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Assignee: Schering-Plough Corporation


Location: Kenilworth, NJ
No. of patents: 15

NumberTitleIssue Date
7816118Methods for the in vitro culture of sp. and uses thereof
The invention relates to a method of excysting and growing protozoal oocysts by in vitro tissue culture resulting in production of a continuous culture of merozoites. The invention also provides an economical and reliable supply of cultured Eimeria sp. for va...
10/19/2010
7803828Functionally selective alpha2C adrenoreceptor agonists
In its many embodiments, the present invention provides a novel class of indolines as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharma...
09/28/2010
7652003Macrocyclic β-secretase inhibitors
Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, n and X are as defined in the sp...
01/26/2010
7250286Methods for the in vitro culture of sp. and uses thereof
The invention relates to a method of excysting and growing protozoal oocysts by in vitro tissue culture resulting in production of a continuous culture of merozoites. The invention also provides an economical and reliable supply of cultured Eimeria sp. for va...
07/31/2007
6667319Neuropeptide Y Y5 receptor antagonists
The present invention discloses compounds which, are novel receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagoni...
12/23/2003
6505126Method to identify fungal genes useful as antifungal targets
The invention provides methods for identifying nucleic acids and polypeptides derived from fungi that are useful as antifungal targets for diagnosis and/or treatment of fungal diseases. The invention also provides isolated fungal-specific nucleic acids an...
01/07/2003
59394192-benzyl-polycyclic guanine derivatives and process for preparing them
Antihypertensive and bronchodilating compounds of the formula or a pharmaceutically acceptable salt thereof, and a process for preparing them are disclosed, wherein: R1, R2, R3, Ra, Rb and Rc as...
08/17/1999
5874442Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
"Novel compounds, such as: ##STR1## are disclosed. Also disclosed are methods for inhibiting the abnormal growth of cells, for inhibiting farnesyl protein transferase and for treating cancers using the novel compounds."...
02/23/1999
5767115Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar1 and Ar2 are aryl or R4 -substituted aryl; Ar3 is aryl or R5
06/16/1998
5691362Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists
Compounds represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein the variables are as defined in the specification; methods of treating asthma, cough, bronchospasm, inflammatory diseases, and gastrointes...
11/25/1997
5686646Chiral hydrazine derivatives
Disclosed are chiral hydrazine derivatives of the formula (Ia), (Ib), (Ic) and (Id) ##STR1## wherein: R1 and R2 are independently C1 -C10 alkyl; R3 is H or R4 wherein R4 is a hyd...
11/11/1997
5382427Use of IL-4 to treat solid tumors
A method of using IL-4, the use of IL-4 for the manufacture of a medicament and pharmaceutical compositions containing IL-4, for treating solid tumor growth by systemically injecting IL-4, such as hIL-4 or recombinant E. coli--derived IL-4, into mammals a...
01/17/1995
4676650Inspection device
A method and apparatus for lighting a container which is to be inspected for particulate contamination comprising a first lighting means consisting of two angularly displaced light beams which create an angular shadow zone, a second lighting means of sign...
06/30/1987
4672078Urea stabilized with a lactone in various pharmaceutical and cosmetic preparations
A pharmaceutical preparation containing 1 to 50% urea and 0.05 to 30% of a lactone is disclosed. A preferred lactone is gamma-butyrolactone which is preferably present in an amount of about 0.05 to 0.1 part by weight per 1 part by weight of urea. The lact...
06/09/1987
4011390Semi-synthetic aminocyclitol aminoglycoside antibiotics and methods for the preparation thereof
Micromonospora inyoensis strain 1550F-1G NRRL 5742 is incapable of producing antibiotics unless an aminocyclitol is added to the fermentation medium. When such a compound is added, mutamicins are produced, said mutamicins being analogs of known aminoglyco...
03/08/1977
 
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