"What, sir, would you make a ship sail against the wind and currents by lighting a bonfire under her deck? I pray you, excuse me, I have not the time to listen to such nonsense."
Napoleon Bonaparte ; When told of the Robert Fulton steamboat
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| Number | Title | Issue Date |
| 7816118 | Methods for the in vitro culture of sp. and uses thereof The invention relates to a method of excysting and growing protozoal oocysts by in vitro tissue culture resulting in production of a continuous culture of merozoites. The invention also provides an economical and reliable supply of cultured Eimeria sp. for va... | 10/19/2010 |
| 7803828 | Functionally selective alpha2C adrenoreceptor agonists In its many embodiments, the present invention provides a novel class of indolines as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharma... | 09/28/2010 |
| 7652003 | Macrocyclic β-secretase inhibitors Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, n and X are as defined in the sp... | 01/26/2010 |
| 7250286 | Methods for the in vitro culture of sp. and uses thereof The invention relates to a method of excysting and growing protozoal oocysts by in vitro tissue culture resulting in production of a continuous culture of merozoites. The invention also provides an economical and reliable supply of cultured Eimeria sp. for va... | 07/31/2007 |
| 6667319 | Neuropeptide Y Y5 receptor antagonists The present invention discloses compounds which, are novel receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagoni... | 12/23/2003 |
| 6505126 | Method to identify fungal genes useful as antifungal targets The invention provides methods for identifying nucleic acids and polypeptides derived from fungi that are useful as antifungal targets for diagnosis and/or treatment of fungal diseases. The invention also provides isolated fungal-specific nucleic acids an... | 01/07/2003 |
| 5939419 | 2-benzyl-polycyclic guanine derivatives and process for preparing them Antihypertensive and bronchodilating compounds of the formula or a pharmaceutically acceptable salt thereof, and a process for preparing them are disclosed, wherein: R1, R2, R3, Ra, Rb and Rc as... | 08/17/1999 |
| 5874442 | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease "Novel compounds, such as: ##STR1## are disclosed. Also disclosed are methods for inhibiting the abnormal growth of cells, for inhibiting farnesyl protein transferase and for treating cancers using the novel compounds."... | 02/23/1999 |
| 5767115 | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar1 and Ar2 are aryl or R4 -substituted aryl; Ar3 is aryl or R5 | 06/16/1998 |
| 5691362 | Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists Compounds represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein the variables are as defined in the specification; methods of treating asthma, cough, bronchospasm, inflammatory diseases, and gastrointes... | 11/25/1997 |
| 5686646 | Chiral hydrazine derivatives Disclosed are chiral hydrazine derivatives of the formula (Ia), (Ib), (Ic) and (Id) ##STR1## wherein: R1 and R2 are independently C1 -C10 alkyl; R3 is H or R4 wherein R4 is a hyd... | 11/11/1997 |
| 5382427 | Use of IL-4 to treat solid tumors A method of using IL-4, the use of IL-4 for the manufacture of a medicament and pharmaceutical compositions containing IL-4, for treating solid tumor growth by systemically injecting IL-4, such as hIL-4 or recombinant E. coli--derived IL-4, into mammals a... | 01/17/1995 |
| 4676650 | Inspection device A method and apparatus for lighting a container which is to be inspected for particulate contamination comprising a first lighting means consisting of two angularly displaced light beams which create an angular shadow zone, a second lighting means of sign... | 06/30/1987 |
| 4672078 | Urea stabilized with a lactone in various pharmaceutical and cosmetic preparations A pharmaceutical preparation containing 1 to 50% urea and 0.05 to 30% of a lactone is disclosed. A preferred lactone is gamma-butyrolactone which is preferably present in an amount of about 0.05 to 0.1 part by weight per 1 part by weight of urea. The lact... | 06/09/1987 |
| 4011390 | Semi-synthetic aminocyclitol aminoglycoside antibiotics and methods for the preparation thereof Micromonospora inyoensis strain 1550F-1G NRRL 5742 is incapable of producing antibiotics unless an aminocyclitol is added to the fermentation medium. When such a compound is added, mutamicins are produced, said mutamicins being analogs of known aminoglyco... | 03/08/1977 |