| 5256814 | Excitatory amino acid antagonists An unexpectedly more potent isomer of 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid, a known excitatory amino acid antagonist, pharmaceutical compositions including this isomer and methods of using this isomer to antagonize excitatory amino acid ... | 10/26/1993 |
| 5250537 | 5,6,7,8,9,10-hexahydro-7 ,10-iminocyclohept[b]indole,-6,7,8,9,10-hexahydro-7,11-imino-5H-cyclooct[ b]indole and substituted derivatives 5,6,7,8,9,10-Hexahydro-7,10-iminocyclohept[b]indole, 6,7,8,9,10,11-hexahydro-7,11-imino-5H-cyclooct[b]indole and substituted derivatives are effective in the treatment of psychoses with limited liability to produce concomitant adverse extrapyramidal sympt... | 10/05/1993 |
| 5223482 | Recombinant Alzheimer's protease inhibitory amyloid protein and method of use DNA sequences encoding ଲ-amyloid-related proteins associated with Alzheimer's disease are disclosed. Also provided herein is a DNA sequence encoding a novel protease inhibitor. These sequences are used in producing or constructing recombinant ³... | 06/29/1993 |
| 5221607 | Assays and reagents for amyloid deposition The present invention provides an in vitro tissue culture-based assay for amyloid deposition specific for Alzheimer's disease which is suitable for routine drug screening analysis. Immunological diagnostic reagents for Alzheimer's disease are also provide... | 06/22/1993 |
| 5219739 | DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121 Isolated DNA sequences, expression vectors and transformant cells are provided which allow for the large scale production of vascular endothelial cell growth factor. The vascular endothelial cell growth factor is useful in the treatment of wounds in which... | 06/15/1993 |
| 5220013 | DNA sequence useful for the detection of Alzheimer's disease DNA sequences encoding the beta-amyloid core protein, and beta-amyloid-related proteins associated with Alzheimer's disease are disclosed. These sequences are used in producing or constructing recombinant beta-amyloid core protein, beta-amyloid-related pr... | 06/15/1993 |
| 5217954 | Formulations for stabilizing fibroblast growth factor Pharmaceutical formulations and a method for their preparation are provided. These formulations provide a stabilized basic fibroblast growth factor (bFGF) which is less susceptible to oxidation or metal-induced aggregation by including an amount of a chel... | 06/08/1993 |
| 5212286 | Atrial Natriuretic/vasodilator peptide compounds Methods, compounds and compositions are provided for inducing natriuresis, diuresis and vasodilatation in mammalian hosts by administering atrial natriuretic/vasodilator peptides to said host. Also provided are methods for producing such peptide compounds... | 05/18/1993 |
| 5202239 | Expression of recombinant polypeptides with improved purification An improved method for expressing peptides as fusion proteins, uses a carrier for a heterologous peptide to provide a fusion protein having a high pI. The high isoelectric point facilitates separation of the fusion protein from all other host cell protein... | 04/13/1993 |
| 5187153 | Methods of treatment using Alzheimer's amyloid polypeptide derivatives Pharmaceutical compositions containing a 57 amino acid protease inhibitor and uses for those compositions are taught. The protease inhibitor is referred to as A4i which is associated with Alzheimer's disease. In addition to the A4i protease, other analogs... | 02/16/1993 |
